Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7C5_LEIDO

TriTrypDb:

LdBPK_231870.1 , LdCL_230025900 , LDHU3_23.2460

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H7C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7C5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.441
CLV_C14_Caspase3-7	164	168	PF00656	0.739
CLV_C14_Caspase3-7	201	205	PF00656	0.714
CLV_C14_Caspase3-7	216	220	PF00656	0.585
CLV_C14_Caspase3-7	75	79	PF00656	0.360
CLV_PCSK_KEX2_1	210	212	PF00082	0.706
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.706
DEG_Nend_UBRbox_2	1	3	PF02207	0.466
DOC_CDC14_PxL_1	29	37	PF14671	0.403
DOC_CKS1_1	129	134	PF01111	0.554
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.533
DOC_MAPK_gen_1	151	160	PF00069	0.520
DOC_MAPK_gen_1	54	62	PF00069	0.372
DOC_MAPK_MEF2A_6	54	62	PF00069	0.470
DOC_PP2B_LxvP_1	96	99	PF13499	0.513
DOC_USP7_MATH_1	147	151	PF00917	0.430
DOC_USP7_MATH_1	89	93	PF00917	0.526
DOC_WW_Pin1_4	128	133	PF00397	0.561
DOC_WW_Pin1_4	37	42	PF00397	0.483
DOC_WW_Pin1_4	82	87	PF00397	0.562
LIG_14-3-3_CanoR_1	111	117	PF00244	0.476
LIG_BIR_III_2	204	208	PF00653	0.642
LIG_Clathr_ClatBox_1	57	61	PF01394	0.472
LIG_CSL_BTD_1	38	41	PF09270	0.477
LIG_FHA_1	154	160	PF00498	0.619
LIG_FHA_1	44	50	PF00498	0.488
LIG_FHA_2	164	170	PF00498	0.669
LIG_FHA_2	191	197	PF00498	0.741
LIG_FHA_2	210	216	PF00498	0.690
LIG_LIR_Gen_1	40	50	PF02991	0.402
LIG_LIR_Nem_3	115	119	PF02991	0.418
LIG_LIR_Nem_3	137	142	PF02991	0.394
LIG_LIR_Nem_3	37	42	PF02991	0.441
LIG_NRBOX	44	50	PF00104	0.507
LIG_NRBOX	92	98	PF00104	0.519
LIG_PCNA_yPIPBox_3	111	125	PF02747	0.330
LIG_Pex14_2	135	139	PF04695	0.416
LIG_SH2_STAT5	42	45	PF00017	0.502
LIG_SH3_3	126	132	PF00018	0.554
LIG_SH3_3	30	36	PF00018	0.377
LIG_SH3_3	80	86	PF00018	0.424
LIG_SUMO_SIM_anti_2	120	126	PF11976	0.480
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.375
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.394
LIG_SUMO_SIM_par_1	120	126	PF11976	0.462
LIG_SUMO_SIM_par_1	144	150	PF11976	0.409
LIG_SUMO_SIM_par_1	56	61	PF11976	0.461
LIG_SUMO_SIM_par_1	72	78	PF11976	0.263
LIG_TRAF2_1	105	108	PF00917	0.529
LIG_TRAF2_1	168	171	PF00917	0.652
LIG_TRAF2_1	176	179	PF00917	0.637
LIG_TRAF2_1	197	200	PF00917	0.644
LIG_TRAF2_1	20	23	PF00917	0.566
LIG_UBA3_1	48	56	PF00899	0.471
LIG_UBA3_1	62	67	PF00899	0.299
MOD_CK1_1	163	169	PF00069	0.621
MOD_CK1_1	189	195	PF00069	0.693
MOD_CK1_1	40	46	PF00069	0.377
MOD_CK2_1	101	107	PF00069	0.503
MOD_CK2_1	165	171	PF00069	0.628
MOD_CK2_1	172	178	PF00069	0.635
MOD_CK2_1	190	196	PF00069	0.507
MOD_CK2_1	209	215	PF00069	0.536
MOD_GlcNHglycan	189	192	PF01048	0.761
MOD_GlcNHglycan	29	32	PF01048	0.472
MOD_GSK3_1	149	156	PF00069	0.493
MOD_GSK3_1	173	180	PF00069	0.685
MOD_GSK3_1	186	193	PF00069	0.726
MOD_GSK3_1	194	201	PF00069	0.735
MOD_GSK3_1	205	212	PF00069	0.638
MOD_NEK2_1	112	117	PF00069	0.474
MOD_NEK2_1	27	32	PF00069	0.504
MOD_NEK2_1	4	9	PF00069	0.405
MOD_PIKK_1	22	28	PF00454	0.587
MOD_PKB_1	151	159	PF00069	0.617
MOD_Plk_1	107	113	PF00069	0.487
MOD_Plk_1	22	28	PF00069	0.450
MOD_Plk_2-3	165	171	PF00069	0.613
MOD_Plk_2-3	173	179	PF00069	0.575
MOD_Plk_2-3	198	204	PF00069	0.713
MOD_Plk_4	134	140	PF00069	0.557
MOD_Plk_4	89	95	PF00069	0.425
MOD_ProDKin_1	128	134	PF00069	0.558
MOD_ProDKin_1	37	43	PF00069	0.487
MOD_ProDKin_1	82	88	PF00069	0.562
TRG_DiLeu_BaEn_4	107	113	PF01217	0.530
TRG_DiLeu_BaEn_4	22	28	PF01217	0.526
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.491
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.524
TRG_ENDOCYTIC_2	42	45	PF00928	0.493
TRG_NLS_MonoExtC_3	209	215	PF00514	0.741
TRG_NLS_MonoExtN_4	207	214	PF00514	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B1	Leptomonas seymouri	72%	100%
A0A0S4JGB7	Bodo saltans	33%	91%
A0A1X0NX37	Trypanosomatidae	46%	100%
A0A422NJD9	Trypanosoma rangeli	52%	72%
A4HD31	Leishmania braziliensis	86%	100%
A4I0L8	Leishmania infantum	99%	100%
C9ZNR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AWH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAZ1	Leishmania major	95%	100%
V5BFS2	Trypanosoma cruzi	52%	81%