LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H7G3_LEIDO
TriTrypDb:
LdBPK_261470.1 , LdCL_260020300 , LDHU3_26.1820
Length:
655

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 8
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
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Expansion

Sequence features

A0A3S5H7G3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7G3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 410 414 PF00656 0.597
CLV_NRD_NRD_1 180 182 PF00675 0.672
CLV_NRD_NRD_1 194 196 PF00675 0.520
CLV_NRD_NRD_1 305 307 PF00675 0.499
CLV_NRD_NRD_1 395 397 PF00675 0.558
CLV_NRD_NRD_1 431 433 PF00675 0.585
CLV_NRD_NRD_1 593 595 PF00675 0.664
CLV_NRD_NRD_1 63 65 PF00675 0.701
CLV_PCSK_KEX2_1 180 182 PF00082 0.672
CLV_PCSK_KEX2_1 194 196 PF00082 0.520
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I1M6 Leptomonas seymouri 60% 100%
A0A0S4JKY7 Bodo saltans 28% 100%
A0A1X0P7Z9 Trypanosomatidae 27% 100%
A0A3S7WV71 Leishmania donovani 25% 79%
A4HF04 Leishmania braziliensis 77% 100%
A4HXX7 Leishmania infantum 26% 79%
A4I283 Leishmania infantum 100% 100%
C9ZZS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AYC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q945 Leishmania major 92% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS