Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7D6_LEIDO

TriTrypDb:

LdBPK_242010.1 , LdCL_240025800 , LDHU3_24.2450

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7D6

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0032957	inositol trisphosphate metabolic process	5	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0047325	inositol tetrakisphosphate 1-kinase activity	6	7
GO:0051765	inositol tetrakisphosphate kinase activity	5	7
GO:0051766	inositol trisphosphate kinase activity	5	7
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	6	7
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.668
CLV_NRD_NRD_1	242	244	PF00675	0.460
CLV_NRD_NRD_1	247	249	PF00675	0.627
CLV_NRD_NRD_1	304	306	PF00675	0.775
CLV_NRD_NRD_1	569	571	PF00675	0.437
CLV_NRD_NRD_1	616	618	PF00675	0.630
CLV_NRD_NRD_1	711	713	PF00675	0.600
CLV_PCSK_FUR_1	104	108	PF00082	0.706
CLV_PCSK_FUR_1	243	247	PF00082	0.422
CLV_PCSK_KEX2_1	106	108	PF00082	0.662
CLV_PCSK_KEX2_1	241	243	PF00082	0.436
CLV_PCSK_KEX2_1	245	247	PF00082	0.462
CLV_PCSK_KEX2_1	304	306	PF00082	0.775
CLV_PCSK_KEX2_1	710	712	PF00082	0.669
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.500
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.669
CLV_PCSK_PC7_1	242	248	PF00082	0.457
CLV_PCSK_SKI1_1	153	157	PF00082	0.416
CLV_PCSK_SKI1_1	219	223	PF00082	0.378
CLV_PCSK_SKI1_1	266	270	PF00082	0.352
CLV_PCSK_SKI1_1	373	377	PF00082	0.471
CLV_PCSK_SKI1_1	382	386	PF00082	0.301
CLV_PCSK_SKI1_1	441	445	PF00082	0.466
DEG_APCC_DBOX_1	247	255	PF00400	0.612
DEG_APCC_DBOX_1	265	273	PF00400	0.271
DEG_APCC_DBOX_1	381	389	PF00400	0.326
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DEG_SCF_FBW7_1	527	533	PF00400	0.378
DOC_CKS1_1	223	228	PF01111	0.462
DOC_CKS1_1	527	532	PF01111	0.373
DOC_CYCLIN_RxL_1	138	148	PF00134	0.393
DOC_MAPK_gen_1	151	158	PF00069	0.430
DOC_MAPK_gen_1	241	253	PF00069	0.443
DOC_MAPK_MEF2A_6	151	158	PF00069	0.430
DOC_MAPK_MEF2A_6	245	254	PF00069	0.433
DOC_MAPK_MEF2A_6	409	416	PF00069	0.381
DOC_MAPK_NFAT4_5	151	159	PF00069	0.440
DOC_PP2B_PxIxI_1	249	255	PF00149	0.395
DOC_PP4_FxxP_1	223	226	PF00568	0.415
DOC_PP4_FxxP_1	524	527	PF00568	0.395
DOC_USP7_MATH_1	119	123	PF00917	0.632
DOC_USP7_MATH_1	204	208	PF00917	0.511
DOC_USP7_MATH_1	22	26	PF00917	0.621
DOC_USP7_MATH_1	344	348	PF00917	0.447
DOC_USP7_MATH_1	364	368	PF00917	0.294
DOC_USP7_MATH_1	412	416	PF00917	0.420
DOC_USP7_MATH_1	435	439	PF00917	0.467
DOC_USP7_MATH_1	448	452	PF00917	0.508
DOC_USP7_MATH_1	461	465	PF00917	0.666
DOC_USP7_MATH_1	504	508	PF00917	0.702
DOC_USP7_MATH_1	510	514	PF00917	0.406
DOC_USP7_MATH_1	589	593	PF00917	0.575
DOC_USP7_MATH_1	597	601	PF00917	0.609
DOC_USP7_MATH_1	612	616	PF00917	0.605
DOC_USP7_MATH_1	622	626	PF00917	0.570
DOC_USP7_UBL2_3	237	241	PF12436	0.395
DOC_WW_Pin1_4	13	18	PF00397	0.631
DOC_WW_Pin1_4	182	187	PF00397	0.737
DOC_WW_Pin1_4	20	25	PF00397	0.544
DOC_WW_Pin1_4	222	227	PF00397	0.405
DOC_WW_Pin1_4	283	288	PF00397	0.369
DOC_WW_Pin1_4	3	8	PF00397	0.746
DOC_WW_Pin1_4	310	315	PF00397	0.432
DOC_WW_Pin1_4	472	477	PF00397	0.610
DOC_WW_Pin1_4	486	491	PF00397	0.668
DOC_WW_Pin1_4	526	531	PF00397	0.417
DOC_WW_Pin1_4	626	631	PF00397	0.606
LIG_14-3-3_CanoR_1	110	119	PF00244	0.655
LIG_14-3-3_CanoR_1	121	130	PF00244	0.525
LIG_14-3-3_CanoR_1	141	146	PF00244	0.232
LIG_14-3-3_CanoR_1	425	430	PF00244	0.497
LIG_14-3-3_CanoR_1	609	619	PF00244	0.619
LIG_14-3-3_CanoR_1	636	643	PF00244	0.424
LIG_14-3-3_CanoR_1	711	716	PF00244	0.625
LIG_BIR_III_2	485	489	PF00653	0.553
LIG_BRCT_BRCA1_1	631	635	PF00533	0.510
LIG_BRCT_BRCA1_1	637	641	PF00533	0.409
LIG_Clathr_ClatBox_1	251	255	PF01394	0.377
LIG_deltaCOP1_diTrp_1	519	524	PF00928	0.401
LIG_FHA_1	110	116	PF00498	0.809
LIG_FHA_1	24	30	PF00498	0.493
LIG_FHA_1	351	357	PF00498	0.389
LIG_FHA_1	411	417	PF00498	0.378
LIG_FHA_1	647	653	PF00498	0.381
LIG_FHA_2	195	201	PF00498	0.511
LIG_FHA_2	319	325	PF00498	0.617
LIG_FHA_2	332	338	PF00498	0.428
LIG_FHA_2	426	432	PF00498	0.480
LIG_FHA_2	495	501	PF00498	0.708
LIG_LIR_Apic_2	222	226	PF02991	0.411
LIG_LIR_Apic_2	289	295	PF02991	0.396
LIG_LIR_Gen_1	319	325	PF02991	0.484
LIG_LIR_Gen_1	44	51	PF02991	0.436
LIG_LIR_Gen_1	519	527	PF02991	0.392
LIG_LIR_Gen_1	529	539	PF02991	0.388
LIG_LIR_Nem_3	319	323	PF02991	0.409
LIG_LIR_Nem_3	44	48	PF02991	0.435
LIG_LIR_Nem_3	519	524	PF02991	0.401
LIG_LIR_Nem_3	529	535	PF02991	0.381
LIG_NRBOX	268	274	PF00104	0.417
LIG_PTB_Apo_2	134	141	PF02174	0.375
LIG_SH2_CRK	391	395	PF00017	0.393
LIG_SH2_CRK	532	536	PF00017	0.431
LIG_SH2_CRK	668	672	PF00017	0.459
LIG_SH2_NCK_1	532	536	PF00017	0.416
LIG_SH2_SRC	389	392	PF00017	0.341
LIG_SH2_STAT3	147	150	PF00017	0.394
LIG_SH2_STAT5	389	392	PF00017	0.341
LIG_SH2_STAT5	400	403	PF00017	0.355
LIG_SH2_STAT5	419	422	PF00017	0.409
LIG_SH2_STAT5	532	535	PF00017	0.515
LIG_SH2_STAT5	563	566	PF00017	0.416
LIG_SH2_STAT5	664	667	PF00017	0.401
LIG_SH3_3	16	22	PF00018	0.607
LIG_SH3_3	250	256	PF00018	0.391
LIG_SH3_3	363	369	PF00018	0.413
LIG_SH3_3	484	490	PF00018	0.599
LIG_SH3_3	524	530	PF00018	0.394
LIG_SH3_3	555	561	PF00018	0.330
LIG_SH3_3	6	12	PF00018	0.716
LIG_SH3_3	624	630	PF00018	0.574
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.435
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.406
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.330
LIG_SUMO_SIM_par_1	249	255	PF11976	0.409
LIG_SUMO_SIM_par_1	281	286	PF11976	0.419
LIG_SUMO_SIM_par_1	654	661	PF11976	0.367
LIG_TRAF2_1	322	325	PF00917	0.527
LIG_TRAF2_1	87	90	PF00917	0.633
LIG_UBA3_1	678	685	PF00899	0.431
LIG_WRC_WIRS_1	220	225	PF05994	0.394
LIG_WRC_WIRS_1	317	322	PF05994	0.464
MOD_CAAXbox	713	716	PF01239	0.667
MOD_CDK_SPK_2	182	187	PF00069	0.568
MOD_CDK_SPK_2	283	288	PF00069	0.369
MOD_CDK_SPxxK_3	626	633	PF00069	0.488
MOD_CK1_1	105	111	PF00069	0.688
MOD_CK1_1	122	128	PF00069	0.614
MOD_CK1_1	178	184	PF00069	0.604
MOD_CK1_1	18	24	PF00069	0.637
MOD_CK1_1	310	316	PF00069	0.489
MOD_CK1_1	319	325	PF00069	0.458
MOD_CK1_1	404	410	PF00069	0.467
MOD_CK1_1	449	455	PF00069	0.571
MOD_CK1_1	498	504	PF00069	0.644
MOD_CK1_1	600	606	PF00069	0.644
MOD_CK1_1	629	635	PF00069	0.484
MOD_CK1_1	694	700	PF00069	0.540
MOD_CK2_1	121	127	PF00069	0.626
MOD_CK2_1	318	324	PF00069	0.598
MOD_CK2_1	331	337	PF00069	0.473
MOD_CK2_1	486	492	PF00069	0.753
MOD_CK2_1	494	500	PF00069	0.648
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.679
MOD_GlcNHglycan	132	135	PF01048	0.444
MOD_GlcNHglycan	168	171	PF01048	0.704
MOD_GlcNHglycan	180	183	PF01048	0.548
MOD_GlcNHglycan	206	209	PF01048	0.441
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	309	312	PF01048	0.664
MOD_GlcNHglycan	448	451	PF01048	0.539
MOD_GlcNHglycan	459	462	PF01048	0.692
MOD_GlcNHglycan	500	503	PF01048	0.777
MOD_GlcNHglycan	541	545	PF01048	0.418
MOD_GlcNHglycan	599	602	PF01048	0.616
MOD_GlcNHglycan	624	627	PF01048	0.586
MOD_GlcNHglycan	644	647	PF01048	0.364
MOD_GlcNHglycan	65	68	PF01048	0.494
MOD_GlcNHglycan	75	79	PF01048	0.600
MOD_GlcNHglycan	93	96	PF01048	0.538
MOD_GSK3_1	106	113	PF00069	0.630
MOD_GSK3_1	119	126	PF00069	0.579
MOD_GSK3_1	162	169	PF00069	0.662
MOD_GSK3_1	178	185	PF00069	0.544
MOD_GSK3_1	18	25	PF00069	0.589
MOD_GSK3_1	303	310	PF00069	0.580
MOD_GSK3_1	421	428	PF00069	0.472
MOD_GSK3_1	442	449	PF00069	0.494
MOD_GSK3_1	457	464	PF00069	0.616
MOD_GSK3_1	474	481	PF00069	0.529
MOD_GSK3_1	494	501	PF00069	0.570
MOD_GSK3_1	526	533	PF00069	0.378
MOD_GSK3_1	576	583	PF00069	0.498
MOD_GSK3_1	622	629	PF00069	0.578
MOD_GSK3_1	642	649	PF00069	0.287
MOD_GSK3_1	690	697	PF00069	0.498
MOD_GSK3_1	98	105	PF00069	0.616
MOD_LATS_1	423	429	PF00433	0.544
MOD_N-GLC_1	1	6	PF02516	0.661
MOD_N-GLC_1	306	311	PF02516	0.564
MOD_N-GLC_1	331	336	PF02516	0.583
MOD_N-GLC_1	478	483	PF02516	0.629
MOD_N-GLC_2	136	138	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	130	135	PF00069	0.413
MOD_NEK2_1	162	167	PF00069	0.505
MOD_NEK2_1	262	267	PF00069	0.377
MOD_NEK2_1	34	39	PF00069	0.415
MOD_NEK2_1	443	448	PF00069	0.490
MOD_NEK2_1	478	483	PF00069	0.632
MOD_NEK2_1	564	569	PF00069	0.430
MOD_NEK2_1	652	657	PF00069	0.350
MOD_NEK2_2	612	617	PF00069	0.649
MOD_PIKK_1	202	208	PF00454	0.566
MOD_PIKK_1	435	441	PF00454	0.427
MOD_PIKK_1	452	458	PF00454	0.582
MOD_PKA_1	106	112	PF00069	0.658
MOD_PKA_1	241	247	PF00069	0.503
MOD_PKA_2	105	111	PF00069	0.663
MOD_PKA_2	122	128	PF00069	0.523
MOD_PKA_2	241	247	PF00069	0.507
MOD_PKA_2	303	309	PF00069	0.620
MOD_PKA_2	424	430	PF00069	0.480
MOD_PKA_2	635	641	PF00069	0.442
MOD_PKB_1	104	112	PF00069	0.704
MOD_PKB_1	121	129	PF00069	0.492
MOD_Plk_1	194	200	PF00069	0.569
MOD_Plk_1	364	370	PF00069	0.517
MOD_Plk_1	504	510	PF00069	0.528
MOD_Plk_4	412	418	PF00069	0.495
MOD_Plk_4	504	510	PF00069	0.549
MOD_Plk_4	548	554	PF00069	0.535
MOD_Plk_4	647	653	PF00069	0.423
MOD_ProDKin_1	13	19	PF00069	0.633
MOD_ProDKin_1	182	188	PF00069	0.737
MOD_ProDKin_1	20	26	PF00069	0.534
MOD_ProDKin_1	222	228	PF00069	0.397
MOD_ProDKin_1	283	289	PF00069	0.367
MOD_ProDKin_1	3	9	PF00069	0.746
MOD_ProDKin_1	310	316	PF00069	0.431
MOD_ProDKin_1	472	478	PF00069	0.612
MOD_ProDKin_1	486	492	PF00069	0.672
MOD_ProDKin_1	526	532	PF00069	0.414
MOD_ProDKin_1	626	632	PF00069	0.595
MOD_SUMO_rev_2	159	165	PF00179	0.571
MOD_SUMO_rev_2	319	329	PF00179	0.438
TRG_DiLeu_BaEn_1	258	263	PF01217	0.395
TRG_DiLeu_BaEn_2	378	384	PF01217	0.376
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.417
TRG_ENDOCYTIC_2	532	535	PF00928	0.431
TRG_ENDOCYTIC_2	668	671	PF00928	0.457
TRG_ER_diArg_1	104	107	PF00400	0.669
TRG_ER_diArg_1	151	154	PF00400	0.429
TRG_ER_diArg_1	242	245	PF00400	0.424
TRG_ER_diArg_1	246	248	PF00400	0.460
TRG_NES_CRM1_1	680	691	PF08389	0.478
TRG_NLS_MonoCore_2	708	713	PF00514	0.623
TRG_NLS_MonoExtC_3	240	245	PF00514	0.465
TRG_NLS_MonoExtN_4	709	714	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV4	Leptomonas seymouri	49%	100%
A4HDQ5	Leishmania braziliensis	68%	98%
A4I101	Leishmania infantum	100%	100%
E9AX39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAD7	Leishmania major	93%	100%