Not1 N-terminal domain, CCR4-Not complex component/NOT2 / NOT3 / NOT5 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

General negative regulator of transcription subunit 5

Species:

Leishmania donovani

UniProt:

A0A3S5H7F0_LEIDO

TriTrypDb:

LdBPK_251920.1 , LdCL_250024900 , LDHU3_25.2380

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005737	cytoplasm	2	8
GO:0030015	CCR4-NOT core complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0140535	intracellular protein-containing complex	2	8
GO:0000932	P-body	5	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1

Expansion

Sequence features

A0A3S5H7F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7F0

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	8
GO:0009889	regulation of biosynthetic process	4	8
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051252	regulation of RNA metabolic process	5	8
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0080090	regulation of primary metabolic process	4	8
GO:1903506	regulation of nucleic acid-templated transcription	7	8
GO:2001141	regulation of RNA biosynthetic process	6	8
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.546
CLV_C14_Caspase3-7	20	24	PF00656	0.504
CLV_NRD_NRD_1	131	133	PF00675	0.257
CLV_NRD_NRD_1	151	153	PF00675	0.171
CLV_NRD_NRD_1	405	407	PF00675	0.555
CLV_NRD_NRD_1	80	82	PF00675	0.300
CLV_PCSK_FUR_1	149	153	PF00082	0.300
CLV_PCSK_KEX2_1	151	153	PF00082	0.300
CLV_PCSK_KEX2_1	405	407	PF00082	0.574
CLV_PCSK_KEX2_1	49	51	PF00082	0.259
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.301
CLV_PCSK_SKI1_1	13	17	PF00082	0.300
CLV_PCSK_SKI1_1	373	377	PF00082	0.836
CLV_PCSK_SKI1_1	50	54	PF00082	0.300
CLV_PCSK_SKI1_1	570	574	PF00082	0.300
CLV_PCSK_SKI1_1	96	100	PF00082	0.326
DEG_SCF_FBW7_1	463	469	PF00400	0.783
DEG_SPOP_SBC_1	275	279	PF00917	0.566
DEG_SPOP_SBC_1	281	285	PF00917	0.678
DEG_SPOP_SBC_1	449	453	PF00917	0.656
DEG_SPOP_SBC_1	593	597	PF00917	0.500
DOC_CKS1_1	463	468	PF01111	0.755
DOC_CYCLIN_yClb5_NLxxxL_5	501	510	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	297	300	PF00134	0.768
DOC_CYCLIN_yCln2_LP_2	454	460	PF00134	0.626
DOC_MAPK_gen_1	227	234	PF00069	0.630
DOC_MAPK_gen_1	72	79	PF00069	0.504
DOC_MAPK_MEF2A_6	227	234	PF00069	0.592
DOC_PP2B_LxvP_1	297	300	PF13499	0.626
DOC_PP2B_LxvP_1	454	457	PF13499	0.616
DOC_PP4_FxxP_1	221	224	PF00568	0.504
DOC_USP7_MATH_1	275	279	PF00917	0.723
DOC_USP7_MATH_1	280	284	PF00917	0.698
DOC_USP7_MATH_1	300	304	PF00917	0.660
DOC_USP7_MATH_1	36	40	PF00917	0.500
DOC_USP7_MATH_1	442	446	PF00917	0.687
DOC_USP7_MATH_1	466	470	PF00917	0.775
DOC_USP7_MATH_1	61	65	PF00917	0.510
DOC_USP7_UBL2_3	154	158	PF12436	0.439
DOC_USP7_UBL2_3	248	252	PF12436	0.683
DOC_USP7_UBL2_3	489	493	PF12436	0.541
DOC_USP7_UBL2_3	49	53	PF12436	0.500
DOC_USP7_UBL2_3	72	76	PF12436	0.500
DOC_WW_Pin1_4	243	248	PF00397	0.611
DOC_WW_Pin1_4	252	257	PF00397	0.622
DOC_WW_Pin1_4	262	267	PF00397	0.616
