Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7D4_LEIDO

TriTrypDb:

LdBPK_241690.1 , LdCL_240022000 , LDHU3_24.2060

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S5H7D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7D4

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.352
CLV_C14_Caspase3-7	346	350	PF00656	0.502
CLV_NRD_NRD_1	188	190	PF00675	0.472
CLV_NRD_NRD_1	24	26	PF00675	0.441
CLV_NRD_NRD_1	51	53	PF00675	0.443
CLV_NRD_NRD_1	80	82	PF00675	0.529
CLV_PCSK_KEX2_1	150	152	PF00082	0.541
CLV_PCSK_KEX2_1	188	190	PF00082	0.459
CLV_PCSK_KEX2_1	239	241	PF00082	0.570
CLV_PCSK_KEX2_1	26	28	PF00082	0.360
CLV_PCSK_KEX2_1	272	274	PF00082	0.539
CLV_PCSK_KEX2_1	326	328	PF00082	0.555
CLV_PCSK_KEX2_1	51	53	PF00082	0.437
CLV_PCSK_KEX2_1	79	81	PF00082	0.547
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.541
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.599
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.360
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.539
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.555
CLV_PCSK_SKI1_1	201	205	PF00082	0.484
CLV_PCSK_SKI1_1	26	30	PF00082	0.526
CLV_PCSK_SKI1_1	273	277	PF00082	0.453
CLV_PCSK_SKI1_1	326	330	PF00082	0.513
CLV_PCSK_SKI1_1	72	76	PF00082	0.584
DEG_APCC_DBOX_1	13	21	PF00400	0.643
DEG_APCC_DBOX_1	79	87	PF00400	0.351
DEG_Nend_UBRbox_1	1	4	PF02207	0.694
DOC_ANK_TNKS_1	50	57	PF00023	0.477
DOC_CYCLIN_RxL_1	270	279	PF00134	0.347
DOC_CYCLIN_RxL_1	323	331	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.331
DOC_MAPK_gen_1	236	243	PF00069	0.337
DOC_MAPK_gen_1	79	85	PF00069	0.332
DOC_MAPK_MEF2A_6	92	100	PF00069	0.354
DOC_MAPK_RevD_3	226	239	PF00069	0.390
DOC_PP1_RVXF_1	199	205	PF00149	0.347
DOC_PP1_RVXF_1	338	344	PF00149	0.450
DOC_PP2B_LxvP_1	137	140	PF13499	0.277
DOC_PP2B_LxvP_1	291	294	PF13499	0.289
DOC_PP4_FxxP_1	99	102	PF00568	0.293
DOC_USP7_MATH_1	13	17	PF00917	0.671
DOC_USP7_MATH_1	171	175	PF00917	0.353
DOC_USP7_MATH_1	245	249	PF00917	0.391
DOC_USP7_MATH_1	30	34	PF00917	0.727
DOC_USP7_UBL2_3	34	38	PF12436	0.704
DOC_WW_Pin1_4	101	106	PF00397	0.357
DOC_WW_Pin1_4	108	113	PF00397	0.330
DOC_WW_Pin1_4	44	49	PF00397	0.657
LIG_14-3-3_CanoR_1	188	192	PF00244	0.324
LIG_14-3-3_CanoR_1	240	250	PF00244	0.340
LIG_14-3-3_CanoR_1	273	281	PF00244	0.341
LIG_14-3-3_CanoR_1	327	336	PF00244	0.360
LIG_14-3-3_CanoR_1	340	348	PF00244	0.489
LIG_14-3-3_CanoR_1	72	77	PF00244	0.400
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.347
LIG_BRCT_BRCA1_1	70	74	PF00533	0.539
LIG_EH1_1	192	200	PF00400	0.338
LIG_eIF4E_1	193	199	PF01652	0.291
LIG_FHA_1	214	220	PF00498	0.390
LIG_FHA_2	113	119	PF00498	0.315
LIG_FHA_2	280	286	PF00498	0.244
LIG_FHA_2	308	314	PF00498	0.350
LIG_FHA_2	73	79	PF00498	0.357
LIG_IRF3_LxIS_1	215	222	PF10401	0.398
LIG_LIR_Gen_1	305	316	PF02991	0.284
LIG_LIR_Gen_1	65	74	PF02991	0.417
LIG_LIR_Gen_1	94	105	PF02991	0.377
LIG_LIR_Nem_3	143	149	PF02991	0.316
LIG_LIR_Nem_3	244	249	PF02991	0.363
LIG_LIR_Nem_3	305	311	PF02991	0.265
LIG_LIR_Nem_3	65	70	PF02991	0.415
LIG_LIR_Nem_3	71	77	PF02991	0.376
LIG_LIR_Nem_3	94	100	PF02991	0.376
LIG_MYND_1	108	112	PF01753	0.332
LIG_Pex14_2	6	10	PF04695	0.674
LIG_SH2_CRK	200	204	PF00017	0.339
LIG_SH2_CRK	246	250	PF00017	0.341
LIG_SH2_CRK	289	293	PF00017	0.271
LIG_SH2_CRK	308	312	PF00017	0.348
LIG_SH2_CRK	67	71	PF00017	0.434
LIG_SH2_GRB2like	320	323	PF00017	0.333
LIG_SH2_NCK_1	308	312	PF00017	0.336
LIG_SH2_STAP1	233	237	PF00017	0.362
LIG_SH2_STAP1	284	288	PF00017	0.238
LIG_SH2_STAP1	289	293	PF00017	0.238
LIG_SH2_STAP1	308	312	PF00017	0.277
LIG_SH2_STAT3	149	152	PF00017	0.345
LIG_SH2_STAT5	274	277	PF00017	0.302
LIG_SH2_STAT5	320	323	PF00017	0.264
LIG_SH2_STAT5	5	8	PF00017	0.659
LIG_SH3_3	99	105	PF00018	0.349
LIG_TYR_ITIM	126	131	PF00017	0.430
LIG_TYR_ITIM	198	203	PF00017	0.363
LIG_UBA3_1	317	326	PF00899	0.432
MOD_CDK_SPxxK_3	44	51	PF00069	0.589
MOD_CK1_1	174	180	PF00069	0.355
MOD_CK1_1	248	254	PF00069	0.500
MOD_CK1_1	342	348	PF00069	0.565
MOD_CK1_1	44	50	PF00069	0.589
MOD_CK2_1	112	118	PF00069	0.388
MOD_CK2_1	72	78	PF00069	0.458
MOD_GlcNHglycan	304	307	PF01048	0.427
MOD_GlcNHglycan	313	316	PF01048	0.347
MOD_GlcNHglycan	333	336	PF01048	0.440
MOD_GSK3_1	108	115	PF00069	0.462
MOD_GSK3_1	183	190	PF00069	0.391
MOD_GSK3_1	241	248	PF00069	0.487
MOD_GSK3_1	276	283	PF00069	0.352
MOD_GSK3_1	302	309	PF00069	0.396
MOD_GSK3_1	327	334	PF00069	0.480
MOD_GSK3_1	339	346	PF00069	0.596
MOD_GSK3_1	62	69	PF00069	0.393
MOD_N-GLC_1	279	284	PF02516	0.449
MOD_NEK2_1	172	177	PF00069	0.362
MOD_NEK2_1	219	224	PF00069	0.545
MOD_NEK2_1	241	246	PF00069	0.447
MOD_NEK2_1	276	281	PF00069	0.338
MOD_NEK2_1	343	348	PF00069	0.642
MOD_PIKK_1	256	262	PF00454	0.395
MOD_PKA_2	13	19	PF00069	0.577
MOD_PKA_2	187	193	PF00069	0.410
MOD_PKA_2	30	36	PF00069	0.672
MOD_PKA_2	322	328	PF00069	0.356
MOD_PKA_2	339	345	PF00069	0.602
MOD_PKA_2	91	97	PF00069	0.473
MOD_Plk_1	172	178	PF00069	0.423
MOD_Plk_1	191	197	PF00069	0.243
MOD_Plk_1	279	285	PF00069	0.407
MOD_Plk_4	245	251	PF00069	0.513
MOD_ProDKin_1	101	107	PF00069	0.453
MOD_ProDKin_1	108	114	PF00069	0.416
MOD_ProDKin_1	44	50	PF00069	0.589
TRG_DiLeu_BaEn_1	143	148	PF01217	0.441
TRG_DiLeu_BaEn_2	92	98	PF01217	0.496
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.363
TRG_ENDOCYTIC_2	128	131	PF00928	0.416
TRG_ENDOCYTIC_2	200	203	PF00928	0.405
TRG_ENDOCYTIC_2	246	249	PF00928	0.431
TRG_ENDOCYTIC_2	289	292	PF00928	0.291
TRG_ENDOCYTIC_2	308	311	PF00928	0.410
TRG_ENDOCYTIC_2	67	70	PF00928	0.358
TRG_ER_diArg_1	151	154	PF00400	0.441
TRG_ER_diArg_1	187	189	PF00400	0.339
TRG_ER_diArg_1	224	227	PF00400	0.442
TRG_ER_diArg_1	25	28	PF00400	0.559
TRG_ER_diArg_1	51	53	PF00400	0.576
TRG_ER_diArg_1	79	81	PF00400	0.440
TRG_NLS_MonoExtC_3	149	155	PF00514	0.441
TRG_NLS_MonoExtN_4	236	242	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM13	Leptomonas seymouri	65%	80%
A0A0N1PD54	Leptomonas seymouri	31%	100%
A0A0S4JQS8	Bodo saltans	30%	100%
A0A1X0NVR0	Trypanosomatidae	33%	100%
A0A1X0NVT0	Trypanosomatidae	26%	76%
A0A422N8G9	Trypanosoma rangeli	29%	100%
A0A422N8I7	Trypanosoma rangeli	32%	88%
A4HDM2	Leishmania braziliensis	81%	100%
C9ZWE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AH69	Leishmania infantum	100%	100%
E9AX07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAG9	Leishmania major	91%	100%
Q95RI5	Drosophila melanogaster	22%	84%
V5BK31	Trypanosoma cruzi	29%	100%
V5DBK9	Trypanosoma cruzi	31%	86%