Modification methylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

modification methylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7E7_LEIDO

TriTrypDb:

LdBPK_251230.1 , LdCL_250018100 , LDHU3_25.1570

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7E7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	5	6
GO:0008168	methyltransferase activity	4	7
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0009008	DNA-methyltransferase activity	4	6
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.677
CLV_C14_Caspase3-7	152	156	PF00656	0.504
CLV_C14_Caspase3-7	210	214	PF00656	0.731
CLV_C14_Caspase3-7	53	57	PF00656	0.566
CLV_C14_Caspase3-7	785	789	PF00656	0.678
CLV_NRD_NRD_1	108	110	PF00675	0.557
CLV_NRD_NRD_1	234	236	PF00675	0.555
CLV_NRD_NRD_1	255	257	PF00675	0.649
CLV_NRD_NRD_1	262	264	PF00675	0.621
CLV_NRD_NRD_1	35	37	PF00675	0.550
CLV_NRD_NRD_1	513	515	PF00675	0.252
CLV_NRD_NRD_1	547	549	PF00675	0.307
CLV_NRD_NRD_1	670	672	PF00675	0.302
CLV_PCSK_FUR_1	511	515	PF00082	0.252
CLV_PCSK_KEX2_1	108	110	PF00082	0.613
CLV_PCSK_KEX2_1	234	236	PF00082	0.555
CLV_PCSK_KEX2_1	255	257	PF00082	0.649
CLV_PCSK_KEX2_1	262	264	PF00082	0.621
CLV_PCSK_KEX2_1	35	37	PF00082	0.622
CLV_PCSK_KEX2_1	513	515	PF00082	0.252
CLV_PCSK_KEX2_1	549	551	PF00082	0.305
CLV_PCSK_KEX2_1	670	672	PF00082	0.303
CLV_PCSK_KEX2_1	838	840	PF00082	0.508
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.312
CLV_PCSK_SKI1_1	147	151	PF00082	0.579
CLV_PCSK_SKI1_1	196	200	PF00082	0.643
CLV_PCSK_SKI1_1	256	260	PF00082	0.594
CLV_PCSK_SKI1_1	339	343	PF00082	0.361
CLV_PCSK_SKI1_1	35	39	PF00082	0.559
CLV_PCSK_SKI1_1	383	387	PF00082	0.650
CLV_PCSK_SKI1_1	41	45	PF00082	0.539
CLV_PCSK_SKI1_1	691	695	PF00082	0.275
CLV_Separin_Metazoa	475	479	PF03568	0.475
DEG_APCC_DBOX_1	329	337	PF00400	0.475
DEG_APCC_DBOX_1	82	90	PF00400	0.612
DEG_SCF_FBW7_2	519	525	PF00400	0.495
DEG_SCF_SKP2-CKS1_1	723	730	PF00560	0.478
DEG_SIAH_1	792	800	PF03145	0.534
DEG_SPOP_SBC_1	640	644	PF00917	0.527
DOC_ANK_TNKS_1	153	160	PF00023	0.516
DOC_CKS1_1	519	524	PF01111	0.469
DOC_CKS1_1	628	633	PF01111	0.478
DOC_CYCLIN_RxL_1	688	696	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.495
DOC_MAPK_gen_1	35	45	PF00069	0.531
DOC_PP1_RVXF_1	547	554	PF00149	0.475
DOC_PP2B_LxvP_1	166	169	PF13499	0.530
DOC_PP2B_LxvP_1	368	371	PF13499	0.561
DOC_PP2B_LxvP_1	618	621	PF13499	0.488
DOC_PP4_FxxP_1	346	349	PF00568	0.475
DOC_PP4_FxxP_1	774	777	PF00568	0.475
DOC_USP7_MATH_1	136	140	PF00917	0.668
DOC_USP7_MATH_1	153	157	PF00917	0.426
DOC_USP7_MATH_1	279	283	PF00917	0.653
DOC_USP7_MATH_1	402	406	PF00917	0.700
DOC_USP7_MATH_1	452	456	PF00917	0.475
DOC_USP7_MATH_1	650	654	PF00917	0.533
DOC_USP7_MATH_1	709	713	PF00917	0.512
DOC_USP7_MATH_1	740	744	PF00917	0.507
DOC_USP7_MATH_1	830	834	PF00917	0.443
DOC_USP7_UBL2_3	726	730	PF12436	0.478
