LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7G5_LEIDO
TriTrypDb:
LdBPK_261830.1 * , LdCL_260023900 , LDHU3_26.2400
Length:
874

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7G5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7G5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 327 331 PF00656 0.602
CLV_C14_Caspase3-7 770 774 PF00656 0.565
CLV_NRD_NRD_1 213 215 PF00675 0.540
CLV_NRD_NRD_1 251 253 PF00675 0.594
CLV_NRD_NRD_1 261 263 PF00675 0.514
CLV_NRD_NRD_1 311 313 PF00675 0.501
CLV_NRD_NRD_1 33 35 PF00675 0.605
CLV_NRD_NRD_1 339 341 PF00675 0.607
CLV_NRD_NRD_1 351 353 PF00675 0.565
CLV_NRD_NRD_1 412 414 PF00675 0.654
CLV_NRD_NRD_1 441 443 PF00675 0.580
CLV_NRD_NRD_1 788 790 PF00675 0.580
CLV_NRD_NRD_1 839 841 PF00675 0.648
CLV_NRD_NRD_1 860 862 PF00675 0.468
CLV_PCSK_FUR_1 248 252 PF00082 0.526
CLV_PCSK_FUR_1 269 273 PF00082 0.569
CLV_PCSK_FUR_1 837 841 PF00082 0.610
CLV_PCSK_FUR_1 858 862 PF00082 0.537
CLV_PCSK_KEX2_1 213 215 PF00082 0.540
CLV_PCSK_KEX2_1 250 252 PF00082 0.599
CLV_PCSK_KEX2_1 261 263 PF00082 0.510
CLV_PCSK_KEX2_1 271 273 PF00082 0.531
CLV_PCSK_KEX2_1 313 315 PF00082 0.503
CLV_PCSK_KEX2_1 32 34 PF00082 0.603
CLV_PCSK_KEX2_1 339 341 PF00082 0.607
CLV_PCSK_KEX2_1 351 353 PF00082 0.565
CLV_PCSK_KEX2_1 412 414 PF00082 0.654
CLV_PCSK_KEX2_1 441 443 PF00082 0.580
CLV_PCSK_KEX2_1 788 790 PF00082 0.580
CLV_PCSK_KEX2_1 839 841 PF00082 0.651
CLV_PCSK_KEX2_1 860 862 PF00082 0.482
CLV_PCSK_PC1ET2_1 271 273 PF00082 0.580
CLV_PCSK_PC1ET2_1 313 315 PF00082 0.469
CLV_PCSK_PC7_1 267 273 PF00082 0.528
CLV_PCSK_SKI1_1 208 212 PF00082 0.591
CLV_PCSK_SKI1_1 27 31 PF00082 0.601
DEG_Nend_Nbox_1 1 3 PF02207 0.574
DEG_SCF_FBW7_2 512 517 PF00400 0.587
DEG_SPOP_SBC_1 117 121 PF00917 0.535
DEG_SPOP_SBC_1 401 405 PF00917 0.645
DEG_SPOP_SBC_1 496 500 PF00917 0.578
DEG_SPOP_SBC_1 809 813 PF00917 0.576
DOC_ANK_TNKS_1 620 627 PF00023 0.605
DOC_CDC14_PxL_1 158 166 PF14671 0.542
DOC_CDC14_PxL_1 168 176 PF14671 0.534
DOC_CKS1_1 715 720 PF01111 0.648
DOC_PP2B_LxvP_1 128 131 PF13499 0.575
DOC_PP2B_LxvP_1 218 221 PF13499 0.608
DOC_PP2B_LxvP_1 588 591 PF13499 0.623
DOC_PP4_FxxP_1 806 809 PF00568 0.636
DOC_SPAK_OSR1_1 206 210 PF12202 0.549
DOC_USP7_MATH_1 110 114 PF00917 0.589
DOC_USP7_MATH_1 152 156 PF00917 0.554
DOC_USP7_MATH_1 173 177 PF00917 0.548
DOC_USP7_MATH_1 222 226 PF00917 0.639
DOC_USP7_MATH_1 279 283 PF00917 0.594
DOC_USP7_MATH_1 290 294 PF00917 0.548
DOC_USP7_MATH_1 325 329 PF00917 0.599
DOC_USP7_MATH_1 360 364 PF00917 0.635
DOC_USP7_MATH_1 38 42 PF00917 0.590
DOC_USP7_MATH_1 402 406 PF00917 0.644
DOC_USP7_MATH_1 44 48 PF00917 0.601
DOC_USP7_MATH_1 453 457 PF00917 0.537
DOC_USP7_MATH_1 496 500 PF00917 0.618
DOC_USP7_MATH_1 58 62 PF00917 0.518
DOC_USP7_MATH_1 732 736 PF00917 0.625
DOC_USP7_MATH_1 762 766 PF00917 0.645
DOC_USP7_MATH_1 810 814 PF00917 0.595
DOC_USP7_UBL2_3 313 317 PF12436 0.465
DOC_WW_Pin1_4 122 127 PF00397 0.588
DOC_WW_Pin1_4 174 179 PF00397 0.558
DOC_WW_Pin1_4 213 218 PF00397 0.569
DOC_WW_Pin1_4 227 232 PF00397 0.581
DOC_WW_Pin1_4 388 393 PF00397 0.671
DOC_WW_Pin1_4 492 497 PF00397 0.596
DOC_WW_Pin1_4 510 515 PF00397 0.515
DOC_WW_Pin1_4 576 581 PF00397 0.634
DOC_WW_Pin1_4 592 597 PF00397 0.511
DOC_WW_Pin1_4 641 646 PF00397 0.621
DOC_WW_Pin1_4 711 716 PF00397 0.637
DOC_WW_Pin1_4 72 77 PF00397 0.585
DOC_WW_Pin1_4 742 747 PF00397 0.570
DOC_WW_Pin1_4 755 760 PF00397 0.525
DOC_WW_Pin1_4 799 804 PF00397 0.589
LIG_14-3-3_CanoR_1 166 175 PF00244 0.563
LIG_14-3-3_CanoR_1 251 257 PF00244 0.593
LIG_14-3-3_CanoR_1 385 390 PF00244 0.588
LIG_14-3-3_CanoR_1 464 470 PF00244 0.544
LIG_14-3-3_CanoR_1 681 689 PF00244 0.619
LIG_14-3-3_CanoR_1 692 701 PF00244 0.540
LIG_14-3-3_CanoR_1 71 76 PF00244 0.585
LIG_14-3-3_CanoR_1 748 757 PF00244 0.588
LIG_14-3-3_CanoR_1 777 787 PF00244 0.567
LIG_14-3-3_CanoR_1 839 849 PF00244 0.587
LIG_Actin_RPEL_3 604 623 PF02755 0.530
LIG_Actin_WH2_2 542 558 PF00022 0.583
LIG_BRCT_BRCA1_1 203 207 PF00533 0.619
LIG_BRCT_BRCA1_1 594 598 PF00533 0.571
LIG_BRCT_BRCA1_1 801 805 PF00533 0.603
LIG_CSL_BTD_1 588 591 PF09270 0.623
LIG_deltaCOP1_diTrp_1 320 324 PF00928 0.565
LIG_EVH1_1 179 183 PF00568 0.574
LIG_EVH1_1 218 222 PF00568 0.613
LIG_EVH1_1 79 83 PF00568 0.528
LIG_FHA_1 118 124 PF00498 0.568
LIG_FHA_1 149 155 PF00498 0.596
LIG_FHA_1 385 391 PF00498 0.791
LIG_FHA_1 43 49 PF00498 0.555
LIG_FHA_1 430 436 PF00498 0.549
LIG_FHA_1 449 455 PF00498 0.518
LIG_FHA_1 480 486 PF00498 0.593
LIG_FHA_1 496 502 PF00498 0.498
LIG_FHA_1 530 536 PF00498 0.773
LIG_FHA_1 573 579 PF00498 0.551
LIG_FHA_1 91 97 PF00498 0.571
LIG_FHA_2 102 108 PF00498 0.572
LIG_FHA_2 117 123 PF00498 0.552
LIG_FHA_2 642 648 PF00498 0.607
LIG_HOMEOBOX 720 723 PF00046 0.622
LIG_LIR_Nem_3 204 210 PF02991 0.621
LIG_LIR_Nem_3 299 304 PF02991 0.557
LIG_LIR_Nem_3 599 604 PF02991 0.737
LIG_LIR_Nem_3 802 808 PF02991 0.604
LIG_SH2_CRK 301 305 PF00017 0.548
LIG_SH2_CRK 615 619 PF00017 0.587
LIG_SH2_NCK_1 168 172 PF00017 0.530
LIG_SH2_NCK_1 301 305 PF00017 0.548
LIG_SH2_STAP1 780 784 PF00017 0.619
LIG_SH2_STAT3 780 783 PF00017 0.651
LIG_SH2_STAT3 794 797 PF00017 0.593
LIG_SH2_STAT5 336 339 PF00017 0.752
LIG_SH2_STAT5 539 542 PF00017 0.573
LIG_SH3_1 214 220 PF00018 0.583
LIG_SH3_1 32 38 PF00018 0.597
LIG_SH3_1 712 718 PF00018 0.645
LIG_SH3_2 22 27 PF14604 0.544
LIG_SH3_3 111 117 PF00018 0.565
LIG_SH3_3 169 175 PF00018 0.594
LIG_SH3_3 177 183 PF00018 0.545
LIG_SH3_3 19 25 PF00018 0.530
LIG_SH3_3 214 220 PF00018 0.614
LIG_SH3_3 32 38 PF00018 0.556
LIG_SH3_3 366 372 PF00018 0.628
LIG_SH3_3 386 392 PF00018 0.652
LIG_SH3_3 396 402 PF00018 0.608
LIG_SH3_3 459 465 PF00018 0.601
LIG_SH3_3 498 504 PF00018 0.578
LIG_SH3_3 566 572 PF00018 0.617
LIG_SH3_3 619 625 PF00018 0.602
LIG_SH3_3 642 648 PF00018 0.583
LIG_SH3_3 712 718 PF00018 0.642
LIG_SH3_3 75 81 PF00018 0.578
LIG_SH3_3 793 799 PF00018 0.634
LIG_SUMO_SIM_par_1 574 579 PF11976 0.551
LIG_TRAF2_1 292 295 PF00917 0.615
LIG_TRAF2_1 644 647 PF00917 0.541
LIG_TRFH_1 806 810 PF08558 0.543
LIG_WRC_WIRS_1 454 459 PF05994 0.524
LIG_WRC_WIRS_1 466 471 PF05994 0.520
LIG_WW_2 172 175 PF00397 0.518
LIG_WW_2 221 224 PF00397 0.597
LIG_WW_3 785 789 PF00397 0.616
LIG_WW_3 847 851 PF00397 0.630
MOD_CDC14_SPxK_1 745 748 PF00782 0.535
MOD_CDK_SPxK_1 596 602 PF00069 0.542
MOD_CDK_SPxK_1 742 748 PF00069 0.541
MOD_CK1_1 157 163 PF00069 0.516
MOD_CK1_1 200 206 PF00069 0.604
MOD_CK1_1 226 232 PF00069 0.604
MOD_CK1_1 283 289 PF00069 0.625
MOD_CK1_1 323 329 PF00069 0.613
MOD_CK1_1 393 399 PF00069 0.637
MOD_CK1_1 403 409 PF00069 0.568
MOD_CK1_1 495 501 PF00069 0.589
MOD_CK1_1 529 535 PF00069 0.535
MOD_CK1_1 61 67 PF00069 0.623
MOD_CK1_1 676 682 PF00069 0.579
MOD_CK1_1 683 689 PF00069 0.606
MOD_CK1_1 714 720 PF00069 0.628
MOD_CK1_1 74 80 PF00069 0.551
MOD_CK1_1 813 819 PF00069 0.645
MOD_CK2_1 101 107 PF00069 0.563
MOD_CK2_1 289 295 PF00069 0.652
MOD_CK2_1 64 70 PF00069 0.599
MOD_CK2_1 641 647 PF00069 0.580
MOD_CMANNOS 321 324 PF00535 0.542
MOD_GlcNHglycan 154 157 PF01048 0.544
MOD_GlcNHglycan 159 162 PF01048 0.510
MOD_GlcNHglycan 168 171 PF01048 0.520
MOD_GlcNHglycan 199 202 PF01048 0.590
MOD_GlcNHglycan 381 384 PF01048 0.630
MOD_GlcNHglycan 457 460 PF01048 0.588
MOD_GlcNHglycan 470 473 PF01048 0.535
MOD_GlcNHglycan 54 57 PF01048 0.581
MOD_GlcNHglycan 540 543 PF01048 0.579
MOD_GlcNHglycan 63 66 PF01048 0.549
MOD_GlcNHglycan 653 656 PF01048 0.647
MOD_GlcNHglycan 685 688 PF01048 0.617
MOD_GlcNHglycan 734 737 PF01048 0.616
MOD_GlcNHglycan 780 783 PF01048 0.625
MOD_GlcNHglycan 815 818 PF01048 0.616
MOD_GSK3_1 117 124 PF00069 0.587
MOD_GSK3_1 148 155 PF00069 0.547
MOD_GSK3_1 162 169 PF00069 0.552
MOD_GSK3_1 174 181 PF00069 0.578
MOD_GSK3_1 192 199 PF00069 0.556
MOD_GSK3_1 222 229 PF00069 0.642
MOD_GSK3_1 252 259 PF00069 0.554
MOD_GSK3_1 279 286 PF00069 0.590
MOD_GSK3_1 320 327 PF00069 0.611
MOD_GSK3_1 38 45 PF00069 0.625
MOD_GSK3_1 381 388 PF00069 0.745
MOD_GSK3_1 390 397 PF00069 0.755
MOD_GSK3_1 403 410 PF00069 0.661
MOD_GSK3_1 441 448 PF00069 0.565
MOD_GSK3_1 492 499 PF00069 0.745
MOD_GSK3_1 52 59 PF00069 0.543
MOD_GSK3_1 572 579 PF00069 0.650
MOD_GSK3_1 592 599 PF00069 0.600
MOD_GSK3_1 60 67 PF00069 0.595
MOD_GSK3_1 646 653 PF00069 0.699
MOD_GSK3_1 673 680 PF00069 0.571
MOD_GSK3_1 688 695 PF00069 0.584
MOD_GSK3_1 710 717 PF00069 0.569
MOD_GSK3_1 809 816 PF00069 0.609
MOD_N-GLC_1 330 335 PF02516 0.565
MOD_N-GLC_1 393 398 PF02516 0.623
MOD_N-GLC_1 852 857 PF02516 0.575
MOD_NEK2_1 2 7 PF00069 0.529
MOD_NEK2_1 256 261 PF00069 0.546
MOD_NEK2_1 497 502 PF00069 0.552
MOD_NEK2_1 633 638 PF00069 0.696
MOD_NEK2_1 704 709 PF00069 0.629
MOD_NEK2_1 763 768 PF00069 0.610
MOD_NEK2_2 436 441 PF00069 0.620
MOD_PIKK_1 341 347 PF00454 0.629
MOD_PIKK_1 524 530 PF00454 0.617
MOD_PIKK_1 58 64 PF00454 0.617
MOD_PIKK_1 704 710 PF00454 0.565
MOD_PKA_1 33 39 PF00069 0.541
MOD_PKA_1 441 447 PF00069 0.566
