Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7C2_LEIDO

TriTrypDb:

LdBPK_231310.1 , LdCL_230020200 , LDHU3_23.1710

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0005929	cilium	4	24
GO:0016020	membrane	2	2
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031966	mitochondrial membrane	4	1
GO:0032991	protein-containing complex	1	1

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Expansion

Sequence features

A0A3S5H7C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7C2

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	3
GO:0010498	proteasomal protein catabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	1
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.493
CLV_NRD_NRD_1	31	33	PF00675	0.616
CLV_NRD_NRD_1	403	405	PF00675	0.409
CLV_NRD_NRD_1	93	95	PF00675	0.542
CLV_PCSK_KEX2_1	31	33	PF00082	0.616
CLV_PCSK_KEX2_1	403	405	PF00082	0.413
CLV_PCSK_SKI1_1	117	121	PF00082	0.436
CLV_PCSK_SKI1_1	148	152	PF00082	0.427
CLV_PCSK_SKI1_1	186	190	PF00082	0.390
CLV_PCSK_SKI1_1	255	259	PF00082	0.415

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F4	Leptomonas seymouri	70%	100%
A0A0N0P8N9	Leptomonas seymouri	24%	74%
A0A0S4IS80	Bodo saltans	34%	95%
A0A0S4JR29	Bodo saltans	27%	95%
A0A0S4JR64	Bodo saltans	22%	75%
A0A1X0NEN5	Trypanosomatidae	27%	84%
A0A1X0NG16	Trypanosomatidae	27%	84%
A0A1X0NXB3	Trypanosomatidae	55%	100%
A0A1X0P4M6	Trypanosomatidae	24%	84%
A0A422NP39	Trypanosoma rangeli	52%	100%

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