Vps52 / Sac2 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps52 / Sac2 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7F6_LEIDO

TriTrypDb:

LdBPK_260340.1 , LdCL_260008900 , LDHU3_26.0450

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0000938	GARP complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A0A3S5H7F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7F6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006896	Golgi to vacuole transport	5	1
GO:0007034	vacuolar transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0032456	endocytic recycling	5	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.671
CLV_C14_Caspase3-7	212	216	PF00656	0.376
CLV_NRD_NRD_1	160	162	PF00675	0.337
CLV_NRD_NRD_1	230	232	PF00675	0.408
CLV_NRD_NRD_1	310	312	PF00675	0.430
CLV_NRD_NRD_1	507	509	PF00675	0.307
CLV_NRD_NRD_1	674	676	PF00675	0.565
CLV_NRD_NRD_1	769	771	PF00675	0.645
CLV_PCSK_KEX2_1	29	31	PF00082	0.670
CLV_PCSK_KEX2_1	529	531	PF00082	0.413
CLV_PCSK_KEX2_1	674	676	PF00082	0.565
CLV_PCSK_KEX2_1	769	771	PF00082	0.645
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.621
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.413
CLV_PCSK_SKI1_1	152	156	PF00082	0.445
CLV_PCSK_SKI1_1	226	230	PF00082	0.354
CLV_PCSK_SKI1_1	412	416	PF00082	0.447
CLV_PCSK_SKI1_1	560	564	PF00082	0.447
CLV_PCSK_SKI1_1	719	723	PF00082	0.537
CLV_PCSK_SKI1_1	833	837	PF00082	0.460
CLV_PCSK_SKI1_1	870	874	PF00082	0.406
DEG_APCC_DBOX_1	151	159	PF00400	0.479
DEG_APCC_DBOX_1	36	44	PF00400	0.529
DEG_APCC_DBOX_1	411	419	PF00400	0.447
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DOC_CDC14_PxL_1	261	269	PF14671	0.526
DOC_CYCLIN_RxL_1	192	203	PF00134	0.415
DOC_MAPK_gen_1	192	201	PF00069	0.335
DOC_MAPK_gen_1	231	238	PF00069	0.335
DOC_MAPK_MEF2A_6	192	201	PF00069	0.422
DOC_MAPK_MEF2A_6	252	260	PF00069	0.447
DOC_MAPK_RevD_3	147	162	PF00069	0.378
DOC_PP1_RVXF_1	114	120	PF00149	0.447
DOC_PP2B_LxvP_1	125	128	PF13499	0.378
DOC_PP2B_LxvP_1	197	200	PF13499	0.479
DOC_PP2B_LxvP_1	236	239	PF13499	0.408
DOC_PP4_FxxP_1	389	392	PF00568	0.378
DOC_USP7_MATH_1	102	106	PF00917	0.447
DOC_USP7_MATH_1	363	367	PF00917	0.447
DOC_USP7_MATH_1	475	479	PF00917	0.568
DOC_USP7_MATH_1	603	607	PF00917	0.726
DOC_USP7_MATH_1	625	629	PF00917	0.710
DOC_USP7_MATH_1	640	644	PF00917	0.735
DOC_USP7_MATH_1	689	693	PF00917	0.477
DOC_USP7_MATH_1	878	882	PF00917	0.474
DOC_USP7_UBL2_3	505	509	PF12436	0.479
DOC_WW_Pin1_4	178	183	PF00397	0.476
DOC_WW_Pin1_4	366	371	PF00397	0.358
DOC_WW_Pin1_4	631	636	PF00397	0.747
LIG_14-3-3_CanoR_1	112	119	PF00244	0.386
LIG_14-3-3_CanoR_1	198	207	PF00244	0.389
LIG_14-3-3_CanoR_1	269	273	PF00244	0.638
LIG_14-3-3_CanoR_1	37	41	PF00244	0.577
LIG_14-3-3_CanoR_1	403	408	PF00244	0.390
LIG_14-3-3_CanoR_1	560	565	PF00244	0.458
LIG_14-3-3_CanoR_1	569	578	PF00244	0.435
LIG_14-3-3_CanoR_1	641	647	PF00244	0.737
LIG_14-3-3_CanoR_1	650	654	PF00244	0.635
LIG_14-3-3_CanoR_1	769	775	PF00244	0.582
LIG_14-3-3_CanoR_1	784	794	PF00244	0.437
LIG_14-3-3_CanoR_1	889	895	PF00244	0.463
LIG_14-3-3_CanoR_1	906	911	PF00244	0.440
LIG_Actin_WH2_2	254	271	PF00022	0.440
LIG_Actin_WH2_2	858	875	PF00022	0.440
LIG_APCC_ABBA_1	204	209	PF00400	0.408
LIG_BRCT_BRCA1_1	16	20	PF00533	0.621
LIG_BRCT_BRCA1_1	27	31	PF00533	0.634
LIG_BRCT_BRCA1_1	329	333	PF00533	0.447
LIG_Clathr_ClatBox_1	427	431	PF01394	0.447
LIG_CtBP_PxDLS_1	128	132	PF00389	0.479
LIG_eIF4E_1	488	494	PF01652	0.343
LIG_FHA_1	11	17	PF00498	0.610
LIG_FHA_1	112	118	PF00498	0.413
LIG_FHA_1	206	212	PF00498	0.436
LIG_FHA_1	288	294	PF00498	0.378
LIG_FHA_1	485	491	PF00498	0.437
LIG_FHA_1	790	796	PF00498	0.529
LIG_FHA_1	867	873	PF00498	0.467
LIG_FHA_1	891	897	PF00498	0.520
LIG_FHA_2	148	154	PF00498	0.447
LIG_FHA_2	37	43	PF00498	0.594
LIG_FHA_2	513	519	PF00498	0.456
LIG_FHA_2	69	75	PF00498	0.479
LIG_FHA_2	76	82	PF00498	0.363
LIG_FHA_2	771	777	PF00498	0.540
LIG_GBD_Chelix_1	748	756	PF00786	0.443
LIG_IRF3_LxIS_1	21	28	PF10401	0.457
LIG_LIR_Apic_2	164	170	PF02991	0.170
LIG_LIR_Apic_2	353	359	PF02991	0.408
LIG_LIR_Apic_2	662	668	PF02991	0.735
LIG_LIR_Gen_1	205	214	PF02991	0.479
LIG_LIR_Gen_1	218	228	PF02991	0.367
LIG_LIR_Gen_1	342	352	PF02991	0.446
LIG_LIR_Gen_1	383	393	PF02991	0.408
LIG_LIR_Gen_1	429	434	PF02991	0.338
LIG_LIR_Gen_1	514	524	PF02991	0.349
LIG_LIR_Gen_1	651	661	PF02991	0.576
LIG_LIR_Gen_1	694	703	PF02991	0.408
LIG_LIR_Gen_1	704	713	PF02991	0.389
LIG_LIR_Gen_1	779	787	PF02991	0.426
LIG_LIR_Gen_1	805	810	PF02991	0.496
LIG_LIR_Gen_1	869	879	PF02991	0.505
LIG_LIR_LC3C_4	123	127	PF02991	0.447
LIG_LIR_Nem_3	202	207	PF02991	0.410
LIG_LIR_Nem_3	218	223	PF02991	0.371
LIG_LIR_Nem_3	330	336	PF02991	0.442
LIG_LIR_Nem_3	342	347	PF02991	0.447
LIG_LIR_Nem_3	383	388	PF02991	0.381
LIG_LIR_Nem_3	429	433	PF02991	0.335
LIG_LIR_Nem_3	485	491	PF02991	0.357
LIG_LIR_Nem_3	499	503	PF02991	0.324
LIG_LIR_Nem_3	514	520	PF02991	0.294
LIG_LIR_Nem_3	651	656	PF02991	0.577
LIG_LIR_Nem_3	694	699	PF02991	0.422
LIG_LIR_Nem_3	704	708	PF02991	0.397
LIG_LIR_Nem_3	779	783	PF02991	0.393
LIG_LIR_Nem_3	785	790	PF02991	0.384
LIG_LIR_Nem_3	805	809	PF02991	0.407
