Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7D3_LEIDO

TriTrypDb:

LdBPK_241450.1 , LdCL_240019700 , LDHU3_24.1760

Length:

956

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S5H7D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.496
CLV_C14_Caspase3-7	526	530	PF00656	0.431
CLV_C14_Caspase3-7	892	896	PF00656	0.532
CLV_NRD_NRD_1	176	178	PF00675	0.698
CLV_NRD_NRD_1	214	216	PF00675	0.585
CLV_NRD_NRD_1	3	5	PF00675	0.665
CLV_NRD_NRD_1	627	629	PF00675	0.701
CLV_NRD_NRD_1	640	642	PF00675	0.711
CLV_NRD_NRD_1	789	791	PF00675	0.742
CLV_PCSK_FUR_1	787	791	PF00082	0.671
CLV_PCSK_KEX2_1	176	178	PF00082	0.740
CLV_PCSK_KEX2_1	214	216	PF00082	0.585
CLV_PCSK_KEX2_1	3	5	PF00082	0.665
CLV_PCSK_KEX2_1	640	642	PF00082	0.738
CLV_PCSK_KEX2_1	789	791	PF00082	0.691
CLV_PCSK_SKI1_1	217	221	PF00082	0.578
CLV_PCSK_SKI1_1	232	236	PF00082	0.639
CLV_PCSK_SKI1_1	317	321	PF00082	0.628
CLV_PCSK_SKI1_1	49	53	PF00082	0.682
CLV_PCSK_SKI1_1	657	661	PF00082	0.622
CLV_PCSK_SKI1_1	695	699	PF00082	0.582
CLV_PCSK_SKI1_1	952	956	PF00082	0.479
CLV_Separin_Metazoa	373	377	PF03568	0.322
DEG_APCC_DBOX_1	771	779	PF00400	0.297
DEG_ODPH_VHL_1	401	414	PF01847	0.300
DEG_SCF_FBW7_1	50	57	PF00400	0.372
DEG_SPOP_SBC_1	147	151	PF00917	0.363
DEG_SPOP_SBC_1	82	86	PF00917	0.477
DOC_ANK_TNKS_1	519	526	PF00023	0.430
DOC_CKS1_1	621	626	PF01111	0.462
DOC_CYCLIN_RxL_1	314	324	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.358
DOC_MAPK_gen_1	857	866	PF00069	0.400
DOC_MAPK_MEF2A_6	810	817	PF00069	0.347
DOC_MAPK_MEF2A_6	859	868	PF00069	0.357
DOC_PP1_RVXF_1	315	322	PF00149	0.403
DOC_PP2B_LxvP_1	400	403	PF13499	0.350
DOC_PP2B_LxvP_1	448	451	PF13499	0.433
DOC_PP2B_LxvP_1	62	65	PF13499	0.363
DOC_PP4_FxxP_1	767	770	PF00568	0.390
DOC_USP7_MATH_1	147	151	PF00917	0.363
DOC_USP7_MATH_1	308	312	PF00917	0.311
DOC_USP7_MATH_1	31	35	PF00917	0.651
DOC_USP7_MATH_1	622	626	PF00917	0.402
DOC_USP7_MATH_1	693	697	PF00917	0.434
DOC_USP7_MATH_1	719	723	PF00917	0.482
DOC_USP7_MATH_1	747	751	PF00917	0.394
DOC_USP7_MATH_1	799	803	PF00917	0.484
DOC_USP7_MATH_1	82	86	PF00917	0.477
DOC_USP7_MATH_1	844	848	PF00917	0.448
DOC_WW_Pin1_4	178	183	PF00397	0.467
DOC_WW_Pin1_4	472	477	PF00397	0.511
DOC_WW_Pin1_4	50	55	PF00397	0.414
DOC_WW_Pin1_4	556	561	PF00397	0.473
DOC_WW_Pin1_4	620	625	PF00397	0.432
DOC_WW_Pin1_4	706	711	PF00397	0.397
DOC_WW_Pin1_4	78	83	PF00397	0.383
DOC_WW_Pin1_4	835	840	PF00397	0.441
DOC_WW_Pin1_4	875	880	PF00397	0.389
LIG_14-3-3_CanoR_1	176	182	PF00244	0.469
LIG_14-3-3_CanoR_1	232	237	PF00244	0.454
LIG_14-3-3_CanoR_1	247	257	PF00244	0.409
LIG_14-3-3_CanoR_1	297	307	PF00244	0.472
LIG_14-3-3_CanoR_1	3	8	PF00244	0.588
LIG_14-3-3_CanoR_1	480	485	PF00244	0.546
LIG_14-3-3_CanoR_1	49	54	PF00244	0.390
LIG_14-3-3_CanoR_1	628	636	PF00244	0.488
LIG_14-3-3_CanoR_1	657	662	PF00244	0.367
LIG_14-3-3_CanoR_1	692	698	PF00244	0.464
LIG_14-3-3_CanoR_1	772	776	PF00244	0.380
LIG_14-3-3_CanoR_1	859	865	PF00244	0.363
LIG_Actin_WH2_2	323	341	PF00022	0.329
LIG_Actin_WH2_2	374	390	PF00022	0.370
LIG_APCC_ABBA_1	884	889	PF00400	0.391
LIG_BIR_III_2	948	952	PF00653	0.656
LIG_BIR_III_4	161	165	PF00653	0.426
LIG_BRCT_BRCA1_1	180	184	PF00533	0.438
LIG_BRCT_BRCA1_1	871	875	PF00533	0.338
LIG_BRCT_BRCA1_1	89	93	PF00533	0.389
LIG_FHA_1	249	255	PF00498	0.410
LIG_FHA_1	338	344	PF00498	0.403
LIG_FHA_1	382	388	PF00498	0.418
LIG_FHA_1	453	459	PF00498	0.438
LIG_FHA_1	557	563	PF00498	0.476
LIG_FHA_1	590	596	PF00498	0.467
LIG_FHA_1	616	622	PF00498	0.378
LIG_FHA_1	677	683	PF00498	0.371
LIG_FHA_1	778	784	PF00498	0.531
LIG_FHA_1	799	805	PF00498	0.436
LIG_FHA_2	108	114	PF00498	0.349
LIG_FHA_2	149	155	PF00498	0.398
LIG_FHA_2	51	57	PF00498	0.367
LIG_FHA_2	658	664	PF00498	0.400
LIG_FHA_2	721	727	PF00498	0.484
LIG_FHA_2	809	815	PF00498	0.438
LIG_GBD_Chelix_1	860	868	PF00786	0.471
LIG_LIR_Apic_2	274	278	PF02991	0.382
LIG_LIR_Apic_2	77	82	PF02991	0.490
LIG_LIR_Gen_1	110	119	PF02991	0.356
LIG_LIR_Gen_1	220	230	PF02991	0.376
LIG_LIR_Gen_1	259	270	PF02991	0.355
LIG_LIR_Gen_1	313	320	PF02991	0.400
LIG_LIR_Gen_1	396	405	PF02991	0.355
LIG_LIR_Gen_1	540	551	PF02991	0.510
LIG_LIR_Gen_1	599	607	PF02991	0.455
LIG_LIR_Gen_1	701	710	PF02991	0.422
LIG_LIR_Gen_1	797	808	PF02991	0.276
LIG_LIR_Gen_1	847	858	PF02991	0.424
LIG_LIR_Gen_1	939	949	PF02991	0.298
LIG_LIR_Nem_3	110	115	PF02991	0.377
LIG_LIR_Nem_3	181	187	PF02991	0.534
LIG_LIR_Nem_3	220	226	PF02991	0.374
LIG_LIR_Nem_3	259	265	PF02991	0.362
LIG_LIR_Nem_3	267	272	PF02991	0.298
LIG_LIR_Nem_3	313	318	PF02991	0.340
LIG_LIR_Nem_3	396	401	PF02991	0.319
LIG_LIR_Nem_3	461	467	PF02991	0.332
LIG_LIR_Nem_3	503	508	PF02991	0.431
LIG_LIR_Nem_3	540	546	PF02991	0.479
LIG_LIR_Nem_3	599	604	PF02991	0.456
LIG_LIR_Nem_3	655	661	PF02991	0.447
LIG_LIR_Nem_3	701	705	PF02991	0.416
LIG_LIR_Nem_3	847	853	PF02991	0.415
LIG_LIR_Nem_3	874	880	PF02991	0.358
LIG_LIR_Nem_3	939	945	PF02991	0.432
LIG_NRBOX	929	935	PF00104	0.392
LIG_NRBOX	939	945	PF00104	0.335
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.391
LIG_PDZ_Class_2	951	956	PF00595	0.666
LIG_Pex14_1	37	41	PF04695	0.429
LIG_Pex14_1	415	419	PF04695	0.367
LIG_Pex14_2	112	116	PF04695	0.296
LIG_SH2_CRK	262	266	PF00017	0.409
LIG_SH2_CRK	543	547	PF00017	0.490
LIG_SH2_CRK	850	854	PF00017	0.422
LIG_SH2_GRB2like	850	853	PF00017	0.378
LIG_SH2_NCK_1	716	720	PF00017	0.479
LIG_SH2_NCK_1	850	854	PF00017	0.382
LIG_SH2_PTP2	315	318	PF00017	0.287
LIG_SH2_PTP2	79	82	PF00017	0.423
LIG_SH2_SRC	850	853	PF00017	0.359
LIG_SH2_SRC	888	891	PF00017	0.478
LIG_SH2_STAP1	262	266	PF00017	0.329
LIG_SH2_STAP1	55	59	PF00017	0.397
LIG_SH2_STAP1	661	665	PF00017	0.424
LIG_SH2_STAT5	198	201	PF00017	0.407
LIG_SH2_STAT5	270	273	PF00017	0.409
LIG_SH2_STAT5	315	318	PF00017	0.346
LIG_SH2_STAT5	601	604	PF00017	0.375
LIG_SH2_STAT5	79	82	PF00017	0.374
LIG_SH2_STAT5	919	922	PF00017	0.341
LIG_SH2_STAT5	942	945	PF00017	0.424
LIG_SH3_3	14	20	PF00018	0.512
LIG_SH3_3	179	185	PF00018	0.500
LIG_SH3_3	345	351	PF00018	0.413
LIG_SH3_3	584	590	PF00018	0.319
LIG_SH3_3	618	624	PF00018	0.441
LIG_Sin3_3	824	831	PF02671	0.344
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.347
LIG_SUMO_SIM_par_1	105	111	PF11976	0.357
LIG_SUMO_SIM_par_1	681	689	PF11976	0.442
LIG_SUMO_SIM_par_1	933	939	PF11976	0.329
LIG_SUMO_SIM_par_1	942	948	PF11976	0.536
LIG_TRAF2_1	239	242	PF00917	0.467
LIG_TRAF2_1	879	882	PF00917	0.350
LIG_TYR_ITIM	940	945	PF00017	0.443
LIG_UBA3_1	330	339	PF00899	0.353
LIG_WRC_WIRS_1	109	114	PF05994	0.292
MOD_CDK_SPxxK_3	556	563	PF00069	0.440
MOD_CK1_1	178	184	PF00069	0.497
MOD_CK1_1	288	294	PF00069	0.581
MOD_CK1_1	311	317	PF00069	0.276
MOD_CK1_1	391	397	PF00069	0.381
MOD_CK1_1	472	478	PF00069	0.467
MOD_CK1_1	483	489	PF00069	0.499
MOD_CK1_1	631	637	PF00069	0.501
MOD_CK1_1	717	723	PF00069	0.467
MOD_CK1_1	81	87	PF00069	0.509
MOD_CK1_1	835	841	PF00069	0.390
MOD_CK1_1	894	900	PF00069	0.539
MOD_CK2_1	235	241	PF00069	0.443
MOD_CK2_1	391	397	PF00069	0.416
MOD_CK2_1	467	473	PF00069	0.413
MOD_CK2_1	631	637	PF00069	0.509
MOD_CK2_1	657	663	PF00069	0.403
MOD_CK2_1	720	726	PF00069	0.569
MOD_CK2_1	808	814	PF00069	0.441
MOD_CK2_1	875	881	PF00069	0.433
MOD_CMANNOS	26	29	PF00535	0.651
MOD_GlcNHglycan	121	125	PF01048	0.626
MOD_GlcNHglycan	190	193	PF01048	0.549
MOD_GlcNHglycan	258	261	PF01048	0.580
MOD_GlcNHglycan	292	295	PF01048	0.781
MOD_GlcNHglycan	300	303	PF01048	0.675
MOD_GlcNHglycan	326	329	PF01048	0.633
MOD_GlcNHglycan	33	36	PF01048	0.654
MOD_GlcNHglycan	42	45	PF01048	0.673
MOD_GlcNHglycan	476	479	PF01048	0.722
MOD_GlcNHglycan	488	492	PF01048	0.632
MOD_GlcNHglycan	575	578	PF01048	0.667
MOD_GlcNHglycan	597	601	PF01048	0.622
MOD_GlcNHglycan	610	613	PF01048	0.685
MOD_GlcNHglycan	624	627	PF01048	0.588
MOD_GlcNHglycan	652	655	PF01048	0.670
MOD_GlcNHglycan	719	722	PF01048	0.727
MOD_GlcNHglycan	728	731	PF01048	0.630
MOD_GlcNHglycan	743	746	PF01048	0.508
MOD_GlcNHglycan	749	752	PF01048	0.567
MOD_GlcNHglycan	759	762	PF01048	0.568
MOD_GlcNHglycan	790	793	PF01048	0.753
MOD_GlcNHglycan	818	822	PF01048	0.642
MOD_GlcNHglycan	829	832	PF01048	0.524
MOD_GlcNHglycan	846	849	PF01048	0.535
MOD_GlcNHglycan	89	92	PF01048	0.660
MOD_GlcNHglycan	898	902	PF01048	0.710
MOD_GlcNHglycan	906	909	PF01048	0.670
MOD_GSK3_1	209	216	PF00069	0.376
MOD_GSK3_1	232	239	PF00069	0.537
MOD_GSK3_1	284	291	PF00069	0.522
MOD_GSK3_1	3	10	PF00069	0.539
MOD_GSK3_1	333	340	PF00069	0.396
MOD_GSK3_1	383	390	PF00069	0.439
MOD_GSK3_1	450	457	PF00069	0.429
MOD_GSK3_1	483	490	PF00069	0.533
MOD_GSK3_1	50	57	PF00069	0.372
MOD_GSK3_1	538	545	PF00069	0.512
MOD_GSK3_1	665	672	PF00069	0.331
MOD_GSK3_1	676	683	PF00069	0.299
MOD_GSK3_1	691	698	PF00069	0.354
MOD_GSK3_1	717	724	PF00069	0.451
MOD_GSK3_1	74	81	PF00069	0.455
MOD_GSK3_1	799	806	PF00069	0.490
MOD_GSK3_1	83	90	PF00069	0.437
MOD_GSK3_1	871	878	PF00069	0.359
MOD_GSK3_1	893	900	PF00069	0.607
MOD_N-GLC_1	388	393	PF02516	0.550
MOD_N-GLC_1	467	472	PF02516	0.577
MOD_N-GLC_1	608	613	PF02516	0.662
MOD_N-GLC_1	851	856	PF02516	0.613
MOD_N-GLC_1	87	92	PF02516	0.632
MOD_NEK2_1	115	120	PF00069	0.377
MOD_NEK2_1	148	153	PF00069	0.463
MOD_NEK2_1	209	214	PF00069	0.380
MOD_NEK2_1	333	338	PF00069	0.344
MOD_NEK2_1	381	386	PF00069	0.462
MOD_NEK2_1	387	392	PF00069	0.401
MOD_NEK2_1	466	471	PF00069	0.385
MOD_NEK2_1	542	547	PF00069	0.488
MOD_NEK2_1	665	670	PF00069	0.327
MOD_NEK2_1	7	12	PF00069	0.720
MOD_NEK2_1	711	716	PF00069	0.405
MOD_NEK2_1	74	79	PF00069	0.409
MOD_NEK2_1	746	751	PF00069	0.470
MOD_NEK2_1	776	781	PF00069	0.405
MOD_NEK2_1	803	808	PF00069	0.402
MOD_NEK2_1	817	822	PF00069	0.404
MOD_NEK2_1	860	865	PF00069	0.320
MOD_NEK2_1	936	941	PF00069	0.327
MOD_NEK2_2	383	388	PF00069	0.347
MOD_NEK2_2	771	776	PF00069	0.458
MOD_PIKK_1	134	140	PF00454	0.450
MOD_PIKK_1	652	658	PF00454	0.429
MOD_PIKK_1	777	783	PF00454	0.473
MOD_PK_1	388	394	PF00069	0.343
MOD_PKA_1	176	182	PF00069	0.469
MOD_PKA_1	3	9	PF00069	0.540
MOD_PKA_1	628	634	PF00069	0.486
MOD_PKA_2	175	181	PF00069	0.523
MOD_PKA_2	213	219	PF00069	0.379
MOD_PKA_2	248	254	PF00069	0.407
MOD_PKA_2	3	9	PF00069	0.540