DOC_WW_Pin1_4	222	227	PF00397	0.581
DOC_WW_Pin1_4	273	278	PF00397	0.672
DOC_WW_Pin1_4	311	316	PF00397	0.561
DOC_WW_Pin1_4	518	523	PF00397	0.469
DOC_WW_Pin1_4	541	546	PF00397	0.475
DOC_WW_Pin1_4	557	562	PF00397	0.475
DOC_WW_Pin1_4	606	611	PF00397	0.529
DOC_WW_Pin1_4	627	632	PF00397	0.495
DOC_WW_Pin1_4	724	729	PF00397	0.495
DOC_WW_Pin1_4	788	793	PF00397	0.771
LIG_14-3-3_CanoR_1	137	141	PF00244	0.611
LIG_14-3-3_CanoR_1	297	301	PF00244	0.749
LIG_14-3-3_CanoR_1	41	46	PF00244	0.524
LIG_14-3-3_CanoR_1	513	522	PF00244	0.474
LIG_14-3-3_CanoR_1	61	67	PF00244	0.681
LIG_14-3-3_CanoR_1	670	676	PF00244	0.491
LIG_14-3-3_CanoR_1	689	694	PF00244	0.529
LIG_14-3-3_CanoR_1	698	702	PF00244	0.449
LIG_Actin_WH2_2	24	40	PF00022	0.553
LIG_Actin_WH2_2	715	732	PF00022	0.512
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_3	1	5	PF00653	0.606
LIG_BIR_III_4	461	465	PF00653	0.529
LIG_BRCT_BRCA1_1	313	317	PF00533	0.514
LIG_BRCT_BRCA1_1	319	323	PF00533	0.446
LIG_BRCT_BRCA1_1	424	428	PF00533	0.528
LIG_BRCT_BRCA1_1	437	441	PF00533	0.416
LIG_Clathr_ClatBox_1	496	500	PF01394	0.529
LIG_deltaCOP1_diTrp_1	468	473	PF00928	0.475
LIG_EH1_1	716	724	PF00400	0.478
LIG_EVH1_2	754	758	PF00568	0.475
LIG_FHA_1	380	386	PF00498	0.645
LIG_FHA_1	484	490	PF00498	0.475
LIG_FHA_1	621	627	PF00498	0.495
LIG_FHA_1	771	777	PF00498	0.530
LIG_FHA_1	778	784	PF00498	0.504
LIG_FHA_2	150	156	PF00498	0.545
LIG_FHA_2	208	214	PF00498	0.724
LIG_FHA_2	316	322	PF00498	0.312
LIG_FHA_2	42	48	PF00498	0.671
LIG_FHA_2	521	527	PF00498	0.529
LIG_FHA_2	713	719	PF00498	0.475
LIG_FHA_2	91	97	PF00498	0.562
LIG_GBD_Chelix_1	54	62	PF00786	0.587
LIG_LIR_Apic_2	345	349	PF02991	0.475
LIG_LIR_Apic_2	625	631	PF02991	0.478
LIG_LIR_Apic_2	771	777	PF02991	0.475
LIG_LIR_Gen_1	160	169	PF02991	0.599
LIG_LIR_Gen_1	318	326	PF02991	0.501
LIG_LIR_Gen_1	49	58	PF02991	0.615
LIG_LIR_Nem_3	160	165	PF02991	0.684
LIG_LIR_Nem_3	176	181	PF02991	0.519
LIG_LIR_Nem_3	314	319	PF02991	0.410
LIG_LIR_Nem_3	320	326	PF02991	0.476
LIG_LIR_Nem_3	468	474	PF02991	0.503
LIG_LIR_Nem_3	49	54	PF02991	0.616
LIG_LIR_Nem_3	608	614	PF02991	0.478
LIG_LIR_Nem_3	663	669	PF02991	0.473
LIG_LIR_Nem_3	699	704	PF02991	0.475
LIG_LIR_Nem_3	705	710	PF02991	0.475
LIG_LYPXL_SIV_4	610	618	PF13949	0.529
LIG_MLH1_MIPbox_1	313	317	PF16413	0.485
LIG_MLH1_MIPbox_1	437	441	PF16413	0.495
LIG_NRBOX	194	200	PF00104	0.573
LIG_NRP_CendR_1	838	840	PF00754	0.496
LIG_PCNA_yPIPBox_3	714	723	PF02747	0.524
LIG_Pex14_2	319	323	PF04695	0.475
LIG_Pex14_2	342	346	PF04695	0.475
LIG_REV1ctd_RIR_1	551	560	PF16727	0.475
LIG_REV1ctd_RIR_1	756	766	PF16727	0.475
LIG_RPA_C_Fungi	588	600	PF08784	0.315
LIG_SH2_CRK	611	615	PF00017	0.352
LIG_SH2_CRK	628	632	PF00017	0.352
LIG_SH2_CRK	812	816	PF00017	0.396
LIG_SH2_NCK_1	628	632	PF00017	0.433
LIG_SH2_STAP1	704	708	PF00017	0.312
