Checkpoint protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Checkpoint protein

Gene product:

Checkpoint protein HUS1, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7B6_LEIDO

TriTrypDb:

LdBPK_230330.1 , LdCL_230008700 , LDHU3_23.0490

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	9
GO:0016020	membrane	2	5
GO:0030896	checkpoint clamp complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9

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Expansion

Sequence features

A0A3S5H7B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B6

Function

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Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	9
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0000077	DNA damage checkpoint signaling	5	9
GO:0000723	telomere maintenance	5	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006289	nucleotide-excision repair	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.517
CLV_C14_Caspase3-7	205	209	PF00656	0.500
CLV_C14_Caspase3-7	266	270	PF00656	0.410
CLV_C14_Caspase3-7	6	10	PF00656	0.499
CLV_NRD_NRD_1	196	198	PF00675	0.251
CLV_NRD_NRD_1	214	216	PF00675	0.301
CLV_NRD_NRD_1	283	285	PF00675	0.309
CLV_NRD_NRD_1	308	310	PF00675	0.291
CLV_PCSK_KEX2_1	196	198	PF00082	0.251
CLV_PCSK_KEX2_1	214	216	PF00082	0.314

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I495	Leptomonas seymouri	65%	99%
A0A1X0NG57	Trypanosomatidae	35%	100%
A0A422NW79	Trypanosoma rangeli	39%	100%
A4HCP3	Leishmania braziliensis	84%	98%
A4I069	Leishmania infantum	99%	100%
E9AW32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBE5	Leishmania major	95%	100%

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