PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7G6_LEIDO

TriTrypDb:

LdBPK_262010.1 , LdCL_260025700 , LDHU3_26.2640

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7G6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.464
CLV_C14_Caspase3-7	302	306	PF00656	0.694
CLV_C14_Caspase3-7	422	426	PF00656	0.584
CLV_C14_Caspase3-7	433	437	PF00656	0.571
CLV_NRD_NRD_1	130	132	PF00675	0.564
CLV_NRD_NRD_1	147	149	PF00675	0.368
CLV_NRD_NRD_1	157	159	PF00675	0.395
CLV_NRD_NRD_1	450	452	PF00675	0.705
CLV_NRD_NRD_1	464	466	PF00675	0.600
CLV_NRD_NRD_1	473	475	PF00675	0.668
CLV_NRD_NRD_1	476	478	PF00675	0.673
CLV_NRD_NRD_1	554	556	PF00675	0.667
CLV_NRD_NRD_1	558	560	PF00675	0.672
CLV_NRD_NRD_1	569	571	PF00675	0.732
CLV_NRD_NRD_1	573	575	PF00675	0.575
CLV_NRD_NRD_1	634	636	PF00675	0.699
CLV_NRD_NRD_1	653	655	PF00675	0.741
CLV_NRD_NRD_1	663	665	PF00675	0.627
CLV_NRD_NRD_1	698	700	PF00675	0.746
CLV_PCSK_FUR_1	474	478	PF00082	0.632
CLV_PCSK_FUR_1	554	558	PF00082	0.767
CLV_PCSK_KEX2_1	130	132	PF00082	0.564
CLV_PCSK_KEX2_1	147	149	PF00082	0.345
CLV_PCSK_KEX2_1	362	364	PF00082	0.646
CLV_PCSK_KEX2_1	371	373	PF00082	0.481
CLV_PCSK_KEX2_1	450	452	PF00082	0.713
CLV_PCSK_KEX2_1	475	477	PF00082	0.691
CLV_PCSK_KEX2_1	554	556	PF00082	0.695
CLV_PCSK_KEX2_1	557	559	PF00082	0.706
CLV_PCSK_KEX2_1	569	571	PF00082	0.734
CLV_PCSK_KEX2_1	573	575	PF00082	0.572
CLV_PCSK_KEX2_1	634	636	PF00082	0.779
CLV_PCSK_KEX2_1	652	654	PF00082	0.742
CLV_PCSK_KEX2_1	663	665	PF00082	0.618
CLV_PCSK_KEX2_1	697	699	PF00082	0.753
CLV_PCSK_KEX2_1	711	713	PF00082	0.527
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.616
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.427
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.684
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.700
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.601
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.671
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.523
CLV_PCSK_PC7_1	554	560	PF00082	0.682
CLV_PCSK_PC7_1	569	575	PF00082	0.634
CLV_PCSK_SKI1_1	268	272	PF00082	0.630
CLV_PCSK_SKI1_1	372	376	PF00082	0.477
CLV_PCSK_SKI1_1	604	608	PF00082	0.634
CLV_PCSK_SKI1_1	64	68	PF00082	0.406
DEG_SPOP_SBC_1	249	253	PF00917	0.718
DEG_SPOP_SBC_1	692	696	PF00917	0.758
DEG_SPOP_SBC_1	716	720	PF00917	0.638
DOC_CKS1_1	141	146	PF01111	0.495
DOC_MAPK_DCC_7	312	322	PF00069	0.506
DOC_MAPK_gen_1	147	155	PF00069	0.533
DOC_MAPK_gen_1	362	369	PF00069	0.606
DOC_MAPK_gen_1	371	379	PF00069	0.483
DOC_PP2B_LxvP_1	210	213	PF13499	0.540
DOC_PP2B_LxvP_1	46	49	PF13499	0.558
DOC_PP2B_LxvP_1	461	464	PF13499	0.576
DOC_PP2B_LxvP_1	625	628	PF13499	0.564
DOC_PP2B_LxvP_1	689	692	PF13499	0.627
DOC_USP7_MATH_1	132	136	PF00917	0.482
DOC_USP7_MATH_1	199	203	PF00917	0.682
DOC_USP7_MATH_1	206	210	PF00917	0.635
DOC_USP7_MATH_1	235	239	PF00917	0.702
DOC_USP7_MATH_1	249	253	PF00917	0.558
DOC_USP7_MATH_1	269	273	PF00917	0.511
DOC_USP7_MATH_1	288	292	PF00917	0.604
DOC_USP7_MATH_1	496	500	PF00917	0.722
DOC_USP7_MATH_1	540	544	PF00917	0.693
DOC_USP7_MATH_1	579	583	PF00917	0.780
DOC_USP7_MATH_1	680	684	PF00917	0.827
DOC_USP7_MATH_1	693	697	PF00917	0.824
DOC_USP7_MATH_1	704	708	PF00917	0.616
DOC_USP7_MATH_1	717	721	PF00917	0.614
DOC_USP7_UBL2_3	443	447	PF12436	0.690
DOC_USP7_UBL2_3	519	523	PF12436	0.640
DOC_WW_Pin1_4	122	127	PF00397	0.491
DOC_WW_Pin1_4	140	145	PF00397	0.430
DOC_WW_Pin1_4	186	191	PF00397	0.432
DOC_WW_Pin1_4	283	288	PF00397	0.649
DOC_WW_Pin1_4	303	308	PF00397	0.528
DOC_WW_Pin1_4	31	36	PF00397	0.678
DOC_WW_Pin1_4	645	650	PF00397	0.725
DOC_WW_Pin1_4	684	689	PF00397	0.635
DOC_WW_Pin1_4	95	100	PF00397	0.539
LIG_14-3-3_CanoR_1	100	106	PF00244	0.371
LIG_14-3-3_CanoR_1	131	141	PF00244	0.499
LIG_14-3-3_CanoR_1	268	278	PF00244	0.655
LIG_14-3-3_CanoR_1	372	379	PF00244	0.450
LIG_14-3-3_CanoR_1	453	463	PF00244	0.639
LIG_14-3-3_CanoR_1	506	511	PF00244	0.683
LIG_BRCT_BRCA1_1	134	138	PF00533	0.452
LIG_BRCT_BRCA1_1	216	220	PF00533	0.639
LIG_BRCT_BRCA1_1	266	270	PF00533	0.637
LIG_BRCT_BRCA1_1	53	57	PF00533	0.531
LIG_CSL_BTD_1	228	231	PF09270	0.627
LIG_DLG_GKlike_1	506	514	PF00625	0.684
LIG_FAT_LD_1	106	114	PF03623	0.449
LIG_FHA_1	116	122	PF00498	0.525
LIG_FHA_1	162	168	PF00498	0.533
LIG_FHA_1	269	275	PF00498	0.598
LIG_FHA_1	313	319	PF00498	0.648
LIG_FHA_1	456	462	PF00498	0.595
LIG_FHA_1	582	588	PF00498	0.615
LIG_FHA_1	598	604	PF00498	0.661
LIG_FHA_2	300	306	PF00498	0.724
LIG_FHA_2	337	343	PF00498	0.483
LIG_FHA_2	40	46	PF00498	0.709
LIG_FHA_2	416	422	PF00498	0.711
LIG_LIR_Gen_1	161	167	PF02991	0.538
LIG_LIR_Nem_3	135	141	PF02991	0.520
LIG_LIR_Nem_3	161	166	PF02991	0.452
LIG_LIR_Nem_3	227	232	PF02991	0.683
LIG_LIR_Nem_3	54	60	PF02991	0.441
LIG_PCNA_TLS_4	395	402	PF02747	0.572
LIG_PTB_Apo_2	273	280	PF02174	0.701
LIG_PTB_Phospho_1	273	279	PF10480	0.699
LIG_Rb_pABgroove_1	108	116	PF01858	0.381
LIG_SH2_CRK	163	167	PF00017	0.535
LIG_SH2_GRB2like	279	282	PF00017	0.564
LIG_SH2_NCK_1	76	80	PF00017	0.474
LIG_SH2_PTP2	60	63	PF00017	0.403
LIG_SH2_STAP1	163	167	PF00017	0.535
LIG_SH2_STAT5	112	115	PF00017	0.376
LIG_SH2_STAT5	163	166	PF00017	0.460
LIG_SH2_STAT5	19	22	PF00017	0.464
LIG_SH2_STAT5	401	404	PF00017	0.588
LIG_SH2_STAT5	60	63	PF00017	0.399
LIG_SH3_2	624	629	PF14604	0.692
LIG_SH3_3	184	190	PF00018	0.507
LIG_SH3_3	215	221	PF00018	0.655
LIG_SH3_3	225	231	PF00018	0.590
LIG_SH3_3	23	29	PF00018	0.586
LIG_SH3_3	349	355	PF00018	0.525
LIG_SH3_3	621	627	PF00018	0.736
