Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7F5_LEIDO

TriTrypDb:

LdBPK_260180.1 , LdCL_260007300 , LDHU3_26.0270

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7F5

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.346
CLV_NRD_NRD_1	270	272	PF00675	0.482
CLV_NRD_NRD_1	36	38	PF00675	0.555
CLV_NRD_NRD_1	6	8	PF00675	0.656
CLV_PCSK_KEX2_1	268	270	PF00082	0.427
CLV_PCSK_KEX2_1	36	38	PF00082	0.555
CLV_PCSK_KEX2_1	6	8	PF00082	0.615
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.478
CLV_PCSK_SKI1_1	189	193	PF00082	0.249
CLV_PCSK_SKI1_1	197	201	PF00082	0.249
CLV_PCSK_SKI1_1	2	6	PF00082	0.667
CLV_PCSK_SKI1_1	272	276	PF00082	0.552
CLV_PCSK_SKI1_1	37	41	PF00082	0.631
DEG_APCC_KENBOX_2	155	159	PF00400	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.454
DEG_SPOP_SBC_1	30	34	PF00917	0.699
DOC_CYCLIN_RxL_1	186	194	PF00134	0.302
DOC_MAPK_MEF2A_6	80	88	PF00069	0.279
DOC_MAPK_RevD_3	116	132	PF00069	0.375
DOC_PP4_FxxP_1	88	91	PF00568	0.302
DOC_USP7_MATH_1	30	34	PF00917	0.691
DOC_USP7_UBL2_3	268	272	PF12436	0.485
DOC_WW_Pin1_4	103	108	PF00397	0.273
DOC_WW_Pin1_4	70	75	PF00397	0.317
DOC_WW_Pin1_4	96	101	PF00397	0.328
LIG_14-3-3_CanoR_1	11	16	PF00244	0.606
LIG_14-3-3_CanoR_1	36	46	PF00244	0.545
LIG_14-3-3_CanoR_1	80	85	PF00244	0.302
LIG_FHA_1	214	220	PF00498	0.463
LIG_FHA_1	38	44	PF00498	0.692
LIG_FHA_2	173	179	PF00498	0.502
LIG_LIR_Apic_2	85	91	PF02991	0.302
LIG_LIR_Gen_1	125	134	PF02991	0.311
LIG_LIR_Gen_1	137	145	PF02991	0.271
LIG_LIR_Gen_1	216	222	PF02991	0.463
LIG_LIR_Nem_3	125	130	PF02991	0.302
LIG_LIR_Nem_3	137	141	PF02991	0.288
LIG_LIR_Nem_3	216	221	PF02991	0.463
LIG_SH2_CRK	104	108	PF00017	0.321
LIG_SH2_PTP2	127	130	PF00017	0.302
LIG_SH2_STAT5	127	130	PF00017	0.298
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.496
LIG_SUMO_SIM_par_1	179	190	PF11976	0.419
LIG_TRAF2_1	163	166	PF00917	0.528
LIG_UBA3_1	141	146	PF00899	0.356
MOD_CK1_1	224	230	PF00069	0.447
MOD_CK1_1	231	237	PF00069	0.427
MOD_CK1_1	24	30	PF00069	0.585
MOD_CK1_1	38	44	PF00069	0.624
MOD_CK1_1	52	58	PF00069	0.593
MOD_CK2_1	234	240	PF00069	0.529
MOD_GlcNHglycan	160	163	PF01048	0.442
MOD_GlcNHglycan	236	239	PF01048	0.257
MOD_GlcNHglycan	51	54	PF01048	0.536
MOD_GlcNHglycan	7	10	PF01048	0.592
MOD_GSK3_1	224	231	PF00069	0.451
MOD_GSK3_1	31	38	PF00069	0.643
MOD_GSK3_1	80	87	PF00069	0.302
MOD_N-GLC_1	172	177	PF02516	0.514
MOD_N-GLC_1	70	75	PF02516	0.409
MOD_NEK2_1	191	196	PF00069	0.463
MOD_NEK2_1	221	226	PF00069	0.519
MOD_NEK2_1	39	44	PF00069	0.591
MOD_NEK2_1	5	10	PF00069	0.577
MOD_NEK2_1	51	56	PF00069	0.558
MOD_NEK2_1	84	89	PF00069	0.286
MOD_NEK2_2	31	36	PF00069	0.527
MOD_PKA_2	24	30	PF00069	0.440
MOD_PKA_2	35	41	PF00069	0.587
MOD_PKA_2	5	11	PF00069	0.595
MOD_Plk_1	84	90	PF00069	0.286
MOD_Plk_1	91	97	PF00069	0.286
MOD_Plk_4	213	219	PF00069	0.449
MOD_Plk_4	39	45	PF00069	0.657
MOD_Plk_4	84	90	PF00069	0.264
MOD_ProDKin_1	103	109	PF00069	0.273
MOD_ProDKin_1	70	76	PF00069	0.317
MOD_ProDKin_1	96	102	PF00069	0.328
MOD_SUMO_for_1	89	92	PF00179	0.414
TRG_DiLeu_BaEn_2	213	219	PF01217	0.552
TRG_ENDOCYTIC_2	127	130	PF00928	0.302
TRG_ER_diArg_1	195	198	PF00400	0.449
TRG_ER_diArg_1	35	37	PF00400	0.561
TRG_ER_diArg_1	5	7	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q0	Leptomonas seymouri	80%	97%
A0A0N1I735	Leptomonas seymouri	31%	100%
A0A0S4IJH0	Bodo saltans	55%	100%
A0A0S4IVB5	Bodo saltans	34%	100%
A0A1X0NST9	Trypanosomatidae	59%	100%
A0A1X0P8F8	Trypanosomatidae	30%	100%
A0A3R7MX73	Trypanosoma rangeli	59%	100%
A0A3S7XAI2	Leishmania donovani	34%	95%
A4HEM5	Leishmania braziliensis	81%	100%
A4HNU8	Leishmania braziliensis	32%	100%
A4I1V6	Leishmania infantum	99%	100%
A4ICP6	Leishmania infantum	34%	100%
B3MRT7	Drosophila ananassae	41%	99%
B3NYF7	Drosophila erecta	43%	100%
B4H303	Drosophila persimilis	42%	100%
B4IMF6	Drosophila sechellia	42%	100%
B4JWR9	Drosophila grimshawi	42%	95%
B4M375	Drosophila virilis	40%	95%
B4NE93	Drosophila willistoni	41%	98%
B4PZ52	Drosophila yakuba	42%	100%
B4R3T1	Drosophila simulans	42%	100%
B5DKJ8	Drosophila pseudoobscura pseudoobscura	43%	99%
C9ZS65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A2R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AY01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P32860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q4Q1Y8	Leishmania major	33%	100%
Q4Q9H2	Leishmania major	95%	100%
Q8SY96	Drosophila melanogaster	42%	100%
Q9C8J2	Arabidopsis thaliana	40%	100%
Q9LIG6	Arabidopsis thaliana	38%	100%
Q9QZ23	Mus musculus	40%	100%
Q9UMS0	Homo sapiens	40%	100%
Q9UUB8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
V5DRN0	Trypanosoma cruzi	32%	100%