LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H7G3_LEIDO
TriTrypDb:
LdBPK_261470.1 , LdCL_260020300 , LDHU3_26.1820
Length:
655

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 8
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A0A3S5H7G3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7G3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 410 414 PF00656 0.597
CLV_NRD_NRD_1 180 182 PF00675 0.672
CLV_NRD_NRD_1 194 196 PF00675 0.520
CLV_NRD_NRD_1 305 307 PF00675 0.499
CLV_NRD_NRD_1 395 397 PF00675 0.558
CLV_NRD_NRD_1 431 433 PF00675 0.585
CLV_NRD_NRD_1 593 595 PF00675 0.664
CLV_NRD_NRD_1 63 65 PF00675 0.701
CLV_PCSK_KEX2_1 180 182 PF00082 0.672
CLV_PCSK_KEX2_1 194 196 PF00082 0.520
CLV_PCSK_KEX2_1 305 307 PF00082 0.499
CLV_PCSK_KEX2_1 395 397 PF00082 0.582
CLV_PCSK_KEX2_1 431 433 PF00082 0.556
CLV_PCSK_KEX2_1 592 594 PF00082 0.631
CLV_PCSK_KEX2_1 63 65 PF00082 0.698
CLV_PCSK_PC1ET2_1 592 594 PF00082 0.597
CLV_PCSK_PC7_1 176 182 PF00082 0.498
CLV_PCSK_SKI1_1 147 151 PF00082 0.601
CLV_PCSK_SKI1_1 210 214 PF00082 0.752
CLV_PCSK_SKI1_1 366 370 PF00082 0.511
CLV_PCSK_SKI1_1 378 382 PF00082 0.469
CLV_PCSK_SKI1_1 477 481 PF00082 0.639
CLV_PCSK_SKI1_1 64 68 PF00082 0.636
DEG_APCC_DBOX_1 194 202 PF00400 0.358
DEG_APCC_DBOX_1 363 371 PF00400 0.280
DEG_APCC_DBOX_1 431 439 PF00400 0.326
DEG_Nend_UBRbox_1 1 4 PF02207 0.677
DOC_ANK_TNKS_1 179 186 PF00023 0.318
DOC_CYCLIN_yCln2_LP_2 22 25 PF00134 0.540
DOC_CYCLIN_yCln2_LP_2 427 430 PF00134 0.297
DOC_MAPK_gen_1 364 371 PF00069 0.283
DOC_MAPK_gen_1 372 382 PF00069 0.262
DOC_MAPK_gen_1 395 404 PF00069 0.447
DOC_MAPK_gen_1 431 438 PF00069 0.329
DOC_MAPK_gen_1 520 527 PF00069 0.329
DOC_MAPK_MEF2A_6 109 118 PF00069 0.294
DOC_MAPK_MEF2A_6 364 371 PF00069 0.299
DOC_MAPK_MEF2A_6 520 527 PF00069 0.296
DOC_MAPK_MEF2A_6 532 540 PF00069 0.369
DOC_MAPK_MEF2A_6 615 624 PF00069 0.348
DOC_MAPK_NFAT4_5 364 372 PF00069 0.300
DOC_PP2B_LxvP_1 21 24 PF13499 0.575
DOC_PP2B_LxvP_1 427 430 PF13499 0.392
DOC_USP7_MATH_1 136 140 PF00917 0.367
DOC_USP7_MATH_1 183 187 PF00917 0.405
DOC_USP7_MATH_1 362 366 PF00917 0.281
DOC_USP7_MATH_1 430 434 PF00917 0.378
DOC_USP7_MATH_1 604 608 PF00917 0.381
DOC_WW_Pin1_4 214 219 PF00397 0.492
DOC_WW_Pin1_4 322 327 PF00397 0.422
DOC_WW_Pin1_4 339 344 PF00397 0.340
DOC_WW_Pin1_4 416 421 PF00397 0.495
DOC_WW_Pin1_4 44 49 PF00397 0.245
LIG_14-3-3_CanoR_1 251 257 PF00244 0.426
LIG_14-3-3_CanoR_1 266 273 PF00244 0.289
LIG_14-3-3_CanoR_1 313 319 PF00244 0.341
LIG_14-3-3_CanoR_1 431 436 PF00244 0.358
LIG_14-3-3_CanoR_1 483 488 PF00244 0.411
LIG_14-3-3_CanoR_1 522 528 PF00244 0.356
LIG_14-3-3_CanoR_1 63 73 PF00244 0.407
LIG_APCC_ABBA_1 579 584 PF00400 0.341
LIG_BIR_III_4 211 215 PF00653 0.406
LIG_BIR_III_4 328 332 PF00653 0.343
LIG_BRCT_BRCA1_1 32 36 PF00533 0.296
LIG_CaM_NSCaTE_8 88 95 PF13499 0.288
LIG_Clathr_ClatBox_1 537 541 PF01394 0.378
LIG_CtBP_PxDLS_1 257 261 PF00389 0.365
LIG_FHA_1 110 116 PF00498 0.374
LIG_FHA_1 243 249 PF00498 0.350
LIG_FHA_1 406 412 PF00498 0.465
LIG_FHA_1 442 448 PF00498 0.376
LIG_FHA_1 491 497 PF00498 0.361
LIG_FHA_1 519 525 PF00498 0.351
LIG_FHA_1 65 71 PF00498 0.393
LIG_FHA_1 7 13 PF00498 0.666
LIG_FHA_2 408 414 PF00498 0.592
LIG_FHA_2 444 450 PF00498 0.434
LIG_FHA_2 483 489 PF00498 0.413
LIG_HP1_1 536 540 PF01393 0.251
LIG_LIR_Apic_2 317 321 PF02991 0.310
LIG_LIR_Gen_1 342 348 PF02991 0.343
LIG_LIR_Gen_1 377 386 PF02991 0.401
LIG_LIR_Gen_1 559 570 PF02991 0.279
LIG_LIR_Nem_3 143 149 PF02991 0.388
LIG_LIR_Nem_3 152 158 PF02991 0.237
LIG_LIR_Nem_3 223 227 PF02991 0.329
LIG_LIR_Nem_3 342 347 PF02991 0.302
LIG_LIR_Nem_3 355 360 PF02991 0.286
LIG_LIR_Nem_3 377 382 PF02991 0.396
LIG_LIR_Nem_3 488 494 PF02991 0.314
LIG_LIR_Nem_3 559 565 PF02991 0.283
LIG_LYPXL_yS_3 588 591 PF13949 0.365
LIG_NRBOX 366 372 PF00104 0.287
LIG_PTB_Apo_2 117 124 PF02174 0.337
LIG_PTB_Phospho_1 117 123 PF10480 0.337
LIG_RPA_C_Fungi 58 70 PF08784 0.394
LIG_SH2_CRK 146 150 PF00017 0.454
LIG_SH2_CRK 562 566 PF00017 0.344
LIG_SH2_NCK_1 123 127 PF00017 0.391
LIG_SH2_NCK_1 582 586 PF00017 0.448
LIG_SH2_SRC 123 126 PF00017 0.329
LIG_SH2_STAT5 197 200 PF00017 0.442
LIG_SH2_STAT5 318 321 PF00017 0.446
LIG_SH3_1 417 423 PF00018 0.619
LIG_SH3_3 401 407 PF00018 0.684
LIG_SH3_3 417 423 PF00018 0.495
LIG_SUMO_SIM_anti_2 365 371 PF11976 0.422
LIG_SUMO_SIM_par_1 205 211 PF11976 0.569
LIG_SUMO_SIM_par_1 244 249 PF11976 0.380
LIG_SUMO_SIM_par_1 433 441 PF11976 0.412
LIG_SUMO_SIM_par_1 523 529 PF11976 0.325
LIG_SUMO_SIM_par_1 536 541 PF11976 0.425
LIG_TRAF2_1 267 270 PF00917 0.380
LIG_TRAF2_1 513 516 PF00917 0.512
LIG_TRAF2_1 554 557 PF00917 0.487
LIG_TYR_ITIM 634 639 PF00017 0.498
LIG_UBA3_1 367 375 PF00899 0.329
LIG_WRC_WIRS_1 221 226 PF05994 0.384
LIG_WW_3 428 432 PF00397 0.385
MOD_CK1_1 242 248 PF00069 0.390
MOD_CK1_1 268 274 PF00069 0.607
MOD_CK1_1 30 36 PF00069 0.304
MOD_CK1_1 4 10 PF00069 0.667
MOD_CK1_1 441 447 PF00069 0.392
MOD_CK1_1 546 552 PF00069 0.456
MOD_CK1_1 57 63 PF00069 0.590
MOD_CK1_1 91 97 PF00069 0.348
MOD_CK2_1 264 270 PF00069 0.402
MOD_CK2_1 431 437 PF00069 0.563
MOD_CK2_1 443 449 PF00069 0.450
MOD_CK2_1 460 466 PF00069 0.550
MOD_CK2_1 482 488 PF00069 0.528
MOD_CK2_1 510 516 PF00069 0.612
MOD_Cter_Amidation 178 181 PF01082 0.360
MOD_Cter_Amidation 303 306 PF01082 0.343
MOD_GlcNHglycan 14 17 PF01048 0.666
MOD_GlcNHglycan 169 172 PF01048 0.422
MOD_GlcNHglycan 382 385 PF01048 0.284
MOD_GlcNHglycan 440 443 PF01048 0.393
MOD_GlcNHglycan 606 609 PF01048 0.586
MOD_GlcNHglycan 93 96 PF01048 0.410
MOD_GSK3_1 105 112 PF00069 0.475
MOD_GSK3_1 183 190 PF00069 0.578
MOD_GSK3_1 210 217 PF00069 0.500
MOD_GSK3_1 264 271 PF00069 0.435
MOD_GSK3_1 335 342 PF00069 0.323
MOD_GSK3_1 405 412 PF00069 0.653
MOD_GSK3_1 418 425 PF00069 0.532
MOD_GSK3_1 437 444 PF00069 0.375