LIG_SH3_3	685	691	PF00018	0.735
LIG_SH3_3	83	89	PF00018	0.660
LIG_SH3_CIN85_PxpxPR_1	624	629	PF14604	0.517
LIG_TRAF2_1	53	56	PF00917	0.511
LIG_TRAF2_1	628	631	PF00917	0.665
LIG_UBA3_1	152	159	PF00899	0.443
LIG_WW_3	462	466	PF00397	0.648
LIG_WW_3	626	630	PF00397	0.629
MOD_CDC14_SPxK_1	125	128	PF00782	0.480
MOD_CDC14_SPxK_1	34	37	PF00782	0.674
MOD_CDK_SPK_2	95	100	PF00069	0.510
MOD_CDK_SPxK_1	122	128	PF00069	0.481
MOD_CDK_SPxK_1	31	37	PF00069	0.671
MOD_CDK_SPxxK_3	140	147	PF00069	0.509
MOD_CDK_SPxxK_3	645	652	PF00069	0.727
MOD_CK1_1	119	125	PF00069	0.566
MOD_CK1_1	233	239	PF00069	0.600
MOD_CK1_1	380	386	PF00069	0.740
MOD_CK1_1	388	394	PF00069	0.653
MOD_CK1_1	409	415	PF00069	0.601
MOD_CK1_1	487	493	PF00069	0.727
MOD_CK1_1	494	500	PF00069	0.663
MOD_CK1_1	50	56	PF00069	0.448
MOD_CK1_1	582	588	PF00069	0.766
MOD_CK1_1	589	595	PF00069	0.674
MOD_CK1_1	596	602	PF00069	0.576
MOD_CK1_1	682	688	PF00069	0.816
MOD_CK1_1	718	724	PF00069	0.785
MOD_CK1_1	98	104	PF00069	0.510
MOD_CK2_1	143	149	PF00069	0.426
MOD_CK2_1	336	342	PF00069	0.481
MOD_CK2_1	388	394	PF00069	0.608
MOD_CK2_1	39	45	PF00069	0.675
MOD_CK2_1	49	55	PF00069	0.475
MOD_CK2_1	574	580	PF00069	0.777
MOD_CK2_1	605	611	PF00069	0.592
MOD_CK2_1	98	104	PF00069	0.510
MOD_Cter_Amidation	360	363	PF01082	0.616
MOD_Cter_Amidation	567	570	PF01082	0.691
MOD_GlcNHglycan	118	121	PF01048	0.406
MOD_GlcNHglycan	134	137	PF01048	0.373
MOD_GlcNHglycan	237	240	PF01048	0.804
MOD_GlcNHglycan	242	245	PF01048	0.709
MOD_GlcNHglycan	271	274	PF01048	0.687
MOD_GlcNHglycan	411	414	PF01048	0.608
MOD_GlcNHglycan	429	432	PF01048	0.513
MOD_GlcNHglycan	490	493	PF01048	0.639
MOD_GlcNHglycan	496	499	PF01048	0.569
MOD_GlcNHglycan	506	509	PF01048	0.506
MOD_GlcNHglycan	526	529	PF01048	0.515
MOD_GlcNHglycan	542	545	PF01048	0.595
MOD_GlcNHglycan	576	579	PF01048	0.652
MOD_GlcNHglycan	592	595	PF01048	0.705
MOD_GlcNHglycan	619	622	PF01048	0.686
MOD_GlcNHglycan	658	661	PF01048	0.818
MOD_GlcNHglycan	671	677	PF01048	0.573
MOD_GlcNHglycan	682	685	PF01048	0.641
MOD_GlcNHglycan	702	705	PF01048	0.669
MOD_GlcNHglycan	706	709	PF01048	0.641
MOD_GSK3_1	115	122	PF00069	0.389
MOD_GSK3_1	161	168	PF00069	0.535
MOD_GSK3_1	260	267	PF00069	0.641
MOD_GSK3_1	290	297	PF00069	0.745
MOD_GSK3_1	299	306	PF00069	0.641
MOD_GSK3_1	308	315	PF00069	0.523
MOD_GSK3_1	377	384	PF00069	0.578
MOD_GSK3_1	385	392	PF00069	0.642
MOD_GSK3_1	47	54	PF00069	0.544
MOD_GSK3_1	480	487	PF00069	0.746
MOD_GSK3_1	490	497	PF00069	0.620
MOD_GSK3_1	498	505	PF00069	0.512
MOD_GSK3_1	579	586	PF00069	0.679
MOD_GSK3_1	588	595	PF00069	0.655
MOD_GSK3_1	612	619	PF00069	0.794
MOD_GSK3_1	634	641	PF00069	0.651
MOD_GSK3_1	678	685	PF00069	0.802
MOD_GSK3_1	700	707	PF00069	0.663
MOD_GSK3_1	715	722	PF00069	0.598
