LeishMANIAdb
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Dynein light chain

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dynein light chain
Gene product:
Dynein light chain 1, cytoplasmic, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H7E1_LEIDO
TriTrypDb:
LdBPK_250260.1 , LdCL_250007700 , LDHU3_25.0320
Length:
89

Annotations

Annotations by Jardim et al.

Structural Proteins, Dynein light chain 1, cytoplasmic

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0005874 microtubule 6 11
GO:0005875 microtubule associated complex 2 11
GO:0030286 dynein complex 3 11
GO:0032991 protein-containing complex 1 11
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
GO:0099512 supramolecular fiber 4 11
GO:0099513 polymeric cytoskeletal fiber 5 11
GO:0110165 cellular anatomical entity 1 11
GO:1902494 catalytic complex 2 11
GO:0005868 cytoplasmic dynein complex 4 1

Expansion

Sequence features

A0A3S5H7E1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7E1

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 11
GO:0009987 cellular process 1 11
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045505 dynein intermediate chain binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.474
CLV_PCSK_KEX2_1 43 45 PF00082 0.260
CLV_PCSK_KEX2_1 48 50 PF00082 0.238
CLV_PCSK_PC1ET2_1 43 45 PF00082 0.260
CLV_PCSK_PC1ET2_1 48 50 PF00082 0.238
CLV_PCSK_PC7_1 44 50 PF00082 0.329
CLV_PCSK_SKI1_1 27 31 PF00082 0.252
DOC_MAPK_gen_1 4 10 PF00069 0.303
DOC_MAPK_MEF2A_6 71 78 PF00069 0.553
DOC_MAPK_NFAT4_5 71 79 PF00069 0.553
DOC_USP7_UBL2_3 5 9 PF12436 0.463
DOC_WW_Pin1_4 11 16 PF00397 0.525
LIG_BIR_II_1 1 5 PF00653 0.556
LIG_FHA_1 24 30 PF00498 0.459
LIG_LIR_Gen_1 53 62 PF02991 0.452
LIG_LIR_Nem_3 53 57 PF02991 0.452
LIG_SH2_SRC 75 78 PF00017 0.553
LIG_SH2_STAT3 77 80 PF00017 0.433
LIG_SH2_STAT5 50 53 PF00017 0.553
LIG_SH2_STAT5 75 78 PF00017 0.450
LIG_SH3_4 5 12 PF00018 0.464
MOD_Plk_4 79 85 PF00069 0.502
MOD_ProDKin_1 11 17 PF00069 0.525
MOD_SUMO_for_1 42 45 PF00179 0.450
MOD_SUMO_rev_2 2 11 PF00179 0.346
MOD_SUMO_rev_2 65 73 PF00179 0.450
TRG_DiLeu_BaEn_2 68 74 PF01217 0.463
TRG_ENDOCYTIC_2 75 78 PF00928 0.450

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0W1 Leptomonas seymouri 53% 98%
A0A0N1I1Z7 Leptomonas seymouri 84% 100%
A0A0N1PBY8 Leptomonas seymouri 52% 98%
A0A0N1PCF1 Leptomonas seymouri 31% 83%
A0A0N1PCX2 Leptomonas seymouri 33% 79%
A0A0S4IS05 Bodo saltans 44% 99%
A0A0S4IUR3 Bodo saltans 55% 98%
A0A0S4J005 Bodo saltans 41% 68%
A0A0S4J1R8 Bodo saltans 56% 98%
A0A0S4JE57 Bodo saltans 69% 100%
A0A0S4JH61 Bodo saltans 56% 71%
A0A0S4JKR9 Bodo saltans 40% 88%
A0A0S4JQ28 Bodo saltans 51% 99%
A0A1X0P6I9 Trypanosomatidae 34% 74%
A0A1X0P8I8 Trypanosomatidae 36% 79%
A0A3Q8IDB7 Leishmania donovani 35% 100%
A0A3Q8IDX2 Leishmania donovani 43% 100%
A0A3R7KXV2 Trypanosoma rangeli 35% 79%
A0A3S5H7R1 Leishmania donovani 53% 100%
A0A3S7WNY4 Leishmania donovani 50% 98%
A0A3S7WTY9 Leishmania donovani 35% 79%
A0A422NC25 Trypanosoma rangeli 71% 82%
A0A422NHE2 Trypanosoma rangeli 42% 79%
A4F4L4 Sus scrofa 33% 85%
A4H453 Leishmania braziliensis 49% 100%
A4H8L8 Leishmania braziliensis 32% 100%
A4HA47 Leishmania braziliensis 34% 100%
A4HDX3 Leishmania braziliensis 91% 100%
A4HGR7 Leishmania braziliensis 41% 100%
A4HK04 Leishmania braziliensis 53% 100%
A4HSD6 Leishmania infantum 50% 100%
A4HWY9 Leishmania infantum 35% 100%
A4HYB3 Leishmania infantum 35% 100%
A4I168 Leishmania infantum 100% 100%
A4I3U2 Leishmania infantum 43% 100%
A4I7I7 Leishmania infantum 53% 100%
C9ZPY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 99%
D0A0N9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 68%
D0A2J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 79%
D0A385 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 71%
D0A5F4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 99%
D0A5K4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 99%
E9AKB1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AQQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AS46 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AXA2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B034 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B2E4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
O02414 Heliocidaris crassispina 62% 100%
O94111 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 52% 95%
O96015 Homo sapiens 33% 85%
O96860 Drosophila melanogaster 61% 100%
P61273 Macaca fascicularis 60% 100%
P61285 Bos taurus 60% 100%
P63167 Homo sapiens 60% 100%
P63168 Mus musculus 60% 100%
P63169 Oryctolagus cuniculus 60% 100%
P63170 Rattus norvegicus 60% 100%
Q02647 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 97%
Q21557 Caenorhabditis elegans 35% 99%
Q22799 Caenorhabditis elegans 60% 100%
Q24117 Drosophila melanogaster 61% 100%
Q32KN5 Bos taurus 33% 85%
Q39579 Chlamydomonas reinhardtii 39% 74%
Q39580 Chlamydomonas reinhardtii 60% 98%
Q3MHR3 Bos taurus 61% 100%
Q4Q5R2 Leishmania major 52% 100%
Q4Q852 Leishmania major 43% 100%
Q4QA70 Leishmania major 99% 100%
Q4QDC0 Leishmania major 35% 100%
Q4QES6 Leishmania major 33% 100%
Q4QJJ6 Leishmania major 51% 100%
Q6BZF8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 39% 98%
Q6CWX4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 40% 100%
Q6FUJ0 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 49% 100%
Q759T0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 43% 100%
Q78P75 Rattus norvegicus 61% 100%
Q86A88 Dictyostelium discoideum 53% 98%
Q94748 Schistosoma mansoni 47% 100%
Q94758 Schistosoma mansoni 58% 100%
Q96FJ2 Homo sapiens 61% 100%
Q9D0M5 Mus musculus 61% 100%
Q9DCM4 Mus musculus 33% 85%
Q9UR05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 54% 100%
V5AV01 Trypanosoma cruzi 49% 99%
V5BSX5 Trypanosoma cruzi 55% 99%
V5BV95 Trypanosoma cruzi 35% 79%
V5BXL9 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS