Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7F3_LEIDO

TriTrypDb:

LdBPK_252460.1 , LdCL_250030400 , LDHU3_25.2940

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.570
CLV_C14_Caspase3-7	255	259	PF00656	0.529
CLV_C14_Caspase3-7	280	284	PF00656	0.466
CLV_C14_Caspase3-7	3	7	PF00656	0.572
CLV_NRD_NRD_1	32	34	PF00675	0.516
CLV_NRD_NRD_1	328	330	PF00675	0.460
CLV_NRD_NRD_1	339	341	PF00675	0.377
CLV_NRD_NRD_1	344	346	PF00675	0.402
CLV_NRD_NRD_1	49	51	PF00675	0.423
CLV_PCSK_KEX2_1	171	173	PF00082	0.556
CLV_PCSK_KEX2_1	272	274	PF00082	0.462
CLV_PCSK_KEX2_1	32	34	PF00082	0.516
CLV_PCSK_KEX2_1	328	330	PF00082	0.433
CLV_PCSK_KEX2_1	338	340	PF00082	0.373
CLV_PCSK_KEX2_1	48	50	PF00082	0.435
CLV_PCSK_KEX2_1	8	10	PF00082	0.520
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.556
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.482
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.520
CLV_PCSK_SKI1_1	168	172	PF00082	0.569
CLV_PCSK_SKI1_1	220	224	PF00082	0.583
CLV_PCSK_SKI1_1	339	343	PF00082	0.422
CLV_PCSK_SKI1_1	5	9	PF00082	0.550
DEG_SIAH_1	16	24	PF03145	0.506
DOC_CDC14_PxL_1	78	86	PF14671	0.628
DOC_PP2B_LxvP_1	84	87	PF13499	0.611
DOC_PP4_FxxP_1	170	173	PF00568	0.513
DOC_PP4_FxxP_1	263	266	PF00568	0.481
DOC_USP7_MATH_1	100	104	PF00917	0.673
DOC_USP7_MATH_1	175	179	PF00917	0.595
DOC_USP7_MATH_1	241	245	PF00917	0.552
DOC_USP7_UBL2_3	342	346	PF12436	0.566
DOC_WW_Pin1_4	130	135	PF00397	0.516
DOC_WW_Pin1_4	178	183	PF00397	0.635
DOC_WW_Pin1_4	60	65	PF00397	0.641
LIG_14-3-3_CanoR_1	220	229	PF00244	0.545
LIG_14-3-3_CanoR_1	240	246	PF00244	0.395
LIG_14-3-3_CanoR_1	254	263	PF00244	0.548
LIG_14-3-3_CanoR_1	345	349	PF00244	0.485
LIG_14-3-3_CanoR_1	85	91	PF00244	0.519
LIG_Actin_WH2_2	140	158	PF00022	0.388
LIG_BRCT_BRCA1_1	180	184	PF00533	0.513
LIG_BRCT_BRCA1_1	25	29	PF00533	0.509
LIG_FHA_1	194	200	PF00498	0.590
LIG_FHA_1	260	266	PF00498	0.584
LIG_FHA_2	158	164	PF00498	0.511
LIG_FHA_2	202	208	PF00498	0.502
LIG_FHA_2	253	259	PF00498	0.534
LIG_FHA_2	68	74	PF00498	0.601
LIG_GBD_Chelix_1	111	119	PF00786	0.546
LIG_LIR_Apic_2	167	173	PF02991	0.505
LIG_LIR_Apic_2	261	266	PF02991	0.484
LIG_LIR_Nem_3	214	218	PF02991	0.481
LIG_NRBOX	302	308	PF00104	0.428
LIG_Rb_pABgroove_1	23	31	PF01858	0.512
LIG_SH2_CRK	14	18	PF00017	0.534
LIG_SH2_NCK_1	97	101	PF00017	0.453
LIG_SH2_PTP2	296	299	PF00017	0.483
LIG_SH2_SRC	97	100	PF00017	0.473
LIG_SH2_STAP1	218	222	PF00017	0.505
LIG_SH2_STAP1	245	249	PF00017	0.627
LIG_SH2_STAP1	275	279	PF00017	0.486
LIG_SH2_STAP1	95	99	PF00017	0.532
LIG_SH2_STAT5	296	299	PF00017	0.489
LIG_SH3_3	17	23	PF00018	0.408
LIG_SH3_3	176	182	PF00018	0.567
LIG_SH3_3	62	68	PF00018	0.779
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.429
LIG_SUMO_SIM_anti_2	300	309	PF11976	0.529
LIG_SUMO_SIM_par_1	276	283	PF11976	0.467
LIG_TRAF2_1	211	214	PF00917	0.478
LIG_WRC_WIRS_1	24	29	PF05994	0.512
MOD_CK1_1	124	130	PF00069	0.643
MOD_CK1_1	133	139	PF00069	0.444
MOD_CK1_1	178	184	PF00069	0.758
MOD_CK1_1	243	249	PF00069	0.576
MOD_CK1_1	60	66	PF00069	0.726
MOD_CK2_1	161	167	PF00069	0.643
MOD_CK2_1	222	228	PF00069	0.472
MOD_CK2_1	60	66	PF00069	0.609
MOD_GlcNHglycan	267	270	PF01048	0.509
MOD_GlcNHglycan	60	63	PF01048	0.637
MOD_GSK3_1	117	124	PF00069	0.593
MOD_GSK3_1	125	132	PF00069	0.720
MOD_GSK3_1	157	164	PF00069	0.582
MOD_GSK3_1	254	261	PF00069	0.650
MOD_GSK3_1	34	41	PF00069	0.460
MOD_GSK3_1	76	83	PF00069	0.521
MOD_N-GLC_1	101	106	PF02516	0.640
MOD_N-GLC_1	124	129	PF02516	0.467
MOD_N-GLC_1	241	246	PF02516	0.468
MOD_NEK2_1	161	166	PF00069	0.645
MOD_NEK2_1	199	204	PF00069	0.531
MOD_NEK2_1	221	226	PF00069	0.500
MOD_NEK2_1	229	234	PF00069	0.579
MOD_NEK2_1	34	39	PF00069	0.414
MOD_PIKK_1	126	132	PF00454	0.590
MOD_PIKK_1	133	139	PF00454	0.484
MOD_PKA_2	344	350	PF00069	0.390
MOD_Plk_1	107	113	PF00069	0.675
MOD_Plk_1	161	167	PF00069	0.600
MOD_Plk_1	175	181	PF00069	0.547
MOD_Plk_1	241	247	PF00069	0.612
MOD_Plk_1	34	40	PF00069	0.498
MOD_Plk_2-3	157	163	PF00069	0.497
MOD_Plk_2-3	277	283	PF00069	0.468
MOD_Plk_2-3	309	315	PF00069	0.436
MOD_Plk_4	107	113	PF00069	0.672
MOD_Plk_4	117	123	PF00069	0.561
MOD_Plk_4	138	144	PF00069	0.516
MOD_Plk_4	23	29	PF00069	0.448
MOD_Plk_4	259	265	PF00069	0.641
MOD_Plk_4	34	40	PF00069	0.404
MOD_ProDKin_1	130	136	PF00069	0.505
MOD_ProDKin_1	178	184	PF00069	0.638
MOD_ProDKin_1	60	66	PF00069	0.644
MOD_SUMO_rev_2	224	232	PF00179	0.480
MOD_SUMO_rev_2	253	262	PF00179	0.588
TRG_DiLeu_BaEn_4	276	282	PF01217	0.468
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.441
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.457
TRG_ENDOCYTIC_2	218	221	PF00928	0.533
TRG_ENDOCYTIC_2	275	278	PF00928	0.403
TRG_ENDOCYTIC_2	296	299	PF00928	0.483
TRG_ER_diArg_1	31	33	PF00400	0.514
TRG_ER_diArg_1	337	340	PF00400	0.389
TRG_ER_diArg_1	356	359	PF00400	0.470
TRG_ER_diArg_1	47	50	PF00400	0.422
TRG_NLS_MonoCore_2	170	175	PF00514	0.584
TRG_NLS_MonoExtC_3	170	175	PF00514	0.580
TRG_NLS_MonoExtN_4	168	175	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE1	Leptomonas seymouri	44%	100%
A0A1X0NZJ6	Trypanosomatidae	27%	100%
A0A3R7KZA5	Trypanosoma rangeli	26%	91%
A4HED8	Leishmania braziliensis	67%	100%
A4I1T5	Leishmania infantum	99%	100%
E9AXW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q9K1	Leishmania major	86%	100%