DOC_WW_Pin1_4	276	281	PF00397	0.725
DOC_WW_Pin1_4	290	295	PF00397	0.665
DOC_WW_Pin1_4	301	306	PF00397	0.694
DOC_WW_Pin1_4	366	371	PF00397	0.657
DOC_WW_Pin1_4	389	394	PF00397	0.686
DOC_WW_Pin1_4	396	401	PF00397	0.714
DOC_WW_Pin1_4	427	432	PF00397	0.629
DOC_WW_Pin1_4	459	464	PF00397	0.713
DOC_WW_Pin1_4	488	493	PF00397	0.614
LIG_14-3-3_CanoR_1	602	608	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_2	525	529	PF00653	0.505
LIG_BRCT_BRCA1_1	337	341	PF00533	0.640
LIG_BRCT_BRCA1_1	474	478	PF00533	0.537
LIG_BRCT_BRCA1_1	603	607	PF00533	0.500
LIG_EVH1_1	478	482	PF00568	0.650
LIG_FHA_1	187	193	PF00498	0.492
LIG_FHA_1	255	261	PF00498	0.635
LIG_FHA_1	351	357	PF00498	0.618
LIG_FHA_1	372	378	PF00498	0.700
LIG_FHA_1	449	455	PF00498	0.679
LIG_FHA_1	507	513	PF00498	0.491
LIG_FHA_2	324	330	PF00498	0.653
LIG_FHA_2	593	599	PF00498	0.537
LIG_FHA_2	604	610	PF00498	0.514
LIG_FHA_2	7	13	PF00498	0.472
LIG_Integrin_isoDGR_2	147	149	PF01839	0.300
LIG_LIR_Apic_2	219	224	PF02991	0.504
LIG_LIR_Gen_1	216	226	PF02991	0.459
LIG_LIR_Gen_1	23	33	PF02991	0.459
LIG_LIR_Gen_1	542	552	PF02991	0.534
LIG_LIR_Gen_1	604	610	PF02991	0.514
LIG_LIR_Nem_3	216	221	PF02991	0.459
LIG_LIR_Nem_3	23	28	PF02991	0.459
LIG_LIR_Nem_3	475	481	PF02991	0.569
LIG_LIR_Nem_3	550	556	PF02991	0.494
LIG_LIR_Nem_3	562	566	PF02991	0.500
LIG_LIR_Nem_3	604	610	PF02991	0.464
LIG_LIR_Nem_3	625	629	PF02991	0.503
LIG_LIR_Nem_3	89	94	PF02991	0.500
LIG_PCNA_PIPBox_1	546	555	PF02747	0.483
LIG_PCNA_yPIPBox_3	541	553	PF02747	0.483
LIG_Pex14_2	610	614	PF04695	0.457
LIG_PTB_Apo_2	65	72	PF02174	0.500
LIG_PTB_Phospho_1	65	71	PF10480	0.500
LIG_REV1ctd_RIR_1	170	178	PF16727	0.504
LIG_SH2_NCK_1	518	522	PF00017	0.500
LIG_SH2_SRC	518	521	PF00017	0.500
LIG_SH2_STAT3	140	143	PF00017	0.500
LIG_SH2_STAT3	529	532	PF00017	0.500
LIG_SH2_STAT3	557	560	PF00017	0.457
LIG_SH2_STAT5	529	532	PF00017	0.510
LIG_SH2_STAT5	566	569	PF00017	0.457
LIG_SH2_STAT5	605	608	PF00017	0.500
LIG_SH2_STAT5	628	631	PF00017	0.519
LIG_SH3_1	227	233	PF00018	0.590
LIG_SH3_1	388	394	PF00018	0.651
LIG_SH3_1	514	520	PF00018	0.500
LIG_SH3_3	227	233	PF00018	0.603
LIG_SH3_3	241	247	PF00018	0.567
LIG_SH3_3	388	394	PF00018	0.734
LIG_SH3_3	428	434	PF00018	0.686
LIG_SH3_3	460	466	PF00018	0.815
LIG_SH3_3	471	477	PF00018	0.585
LIG_SH3_3	514	520	PF00018	0.491
LIG_SH3_3	525	531	PF00018	0.433
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.504
LIG_TRAF2_1	127	130	PF00917	0.573
LIG_TRAF2_1	384	387	PF00917	0.657
LIG_WRC_WIRS_1	218	223	PF05994	0.500
LIG_WRC_WIRS_1	62	67	PF05994	0.504
LIG_WRC_WIRS_1	88	93	PF05994	0.457
MOD_CDK_SPK_2	243	248	PF00069	0.670
MOD_CDK_SPK_2	267	272	PF00069	0.649
MOD_CDK_SPK_2	488	493	PF00069	0.545
MOD_CDK_SPxK_1	488	494	PF00069	0.537
MOD_CDK_SPxxK_3	366	373	PF00069	0.634
MOD_CK1_1	246	252	PF00069	0.655
MOD_CK1_1	351	357	PF00069	0.568
MOD_CK1_1	462	468	PF00069	0.685
MOD_CK1_1	469	475	PF00069	0.581
MOD_CK1_1	488	494	PF00069	0.399
MOD_CK2_1	115	121	PF00069	0.500
MOD_CK2_1	234	240	PF00069	0.641
MOD_CK2_1	267	273	PF00069	0.709
MOD_CK2_1	342	348	PF00069	0.648
MOD_CK2_1	36	42	PF00069	0.500
MOD_CK2_1	442	448	PF00069	0.704
MOD_CK2_1	592	598	PF00069	0.526
MOD_Cter_Amidation	130	133	PF01082	0.300
MOD_GlcNHglycan	109	112	PF01048	0.271
MOD_GlcNHglycan	117	120	PF01048	0.278
MOD_GlcNHglycan	337	340	PF01048	0.639
MOD_GlcNHglycan	350	353	PF01048	0.479
MOD_GlcNHglycan	379	382	PF01048	0.606
MOD_GlcNHglycan	38	41	PF01048	0.304
MOD_GlcNHglycan	443	447	PF01048	0.676
MOD_GSK3_1	213	220	PF00069	0.500
MOD_GSK3_1	243	250	PF00069	0.752
MOD_GSK3_1	252	259	PF00069	0.687
MOD_GSK3_1	262	269	PF00069	0.563
MOD_GSK3_1	271	278	PF00069	0.553
MOD_GSK3_1	335	342	PF00069	0.817
MOD_GSK3_1	350	357	PF00069	0.493
MOD_GSK3_1	371	378	PF00069	0.631
MOD_GSK3_1	438	445	PF00069	0.566
MOD_GSK3_1	462	469	PF00069	0.731
MOD_GSK3_1	592	599	PF00069	0.483
MOD_GSK3_1	97	104	PF00069	0.474
MOD_N-GLC_1	36	41	PF02516	0.264
MOD_NEK2_1	499	504	PF00069	0.578
MOD_NEK2_1	77	82	PF00069	0.503
MOD_NEK2_2	603	608	PF00069	0.500
MOD_PIKK_1	282	288	PF00454	0.577
MOD_PIKK_1	354	360	PF00454	0.617
MOD_PIKK_1	472	478	PF00454	0.701
MOD_PKA_2	601	607	PF00069	0.513
MOD_Plk_1	213	219	PF00069	0.500
MOD_Plk_1	328	334	PF00069	0.622
MOD_Plk_1	499	505	PF00069	0.292
MOD_Plk_2-3	186	192	PF00069	0.492
MOD_Plk_2-3	213	219	PF00069	0.500
MOD_Plk_4	174	180	PF00069	0.504
MOD_Plk_4	213	219	PF00069	0.500
MOD_Plk_4	450	456	PF00069	0.695
MOD_Plk_4	548	554	PF00069	0.472
MOD_Plk_4	603	609	PF00069	0.500
MOD_Plk_4	61	67	PF00069	0.504
MOD_ProDKin_1	243	249	PF00069	0.612
MOD_ProDKin_1	252	258	PF00069	0.621
MOD_ProDKin_1	262	268	PF00069	0.616
MOD_ProDKin_1	276	282	PF00069	0.723
MOD_ProDKin_1	290	296	PF00069	0.665
MOD_ProDKin_1	301	307	PF00069	0.694
MOD_ProDKin_1	366	372	PF00069	0.657
MOD_ProDKin_1	389	395	PF00069	0.687
MOD_ProDKin_1	396	402	PF00069	0.713
MOD_ProDKin_1	427	433	PF00069	0.628
MOD_ProDKin_1	459	465	PF00069	0.714
MOD_ProDKin_1	488	494	PF00069	0.605
MOD_SUMO_for_1	173	176	PF00179	0.504
MOD_SUMO_for_1	48	51	PF00179	0.500
MOD_SUMO_rev_2	219	228	PF00179	0.647
MOD_SUMO_rev_2	235	244	PF00179	0.644
MOD_SUMO_rev_2	369	375	PF00179	0.723
MOD_SUMO_rev_2	380	389	PF00179	0.611
MOD_SUMO_rev_2	45	55	PF00179	0.500
MOD_SUMO_rev_2	620	629	PF00179	0.457
MOD_SUMO_rev_2	95	100	PF00179	0.500
TRG_DiLeu_BaEn_1	10	15	PF01217	0.457
TRG_DiLeu_LyEn_5	10	15	PF01217	0.457
TRG_ENDOCYTIC_2	218	221	PF00928	0.457
TRG_ENDOCYTIC_2	25	28	PF00928	0.457
TRG_ENDOCYTIC_2	544	547	PF00928	0.492
TRG_ENDOCYTIC_2	587	590	PF00928	0.534
TRG_ENDOCYTIC_2	605	608	PF00928	0.534
TRG_ENDOCYTIC_2	626	629	PF00928	0.457
TRG_ER_diArg_1	149	152	PF00400	0.500
TRG_ER_diArg_1	514	517	PF00400	0.501
TRG_NES_CRM1_1	197	213	PF08389	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ8	Leptomonas seymouri	68%	94%
A4HE86	Leishmania braziliensis	87%	100%
A4I1N2	Leishmania infantum	100%	100%
C9ZK81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9Q5	Leishmania major	94%	100%