LIG_SH2_STAT3	531	534	PF00017	0.364
LIG_SH2_STAT5	229	232	PF00017	0.648
LIG_SH2_STAT5	552	555	PF00017	0.294
LIG_SH2_STAT5	834	837	PF00017	0.402
LIG_SH3_2	561	566	PF14604	0.255
LIG_SH3_2	752	757	PF14604	0.315
LIG_SH3_3	236	242	PF00018	0.537
LIG_SH3_3	309	315	PF00018	0.636
LIG_SH3_3	555	561	PF00018	0.237
LIG_SH3_3	6	12	PF00018	0.593
LIG_SH3_3	725	731	PF00018	0.340
LIG_SH3_3	743	749	PF00018	0.306
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.595
LIG_SUMO_SIM_par_1	494	500	PF11976	0.388
LIG_SUMO_SIM_par_1	622	627	PF11976	0.263
LIG_TRAF2_1	20	23	PF00917	0.534
LIG_TRAF2_1	373	376	PF00917	0.619
LIG_TYR_ITIM	472	477	PF00017	0.312
LIG_WRC_WIRS_1	316	321	PF05994	0.388
LIG_WW_1	8	11	PF00397	0.608
MOD_CDC14_SPxK_1	609	612	PF00782	0.388
MOD_CDK_SPxK_1	606	612	PF00069	0.388
MOD_CDK_SPxK_1	724	730	PF00069	0.315
MOD_CDK_SPxxK_3	541	548	PF00069	0.312
MOD_CDK_SPxxK_3	627	634	PF00069	0.340
MOD_CK1_1	125	131	PF00069	0.775
MOD_CK1_1	201	207	PF00069	0.679
MOD_CK1_1	209	215	PF00069	0.714
MOD_CK1_1	220	226	PF00069	0.630
MOD_CK1_1	280	286	PF00069	0.606
MOD_CK1_1	291	297	PF00069	0.625
MOD_CK1_1	3	9	PF00069	0.664
MOD_CK1_1	517	523	PF00069	0.357
MOD_CK1_1	606	612	PF00069	0.326
MOD_CK1_1	627	633	PF00069	0.476
MOD_CK1_1	696	702	PF00069	0.332
MOD_CK1_1	712	718	PF00069	0.376
MOD_CK2_1	17	23	PF00069	0.567
MOD_CK2_1	315	321	PF00069	0.312
MOD_CK2_1	328	334	PF00069	0.312
MOD_CK2_1	62	68	PF00069	0.636
MOD_CK2_1	641	647	PF00069	0.334
MOD_CK2_1	712	718	PF00069	0.302
MOD_CK2_1	90	96	PF00069	0.568
MOD_Cter_Amidation	106	109	PF01082	0.586
MOD_DYRK1A_RPxSP_1	557	561	PF00069	0.255
MOD_GlcNHglycan	112	115	PF01048	0.695
MOD_GlcNHglycan	118	121	PF01048	0.667
MOD_GlcNHglycan	134	137	PF01048	0.657
MOD_GlcNHglycan	138	141	PF01048	0.597
MOD_GlcNHglycan	2	5	PF01048	0.692
MOD_GlcNHglycan	204	207	PF01048	0.629
MOD_GlcNHglycan	248	251	PF01048	0.538
MOD_GlcNHglycan	290	293	PF01048	0.737
MOD_GlcNHglycan	298	301	PF01048	0.662
MOD_GlcNHglycan	330	333	PF01048	0.454
MOD_GlcNHglycan	395	398	PF01048	0.775
MOD_GlcNHglycan	400	403	PF01048	0.710
MOD_GlcNHglycan	404	407	PF01048	0.648
MOD_GlcNHglycan	437	440	PF01048	0.453
MOD_GlcNHglycan	516	519	PF01048	0.433
MOD_GlcNHglycan	576	579	PF01048	0.318
MOD_GlcNHglycan	586	590	PF01048	0.289
MOD_GlcNHglycan	62	65	PF01048	0.720
MOD_GlcNHglycan	647	651	PF01048	0.485
MOD_GlcNHglycan	653	656	PF01048	0.397
MOD_GlcNHglycan	662	665	PF01048	0.285
MOD_GlcNHglycan	785	788	PF01048	0.676
MOD_GlcNHglycan	807	810	PF01048	0.441
MOD_GSK3_1	103	110	PF00069	0.608
MOD_GSK3_1	121	128	PF00069	0.593
MOD_GSK3_1	132	139	PF00069	0.684
MOD_GSK3_1	149	156	PF00069	0.600
MOD_GSK3_1	197	204	PF00069	0.643
MOD_GSK3_1	217	224	PF00069	0.591
MOD_GSK3_1	273	280	PF00069	0.578
MOD_GSK3_1	291	298	PF00069	0.700
MOD_GSK3_1	3	10	PF00069	0.606
MOD_GSK3_1	311	318	PF00069	0.617
MOD_GSK3_1	398	405	PF00069	0.689
MOD_GSK3_1	431	438	PF00069	0.294
MOD_GSK3_1	514	521	PF00069	0.325
MOD_GSK3_1	620	627	PF00069	0.381
MOD_GSK3_1	646	653	PF00069	0.451
MOD_GSK3_1	689	696	PF00069	0.339
MOD_GSK3_1	708	715	PF00069	0.320
MOD_GSK3_1	777	784	PF00069	0.404
MOD_LATS_1	88	94	PF00433	0.605
MOD_N-GLC_1	41	46	PF02516	0.545
MOD_NEK2_1	221	226	PF00069	0.687
MOD_NEK2_1	295	300	PF00069	0.655
MOD_NEK2_1	328	333	PF00069	0.388
MOD_NEK2_1	480	485	PF00069	0.291
MOD_NEK2_1	574	579	PF00069	0.327
MOD_NEK2_1	62	67	PF00069	0.609
MOD_NEK2_1	626	631	PF00069	0.255
MOD_NEK2_1	693	698	PF00069	0.328
MOD_NEK2_1	82	87	PF00069	0.634
MOD_NEK2_2	217	222	PF00069	0.576
MOD_PIKK_1	101	107	PF00454	0.651
MOD_PIKK_1	384	390	PF00454	0.641
MOD_PIKK_1	712	718	PF00454	0.388
MOD_PIKK_1	778	784	PF00454	0.331
MOD_PKA_2	107	113	PF00069	0.483
MOD_PKA_2	136	142	PF00069	0.636
MOD_PKA_2	153	159	PF00069	0.406
MOD_PKA_2	296	302	PF00069	0.771
MOD_PKA_2	483	489	PF00069	0.340
MOD_PKA_2	60	66	PF00069	0.601
MOD_PKA_2	669	675	PF00069	0.334
MOD_PKA_2	697	703	PF00069	0.312
MOD_PKA_2	82	88	PF00069	0.767
MOD_PKA_2	89	95	PF00069	0.576
MOD_PKB_1	393	401	PF00069	0.607
MOD_Plk_1	41	47	PF00069	0.523
MOD_Plk_1	624	630	PF00069	0.364
MOD_Plk_1	770	776	PF00069	0.369
MOD_Plk_1	778	784	PF00069	0.325
MOD_Plk_4	122	128	PF00069	0.593
MOD_Plk_4	161	167	PF00069	0.595
MOD_Plk_4	41	47	PF00069	0.556
MOD_Plk_4	770	776	PF00069	0.340
MOD_Plk_4	82	88	PF00069	0.677
MOD_Plk_4	830	836	PF00069	0.490
MOD_ProDKin_1	222	228	PF00069	0.578
MOD_ProDKin_1	273	279	PF00069	0.674
MOD_ProDKin_1	311	317	PF00069	0.538
MOD_ProDKin_1	518	524	PF00069	0.304
MOD_ProDKin_1	541	547	PF00069	0.312
MOD_ProDKin_1	557	563	PF00069	0.312
MOD_ProDKin_1	606	612	PF00069	0.388
MOD_ProDKin_1	627	633	PF00069	0.340
MOD_ProDKin_1	724	730	PF00069	0.340
MOD_ProDKin_1	788	794	PF00069	0.768
MOD_SUMO_for_1	373	376	PF00179	0.655
TRG_DiLeu_BaEn_1	146	151	PF01217	0.533
TRG_DiLeu_BaEn_1	161	166	PF01217	0.712
TRG_DiLeu_BaEn_1	194	199	PF01217	0.570
TRG_DiLeu_BaEn_1	771	776	PF01217	0.388
TRG_DiLeu_BaEn_1	96	101	PF01217	0.594
TRG_DiLeu_BaEn_2	157	163	PF01217	0.510
TRG_ENDOCYTIC_2	474	477	PF00928	0.352
TRG_ENDOCYTIC_2	611	614	PF00928	0.352
TRG_ENDOCYTIC_2	704	707	PF00928	0.312
TRG_ENDOCYTIC_2	812	815	PF00928	0.399
TRG_ER_diArg_1	233	235	PF00400	0.560
TRG_ER_diArg_1	254	256	PF00400	0.616
TRG_ER_diArg_1	262	265	PF00400	0.517
TRG_ER_diArg_1	35	37	PF00400	0.622
TRG_ER_diArg_1	511	514	PF00400	0.258
TRG_ER_diArg_1	548	551	PF00400	0.352
TRG_ER_diArg_1	669	671	PF00400	0.352
TRG_ER_diArg_1	838	840	PF00400	0.617
TRG_NLS_MonoExtN_4	545	552	PF00514	0.364
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE0	Leptomonas seymouri	49%	100%
A4HE63	Leishmania braziliensis	74%	99%
A4I1G3	Leishmania infantum	99%	100%
E9AXJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9X3	Leishmania major	94%	100%