MOD_PKA_2	486	492	PF00069	0.545
MOD_PKA_2	691	697	PF00069	0.433
MOD_PKA_2	757	763	PF00069	0.354
MOD_PKA_2	771	777	PF00069	0.347
MOD_PKA_2	788	794	PF00069	0.468
MOD_PKB_1	215	223	PF00069	0.373
MOD_Plk_1	209	215	PF00069	0.460
MOD_Plk_1	308	314	PF00069	0.441
MOD_Plk_1	388	394	PF00069	0.397
MOD_Plk_1	467	473	PF00069	0.423
MOD_Plk_1	537	543	PF00069	0.477
MOD_Plk_1	686	692	PF00069	0.454
MOD_Plk_1	851	857	PF00069	0.392
MOD_Plk_1	87	93	PF00069	0.441
MOD_Plk_4	271	277	PF00069	0.452
MOD_Plk_4	311	317	PF00069	0.417
MOD_Plk_4	388	394	PF00069	0.388
MOD_Plk_4	458	464	PF00069	0.329
MOD_Plk_4	500	506	PF00069	0.508
MOD_Plk_4	538	544	PF00069	0.490
MOD_Plk_4	631	637	PF00069	0.485
MOD_Plk_4	74	80	PF00069	0.489
MOD_Plk_4	771	777	PF00069	0.389
MOD_Plk_4	799	805	PF00069	0.318
MOD_Plk_4	936	942	PF00069	0.337
MOD_Plk_4	99	105	PF00069	0.356
MOD_ProDKin_1	178	184	PF00069	0.466
MOD_ProDKin_1	472	478	PF00069	0.510
MOD_ProDKin_1	50	56	PF00069	0.415
MOD_ProDKin_1	556	562	PF00069	0.469
MOD_ProDKin_1	620	626	PF00069	0.435
MOD_ProDKin_1	706	712	PF00069	0.401
MOD_ProDKin_1	78	84	PF00069	0.389
MOD_ProDKin_1	835	841	PF00069	0.440
MOD_ProDKin_1	875	881	PF00069	0.390
MOD_SUMO_for_1	207	210	PF00179	0.448
MOD_SUMO_rev_2	625	631	PF00179	0.419
TRG_DiLeu_BaEn_1	241	246	PF01217	0.465
TRG_DiLeu_BaEn_1	58	63	PF01217	0.425
TRG_DiLeu_BaEn_4	241	247	PF01217	0.460
TRG_DiLeu_BaEn_4	881	887	PF01217	0.322
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.406
TRG_DiLeu_LyEn_5	241	246	PF01217	0.465
TRG_ENDOCYTIC_2	262	265	PF00928	0.354
TRG_ENDOCYTIC_2	269	272	PF00928	0.346
TRG_ENDOCYTIC_2	315	318	PF00928	0.409
TRG_ENDOCYTIC_2	463	466	PF00928	0.350
TRG_ENDOCYTIC_2	543	546	PF00928	0.480
TRG_ENDOCYTIC_2	601	604	PF00928	0.375
TRG_ENDOCYTIC_2	773	776	PF00928	0.316
TRG_ENDOCYTIC_2	850	853	PF00928	0.416
TRG_ENDOCYTIC_2	942	945	PF00928	0.443
TRG_ER_diArg_1	2	4	PF00400	0.589
TRG_ER_diArg_1	213	215	PF00400	0.377
TRG_ER_diArg_1	246	249	PF00400	0.475
TRG_ER_diArg_1	479	482	PF00400	0.546
TRG_ER_diArg_1	787	790	PF00400	0.475
TRG_ER_diArg_1	864	867	PF00400	0.389
TRG_NES_CRM1_1	360	373	PF08389	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L3	Leptomonas seymouri	48%	100%
A0A1X0PBB4	Trypanosomatidae	25%	99%
A0A3R7KLJ4	Trypanosoma rangeli	25%	99%
A4HDK1	Leishmania braziliensis	75%	100%
A4I0Y0	Leishmania infantum	99%	100%
C9ZLZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AWY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAJ0	Leishmania major	94%	100%
V5BQI0	Trypanosoma cruzi	25%	100%