MOD_GSK3_1 468 475 PF00069 0.674
MOD_GSK3_1 479 486 PF00069 0.531
MOD_GSK3_1 64 71 PF00069 0.438
MOD_GSK3_1 79 86 PF00069 0.515
MOD_GSK3_1 87 94 PF00069 0.456
MOD_N-GLC_1 105 110 PF02516 0.474
MOD_N-GLC_1 483 488 PF02516 0.393
MOD_NEK2_1 1 6 PF00069 0.531
MOD_NEK2_1 149 154 PF00069 0.353
MOD_NEK2_1 239 244 PF00069 0.436
MOD_NEK2_1 27 32 PF00069 0.326
MOD_NEK2_1 275 280 PF00069 0.568
MOD_NEK2_1 311 316 PF00069 0.440
MOD_NEK2_1 411 416 PF00069 0.654
MOD_NEK2_1 443 448 PF00069 0.419
MOD_NEK2_1 460 465 PF00069 0.615
MOD_NEK2_1 479 484 PF00069 0.531
MOD_NEK2_1 518 523 PF00069 0.429
MOD_NEK2_1 87 92 PF00069 0.427
MOD_PIKK_1 249 255 PF00454 0.499
MOD_PIKK_1 472 478 PF00454 0.468
MOD_PIKK_1 54 60 PF00454 0.665
MOD_PKA_1 395 401 PF00069 0.401
MOD_PKA_1 431 437 PF00069 0.371
MOD_PKA_2 136 142 PF00069 0.394
MOD_PKA_2 265 271 PF00069 0.521
MOD_PKA_2 275 281 PF00069 0.595
MOD_PKA_2 395 401 PF00069 0.527
MOD_PKA_2 430 436 PF00069 0.438
MOD_PKA_2 482 488 PF00069 0.527
MOD_PKA_2 79 85 PF00069 0.536
MOD_Plk_1 150 156 PF00069 0.350
MOD_Plk_1 311 317 PF00069 0.475
MOD_Plk_1 483 489 PF00069 0.388
MOD_Plk_1 540 546 PF00069 0.426
MOD_Plk_1 83 89 PF00069 0.421
MOD_Plk_4 150 156 PF00069 0.350
MOD_Plk_4 30 36 PF00069 0.426
MOD_Plk_4 314 320 PF00069 0.402
MOD_Plk_4 335 341 PF00069 0.285
MOD_Plk_4 431 437 PF00069 0.463
MOD_Plk_4 83 89 PF00069 0.391
MOD_ProDKin_1 214 220 PF00069 0.615
MOD_ProDKin_1 322 328 PF00069 0.521
MOD_ProDKin_1 339 345 PF00069 0.415
MOD_ProDKin_1 416 422 PF00069 0.615
MOD_ProDKin_1 44 50 PF00069 0.245
MOD_SUMO_rev_2 139 149 PF00179 0.476
MOD_SUMO_rev_2 463 471 PF00179 0.490
TRG_DiLeu_BaEn_2 376 382 PF01217 0.394
TRG_DiLeu_BaLyEn_6 363 368 PF01217 0.402
TRG_ENDOCYTIC_2 123 126 PF00928 0.375
TRG_ENDOCYTIC_2 146 149 PF00928 0.455
TRG_ENDOCYTIC_2 155 158 PF00928 0.350
TRG_ENDOCYTIC_2 562 565 PF00928 0.338
TRG_ENDOCYTIC_2 588 591 PF00928 0.644
TRG_ENDOCYTIC_2 636 639 PF00928 0.503
TRG_ER_diArg_1 193 195 PF00400 0.451
TRG_ER_diArg_1 273 276 PF00400 0.455
TRG_ER_diArg_1 293 296 PF00400 0.343
TRG_ER_diArg_1 364 367 PF00400 0.377
TRG_ER_diArg_1 394 396 PF00400 0.458
TRG_ER_diArg_1 430 432 PF00400 0.427
TRG_ER_diArg_1 520 523 PF00400 0.425
TRG_ER_diArg_1 593 595 PF00400 0.547
TRG_ER_diLys_1 651 655 PF00400 0.528
TRG_NLS_MonoExtC_3 371 377 PF00514 0.301
TRG_NLS_MonoExtN_4 589 596 PF00514 0.572
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M6 Leptomonas seymouri 60% 100%
A0A0S4JKY7 Bodo saltans 28% 100%
A0A1X0P7Z9 Trypanosomatidae 27% 100%
A0A3S7WV71 Leishmania donovani 25% 79%
A4HF04 Leishmania braziliensis 77% 100%
A4HXX7 Leishmania infantum 26% 79%
A4I283 Leishmania infantum 100% 100%
C9ZZS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AYC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q945 Leishmania major 92% 100%
V5B6M4 Trypanosoma cruzi 26% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS