Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7H0_LEIDO

TriTrypDb:

LdBPK_262630.1 , LdCL_260032200 , LDHU3_26.3420

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.590
CLV_C14_Caspase3-7	618	622	PF00656	0.770
CLV_C14_Caspase3-7	628	632	PF00656	0.768
CLV_NRD_NRD_1	188	190	PF00675	0.594
CLV_NRD_NRD_1	199	201	PF00675	0.612
CLV_NRD_NRD_1	256	258	PF00675	0.577
CLV_NRD_NRD_1	313	315	PF00675	0.643
CLV_NRD_NRD_1	327	329	PF00675	0.424
CLV_PCSK_FUR_1	254	258	PF00082	0.551
CLV_PCSK_FUR_1	58	62	PF00082	0.669
CLV_PCSK_KEX2_1	188	190	PF00082	0.594
CLV_PCSK_KEX2_1	256	258	PF00082	0.577
CLV_PCSK_KEX2_1	315	317	PF00082	0.560
CLV_PCSK_KEX2_1	329	331	PF00082	0.499
CLV_PCSK_KEX2_1	39	41	PF00082	0.635
CLV_PCSK_KEX2_1	57	59	PF00082	0.711
CLV_PCSK_KEX2_1	60	62	PF00082	0.699
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.560
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.499
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.635
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.729
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.716
CLV_PCSK_SKI1_1	121	125	PF00082	0.714
CLV_PCSK_SKI1_1	57	61	PF00082	0.746
CLV_PCSK_SKI1_1	99	103	PF00082	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DEG_SCF_FBW7_1	147	154	PF00400	0.678
DEG_SPOP_SBC_1	461	465	PF00917	0.752
DOC_ANK_TNKS_1	313	320	PF00023	0.525
DOC_CYCLIN_RxL_1	96	104	PF00134	0.592
DOC_MAPK_DCC_7	236	244	PF00069	0.596
DOC_MAPK_gen_1	171	180	PF00069	0.625
DOC_PP1_RVXF_1	375	381	PF00149	0.567
DOC_PP2B_LxvP_1	267	270	PF13499	0.668
DOC_USP7_MATH_1	141	145	PF00917	0.726
DOC_USP7_MATH_1	473	477	PF00917	0.727
DOC_USP7_MATH_1	517	521	PF00917	0.661
DOC_USP7_MATH_1	532	536	PF00917	0.703
DOC_USP7_MATH_1	569	573	PF00917	0.799
DOC_USP7_MATH_1	575	579	PF00917	0.803
DOC_USP7_MATH_1	596	600	PF00917	0.730
DOC_USP7_MATH_1	79	83	PF00917	0.678
DOC_WW_Pin1_4	101	106	PF00397	0.737
DOC_WW_Pin1_4	147	152	PF00397	0.739
DOC_WW_Pin1_4	513	518	PF00397	0.759
DOC_WW_Pin1_4	528	533	PF00397	0.695
DOC_WW_Pin1_4	562	567	PF00397	0.825
DOC_WW_Pin1_4	676	681	PF00397	0.777
LIG_14-3-3_CanoR_1	116	121	PF00244	0.698
LIG_14-3-3_CanoR_1	19	28	PF00244	0.576
LIG_14-3-3_CanoR_1	305	313	PF00244	0.577
LIG_14-3-3_CanoR_1	525	532	PF00244	0.734
LIG_Actin_WH2_2	148	165	PF00022	0.534
LIG_Actin_WH2_2	199	214	PF00022	0.611
LIG_Actin_WH2_2	415	430	PF00022	0.464
LIG_APCC_ABBA_1	178	183	PF00400	0.698
LIG_BRCT_BRCA1_1	103	107	PF00533	0.662
LIG_DLG_GKlike_1	116	124	PF00625	0.697
LIG_FHA_1	128	134	PF00498	0.741
LIG_FHA_1	172	178	PF00498	0.703
LIG_FHA_1	384	390	PF00498	0.519
LIG_FHA_1	398	404	PF00498	0.530
LIG_FHA_1	655	661	PF00498	0.804
LIG_FHA_2	281	287	PF00498	0.617
LIG_FHA_2	345	351	PF00498	0.574
LIG_FHA_2	45	51	PF00498	0.752
LIG_FHA_2	453	459	PF00498	0.726
LIG_FHA_2	541	547	PF00498	0.724
LIG_GBD_Chelix_1	274	282	PF00786	0.557
LIG_GBD_Chelix_1	374	382	PF00786	0.641
LIG_LIR_Gen_1	207	216	PF02991	0.553
LIG_LIR_Gen_1	386	395	PF02991	0.552
LIG_LIR_Gen_1	68	78	PF02991	0.783
LIG_LIR_Nem_3	207	211	PF02991	0.561
LIG_LIR_Nem_3	386	390	PF02991	0.566
LIG_LIR_Nem_3	68	73	PF02991	0.770
LIG_PTB_Apo_2	381	388	PF02174	0.558
LIG_SH2_CRK	407	411	PF00017	0.543
LIG_SH2_CRK	645	649	PF00017	0.749
LIG_SH2_GRB2like	645	648	PF00017	0.729
LIG_SH2_NCK_1	407	411	PF00017	0.543
LIG_SH2_STAP1	686	690	PF00017	0.812
LIG_SH2_STAT5	354	357	PF00017	0.560
LIG_SH2_STAT5	425	428	PF00017	0.561
LIG_SH2_STAT5	477	480	PF00017	0.725
LIG_SH3_1	677	683	PF00018	0.685
LIG_SH3_3	135	141	PF00018	0.796
LIG_SH3_3	262	268	PF00018	0.561
LIG_SH3_3	442	448	PF00018	0.658
LIG_SH3_3	563	569	PF00018	0.747
LIG_SH3_3	677	683	PF00018	0.821
LIG_SH3_3	75	81	PF00018	0.667
LIG_SxIP_EBH_1	80	90	PF03271	0.677
LIG_TRAF2_1	544	547	PF00917	0.676
LIG_TRAF2_1	637	640	PF00917	0.721
LIG_UBA3_1	266	272	PF00899	0.672
LIG_WRC_WIRS_1	686	691	PF05994	0.813
MOD_CDK_SPxxK_3	515	522	PF00069	0.632
MOD_CK1_1	397	403	PF00069	0.559
MOD_CK1_1	430	436	PF00069	0.536
MOD_CK1_1	462	468	PF00069	0.767
MOD_CK1_1	531	537	PF00069	0.731
MOD_CK1_1	565	571	PF00069	0.766
MOD_CK1_1	600	606	PF00069	0.760
MOD_CK1_1	654	660	PF00069	0.794
MOD_CK1_1	668	674	PF00069	0.801
MOD_CK1_1	688	694	PF00069	0.555
MOD_CK2_1	125	131	PF00069	0.706
MOD_CK2_1	219	225	PF00069	0.492
MOD_CK2_1	27	33	PF00069	0.616
MOD_CK2_1	280	286	PF00069	0.615
MOD_CK2_1	452	458	PF00069	0.738
MOD_CK2_1	535	541	PF00069	0.780
MOD_CK2_1	553	559	PF00069	0.631
MOD_CK2_1	575	581	PF00069	0.774
MOD_CK2_1	632	638	PF00069	0.732
MOD_CK2_1	695	701	PF00069	0.745
MOD_GlcNHglycan	127	130	PF01048	0.728
MOD_GlcNHglycan	13	16	PF01048	0.661
MOD_GlcNHglycan	133	136	PF01048	0.702
MOD_GlcNHglycan	143	146	PF01048	0.555
MOD_GlcNHglycan	21	24	PF01048	0.666
MOD_GlcNHglycan	396	399	PF01048	0.658
MOD_GlcNHglycan	479	482	PF01048	0.729
MOD_GlcNHglycan	513	516	PF01048	0.823
MOD_GlcNHglycan	519	522	PF01048	0.749
MOD_GlcNHglycan	526	529	PF01048	0.560
MOD_GlcNHglycan	534	537	PF01048	0.823
MOD_GlcNHglycan	553	556	PF01048	0.562
MOD_GlcNHglycan	571	574	PF01048	0.571
MOD_GlcNHglycan	621	624	PF01048	0.675
MOD_GlcNHglycan	651	656	PF01048	0.757
MOD_GlcNHglycan	662	665	PF01048	0.692
MOD_GlcNHglycan	668	671	PF01048	0.831
MOD_GSK3_1	11	18	PF00069	0.671
MOD_GSK3_1	127	134	PF00069	0.686
MOD_GSK3_1	147	154	PF00069	0.746
MOD_GSK3_1	167	174	PF00069	0.644
MOD_GSK3_1	276	283	PF00069	0.684
MOD_GSK3_1	300	307	PF00069	0.617
MOD_GSK3_1	462	469	PF00069	0.780
MOD_GSK3_1	473	480	PF00069	0.665
MOD_GSK3_1	511	518	PF00069	0.839
MOD_GSK3_1	524	531	PF00069	0.809
MOD_GSK3_1	565	572	PF00069	0.756
MOD_GSK3_1	576	583	PF00069	0.821
MOD_GSK3_1	596	603	PF00069	0.595
MOD_GSK3_1	643	650	PF00069	0.737
MOD_GSK3_1	651	658	PF00069	0.751
MOD_GSK3_1	685	692	PF00069	0.690
MOD_N-GLC_1	383	388	PF02516	0.543
MOD_N-GLC_1	655	660	PF02516	0.803
MOD_NEK2_1	133	138	PF00069	0.760
MOD_NEK2_1	226	231	PF00069	0.639
MOD_NEK2_1	378	383	PF00069	0.519
MOD_NEK2_1	660	665	PF00069	0.829
MOD_NEK2_1	685	690	PF00069	0.717
MOD_PIKK_1	219	225	PF00454	0.450
MOD_PIKK_1	300	306	PF00454	0.691
MOD_PIKK_1	491	497	PF00454	0.761
MOD_PKA_2	304	310	PF00069	0.586
MOD_PKA_2	524	530	PF00069	0.772
MOD_PKA_2	79	85	PF00069	0.691
MOD_PKB_1	171	179	PF00069	0.625
MOD_Plk_1	383	389	PF00069	0.564
MOD_Plk_1	655	661	PF00069	0.800
MOD_Plk_4	173	179	PF00069	0.682
MOD_Plk_4	473	479	PF00069	0.727
MOD_Plk_4	685	691	PF00069	0.811
MOD_ProDKin_1	101	107	PF00069	0.739
MOD_ProDKin_1	147	153	PF00069	0.735
MOD_ProDKin_1	513	519	PF00069	0.755
MOD_ProDKin_1	528	534	PF00069	0.696
MOD_ProDKin_1	562	568	PF00069	0.824
MOD_ProDKin_1	676	682	PF00069	0.776
MOD_SUMO_for_1	59	62	PF00179	0.744
TRG_ENDOCYTIC_2	181	184	PF00928	0.592
TRG_ENDOCYTIC_2	407	410	PF00928	0.544
TRG_ENDOCYTIC_2	645	648	PF00928	0.751
TRG_ENDOCYTIC_2	686	689	PF00928	0.710
TRG_ER_diArg_1	187	189	PF00400	0.600
TRG_ER_diArg_1	255	257	PF00400	0.573
TRG_ER_diArg_1	313	316	PF00400	0.521
TRG_NLS_Bipartite_1	314	332	PF00514	0.642
TRG_NLS_Bipartite_1	39	61	PF00514	0.681
TRG_NLS_MonoExtC_3	327	333	PF00514	0.647
TRG_NLS_MonoExtC_3	38	44	PF00514	0.671
TRG_NLS_MonoExtC_3	56	61	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6M7	Leptomonas seymouri	32%	86%
A4HFA4	Leishmania braziliensis	62%	100%
A4I2I1	Leishmania infantum	99%	100%
E9AYP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q8T1	Leishmania major	90%	100%