Beta-ketoacyl-ACP reductase 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7D5_LEIDO

TriTrypDb:

LdBPK_241880.1 , LdCL_240024400 , LDHU3_24.2310

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 33
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	19
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H7D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7D5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004312	fatty acid synthase activity	5	4
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0016740	transferase activity	2	4
GO:0016746	acyltransferase activity	3	4
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	183	189	PF00089	0.280
CLV_NRD_NRD_1	301	303	PF00675	0.568
CLV_NRD_NRD_1	308	310	PF00675	0.538
CLV_NRD_NRD_1	75	77	PF00675	0.385
CLV_PCSK_KEX2_1	159	161	PF00082	0.276
CLV_PCSK_KEX2_1	308	310	PF00082	0.556
CLV_PCSK_KEX2_1	75	77	PF00082	0.410
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.304
CLV_PCSK_PC7_1	155	161	PF00082	0.278
CLV_PCSK_SKI1_1	181	185	PF00082	0.351
CLV_PCSK_SKI1_1	279	283	PF00082	0.554
CLV_PCSK_SKI1_1	81	85	PF00082	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_CKS1_1	296	301	PF01111	0.738
DOC_MAPK_HePTP_8	183	195	PF00069	0.402
DOC_MAPK_MEF2A_6	186	195	PF00069	0.462
DOC_PP4_FxxP_1	197	200	PF00568	0.509
DOC_USP7_MATH_1	133	137	PF00917	0.506
DOC_USP7_MATH_1	161	165	PF00917	0.511
DOC_USP7_MATH_1	273	277	PF00917	0.522
DOC_USP7_MATH_1	280	284	PF00917	0.628
DOC_USP7_MATH_1	319	323	PF00917	0.744
DOC_USP7_UBL2_3	434	438	PF12436	0.381
DOC_WW_Pin1_4	116	121	PF00397	0.602
DOC_WW_Pin1_4	242	247	PF00397	0.590
DOC_WW_Pin1_4	295	300	PF00397	0.762
DOC_WW_Pin1_4	345	350	PF00397	0.533
DOC_WW_Pin1_4	357	362	PF00397	0.552
LIG_14-3-3_CanoR_1	18	22	PF00244	0.662
LIG_14-3-3_CanoR_1	288	292	PF00244	0.697
LIG_14-3-3_CanoR_1	3	8	PF00244	0.766
LIG_14-3-3_CanoR_1	341	349	PF00244	0.504
LIG_BRCT_BRCA1_1	358	362	PF00533	0.640
LIG_CSL_BTD_1	243	246	PF09270	0.598
LIG_eIF4E_1	370	376	PF01652	0.306
LIG_FHA_1	18	24	PF00498	0.580
LIG_FHA_1	202	208	PF00498	0.465
LIG_FHA_1	331	337	PF00498	0.698
LIG_FHA_1	78	84	PF00498	0.607
LIG_FHA_1	92	98	PF00498	0.479
LIG_FHA_2	377	383	PF00498	0.334
LIG_HCF-1_HBM_1	11	14	PF13415	0.617
LIG_LIR_Apic_2	276	280	PF02991	0.666
LIG_LIR_Gen_1	149	157	PF02991	0.485
LIG_LIR_Gen_1	20	29	PF02991	0.569
LIG_LIR_Gen_1	363	374	PF02991	0.416
LIG_LIR_Nem_3	149	154	PF02991	0.462
LIG_LIR_Nem_3	250	255	PF02991	0.595
LIG_LIR_Nem_3	363	369	PF02991	0.372
LIG_Pex14_2	362	366	PF04695	0.459
LIG_PTB_Apo_2	395	402	PF02174	0.315
LIG_PTB_Phospho_1	395	401	PF10480	0.317
LIG_RPA_C_Fungi	64	76	PF08784	0.501
LIG_SH2_GRB2like	402	405	PF00017	0.359
LIG_SH2_PTP2	373	376	PF00017	0.484
LIG_SH2_SRC	371	374	PF00017	0.240
LIG_SH2_SRC	407	410	PF00017	0.472
LIG_SH2_STAP1	312	316	PF00017	0.624
LIG_SH2_STAT5	128	131	PF00017	0.303
LIG_SH2_STAT5	157	160	PF00017	0.368
LIG_SH2_STAT5	182	185	PF00017	0.220
LIG_SH2_STAT5	201	204	PF00017	0.370
LIG_SH2_STAT5	220	223	PF00017	0.349
LIG_SH2_STAT5	237	240	PF00017	0.456
LIG_SH2_STAT5	368	371	PF00017	0.306
LIG_SH2_STAT5	373	376	PF00017	0.284
LIG_SH2_STAT5	41	44	PF00017	0.386
LIG_SH3_3	240	246	PF00018	0.531
LIG_SH3_3	44	50	PF00018	0.440
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.386
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.348
LIG_TYR_ITIM	369	374	PF00017	0.346
MOD_CDK_SPK_2	242	247	PF00069	0.500
MOD_CDK_SPxxK_3	295	302	PF00069	0.752
MOD_CK1_1	164	170	PF00069	0.450
MOD_CK1_1	283	289	PF00069	0.547
MOD_CK1_1	307	313	PF00069	0.620
MOD_CK1_1	322	328	PF00069	0.676
MOD_CK2_1	3	9	PF00069	0.631
MOD_CK2_1	322	328	PF00069	0.699
MOD_CK2_1	376	382	PF00069	0.406
MOD_Cter_Amidation	300	303	PF01082	0.658
MOD_Cter_Amidation	73	76	PF01082	0.525
MOD_GlcNHglycan	223	226	PF01048	0.238
MOD_GlcNHglycan	238	241	PF01048	0.564
MOD_GlcNHglycan	309	312	PF01048	0.639
MOD_GlcNHglycan	324	327	PF01048	0.620
MOD_GlcNHglycan	362	365	PF01048	0.401
MOD_GlcNHglycan	47	50	PF01048	0.470
MOD_GlcNHglycan	94	97	PF01048	0.338
MOD_GSK3_1	280	287	PF00069	0.623
MOD_GSK3_1	356	363	PF00069	0.458
MOD_GSK3_1	41	48	PF00069	0.434
MOD_GSK3_1	77	84	PF00069	0.536
MOD_GSK3_1	88	95	PF00069	0.317
MOD_N-GLC_1	164	169	PF02516	0.495
MOD_N-GLC_2	389	391	PF02516	0.336
MOD_N-GLC_2	77	79	PF02516	0.338
MOD_NEK2_1	24	29	PF00069	0.492
MOD_NEK2_1	356	361	PF00069	0.455
MOD_NEK2_1	362	367	PF00069	0.328
MOD_NEK2_1	412	417	PF00069	0.541
MOD_NEK2_1	65	70	PF00069	0.418
MOD_PIKK_1	319	325	PF00454	0.705
MOD_PIKK_1	381	387	PF00454	0.322
MOD_PKA_2	161	167	PF00069	0.365
MOD_PKA_2	17	23	PF00069	0.514
MOD_PKA_2	24	30	PF00069	0.317
MOD_PKA_2	287	293	PF00069	0.628
MOD_PKA_2	307	313	PF00069	0.661
MOD_PKA_2	340	346	PF00069	0.391
MOD_PKA_2	77	83	PF00069	0.482
MOD_Plk_1	110	116	PF00069	0.332
MOD_Plk_1	164	170	PF00069	0.425
MOD_Plk_4	233	239	PF00069	0.507
MOD_Plk_4	24	30	PF00069	0.370
MOD_Plk_4	3	9	PF00069	0.612
MOD_Plk_4	362	368	PF00069	0.406
MOD_Plk_4	383	389	PF00069	0.334
MOD_Plk_4	424	430	PF00069	0.299
MOD_ProDKin_1	116	122	PF00069	0.501
MOD_ProDKin_1	242	248	PF00069	0.484
MOD_ProDKin_1	295	301	PF00069	0.727
MOD_ProDKin_1	345	351	PF00069	0.413
MOD_ProDKin_1	357	363	PF00069	0.428
MOD_SUMO_for_1	437	440	PF00179	0.509
TRG_ENDOCYTIC_2	371	374	PF00928	0.367
TRG_ER_diArg_1	75	78	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	33%	86%
A0A0N1HZ81	Leptomonas seymouri	70%	79%
A0A0N1I1M5	Leptomonas seymouri	23%	89%
A0A0S4IWT0	Bodo saltans	33%	94%
A0A0S4IZG2	Bodo saltans	35%	97%
A0A0S4J1I6	Bodo saltans	43%	100%
A0A1X0NVT8	Trypanosomatidae	36%	88%
A0A1X0NVV6	Trypanosomatidae	52%	86%
A0A3Q8ID46	Leishmania donovani	34%	100%
A0A3Q8IM89	Leishmania donovani	28%	100%
A0A3R7K071	Trypanosoma rangeli	52%	91%
A0A3S7X986	Leishmania donovani	24%	91%
A0A422N2B6	Trypanosoma rangeli	35%	92%
A4HDP2	Leishmania braziliensis	86%	100%
A4HDP3	Leishmania braziliensis	32%	98%
A4HMN7	Leishmania braziliensis	27%	100%
A4HMN9	Leishmania braziliensis	24%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AF41	Leishmania major	23%	100%
E9AH88	Leishmania infantum	99%	100%
E9AH89	Leishmania infantum	33%	100%
E9AHV6	Leishmania infantum	28%	100%
E9AHV8	Leishmania infantum	24%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4QAE9	Leishmania major	34%	100%
Q4QAF0	Leishmania major	93%	100%
V5BAF4	Trypanosoma cruzi	35%	92%
V5BNY6	Trypanosoma cruzi	28%	100%