LIG_LIR_Nem_3	869	874	PF02991	0.506
LIG_MYND_1	391	395	PF01753	0.354
LIG_NRBOX	150	156	PF00104	0.413
LIG_NRBOX	519	525	PF00104	0.346
LIG_NRBOX	794	800	PF00104	0.523
LIG_PCNA_yPIPBox_3	148	162	PF02747	0.447
LIG_PCNA_yPIPBox_3	859	873	PF02747	0.497
LIG_Pex14_2	385	389	PF04695	0.447
LIG_Pex14_2	428	432	PF04695	0.342
LIG_Pex14_2	47	51	PF04695	0.478
LIG_Pex14_2	528	532	PF04695	0.378
LIG_Pex14_2	828	832	PF04695	0.388
LIG_Pex3_1	795	806	PF04882	0.336
LIG_PTB_Apo_2	699	706	PF02174	0.471
LIG_PTB_Apo_2	865	872	PF02174	0.421
LIG_Rb_pABgroove_1	842	850	PF01858	0.479
LIG_SH2_CRK	301	305	PF00017	0.370
LIG_SH2_CRK	356	360	PF00017	0.447
LIG_SH2_CRK	488	492	PF00017	0.346
LIG_SH2_CRK	571	575	PF00017	0.447
LIG_SH2_CRK	804	808	PF00017	0.471
LIG_SH2_GRB2like	157	160	PF00017	0.463
LIG_SH2_NCK_1	325	329	PF00017	0.417
LIG_SH2_NCK_1	356	360	PF00017	0.447
LIG_SH2_STAP1	207	211	PF00017	0.479
LIG_SH2_STAP1	407	411	PF00017	0.335
LIG_SH2_STAP1	713	717	PF00017	0.487
LIG_SH2_STAP1	848	852	PF00017	0.511
LIG_SH2_STAP1	908	912	PF00017	0.613
LIG_SH2_STAT3	848	851	PF00017	0.523
LIG_SH2_STAT5	157	160	PF00017	0.420
LIG_SH2_STAT5	207	210	PF00017	0.479
LIG_SH2_STAT5	234	237	PF00017	0.393
LIG_SH2_STAT5	301	304	PF00017	0.348
LIG_SH2_STAT5	309	312	PF00017	0.324
LIG_SH2_STAT5	316	319	PF00017	0.311
LIG_SH2_STAT5	356	359	PF00017	0.354
LIG_SH2_STAT5	426	429	PF00017	0.447
LIG_SH2_STAT5	454	457	PF00017	0.311
LIG_SH2_STAT5	571	574	PF00017	0.479
LIG_SH2_STAT5	747	750	PF00017	0.405
LIG_SH3_1	346	352	PF00018	0.447
LIG_SH3_3	123	129	PF00018	0.410
LIG_SH3_3	346	352	PF00018	0.447
LIG_SH3_3	385	391	PF00018	0.335
LIG_SH3_3	440	446	PF00018	0.354
LIG_SH3_3	634	640	PF00018	0.780
LIG_SH3_3	813	819	PF00018	0.569
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.384
LIG_SUMO_SIM_anti_2	518	525	PF11976	0.354
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.447
LIG_SUMO_SIM_par_1	12	19	PF11976	0.599
LIG_SUMO_SIM_par_1	208	215	PF11976	0.376
LIG_SUMO_SIM_par_1	892	897	PF11976	0.537
LIG_TRAF2_1	406	409	PF00917	0.408
LIG_TRAF2_1	765	768	PF00917	0.640
LIG_TRAF2_1	812	815	PF00917	0.586
LIG_TRAF2_2	602	607	PF00917	0.646
LIG_UBA3_1	154	162	PF00899	0.364
LIG_UBA3_1	304	312	PF00899	0.447
LIG_UBA3_1	393	399	PF00899	0.447
LIG_UBA3_1	520	529	PF00899	0.447
LIG_WRC_WIRS_1	427	432	PF05994	0.335
LIG_WRC_WIRS_1	48	53	PF05994	0.498
LIG_WRC_WIRS_1	513	518	PF05994	0.479
MOD_CDK_SPK_2	631	636	PF00069	0.650
MOD_CDK_SPxxK_3	178	185	PF00069	0.479
MOD_CK1_1	178	184	PF00069	0.479
MOD_CK1_1	326	332	PF00069	0.375
MOD_CK1_1	335	341	PF00069	0.382
MOD_CK1_1	342	348	PF00069	0.386
MOD_CK1_1	36	42	PF00069	0.629
MOD_CK1_1	366	372	PF00069	0.450
MOD_CK1_1	463	469	PF00069	0.596
MOD_CK1_1	597	603	PF00069	0.708
MOD_CK1_1	606	612	PF00069	0.682
MOD_CK1_1	614	620	PF00069	0.673
MOD_CK1_1	649	655	PF00069	0.644
MOD_CK1_1	730	736	PF00069	0.696
MOD_CK1_1	785	791	PF00069	0.331
MOD_CK1_1	881	887	PF00069	0.474
MOD_CK2_1	147	153	PF00069	0.383
MOD_CK2_1	16	22	PF00069	0.653
MOD_CK2_1	403	409	PF00069	0.408
MOD_CK2_1	512	518	PF00069	0.313
MOD_CK2_1	553	559	PF00069	0.411
MOD_CK2_1	62	68	PF00069	0.447
MOD_CK2_1	75	81	PF00069	0.447
MOD_CK2_1	809	815	PF00069	0.517
MOD_GlcNHglycan	177	180	PF01048	0.422
MOD_GlcNHglycan	185	188	PF01048	0.328
MOD_GlcNHglycan	262	265	PF01048	0.468
MOD_GlcNHglycan	329	332	PF01048	0.401
MOD_GlcNHglycan	341	344	PF01048	0.336
MOD_GlcNHglycan	463	466	PF01048	0.601
MOD_GlcNHglycan	617	620	PF01048	0.743
MOD_GlcNHglycan	627	630	PF01048	0.737
MOD_GlcNHglycan	811	814	PF01048	0.400
MOD_GlcNHglycan	875	878	PF01048	0.443
MOD_GlcNHglycan	883	886	PF01048	0.454
MOD_GSK3_1	10	17	PF00069	0.589
MOD_GSK3_1	181	188	PF00069	0.378
MOD_GSK3_1	205	212	PF00069	0.376
MOD_GSK3_1	234	241	PF00069	0.388
MOD_GSK3_1	32	39	PF00069	0.591
MOD_GSK3_1	323	330	PF00069	0.408
MOD_GSK3_1	335	342	PF00069	0.408
MOD_GSK3_1	359	366	PF00069	0.373
MOD_GSK3_1	403	410	PF00069	0.406
MOD_GSK3_1	416	423	PF00069	0.361
MOD_GSK3_1	512	519	PF00069	0.476
MOD_GSK3_1	524	531	PF00069	0.392
MOD_GSK3_1	58	65	PF00069	0.447
MOD_GSK3_1	603	610	PF00069	0.735
MOD_GSK3_1	611	618	PF00069	0.695
MOD_GSK3_1	642	649	PF00069	0.704
MOD_GSK3_1	778	785	PF00069	0.571
MOD_GSK3_1	838	845	PF00069	0.492
MOD_GSK3_1	890	897	PF00069	0.472
MOD_GSK3_1	97	104	PF00069	0.412
MOD_LATS_1	904	910	PF00433	0.557
MOD_N-GLC_1	569	574	PF02516	0.442
MOD_N-GLC_1	641	646	PF02516	0.734
MOD_N-GLC_1	906	911	PF02516	0.571
MOD_N-GLC_2	242	244	PF02516	0.447
MOD_NEK2_1	101	106	PF00069	0.410
MOD_NEK2_1	147	152	PF00069	0.335
MOD_NEK2_1	16	21	PF00069	0.600
MOD_NEK2_1	25	30	PF00069	0.574
MOD_NEK2_1	260	265	PF00069	0.378
MOD_NEK2_1	268	273	PF00069	0.545
MOD_NEK2_1	303	308	PF00069	0.438
MOD_NEK2_1	323	328	PF00069	0.150
MOD_NEK2_1	418	423	PF00069	0.350
MOD_NEK2_1	460	465	PF00069	0.505
MOD_NEK2_1	47	52	PF00069	0.508
MOD_NEK2_1	516	521	PF00069	0.335
MOD_NEK2_1	574	579	PF00069	0.379
MOD_NEK2_1	62	67	PF00069	0.354
MOD_NEK2_1	646	651	PF00069	0.697
MOD_NEK2_1	727	732	PF00069	0.708
MOD_NEK2_1	778	783	PF00069	0.487
MOD_NEK2_1	786	791	PF00069	0.401
MOD_NEK2_1	828	833	PF00069	0.454
MOD_NEK2_1	894	899	PF00069	0.390
MOD_NEK2_2	407	412	PF00069	0.335
MOD_NEK2_2	435	440	PF00069	0.335
MOD_NEK2_2	503	508	PF00069	0.440
MOD_NEK2_2	512	517	PF00069	0.456
MOD_NEK2_2	58	63	PF00069	0.397
MOD_PIKK_1	689	695	PF00454	0.597
MOD_PIKK_1	728	734	PF00454	0.725
MOD_PIKK_1	838	844	PF00454	0.523
MOD_PKA_1	161	167	PF00069	0.449
MOD_PKA_1	769	775	PF00069	0.592
MOD_PKA_2	111	117	PF00069	0.258
MOD_PKA_2	175	181	PF00069	0.485
MOD_PKA_2	191	197	PF00069	0.294
MOD_PKA_2	268	274	PF00069	0.636
MOD_PKA_2	287	293	PF00069	0.478
MOD_PKA_2	36	42	PF00069	0.590
MOD_PKA_2	607	613	PF00069	0.778
MOD_PKA_2	640	646	PF00069	0.773
MOD_PKA_2	649	655	PF00069	0.697
MOD_PKA_2	769	775	PF00069	0.622
MOD_PKA_2	97	103	PF00069	0.468
MOD_Plk_1	202	208	PF00069	0.479
MOD_Plk_1	247	253	PF00069	0.410
MOD_Plk_1	407	413	PF00069	0.335
MOD_Plk_1	435	441	PF00069	0.335
MOD_Plk_1	484	490	PF00069	0.437
MOD_Plk_1	569	575	PF00069	0.447
MOD_Plk_1	641	647	PF00069	0.780
MOD_Plk_1	778	784	PF00069	0.495
MOD_Plk_1	906	912	PF00069	0.593
MOD_Plk_2-3	10	16	PF00069	0.639
MOD_Plk_2-3	209	215	PF00069	0.376
MOD_Plk_2-3	68	74	PF00069	0.479
MOD_Plk_4	16	22	PF00069	0.645
MOD_Plk_4	209	215	PF00069	0.399
MOD_Plk_4	280	286	PF00069	0.608
MOD_Plk_4	304	310	PF00069	0.447
MOD_Plk_4	351	357	PF00069	0.482
MOD_Plk_4	47	53	PF00069	0.523
MOD_Plk_4	512	518	PF00069	0.364
MOD_Plk_4	574	580	PF00069	0.393
MOD_Plk_4	68	74	PF00069	0.463
MOD_Plk_4	75	81	PF00069	0.424
MOD_Plk_4	842	848	PF00069	0.462
MOD_ProDKin_1	178	184	PF00069	0.476
MOD_ProDKin_1	366	372	PF00069	0.358
MOD_ProDKin_1	631	637	PF00069	0.744
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.436
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.413
TRG_DiLeu_BaLyEn_6	790	795	PF01217	0.518
TRG_ENDOCYTIC_2	207	210	PF00928	0.408
TRG_ENDOCYTIC_2	294	297	PF00928	0.341
TRG_ENDOCYTIC_2	301	304	PF00928	0.345
TRG_ENDOCYTIC_2	488	491	PF00928	0.346
TRG_ENDOCYTIC_2	571	574	PF00928	0.347
TRG_ENDOCYTIC_2	804	807	PF00928	0.487
TRG_ER_diArg_1	673	675	PF00400	0.582
TRG_ER_diArg_1	790	793	PF00400	0.502
TRG_NES_CRM1_1	142	153	PF08389	0.447
TRG_NES_CRM1_1	196	209	PF08389	0.446
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	793	797	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E7	Leptomonas seymouri	66%	98%
A0A1X0NSI1	Trypanosomatidae	35%	100%
A0A422NVH8	Trypanosoma rangeli	37%	100%
A4HEP1	Leishmania braziliensis	81%	100%
A4I1X1	Leishmania infantum	100%	100%
C9ZS49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AY17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9F6	Leishmania major	93%	100%
V5BUK9	Trypanosoma cruzi	37%	100%