Molybdopterin guanine dinucleotide synthesis protein B, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7F2_LEIDO

TriTrypDb:

LdBPK_252270.1 , LdCL_250028500 , LDHU3_25.2750

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H7F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7F2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0019205	nucleobase-containing compound kinase activity	5	11
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	103	107	PF00082	0.452
CLV_PCSK_SKI1_1	160	164	PF00082	0.381
CLV_PCSK_SKI1_1	231	235	PF00082	0.322
CLV_PCSK_SKI1_1	440	444	PF00082	0.400
DEG_SPOP_SBC_1	79	83	PF00917	0.426
DOC_CYCLIN_RxL_1	228	235	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.247
DOC_MAPK_FxFP_2	425	428	PF00069	0.430
DOC_MAPK_MEF2A_6	353	362	PF00069	0.332
DOC_PP4_FxxP_1	4	7	PF00568	0.596
DOC_PP4_FxxP_1	425	428	PF00568	0.430
DOC_USP7_MATH_1	35	39	PF00917	0.305
DOC_USP7_MATH_1	354	358	PF00917	0.443
DOC_USP7_MATH_1	398	402	PF00917	0.400
DOC_USP7_MATH_1	49	53	PF00917	0.357
DOC_WW_Pin1_4	370	375	PF00397	0.463
DOC_WW_Pin1_4	399	404	PF00397	0.436
DOC_WW_Pin1_4	56	61	PF00397	0.434
LIG_14-3-3_CanoR_1	240	248	PF00244	0.325
LIG_14-3-3_CanoR_1	313	321	PF00244	0.338
LIG_14-3-3_CanoR_1	333	339	PF00244	0.244
LIG_14-3-3_CanoR_1	99	105	PF00244	0.291
LIG_14-3-3_CterR_2	440	445	PF00244	0.395
LIG_Actin_WH2_2	80	97	PF00022	0.313
LIG_BRCT_BRCA1_1	314	318	PF00533	0.361
LIG_BRCT_BRCA1_1	334	338	PF00533	0.392
LIG_BRCT_BRCA1_1	351	355	PF00533	0.454
LIG_BRCT_BRCA1_1	421	425	PF00533	0.406
LIG_Clathr_ClatBox_1	163	167	PF01394	0.267
LIG_FHA_1	100	106	PF00498	0.458
LIG_FHA_1	11	17	PF00498	0.505
LIG_FHA_1	116	122	PF00498	0.313
LIG_FHA_1	171	177	PF00498	0.433
LIG_FHA_1	201	207	PF00498	0.332
LIG_FHA_1	291	297	PF00498	0.428
LIG_FHA_1	339	345	PF00498	0.336
LIG_FHA_1	431	437	PF00498	0.408
LIG_FHA_1	72	78	PF00498	0.309
LIG_FHA_1	79	85	PF00498	0.285
LIG_FHA_2	207	213	PF00498	0.459
LIG_GBD_Chelix_1	61	69	PF00786	0.313
LIG_LIR_Apic_2	186	190	PF02991	0.269
LIG_LIR_Apic_2	2	7	PF02991	0.544
LIG_LIR_Apic_2	349	354	PF02991	0.457
LIG_LIR_Apic_2	422	428	PF02991	0.491
LIG_LIR_Apic_2	66	71	PF02991	0.388
LIG_LIR_Gen_1	111	116	PF02991	0.307
LIG_LIR_Gen_1	212	222	PF02991	0.313
LIG_LIR_Gen_1	288	296	PF02991	0.409
LIG_LIR_Gen_1	307	314	PF02991	0.509
LIG_LIR_Gen_1	315	326	PF02991	0.528
LIG_LIR_Gen_1	352	363	PF02991	0.438
LIG_LIR_Nem_3	111	115	PF02991	0.307
LIG_LIR_Nem_3	212	217	PF02991	0.313
LIG_LIR_Nem_3	288	294	PF02991	0.286
LIG_LIR_Nem_3	307	311	PF02991	0.512
LIG_LIR_Nem_3	315	321	PF02991	0.519
LIG_LIR_Nem_3	332	337	PF02991	0.520
LIG_LIR_Nem_3	352	358	PF02991	0.445
LIG_LIR_Nem_3	64	70	PF02991	0.302
LIG_MLH1_MIPbox_1	334	338	PF16413	0.433
LIG_Pex14_1	351	355	PF04695	0.454
LIG_SH2_CRK	112	116	PF00017	0.291
LIG_SH2_CRK	406	410	PF00017	0.480
LIG_SH2_NCK_1	406	410	PF00017	0.427
LIG_SH2_PTP2	308	311	PF00017	0.389
LIG_SH2_STAP1	153	157	PF00017	0.326
LIG_SH2_STAP1	334	338	PF00017	0.433
LIG_SH2_STAT5	204	207	PF00017	0.326
LIG_SH2_STAT5	226	229	PF00017	0.276
LIG_SH2_STAT5	295	298	PF00017	0.475
LIG_SH2_STAT5	308	311	PF00017	0.457
LIG_SH2_STAT5	337	340	PF00017	0.337
LIG_SH2_STAT5	418	421	PF00017	0.454
LIG_SH2_STAT5	68	71	PF00017	0.448
LIG_SH3_3	15	21	PF00018	0.416
LIG_SH3_3	368	374	PF00018	0.511
LIG_SUMO_SIM_anti_2	357	362	PF11976	0.327
LIG_SUMO_SIM_anti_2	429	436	PF11976	0.353
LIG_SUMO_SIM_par_1	162	167	PF11976	0.262
LIG_SUMO_SIM_par_1	25	32	PF11976	0.447
LIG_SUMO_SIM_par_1	254	260	PF11976	0.291
LIG_SUMO_SIM_par_1	359	366	PF11976	0.323
LIG_SUMO_SIM_par_1	432	438	PF11976	0.307
LIG_TRAF2_1	376	379	PF00917	0.436
LIG_TRFH_1	67	71	PF08558	0.267
LIG_TYR_ITIM	110	115	PF00017	0.291
LIG_TYR_ITIM	65	70	PF00017	0.326
LIG_WRC_WIRS_1	211	216	PF05994	0.313
MOD_CDK_SPxxK_3	370	377	PF00069	0.406
MOD_CK1_1	101	107	PF00069	0.470
MOD_CK1_1	12	18	PF00069	0.601
MOD_CK1_1	198	204	PF00069	0.305
MOD_CK1_1	332	338	PF00069	0.470
MOD_CK1_1	349	355	PF00069	0.405
MOD_CK1_1	392	398	PF00069	0.421
MOD_CK2_1	19	25	PF00069	0.361
MOD_CK2_1	206	212	PF00069	0.320
MOD_GlcNHglycan	251	254	PF01048	0.259
MOD_GlcNHglycan	264	267	PF01048	0.274
MOD_GlcNHglycan	37	40	PF01048	0.302
MOD_GlcNHglycan	394	397	PF01048	0.458
MOD_GSK3_1	195	202	PF00069	0.303
MOD_GSK3_1	206	213	PF00069	0.315
MOD_GSK3_1	312	319	PF00069	0.427
MOD_GSK3_1	325	332	PF00069	0.371
MOD_GSK3_1	419	426	PF00069	0.321
MOD_GSK3_1	43	50	PF00069	0.399
MOD_GSK3_1	56	63	PF00069	0.448
MOD_GSK3_1	8	15	PF00069	0.539
MOD_GSK3_1	97	104	PF00069	0.385
MOD_N-GLC_1	316	321	PF02516	0.522
MOD_NEK2_1	195	200	PF00069	0.381
MOD_NEK2_1	232	237	PF00069	0.234
MOD_NEK2_1	26	31	PF00069	0.330
MOD_NEK2_1	290	295	PF00069	0.358
MOD_NEK2_1	338	343	PF00069	0.445
MOD_NEK2_1	390	395	PF00069	0.346
MOD_NEK2_1	419	424	PF00069	0.313
MOD_NEK2_1	435	440	PF00069	0.466
MOD_NEK2_1	78	83	PF00069	0.307
MOD_NEK2_2	37	42	PF00069	0.333
MOD_PIKK_1	115	121	PF00454	0.348
MOD_PIKK_1	123	129	PF00454	0.424
MOD_PIKK_1	346	352	PF00454	0.465
MOD_PK_1	14	20	PF00069	0.417
MOD_PKA_2	239	245	PF00069	0.361
MOD_PKA_2	312	318	PF00069	0.401
MOD_PKA_2	332	338	PF00069	0.247
MOD_PKA_2	98	104	PF00069	0.267
MOD_PKB_1	238	246	PF00069	0.361
MOD_Plk_1	316	322	PF00069	0.530
MOD_Plk_1	63	69	PF00069	0.291
MOD_Plk_4	130	136	PF00069	0.390
MOD_Plk_4	141	147	PF00069	0.278
MOD_Plk_4	195	201	PF00069	0.381
MOD_Plk_4	290	296	PF00069	0.381
MOD_Plk_4	325	331	PF00069	0.494
MOD_Plk_4	430	436	PF00069	0.395
MOD_Plk_4	80	86	PF00069	0.388
MOD_ProDKin_1	370	376	PF00069	0.466
MOD_ProDKin_1	399	405	PF00069	0.432
MOD_ProDKin_1	56	62	PF00069	0.434
MOD_SUMO_for_1	363	366	PF00179	0.468
MOD_SUMO_for_1	376	379	PF00179	0.505
MOD_SUMO_for_1	41	44	PF00179	0.313
MOD_SUMO_rev_2	32	38	PF00179	0.328
TRG_DiLeu_BaEn_1	430	435	PF01217	0.338
TRG_DiLeu_BaEn_3	378	384	PF01217	0.397
TRG_ENDOCYTIC_2	112	115	PF00928	0.291
TRG_ENDOCYTIC_2	226	229	PF00928	0.276
TRG_ENDOCYTIC_2	308	311	PF00928	0.511
TRG_ENDOCYTIC_2	406	409	PF00928	0.453
TRG_ENDOCYTIC_2	67	70	PF00928	0.309
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q0	Leptomonas seymouri	76%	100%
A0A0S4J450	Bodo saltans	31%	100%
A0A1X0NYA9	Trypanosomatidae	44%	100%
A4HEC1	Leishmania braziliensis	86%	100%
A4I1R6	Leishmania infantum	100%	100%
A6S936	Botryotinia fuckeliana (strain B05.10)	25%	97%
A7RG82	Nematostella vectensis	25%	100%
A8PB32	Brugia malayi	24%	100%
A8X9U4	Caenorhabditis briggsae	23%	100%
B0VZR4	Culex quinquefasciatus	25%	100%
C9ZKC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E7F3I6	Danio rerio	23%	100%
E9AXV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0U2G5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	95%
Q16WA6	Aedes aegypti	24%	100%
Q2H1L0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	90%
Q4Q9M0	Leishmania major	96%	100%
Q59ST8	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	91%
Q66JK4	Xenopus tropicalis	26%	100%
Q6NS21	Xenopus laevis	26%	100%
Q9SR06	Arabidopsis thaliana	25%	100%
V5BCI8	Trypanosoma cruzi	43%	100%