Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7C0_LEIDO

TriTrypDb:

LdBPK_231020.1 , LdCL_230016900 , LDHU3_23.1380

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H7C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.462
CLV_NRD_NRD_1	361	363	PF00675	0.727
CLV_NRD_NRD_1	514	516	PF00675	0.611
CLV_NRD_NRD_1	6	8	PF00675	0.804
CLV_PCSK_KEX2_1	361	363	PF00082	0.720
CLV_PCSK_KEX2_1	437	439	PF00082	0.756
CLV_PCSK_KEX2_1	516	518	PF00082	0.643
CLV_PCSK_KEX2_1	6	8	PF00082	0.804
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.756
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.646
CLV_PCSK_SKI1_1	362	366	PF00082	0.821
CLV_PCSK_SKI1_1	517	521	PF00082	0.589
CLV_PCSK_SKI1_1	96	100	PF00082	0.736
DEG_APCC_DBOX_1	63	71	PF00400	0.423
DEG_Nend_UBRbox_1	1	4	PF02207	0.833
DEG_SIAH_1	242	250	PF03145	0.565
DOC_CDC14_PxL_1	275	283	PF14671	0.549
DOC_CKS1_1	249	254	PF01111	0.579
DOC_CKS1_1	97	102	PF01111	0.472
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.466
DOC_MAPK_FxFP_2	198	201	PF00069	0.493
DOC_MAPK_gen_1	472	482	PF00069	0.436
DOC_MAPK_HePTP_8	19	31	PF00069	0.622
DOC_MAPK_MEF2A_6	14	23	PF00069	0.622
DOC_MAPK_MEF2A_6	475	482	PF00069	0.463
DOC_PP1_RVXF_1	85	92	PF00149	0.412
DOC_PP2B_LxvP_1	49	52	PF13499	0.528
DOC_PP4_FxxP_1	198	201	PF00568	0.548
DOC_USP7_MATH_1	103	107	PF00917	0.514
DOC_USP7_MATH_1	130	134	PF00917	0.537
DOC_USP7_MATH_1	209	213	PF00917	0.452
DOC_USP7_MATH_1	259	263	PF00917	0.588
DOC_USP7_MATH_1	377	381	PF00917	0.578
DOC_USP7_MATH_1	441	445	PF00917	0.644
DOC_USP7_MATH_1	461	465	PF00917	0.604
DOC_USP7_MATH_1	83	87	PF00917	0.556
DOC_WW_Pin1_4	219	224	PF00397	0.534
DOC_WW_Pin1_4	245	250	PF00397	0.536
DOC_WW_Pin1_4	293	298	PF00397	0.543
DOC_WW_Pin1_4	402	407	PF00397	0.609
DOC_WW_Pin1_4	453	458	PF00397	0.612
DOC_WW_Pin1_4	96	101	PF00397	0.503
LIG_14-3-3_CanoR_1	132	139	PF00244	0.477
LIG_14-3-3_CanoR_1	269	275	PF00244	0.464
LIG_14-3-3_CanoR_1	361	365	PF00244	0.599
LIG_14-3-3_CanoR_1	367	377	PF00244	0.558
LIG_14-3-3_CanoR_1	438	448	PF00244	0.550
LIG_14-3-3_CanoR_1	517	527	PF00244	0.836
LIG_Actin_WH2_2	124	139	PF00022	0.548
LIG_BRCT_BRCA1_1	144	148	PF00533	0.506
LIG_BRCT_BRCA1_1	175	179	PF00533	0.583
LIG_CSL_BTD_1	403	406	PF09270	0.544
LIG_deltaCOP1_diTrp_1	334	340	PF00928	0.547
LIG_EH_1	300	304	PF12763	0.704
LIG_EH1_1	475	483	PF00400	0.366
LIG_FHA_1	223	229	PF00498	0.599
LIG_FHA_1	294	300	PF00498	0.561
LIG_FHA_1	419	425	PF00498	0.528
LIG_FHA_1	460	466	PF00498	0.559
LIG_FHA_2	249	255	PF00498	0.598
LIG_FHA_2	271	277	PF00498	0.559
LIG_LIR_Apic_2	196	201	PF02991	0.553
LIG_LIR_Gen_1	177	188	PF02991	0.503
LIG_LIR_Gen_1	312	319	PF02991	0.635
LIG_LIR_Gen_1	322	333	PF02991	0.495
LIG_LIR_Gen_1	54	63	PF02991	0.485
LIG_LIR_Nem_3	176	182	PF02991	0.478
LIG_LIR_Nem_3	231	237	PF02991	0.502
LIG_LIR_Nem_3	276	281	PF02991	0.558
LIG_LIR_Nem_3	312	318	PF02991	0.675
LIG_LIR_Nem_3	322	328	PF02991	0.498
LIG_LIR_Nem_3	334	339	PF02991	0.463
LIG_LIR_Nem_3	54	59	PF02991	0.477
LIG_LYPXL_yS_3	278	281	PF13949	0.592
LIG_MLH1_MIPbox_1	175	179	PF16413	0.583
LIG_MYND_1	168	172	PF01753	0.535
LIG_PAM2_1	47	59	PF00658	0.441
LIG_PCNA_PIPBox_1	17	26	PF02747	0.636
LIG_PCNA_yPIPBox_3	14	24	PF02747	0.652
LIG_Pex14_1	233	237	PF04695	0.508
LIG_PTB_Apo_2	363	370	PF02174	0.548
LIG_SH2_GRB2like	270	273	PF00017	0.429
LIG_SH2_SRC	476	479	PF00017	0.442
LIG_SH2_STAP1	284	288	PF00017	0.542
LIG_SH2_STAP1	467	471	PF00017	0.589
LIG_SH2_STAT3	200	203	PF00017	0.491
LIG_SH2_STAT5	217	220	PF00017	0.468
LIG_SH2_STAT5	234	237	PF00017	0.420
LIG_SH2_STAT5	325	328	PF00017	0.512
LIG_SH2_STAT5	425	428	PF00017	0.585
LIG_SH2_STAT5	435	438	PF00017	0.562
LIG_SH2_STAT5	476	479	PF00017	0.447
LIG_SH3_2	97	102	PF14604	0.472
LIG_SH3_3	10	16	PF00018	0.790
LIG_SH3_3	166	172	PF00018	0.539
LIG_SH3_3	246	252	PF00018	0.607
LIG_SH3_3	400	406	PF00018	0.577
LIG_SH3_3	57	63	PF00018	0.495
LIG_SH3_3	94	100	PF00018	0.433
LIG_SUMO_SIM_anti_2	484	489	PF11976	0.582
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.512
LIG_SUMO_SIM_par_1	495	500	PF11976	0.536
LIG_TRAF2_1	123	126	PF00917	0.432
LIG_TRAF2_1	350	353	PF00917	0.561
LIG_TRAF2_1	405	408	PF00917	0.630
MOD_CDK_SPxK_1	96	102	PF00069	0.542
MOD_CK1_1	174	180	PF00069	0.581
MOD_CK1_1	250	256	PF00069	0.645
MOD_CK1_1	372	378	PF00069	0.739
MOD_CK1_1	456	462	PF00069	0.689
MOD_CK1_1	518	524	PF00069	0.779
MOD_CK1_1	54	60	PF00069	0.548
MOD_CK2_1	120	126	PF00069	0.521
MOD_CK2_1	347	353	PF00069	0.674
MOD_CK2_1	402	408	PF00069	0.771
MOD_GlcNHglycan	105	108	PF01048	0.543
MOD_GlcNHglycan	173	176	PF01048	0.610
MOD_GlcNHglycan	329	332	PF01048	0.642
MOD_GlcNHglycan	371	374	PF01048	0.620
MOD_GlcNHglycan	418	421	PF01048	0.694
MOD_GlcNHglycan	426	429	PF01048	0.792
MOD_GlcNHglycan	49	52	PF01048	0.521
MOD_GlcNHglycan	517	520	PF01048	0.697
MOD_GlcNHglycan	78	81	PF01048	0.574
MOD_GSK3_1	131	138	PF00069	0.566
MOD_GSK3_1	229	236	PF00069	0.652
MOD_GSK3_1	270	277	PF00069	0.653
MOD_GSK3_1	368	375	PF00069	0.613
MOD_GSK3_1	439	446	PF00069	0.767
MOD_GSK3_1	449	456	PF00069	0.657
MOD_GSK3_1	459	466	PF00069	0.633
MOD_GSK3_1	47	54	PF00069	0.558
MOD_GSK3_1	58	65	PF00069	0.645
MOD_N-GLC_1	228	233	PF02516	0.625
MOD_N-GLC_1	319	324	PF02516	0.711
MOD_N-GLC_1	377	382	PF02516	0.697
MOD_N-GLC_1	416	421	PF02516	0.709
MOD_NEK2_1	183	188	PF00069	0.620
MOD_NEK2_1	369	374	PF00069	0.642
MOD_NEK2_1	424	429	PF00069	0.716
MOD_NEK2_1	449	454	PF00069	0.673
MOD_NEK2_1	91	96	PF00069	0.527
MOD_PIKK_1	186	192	PF00454	0.582
MOD_PIKK_1	418	424	PF00454	0.644
MOD_PIKK_1	441	447	PF00454	0.805
MOD_PKA_1	515	521	PF00069	0.792
MOD_PKA_2	120	126	PF00069	0.599
MOD_PKA_2	131	137	PF00069	0.557
MOD_PKA_2	360	366	PF00069	0.649
MOD_Plk_1	210	216	PF00069	0.681
MOD_Plk_1	228	234	PF00069	0.459
MOD_Plk_1	377	383	PF00069	0.678
MOD_Plk_4	174	180	PF00069	0.548
MOD_Plk_4	183	189	PF00069	0.569
MOD_Plk_4	229	235	PF00069	0.600
MOD_Plk_4	270	276	PF00069	0.604
MOD_Plk_4	287	293	PF00069	0.584
MOD_Plk_4	443	449	PF00069	0.748
MOD_Plk_4	481	487	PF00069	0.536
MOD_Plk_4	488	494	PF00069	0.434
MOD_Plk_4	51	57	PF00069	0.571
MOD_ProDKin_1	219	225	PF00069	0.643
MOD_ProDKin_1	245	251	PF00069	0.635
MOD_ProDKin_1	293	299	PF00069	0.665
MOD_ProDKin_1	402	408	PF00069	0.743
MOD_ProDKin_1	453	459	PF00069	0.740
MOD_ProDKin_1	96	102	PF00069	0.608
MOD_SUMO_rev_2	79	89	PF00179	0.468
TRG_DiLeu_LyEn_5	408	413	PF01217	0.670
TRG_ENDOCYTIC_2	113	116	PF00928	0.553
TRG_ENDOCYTIC_2	278	281	PF00928	0.613
TRG_ENDOCYTIC_2	284	287	PF00928	0.662
TRG_ENDOCYTIC_2	325	328	PF00928	0.706
TRG_ER_diArg_1	469	472	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q7	Leptomonas seymouri	33%	95%
A4HCV5	Leishmania braziliensis	53%	99%
A4I0D6	Leishmania infantum	99%	100%
E9AW99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QB79	Leishmania major	86%	100%