LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical predicted multipass transmembrane protein
Species:
Leishmania donovani
UniProt:
A0A3S5H7D1_LEIDO
TriTrypDb:
LdBPK_241110.1 * , LdCL_240016100 , LDHU3_24.1290
Length:
517

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

A0A3S5H7D1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7D1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 174 176 PF00675 0.345
CLV_NRD_NRD_1 483 485 PF00675 0.430
CLV_PCSK_KEX2_1 176 178 PF00082 0.354
CLV_PCSK_KEX2_1 320 322 PF00082 0.458
CLV_PCSK_KEX2_1 482 484 PF00082 0.428
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.368
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.473
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.443
CLV_PCSK_SKI1_1 122 126 PF00082 0.282
CLV_PCSK_SKI1_1 334 338 PF00082 0.325
CLV_PCSK_SKI1_1 472 476 PF00082 0.353
DEG_APCC_DBOX_1 235 243 PF00400 0.544
DEG_APCC_DBOX_1 471 479 PF00400 0.409
DEG_Nend_UBRbox_1 1 4 PF02207 0.583
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.669
DOC_MAPK_gen_1 175 184 PF00069 0.532
DOC_MAPK_gen_1 28 36 PF00069 0.556
DOC_MAPK_HePTP_8 386 398 PF00069 0.303
DOC_MAPK_HePTP_8 446 458 PF00069 0.383
DOC_MAPK_MEF2A_6 28 36 PF00069 0.610
DOC_MAPK_MEF2A_6 334 342 PF00069 0.515
DOC_MAPK_MEF2A_6 389 398 PF00069 0.403
DOC_MAPK_MEF2A_6 449 458 PF00069 0.383
DOC_MAPK_NFAT4_5 389 397 PF00069 0.403
DOC_PP2B_LxvP_1 244 247 PF13499 0.561
DOC_PP4_FxxP_1 203 206 PF00568 0.378
DOC_USP7_MATH_1 4 8 PF00917 0.604
DOC_USP7_MATH_1 425 429 PF00917 0.421
DOC_USP7_MATH_1 488 492 PF00917 0.624
DOC_USP7_MATH_1 70 74 PF00917 0.412
DOC_WW_Pin1_4 144 149 PF00397 0.328
DOC_WW_Pin1_4 273 278 PF00397 0.696
DOC_WW_Pin1_4 283 288 PF00397 0.657
DOC_WW_Pin1_4 309 314 PF00397 0.694
DOC_WW_Pin1_4 409 414 PF00397 0.503
LIG_14-3-3_CanoR_1 375 379 PF00244 0.366
LIG_14-3-3_CanoR_1 494 501 PF00244 0.635
LIG_14-3-3_CanoR_1 506 512 PF00244 0.668
LIG_BIR_III_2 280 284 PF00653 0.650
LIG_BIR_III_2 356 360 PF00653 0.359
LIG_BRCT_BRCA1_1 180 184 PF00533 0.395
LIG_BRCT_BRCA1_1 224 228 PF00533 0.397
LIG_BRCT_BRCA1_1 376 380 PF00533 0.336
LIG_Clathr_ClatBox_1 300 304 PF01394 0.668
LIG_eIF4E_1 121 127 PF01652 0.541
LIG_FHA_1 277 283 PF00498 0.699
LIG_FHA_1 428 434 PF00498 0.353
LIG_FHA_1 64 70 PF00498 0.449
LIG_FHA_1 80 86 PF00498 0.356
LIG_FHA_2 14 20 PF00498 0.575
LIG_GBD_Chelix_1 192 200 PF00786 0.373
LIG_GBD_Chelix_1 339 347 PF00786 0.400
LIG_GBD_Chelix_1 457 465 PF00786 0.339
LIG_LIR_Apic_2 201 206 PF02991 0.364
LIG_LIR_Gen_1 178 186 PF02991 0.497
LIG_LIR_Gen_1 187 196 PF02991 0.282
LIG_LIR_Gen_1 214 223 PF02991 0.313
LIG_LIR_Gen_1 255 261 PF02991 0.557
LIG_LIR_Gen_1 349 358 PF02991 0.434
LIG_LIR_Gen_1 384 393 PF02991 0.305
LIG_LIR_Nem_3 167 173 PF02991 0.388
LIG_LIR_Nem_3 187 191 PF02991 0.327
LIG_LIR_Nem_3 214 220 PF02991 0.303
LIG_LIR_Nem_3 255 259 PF02991 0.705
LIG_LIR_Nem_3 349 353 PF02991 0.362
LIG_LIR_Nem_3 384 388 PF02991 0.345
LIG_LIR_Nem_3 98 104 PF02991 0.483
LIG_MLH1_MIPbox_1 180 184 PF16413 0.339
LIG_NRBOX 342 348 PF00104 0.455
LIG_NRBOX 470 476 PF00104 0.608
LIG_Pex14_1 120 124 PF04695 0.579
LIG_Pex14_1 166 170 PF04695 0.431
LIG_Pex14_1 217 221 PF04695 0.312
LIG_Pex14_1 60 64 PF04695 0.321
LIG_Pex14_2 184 188 PF04695 0.428
LIG_Pex14_2 398 402 PF04695 0.402
LIG_Pex14_2 9 13 PF04695 0.607
LIG_REV1ctd_RIR_1 6 15 PF16727 0.604
LIG_SH2_CRK 101 105 PF00017 0.623
LIG_SH2_CRK 256 260 PF00017 0.559
LIG_SH2_GRB2like 407 410 PF00017 0.487
LIG_SH2_NCK_1 487 491 PF00017 0.653
LIG_SH2_SRC 238 241 PF00017 0.522
LIG_SH2_SRC 440 443 PF00017 0.440
LIG_SH2_STAT5 179 182 PF00017 0.521
LIG_SH2_STAT5 221 224 PF00017 0.366
LIG_SH2_STAT5 238 241 PF00017 0.520
LIG_SH2_STAT5 407 410 PF00017 0.519
LIG_SH3_3 113 119 PF00018 0.566
LIG_SH3_3 307 313 PF00018 0.718
LIG_SH3_3 348 354 PF00018 0.447
LIG_SH3_3 59 65 PF00018 0.412
LIG_Sin3_3 216 223 PF02671 0.459
LIG_SUMO_SIM_anti_2 427 433 PF11976 0.346
LIG_TRAF2_1 16 19 PF00917 0.624
LIG_UBA3_1 169 176 PF00899 0.494
LIG_WRC_WIRS_1 185 190 PF05994 0.343
LIG_WRC_WIRS_1 347 352 PF05994 0.402
LIG_WRC_WIRS_1 5 10 PF05994 0.559
MOD_CDK_SPK_2 283 288 PF00069 0.595
MOD_CK1_1 129 135 PF00069 0.402
MOD_CK1_1 198 204 PF00069 0.463
MOD_CK2_1 13 19 PF00069 0.567
MOD_GlcNHglycan 128 131 PF01048 0.362
MOD_GlcNHglycan 161 164 PF01048 0.433
MOD_GlcNHglycan 200 203 PF01048 0.617
MOD_GlcNHglycan 269 274 PF01048 0.494
MOD_GlcNHglycan 313 316 PF01048 0.483
MOD_GlcNHglycan 490 493 PF01048 0.468
MOD_GSK3_1 129 136 PF00069 0.385
MOD_GSK3_1 269 276 PF00069 0.725
MOD_N-GLC_1 71 76 PF02516 0.579
MOD_NEK2_1 126 131 PF00069 0.395
MOD_NEK2_1 184 189 PF00069 0.343
MOD_NEK2_1 196 201 PF00069 0.395
MOD_NEK2_1 222 227 PF00069 0.363
MOD_NEK2_1 259 264 PF00069 0.718
MOD_NEK2_1 271 276 PF00069 0.686
MOD_NEK2_1 346 351 PF00069 0.401
MOD_NEK2_1 392 397 PF00069 0.350
MOD_NEK2_1 398 403 PF00069 0.318
MOD_NEK2_1 88 93 PF00069 0.354
MOD_NEK2_2 4 9 PF00069 0.605
MOD_PIKK_1 322 328 PF00454 0.656
MOD_PIKK_1 71 77 PF00454 0.355
MOD_PKA_2 259 265 PF00069 0.714
MOD_PKA_2 27 33 PF00069 0.631
MOD_PKA_2 374 380 PF00069 0.386
MOD_PKA_2 493 499 PF00069 0.685
MOD_PKA_2 505 511 PF00069 0.719
MOD_Plk_1 441 447 PF00069 0.417
MOD_Plk_1 71 77 PF00069 0.353
MOD_Plk_4 134 140 PF00069 0.379
MOD_Plk_4 178 184 PF00069 0.472
MOD_Plk_4 222 228 PF00069 0.367
MOD_Plk_4 346 352 PF00069 0.422
MOD_Plk_4 363 369 PF00069 0.191
MOD_Plk_4 381 387 PF00069 0.329
MOD_Plk_4 398 404 PF00069 0.327
MOD_Plk_4 4 10 PF00069 0.640
MOD_Plk_4 414 420 PF00069 0.454
MOD_Plk_4 427 433 PF00069 0.326
MOD_Plk_4 79 85 PF00069 0.381
MOD_ProDKin_1 144 150 PF00069 0.326
MOD_ProDKin_1 273 279 PF00069 0.695
MOD_ProDKin_1 283 289 PF00069 0.658
MOD_ProDKin_1 309 315 PF00069 0.686
MOD_ProDKin_1 409 415 PF00069 0.505
MOD_SUMO_for_1 476 479 PF00179 0.635
TRG_ENDOCYTIC_2 101 104 PF00928 0.553
TRG_ENDOCYTIC_2 121 124 PF00928 0.557
TRG_ENDOCYTIC_2 179 182 PF00928 0.517
TRG_ENDOCYTIC_2 256 259 PF00928 0.695
TRG_ER_diArg_1 113 116 PF00400 0.630
TRG_NES_CRM1_1 345 356 PF08389 0.397

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4ILP9 Bodo saltans 21% 100%
A0A0S4J6C9 Bodo saltans 25% 100%
A0A0S4J9G3 Bodo saltans 26% 100%
A0A0S4JFU7 Bodo saltans 25% 100%
A0A1X0NW47 Trypanosomatidae 49% 99%
A0A1X0P8U7 Trypanosomatidae 26% 99%
A0A3R7KUT2 Trypanosoma rangeli 49% 100%
A0A422NMM7 Trypanosoma rangeli 29% 97%
A4H3M6 Leishmania braziliensis 25% 100%
A4HDG5 Leishmania braziliensis 74% 100%
A4I0U6 Leishmania infantum 100% 100%
D0A268 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 96%
D0A775 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AWV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QAM4 Leishmania major 92% 100%
V5BAL2 Trypanosoma cruzi 53% 100%
V5C284 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS