Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7B8_LEIDO

TriTrypDb:

LdBPK_230640.1 , LdCL_230011900 , LDHU3_23.0890

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.536
CLV_NRD_NRD_1	103	105	PF00675	0.440
CLV_NRD_NRD_1	194	196	PF00675	0.602
CLV_NRD_NRD_1	334	336	PF00675	0.551
CLV_PCSK_KEX2_1	103	105	PF00082	0.450
CLV_PCSK_KEX2_1	196	198	PF00082	0.600
CLV_PCSK_KEX2_1	321	323	PF00082	0.558
CLV_PCSK_KEX2_1	334	336	PF00082	0.382
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.600
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.533
CLV_PCSK_SKI1_1	334	338	PF00082	0.482
DEG_SCF_FBW7_1	131	136	PF00400	0.605
DEG_SPOP_SBC_1	262	266	PF00917	0.627
DOC_ANK_TNKS_1	203	210	PF00023	0.665
DOC_CKS1_1	139	144	PF01111	0.571
DOC_CKS1_1	27	32	PF01111	0.586
DOC_CYCLIN_RxL_1	182	194	PF00134	0.593
DOC_CYCLIN_RxL_1	278	289	PF00134	0.567
DOC_CYCLIN_RxL_1	332	342	PF00134	0.474
DOC_PP1_RVXF_1	279	286	PF00149	0.598
DOC_PP1_RVXF_1	332	339	PF00149	0.454
DOC_PP1_RVXF_1	81	88	PF00149	0.465
DOC_PP2B_LxvP_1	253	256	PF13499	0.549
DOC_PP4_FxxP_1	87	90	PF00568	0.432
DOC_USP7_MATH_1	110	114	PF00917	0.545
DOC_USP7_MATH_1	190	194	PF00917	0.660
DOC_USP7_MATH_1	207	211	PF00917	0.550
DOC_USP7_MATH_1	256	260	PF00917	0.541
DOC_USP7_MATH_1	279	283	PF00917	0.588
DOC_USP7_MATH_1	4	8	PF00917	0.605
DOC_USP7_MATH_2	198	204	PF00917	0.677
DOC_USP7_UBL2_3	120	124	PF12436	0.542
DOC_WW_Pin1_4	129	134	PF00397	0.573
DOC_WW_Pin1_4	138	143	PF00397	0.607
DOC_WW_Pin1_4	162	167	PF00397	0.589
DOC_WW_Pin1_4	26	31	PF00397	0.602
DOC_WW_Pin1_4	86	91	PF00397	0.462
LIG_14-3-3_CanoR_1	335	343	PF00244	0.558
LIG_APCC_ABBA_1	285	290	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BIR_III_4	75	79	PF00653	0.437
LIG_BRCT_BRCA1_1	281	285	PF00533	0.533
LIG_BRCT_BRCA1_1	44	48	PF00533	0.528
LIG_FHA_1	139	145	PF00498	0.553
LIG_FHA_1	325	331	PF00498	0.437
LIG_FHA_1	338	344	PF00498	0.523
LIG_FHA_1	35	41	PF00498	0.406
LIG_FHA_2	203	209	PF00498	0.644
LIG_FHA_2	266	272	PF00498	0.632
LIG_FHA_2	289	295	PF00498	0.546
LIG_FHA_2	299	305	PF00498	0.441
LIG_FHA_2	312	318	PF00498	0.404
LIG_FHA_2	337	343	PF00498	0.572
LIG_FHA_2	56	62	PF00498	0.392
LIG_LIR_Gen_1	113	122	PF02991	0.591
LIG_LIR_Gen_1	296	305	PF02991	0.467
LIG_LIR_Nem_3	113	117	PF02991	0.597
LIG_LIR_Nem_3	282	288	PF02991	0.517
LIG_LIR_Nem_3	296	302	PF02991	0.471
LIG_LIR_Nem_3	45	51	PF02991	0.513
LIG_SH2_CRK	159	163	PF00017	0.535
LIG_SH2_NCK_1	159	163	PF00017	0.535
LIG_SH2_PTP2	299	302	PF00017	0.460
LIG_SH2_STAT5	100	103	PF00017	0.403
LIG_SH2_STAT5	114	117	PF00017	0.566
LIG_SH2_STAT5	299	302	PF00017	0.460
LIG_SH3_3	128	134	PF00018	0.598
LIG_SH3_3	165	171	PF00018	0.537
LIG_SH3_3	27	33	PF00018	0.776
LIG_TRAF2_1	313	316	PF00917	0.525
LIG_WRC_WIRS_1	114	119	PF05994	0.588
MOD_CK1_1	113	119	PF00069	0.528
MOD_CK1_1	15	21	PF00069	0.669
MOD_CK1_1	183	189	PF00069	0.618
MOD_CK1_1	2	8	PF00069	0.583
MOD_CK1_1	203	209	PF00069	0.502
MOD_CK1_1	210	216	PF00069	0.648
MOD_CK1_1	231	237	PF00069	0.676
MOD_CK1_1	265	271	PF00069	0.673
MOD_CK1_1	293	299	PF00069	0.559
MOD_CK1_1	55	61	PF00069	0.404
MOD_CK2_1	202	208	PF00069	0.607
MOD_CK2_1	261	267	PF00069	0.625
MOD_CK2_1	271	277	PF00069	0.527
MOD_CK2_1	311	317	PF00069	0.465
MOD_CK2_1	336	342	PF00069	0.559
MOD_CK2_1	67	73	PF00069	0.402
MOD_GlcNHglycan	1	4	PF01048	0.570
MOD_GlcNHglycan	14	17	PF01048	0.661
MOD_GlcNHglycan	150	153	PF01048	0.698
MOD_GlcNHglycan	159	162	PF01048	0.727
MOD_GlcNHglycan	205	208	PF01048	0.668
MOD_GlcNHglycan	209	212	PF01048	0.640
MOD_GlcNHglycan	231	234	PF01048	0.650
MOD_GlcNHglycan	331	334	PF01048	0.500
MOD_GlcNHglycan	6	9	PF01048	0.575
MOD_GlcNHglycan	95	98	PF01048	0.475
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	203	210	PF00069	0.643
MOD_GSK3_1	22	29	PF00069	0.656
MOD_GSK3_1	231	238	PF00069	0.573
MOD_GSK3_1	257	264	PF00069	0.668
MOD_GSK3_1	286	293	PF00069	0.516
MOD_N-GLC_1	21	26	PF02516	0.633
MOD_N-GLC_1	66	71	PF02516	0.384
MOD_NEK2_1	288	293	PF00069	0.689
MOD_NEK2_1	66	71	PF00069	0.402
MOD_NEK2_2	279	284	PF00069	0.609
MOD_PIKK_1	217	223	PF00454	0.671
MOD_PIKK_1	311	317	PF00454	0.525
MOD_PKA_2	181	187	PF00069	0.618
MOD_PKA_2	203	209	PF00069	0.611
MOD_Plk_1	21	27	PF00069	0.661
MOD_Plk_1	271	277	PF00069	0.607
MOD_Plk_1	66	72	PF00069	0.397
MOD_Plk_2-3	271	277	PF00069	0.608
MOD_Plk_4	110	116	PF00069	0.598
MOD_Plk_4	22	28	PF00069	0.677
MOD_Plk_4	237	243	PF00069	0.590
MOD_Plk_4	295	301	PF00069	0.497
MOD_Plk_4	34	40	PF00069	0.376
MOD_Plk_4	67	73	PF00069	0.444
MOD_ProDKin_1	129	135	PF00069	0.576
MOD_ProDKin_1	138	144	PF00069	0.607
MOD_ProDKin_1	162	168	PF00069	0.585
MOD_ProDKin_1	26	32	PF00069	0.595
MOD_ProDKin_1	86	92	PF00069	0.458
MOD_SUMO_rev_2	192	198	PF00179	0.662
TRG_ENDOCYTIC_2	114	117	PF00928	0.592
TRG_ENDOCYTIC_2	299	302	PF00928	0.460
TRG_ER_diArg_1	195	198	PF00400	0.664
TRG_ER_diArg_1	334	336	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE95	Leptomonas seymouri	47%	88%
A4HCS4	Leishmania braziliensis	74%	100%
A4I098	Leishmania infantum	99%	100%
E9AW63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBB5	Leishmania major	88%	100%