MOD_GSK3_1	95	102	PF00069	0.478
MOD_LATS_1	310	316	PF00433	0.582
MOD_LATS_1	572	578	PF00433	0.623
MOD_N-GLC_1	377	382	PF02516	0.531
MOD_N-GLC_1	416	421	PF02516	0.710
MOD_N-GLC_1	704	709	PF02516	0.768
MOD_N-GLC_2	262	264	PF02516	0.648
MOD_N-GLC_2	368	370	PF02516	0.399
MOD_N-GLC_2	80	82	PF02516	0.486
MOD_NEK2_1	114	119	PF00069	0.468
MOD_NEK2_1	174	179	PF00069	0.432
MOD_NEK2_1	308	313	PF00069	0.549
MOD_NEK2_1	336	341	PF00069	0.437
MOD_NEK2_1	377	382	PF00069	0.531
MOD_NEK2_1	386	391	PF00069	0.622
MOD_NEK2_1	587	592	PF00069	0.732
MOD_NEK2_1	605	610	PF00069	0.588
MOD_PIKK_1	166	172	PF00454	0.475
MOD_PIKK_1	174	180	PF00454	0.393
MOD_PIKK_1	199	205	PF00454	0.674
MOD_PIKK_1	336	342	PF00454	0.445
MOD_PIKK_1	605	611	PF00454	0.615
MOD_PIKK_1	612	618	PF00454	0.637
MOD_PKA_1	574	580	PF00069	0.622
MOD_PKA_1	634	640	PF00069	0.567
MOD_PKA_2	214	220	PF00069	0.581
MOD_PKA_2	386	392	PF00069	0.619
MOD_PKA_2	634	640	PF00069	0.583
MOD_PKA_2	99	105	PF00069	0.410
MOD_Plk_1	206	212	PF00069	0.629
MOD_Plk_1	406	412	PF00069	0.599
MOD_Plk_1	582	588	PF00069	0.621
MOD_Plk_1	672	678	PF00069	0.588
MOD_Plk_4	161	167	PF00069	0.538
MOD_Plk_4	214	220	PF00069	0.584
MOD_Plk_4	224	230	PF00069	0.591
MOD_ProDKin_1	122	128	PF00069	0.496
MOD_ProDKin_1	140	146	PF00069	0.431
MOD_ProDKin_1	186	192	PF00069	0.436
MOD_ProDKin_1	283	289	PF00069	0.650
MOD_ProDKin_1	303	309	PF00069	0.530
MOD_ProDKin_1	31	37	PF00069	0.680
MOD_ProDKin_1	645	651	PF00069	0.726
MOD_ProDKin_1	684	690	PF00069	0.636
MOD_ProDKin_1	95	101	PF00069	0.523
TRG_DiLeu_BaEn_4	672	678	PF01217	0.700
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.435
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.647
TRG_ENDOCYTIC_2	163	166	PF00928	0.451
TRG_ER_diArg_1	130	132	PF00400	0.510
TRG_ER_diArg_1	450	453	PF00400	0.581
TRG_ER_diArg_1	474	477	PF00400	0.635
TRG_ER_diArg_1	554	557	PF00400	0.674
TRG_ER_diArg_1	558	561	PF00400	0.677
TRG_ER_diArg_1	634	636	PF00400	0.741
TRG_ER_diArg_1	652	654	PF00400	0.693
TRG_ER_diArg_1	662	664	PF00400	0.600
TRG_NLS_Bipartite_1	465	479	PF00514	0.631
TRG_NLS_Bipartite_1	555	577	PF00514	0.714
TRG_NLS_Bipartite_1	697	715	PF00514	0.641
TRG_NLS_MonoCore_2	473	478	PF00514	0.631
TRG_NLS_MonoCore_2	554	559	PF00514	0.745
TRG_NLS_MonoCore_2	572	577	PF00514	0.528
TRG_NLS_MonoExtC_3	473	478	PF00514	0.604
TRG_NLS_MonoExtC_3	554	559	PF00514	0.745
TRG_NLS_MonoExtN_4	472	479	PF00514	0.698
TRG_NLS_MonoExtN_4	554	560	PF00514	0.760
TRG_NLS_MonoExtN_4	570	577	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I226	Leptomonas seymouri	40%	100%
A4HF45	Leishmania braziliensis	63%	100%
A4I2C9	Leishmania infantum	99%	100%
E9AYI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8Z1	Leishmania major	86%	100%