Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7C2_LEIDO

TriTrypDb:

LdBPK_231310.1 , LdCL_230020200 , LDHU3_23.1710

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	24
GO:0042995	cell projection	2	24
GO:0043226	organelle	2	24
GO:0043227	membrane-bounded organelle	3	24
GO:0110165	cellular anatomical entity	1	24
GO:0120025	plasma membrane bounded cell projection	3	24
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A0A3S5H7C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7C2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	3
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.493
CLV_NRD_NRD_1	31	33	PF00675	0.616
CLV_NRD_NRD_1	403	405	PF00675	0.409
CLV_NRD_NRD_1	93	95	PF00675	0.542
CLV_PCSK_KEX2_1	31	33	PF00082	0.616
CLV_PCSK_KEX2_1	403	405	PF00082	0.413
CLV_PCSK_SKI1_1	117	121	PF00082	0.436
CLV_PCSK_SKI1_1	148	152	PF00082	0.427
CLV_PCSK_SKI1_1	186	190	PF00082	0.390
CLV_PCSK_SKI1_1	255	259	PF00082	0.415
CLV_PCSK_SKI1_1	32	36	PF00082	0.613
CLV_PCSK_SKI1_1	403	407	PF00082	0.432
CLV_Separin_Metazoa	22	26	PF03568	0.683
DEG_APCC_DBOX_1	30	38	PF00400	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.646
DEG_SCF_FBW7_1	266	273	PF00400	0.515
DOC_MAPK_gen_1	158	167	PF00069	0.470
DOC_MAPK_gen_1	308	315	PF00069	0.441
DOC_MAPK_MEF2A_6	160	169	PF00069	0.499
DOC_MAPK_MEF2A_6	285	292	PF00069	0.256
DOC_MAPK_MEF2A_6	441	450	PF00069	0.364
DOC_MAPK_MEF2A_6	465	474	PF00069	0.386
DOC_PP1_RVXF_1	306	313	PF00149	0.495
DOC_PP4_FxxP_1	129	132	PF00568	0.527
DOC_USP7_MATH_1	201	205	PF00917	0.510
DOC_USP7_MATH_1	257	261	PF00917	0.408
DOC_USP7_MATH_1	270	274	PF00917	0.532
DOC_USP7_MATH_1	303	307	PF00917	0.482
DOC_USP7_MATH_1	43	47	PF00917	0.654
DOC_WW_Pin1_4	266	271	PF00397	0.456
DOC_WW_Pin1_4	373	378	PF00397	0.519
DOC_WW_Pin1_4	47	52	PF00397	0.669
DOC_WW_Pin1_4	5	10	PF00397	0.698
LIG_14-3-3_CanoR_1	148	154	PF00244	0.481
LIG_14-3-3_CanoR_1	158	163	PF00244	0.457
LIG_14-3-3_CanoR_1	31	40	PF00244	0.567
LIG_14-3-3_CanoR_1	317	321	PF00244	0.458
LIG_14-3-3_CanoR_1	337	346	PF00244	0.419
LIG_14-3-3_CanoR_1	42	51	PF00244	0.542
LIG_14-3-3_CanoR_1	81	87	PF00244	0.519
LIG_14-3-3_CanoR_1	94	104	PF00244	0.521
LIG_Actin_WH2_2	267	282	PF00022	0.477
LIG_Actin_WH2_2	435	451	PF00022	0.421
LIG_APCC_ABBA_1	211	216	PF00400	0.398
LIG_BRCT_BRCA1_1	224	228	PF00533	0.477
LIG_BRCT_BRCA1_1	40	44	PF00533	0.679
LIG_Clathr_ClatBox_1	370	374	PF01394	0.435
LIG_DLG_GKlike_1	158	165	PF00625	0.485
LIG_FHA_1	236	242	PF00498	0.398
LIG_FHA_1	260	266	PF00498	0.479
LIG_FHA_1	379	385	PF00498	0.403
LIG_FHA_1	9	15	PF00498	0.636
LIG_FHA_2	17	23	PF00498	0.637
LIG_FHA_2	242	248	PF00498	0.481
LIG_FHA_2	329	335	PF00498	0.462
LIG_FHA_2	423	429	PF00498	0.422
LIG_IRF3_LxIS_1	384	391	PF10401	0.403
LIG_LIR_Apic_2	126	132	PF02991	0.534
LIG_LIR_Gen_1	226	236	PF02991	0.473
LIG_LIR_Gen_1	366	373	PF02991	0.525
LIG_LIR_Nem_3	128	133	PF02991	0.401
LIG_LIR_Nem_3	166	172	PF02991	0.472
LIG_LIR_Nem_3	226	232	PF02991	0.452
LIG_LIR_Nem_3	366	371	PF02991	0.533
LIG_LIR_Nem_3	82	87	PF02991	0.593
LIG_MLH1_MIPbox_1	225	229	PF16413	0.399
LIG_NRBOX	260	266	PF00104	0.506
LIG_PCNA_yPIPBox_3	460	469	PF02747	0.430
LIG_PTB_Apo_2	124	131	PF02174	0.445
LIG_PTB_Apo_2	342	349	PF02174	0.425
LIG_SH2_CRK	107	111	PF00017	0.598
LIG_SH2_CRK	368	372	PF00017	0.532
LIG_SH2_STAT5	368	371	PF00017	0.500
LIG_SH2_STAT5	389	392	PF00017	0.478
LIG_SH3_2	54	59	PF14604	0.533
LIG_SH3_3	165	171	PF00018	0.441
LIG_SH3_3	37	43	PF00018	0.588
LIG_SH3_3	45	51	PF00018	0.570
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.501
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.478
LIG_SUMO_SIM_anti_2	316	323	PF11976	0.551
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.535
LIG_SUMO_SIM_par_1	237	242	PF11976	0.406
LIG_SUMO_SIM_par_1	380	385	PF11976	0.381
LIG_TRAF2_1	425	428	PF00917	0.514
LIG_TRAF2_1	478	481	PF00917	0.616
LIG_TYR_ITSM	364	371	PF00017	0.522
MOD_CK1_1	161	167	PF00069	0.384
MOD_CK1_1	194	200	PF00069	0.511
MOD_CK1_1	230	236	PF00069	0.462
MOD_CK1_1	260	266	PF00069	0.423
MOD_CK1_1	3	9	PF00069	0.592
MOD_CK1_1	316	322	PF00069	0.488
MOD_CK1_1	50	56	PF00069	0.643
MOD_CK1_1	82	88	PF00069	0.547
MOD_CK2_1	125	131	PF00069	0.507
MOD_CK2_1	16	22	PF00069	0.640
MOD_CK2_1	328	334	PF00069	0.424
MOD_CK2_1	422	428	PF00069	0.420
MOD_CK2_1	475	481	PF00069	0.529
MOD_Cter_Amidation	92	95	PF01082	0.550
MOD_GlcNHglycan	177	180	PF01048	0.389
MOD_GlcNHglycan	225	228	PF01048	0.474
MOD_GlcNHglycan	300	304	PF01048	0.486
MOD_GlcNHglycan	45	48	PF01048	0.632
MOD_GlcNHglycan	5	8	PF01048	0.713
MOD_GlcNHglycan	99	102	PF01048	0.541
MOD_GSK3_1	154	161	PF00069	0.381
MOD_GSK3_1	223	230	PF00069	0.477
MOD_GSK3_1	231	238	PF00069	0.446
MOD_GSK3_1	241	248	PF00069	0.364
MOD_GSK3_1	260	267	PF00069	0.437
MOD_GSK3_1	275	282	PF00069	0.375
MOD_GSK3_1	299	306	PF00069	0.431
MOD_GSK3_1	378	385	PF00069	0.400
MOD_GSK3_1	418	425	PF00069	0.450
MOD_GSK3_1	43	50	PF00069	0.658
MOD_N-GLC_1	344	349	PF02516	0.502
MOD_N-GLC_1	434	439	PF02516	0.438
MOD_N-GLC_1	82	87	PF02516	0.577
MOD_N-GLC_2	452	454	PF02516	0.410
MOD_NEK2_1	180	185	PF00069	0.471
MOD_NEK2_1	2	7	PF00069	0.664
MOD_NEK2_1	239	244	PF00069	0.373
MOD_NEK2_1	245	250	PF00069	0.421
MOD_NEK2_1	279	284	PF00069	0.467
MOD_NEK2_1	313	318	PF00069	0.381
MOD_NEK2_1	358	363	PF00069	0.443
MOD_NEK2_1	388	393	PF00069	0.427
MOD_NEK2_1	431	436	PF00069	0.415
MOD_NEK2_2	303	308	PF00069	0.347
MOD_PIKK_1	248	254	PF00454	0.508
MOD_PIKK_1	328	334	PF00454	0.428
MOD_PKA_1	186	192	PF00069	0.488
MOD_PKA_2	30	36	PF00069	0.594
MOD_PKA_2	316	322	PF00069	0.452
MOD_Plk_1	125	131	PF00069	0.534
MOD_Plk_1	154	160	PF00069	0.423
MOD_Plk_1	299	305	PF00069	0.495
MOD_Plk_1	313	319	PF00069	0.323
MOD_Plk_1	344	350	PF00069	0.507
MOD_Plk_1	366	372	PF00069	0.471
MOD_Plk_1	82	88	PF00069	0.565
MOD_Plk_2-3	16	22	PF00069	0.642
MOD_Plk_2-3	422	428	PF00069	0.504
MOD_Plk_2-3	468	474	PF00069	0.444
MOD_Plk_4	125	131	PF00069	0.522
MOD_Plk_4	163	169	PF00069	0.474
MOD_Plk_4	206	212	PF00069	0.467
MOD_Plk_4	241	247	PF00069	0.462
MOD_Plk_4	260	266	PF00069	0.519
MOD_Plk_4	316	322	PF00069	0.506
MOD_Plk_4	366	372	PF00069	0.420
MOD_Plk_4	378	384	PF00069	0.366
MOD_Plk_4	453	459	PF00069	0.511
MOD_Plk_4	82	88	PF00069	0.590
MOD_ProDKin_1	266	272	PF00069	0.461
MOD_ProDKin_1	373	379	PF00069	0.511
MOD_ProDKin_1	47	53	PF00069	0.662
MOD_ProDKin_1	5	11	PF00069	0.700
MOD_SUMO_rev_2	427	434	PF00179	0.453
TRG_DiLeu_BaEn_4	296	302	PF01217	0.436
TRG_DiLeu_BaEn_4	374	380	PF01217	0.506
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.416
TRG_ENDOCYTIC_2	107	110	PF00928	0.600
TRG_ENDOCYTIC_2	368	371	PF00928	0.534
TRG_ER_diArg_1	402	404	PF00400	0.428
TRG_NES_CRM1_1	256	268	PF08389	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F4	Leptomonas seymouri	70%	100%
A0A0N0P8N9	Leptomonas seymouri	24%	74%
A0A0S4IS80	Bodo saltans	34%	95%
A0A0S4JR29	Bodo saltans	27%	95%
A0A0S4JR64	Bodo saltans	22%	75%
A0A1X0NEN5	Trypanosomatidae	27%	84%
A0A1X0NG16	Trypanosomatidae	27%	84%
A0A1X0NXB3	Trypanosomatidae	55%	100%
A0A1X0P4M6	Trypanosomatidae	24%	84%
A0A422NP39	Trypanosoma rangeli	52%	100%
A4H3R1	Leishmania braziliensis	26%	70%
A4HCY0	Leishmania braziliensis	90%	100%
A4HJE4	Leishmania braziliensis	24%	100%
A4I0G3	Leishmania infantum	100%	100%
C9ZS86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	90%
C9ZV75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	72%
E9AIU4	Leishmania braziliensis	25%	88%
E9AWC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P23799	Trypanosoma brucei brucei	25%	77%
Q4QB46	Leishmania major	99%	100%
V5BMQ2	Trypanosoma cruzi	23%	87%
V5DFL9	Trypanosoma cruzi	51%	100%