Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein 24 kDa

Species:

Leishmania donovani

UniProt:

A0A3S5H7E8_LEIDO

TriTrypDb:

LdBPK_251490.1 , LdCL_250020500 , LDHU3_25.1830

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7E8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.471
CLV_NRD_NRD_1	217	219	PF00675	0.555
CLV_NRD_NRD_1	251	253	PF00675	0.488
CLV_NRD_NRD_1	38	40	PF00675	0.396
CLV_NRD_NRD_1	83	85	PF00675	0.577
CLV_PCSK_KEX2_1	117	119	PF00082	0.514
CLV_PCSK_KEX2_1	217	219	PF00082	0.555
CLV_PCSK_KEX2_1	251	253	PF00082	0.517
CLV_PCSK_KEX2_1	38	40	PF00082	0.396
CLV_PCSK_KEX2_1	82	84	PF00082	0.598
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.590
CLV_PCSK_SKI1_1	39	43	PF00082	0.429
DOC_CKS1_1	154	159	PF01111	0.345
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.632
DOC_MAPK_DCC_7	99	108	PF00069	0.513
DOC_MAPK_gen_1	99	108	PF00069	0.337
DOC_MAPK_JIP1_4	196	202	PF00069	0.485
DOC_MAPK_MEF2A_6	196	204	PF00069	0.481
DOC_PP1_RVXF_1	82	89	PF00149	0.571
DOC_USP7_MATH_1	58	62	PF00917	0.670
DOC_WW_Pin1_4	122	127	PF00397	0.623
DOC_WW_Pin1_4	153	158	PF00397	0.344
LIG_14-3-3_CanoR_1	217	224	PF00244	0.616
LIG_14-3-3_CanoR_1	252	260	PF00244	0.474
LIG_14-3-3_CanoR_1	82	87	PF00244	0.627
LIG_deltaCOP1_diTrp_1	242	248	PF00928	0.508
LIG_eIF4E_1	69	75	PF01652	0.603
LIG_FHA_1	217	223	PF00498	0.582
LIG_FHA_2	209	215	PF00498	0.489
LIG_LIR_Gen_1	30	36	PF02991	0.345
LIG_LIR_Gen_1	85	96	PF02991	0.643
LIG_LIR_Nem_3	12	17	PF02991	0.447
LIG_LIR_Nem_3	30	34	PF02991	0.236
LIG_LIR_Nem_3	85	91	PF02991	0.638
LIG_MYND_1	101	105	PF01753	0.499
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.660
LIG_SH2_CRK	14	18	PF00017	0.422
LIG_SH2_GRB2like	201	204	PF00017	0.501
LIG_SH2_SRC	147	150	PF00017	0.377
LIG_SH2_STAT5	113	116	PF00017	0.507
LIG_SH2_STAT5	147	150	PF00017	0.352
LIG_SH2_STAT5	16	19	PF00017	0.419
LIG_SH2_STAT5	161	164	PF00017	0.405
LIG_SH2_STAT5	201	204	PF00017	0.501
LIG_SH2_STAT5	69	72	PF00017	0.574
LIG_SH3_3	154	160	PF00018	0.345
LIG_SH3_3	183	189	PF00018	0.541
LIG_SH3_3	30	36	PF00018	0.481
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.460
LIG_TRAF2_1	211	214	PF00917	0.520
LIG_TRAF2_1	236	239	PF00917	0.625
LIG_TYR_ITIM	199	204	PF00017	0.535
LIG_WRC_WIRS_1	223	228	PF05994	0.559
LIG_WRC_WIRS_1	93	98	PF05994	0.718
MOD_CDK_SPxK_1	153	159	PF00069	0.464
MOD_CK1_1	225	231	PF00069	0.700
MOD_CK1_1	60	66	PF00069	0.625
MOD_CK1_1	95	101	PF00069	0.550
MOD_CK2_1	208	214	PF00069	0.510
MOD_CK2_1	232	238	PF00069	0.630
MOD_CK2_1	45	51	PF00069	0.523
MOD_CMANNOS	245	248	PF00535	0.495
MOD_GlcNHglycan	140	143	PF01048	0.618
MOD_GlcNHglycan	191	194	PF01048	0.555
MOD_GlcNHglycan	228	231	PF01048	0.739
MOD_GlcNHglycan	234	237	PF01048	0.646
MOD_GlcNHglycan	47	50	PF01048	0.560
MOD_GlcNHglycan	60	63	PF01048	0.745
MOD_GSK3_1	122	129	PF00069	0.648
MOD_GSK3_1	222	229	PF00069	0.659
MOD_GSK3_1	45	52	PF00069	0.540
MOD_GSK3_1	57	64	PF00069	0.620
MOD_NEK2_1	184	189	PF00069	0.488
MOD_NEK2_1	226	231	PF00069	0.565
MOD_NEK2_1	250	255	PF00069	0.507
MOD_PIKK_1	253	259	PF00454	0.521
MOD_PIKK_1	69	75	PF00454	0.571
MOD_PK_1	130	136	PF00069	0.605
MOD_PKA_1	217	223	PF00069	0.557
MOD_PKA_1	82	88	PF00069	0.570
MOD_PKA_2	129	135	PF00069	0.664
MOD_PKA_2	216	222	PF00069	0.547
MOD_PKA_2	250	256	PF00069	0.508
MOD_PKA_2	82	88	PF00069	0.634
MOD_Plk_1	130	136	PF00069	0.671
MOD_Plk_2-3	178	184	PF00069	0.471
MOD_Plk_4	6	12	PF00069	0.494
MOD_Plk_4	61	67	PF00069	0.645
MOD_ProDKin_1	122	128	PF00069	0.626
MOD_ProDKin_1	153	159	PF00069	0.348
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.385
TRG_ENDOCYTIC_2	14	17	PF00928	0.416
TRG_ENDOCYTIC_2	147	150	PF00928	0.412
TRG_ENDOCYTIC_2	201	204	PF00928	0.530
TRG_ER_diArg_1	116	119	PF00400	0.501
TRG_ER_diArg_1	216	218	PF00400	0.567
TRG_ER_diArg_1	250	252	PF00400	0.519
TRG_ER_diArg_1	81	84	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN1	Leptomonas seymouri	55%	100%
A0A1X0NM21	Trypanosomatidae	27%	100%
A4HE80	Leishmania braziliensis	86%	100%
A4I1I9	Leishmania infantum	100%	100%
C9ZJX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9U8	Leishmania major	94%	100%
V5BCP1	Trypanosoma cruzi	27%	100%