MOD_PKA_2 2 8 PF00069 0.520
MOD_PKA_2 257 263 PF00069 0.540
MOD_PKA_2 283 289 PF00069 0.592
MOD_PKA_2 33 39 PF00069 0.569
MOD_PKA_2 384 390 PF00069 0.587
MOD_PKA_2 441 447 PF00069 0.593
MOD_PKA_2 680 686 PF00069 0.627
MOD_PKA_2 833 839 PF00069 0.670
MOD_PKA_2 866 872 PF00069 0.555
MOD_PKB_1 250 258 PF00069 0.565
MOD_Plk_1 360 366 PF00069 0.631
MOD_Plk_4 101 107 PF00069 0.563
MOD_Plk_4 385 391 PF00069 0.773
MOD_Plk_4 558 564 PF00069 0.766
MOD_Plk_4 646 652 PF00069 0.692
MOD_Plk_4 74 80 PF00069 0.573
MOD_Plk_4 810 816 PF00069 0.581
MOD_ProDKin_1 122 128 PF00069 0.588
MOD_ProDKin_1 174 180 PF00069 0.559
MOD_ProDKin_1 213 219 PF00069 0.564
MOD_ProDKin_1 227 233 PF00069 0.574
MOD_ProDKin_1 388 394 PF00069 0.672
MOD_ProDKin_1 492 498 PF00069 0.597
MOD_ProDKin_1 510 516 PF00069 0.516
MOD_ProDKin_1 576 582 PF00069 0.634
MOD_ProDKin_1 592 598 PF00069 0.512
MOD_ProDKin_1 641 647 PF00069 0.621
MOD_ProDKin_1 711 717 PF00069 0.638
MOD_ProDKin_1 72 78 PF00069 0.587
MOD_ProDKin_1 742 748 PF00069 0.570
MOD_ProDKin_1 755 761 PF00069 0.528
MOD_ProDKin_1 799 805 PF00069 0.590
MOD_SUMO_rev_2 240 247 PF00179 0.575
TRG_DiLeu_BaEn_1 647 652 PF01217 0.543
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.554
TRG_DiLeu_BaLyEn_6 24 29 PF01217 0.585
TRG_ENDOCYTIC_2 301 304 PF00928 0.553
TRG_ER_diArg_1 247 250 PF00400 0.551
TRG_ER_diArg_1 261 264 PF00400 0.517
TRG_ER_diArg_1 266 269 PF00400 0.491
TRG_ER_diArg_1 272 275 PF00400 0.567
TRG_ER_diArg_1 312 315 PF00400 0.535
TRG_ER_diArg_1 32 34 PF00400 0.603
TRG_ER_diArg_1 351 353 PF00400 0.653
TRG_ER_diArg_1 356 359 PF00400 0.631
TRG_ER_diArg_1 440 442 PF00400 0.581
TRG_ER_diArg_1 637 640 PF00400 0.587
TRG_ER_diArg_1 775 778 PF00400 0.560
TRG_ER_diArg_1 787 789 PF00400 0.541
TRG_ER_diArg_1 837 840 PF00400 0.676
TRG_ER_diArg_1 858 861 PF00400 0.505
TRG_NLS_Bipartite_1 261 275 PF00514 0.507
TRG_NLS_MonoExtN_4 269 275 PF00514 0.576
TRG_Pf-PMV_PEXEL_1 602 607 PF00026 0.551

Homologs

Protein Taxonomy Sequence identity Coverage
A4I2B6 Leishmania infantum 100% 100%
E9AIS3 Leishmania braziliensis 58% 98%
E9AYG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q909 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS