Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7C1_LEIDO

TriTrypDb:

LdBPK_231140.1 , LdCL_230018700 , LDHU3_23.1500

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.641
CLV_C14_Caspase3-7	173	177	PF00656	0.610
CLV_C14_Caspase3-7	182	186	PF00656	0.473
CLV_C14_Caspase3-7	336	340	PF00656	0.685
CLV_NRD_NRD_1	292	294	PF00675	0.460
CLV_NRD_NRD_1	295	297	PF00675	0.496
CLV_NRD_NRD_1	343	345	PF00675	0.683
CLV_NRD_NRD_1	378	380	PF00675	0.572
CLV_PCSK_FUR_1	293	297	PF00082	0.488
CLV_PCSK_KEX2_1	294	296	PF00082	0.481
CLV_PCSK_KEX2_1	310	312	PF00082	0.600
CLV_PCSK_KEX2_1	343	345	PF00082	0.693
CLV_PCSK_KEX2_1	378	380	PF00082	0.572
CLV_PCSK_KEX2_1	387	389	PF00082	0.590
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.481
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.600
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.724
CLV_PCSK_SKI1_1	262	266	PF00082	0.405
CLV_PCSK_SKI1_1	282	286	PF00082	0.349
CLV_PCSK_SKI1_1	295	299	PF00082	0.503
CLV_PCSK_SKI1_1	374	378	PF00082	0.494
CLV_PCSK_SKI1_1	46	50	PF00082	0.396
CLV_Separin_Fungi	330	336	PF03568	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DOC_MAPK_gen_1	258	265	PF00069	0.429
DOC_MAPK_gen_1	293	300	PF00069	0.500
DOC_PP2B_LxvP_1	71	74	PF13499	0.460
DOC_USP7_MATH_1	206	210	PF00917	0.676
DOC_USP7_MATH_1	220	224	PF00917	0.622
DOC_USP7_MATH_1	232	236	PF00917	0.413
DOC_USP7_MATH_1	275	279	PF00917	0.418
DOC_USP7_MATH_1	325	329	PF00917	0.705
DOC_USP7_MATH_1	382	386	PF00917	0.664
DOC_WW_Pin1_4	11	16	PF00397	0.695
DOC_WW_Pin1_4	144	149	PF00397	0.638
DOC_WW_Pin1_4	305	310	PF00397	0.605
LIG_14-3-3_CanoR_1	171	175	PF00244	0.635
LIG_14-3-3_CanoR_1	381	389	PF00244	0.683
LIG_14-3-3_CanoR_1	6	16	PF00244	0.579
LIG_BIR_III_2	92	96	PF00653	0.463
LIG_BIR_III_4	339	343	PF00653	0.682
LIG_DCNL_PONY_1	1	4	PF03556	0.749
LIG_deltaCOP1_diTrp_1	312	319	PF00928	0.646
LIG_eIF4E_1	44	50	PF01652	0.396
LIG_FHA_1	12	18	PF00498	0.689
LIG_FHA_1	45	51	PF00498	0.395
LIG_FHA_2	106	112	PF00498	0.610
LIG_FHA_2	353	359	PF00498	0.557
LIG_FHA_2	81	87	PF00498	0.455
LIG_Integrin_RGD_1	349	351	PF01839	0.658
LIG_LIR_Gen_1	313	322	PF02991	0.615
LIG_LIR_Gen_1	39	50	PF02991	0.490
LIG_LIR_Nem_3	10	16	PF02991	0.565
LIG_LIR_Nem_3	313	319	PF02991	0.652
LIG_LIR_Nem_3	386	392	PF02991	0.655
LIG_LIR_Nem_3	39	45	PF02991	0.462
LIG_LYPXL_SIV_4	41	49	PF13949	0.409
LIG_NRBOX	67	73	PF00104	0.444
LIG_SH2_CRK	13	17	PF00017	0.692
LIG_SH2_CRK	243	247	PF00017	0.380
LIG_SH2_CRK	38	42	PF00017	0.467
LIG_SH2_NCK_1	38	42	PF00017	0.467
LIG_SH2_PTP2	42	45	PF00017	0.413
LIG_SH2_SRC	42	45	PF00017	0.413
LIG_SH2_SRC	64	67	PF00017	0.410
LIG_SH2_STAP1	31	35	PF00017	0.515
LIG_SH2_STAT5	13	16	PF00017	0.694
LIG_SH2_STAT5	143	146	PF00017	0.630
LIG_SH2_STAT5	42	45	PF00017	0.413
LIG_SH2_STAT5	64	67	PF00017	0.433
LIG_SUMO_SIM_anti_2	261	268	PF11976	0.427
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.443
LIG_TRAF2_1	284	287	PF00917	0.433
LIG_TRAF2_1	363	366	PF00917	0.648
LIG_TYR_ITIM	241	246	PF00017	0.375
LIG_UBA3_1	299	307	PF00899	0.554
LIG_WRC_WIRS_1	224	229	PF05994	0.457
MOD_CDK_SPK_2	305	310	PF00069	0.525
MOD_CDK_SPxK_1	305	311	PF00069	0.638
MOD_CK1_1	131	137	PF00069	0.583
MOD_CK1_1	146	152	PF00069	0.632
MOD_CK1_1	166	172	PF00069	0.665
MOD_CK1_1	223	229	PF00069	0.477
MOD_CK1_1	29	35	PF00069	0.530
MOD_CK1_1	5	11	PF00069	0.506
MOD_CK1_1	75	81	PF00069	0.504
MOD_CK2_1	105	111	PF00069	0.621
MOD_CK2_1	206	212	PF00069	0.526
MOD_CK2_1	253	259	PF00069	0.413
MOD_CK2_1	275	281	PF00069	0.375
MOD_CK2_1	352	358	PF00069	0.564
MOD_CK2_1	80	86	PF00069	0.460
MOD_Cter_Amidation	341	344	PF01082	0.692
MOD_GlcNHglycan	100	103	PF01048	0.750
MOD_GlcNHglycan	228	231	PF01048	0.601
MOD_GlcNHglycan	255	258	PF01048	0.429
MOD_GlcNHglycan	273	276	PF01048	0.543
MOD_GlcNHglycan	31	34	PF01048	0.523
MOD_GlcNHglycan	323	326	PF01048	0.741
MOD_GlcNHglycan	335	338	PF01048	0.575
MOD_GSK3_1	127	134	PF00069	0.604
MOD_GSK3_1	166	173	PF00069	0.637
MOD_GSK3_1	22	29	PF00069	0.581
MOD_GSK3_1	228	235	PF00069	0.462
MOD_GSK3_1	271	278	PF00069	0.414
MOD_GSK3_1	317	324	PF00069	0.621
MOD_GSK3_1	7	14	PF00069	0.735
MOD_N-GLC_1	305	310	PF02516	0.742
MOD_N-GLC_1	80	85	PF02516	0.460
MOD_NEK2_1	2	7	PF00069	0.610
MOD_NEK2_1	22	27	PF00069	0.520
MOD_NEK2_1	265	270	PF00069	0.432
MOD_NEK2_1	50	55	PF00069	0.411
MOD_PIKK_1	275	281	PF00454	0.375
MOD_PIKK_1	75	81	PF00454	0.504
MOD_PK_1	288	294	PF00069	0.446
MOD_PKA_2	170	176	PF00069	0.751
MOD_PKA_2	383	389	PF00069	0.690
MOD_PKA_2	5	11	PF00069	0.578
MOD_Plk_1	104	110	PF00069	0.610
MOD_Plk_2-3	105	111	PF00069	0.709
MOD_Plk_2-3	128	134	PF00069	0.651
MOD_Plk_4	22	28	PF00069	0.599
MOD_Plk_4	220	226	PF00069	0.496
MOD_Plk_4	372	378	PF00069	0.558
MOD_Plk_4	44	50	PF00069	0.397
MOD_ProDKin_1	11	17	PF00069	0.694
MOD_ProDKin_1	144	150	PF00069	0.640
MOD_ProDKin_1	305	311	PF00069	0.606
TRG_DiLeu_BaEn_1	261	266	PF01217	0.425
TRG_DiLeu_BaEn_2	85	91	PF01217	0.441
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.627
TRG_ENDOCYTIC_2	13	16	PF00928	0.557
TRG_ENDOCYTIC_2	243	246	PF00928	0.376
TRG_ENDOCYTIC_2	389	392	PF00928	0.669
TRG_ENDOCYTIC_2	42	45	PF00928	0.413
TRG_ER_diArg_1	292	295	PF00400	0.465
TRG_ER_diArg_1	377	379	PF00400	0.504
TRG_NLS_MonoCore_2	292	297	PF00514	0.478
TRG_NLS_MonoExtN_4	293	298	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP9	Leptomonas seymouri	51%	100%
A4HCW6	Leishmania braziliensis	70%	98%
A4I0E6	Leishmania infantum	98%	99%
E9AWA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QB66	Leishmania major	89%	99%