Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7B5_LEIDO

TriTrypDb:

LdBPK_230180.1 , LdCL_230006700 , LDHU3_23.0220

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S5H7B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.572
CLV_NRD_NRD_1	219	221	PF00675	0.597
CLV_NRD_NRD_1	248	250	PF00675	0.507
CLV_NRD_NRD_1	466	468	PF00675	0.469
CLV_PCSK_KEX2_1	219	221	PF00082	0.585
CLV_PCSK_KEX2_1	468	470	PF00082	0.492
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.558
CLV_PCSK_SKI1_1	105	109	PF00082	0.327
CLV_PCSK_SKI1_1	259	263	PF00082	0.464
CLV_PCSK_SKI1_1	27	31	PF00082	0.472
CLV_PCSK_SKI1_1	450	454	PF00082	0.515
CLV_PCSK_SKI1_1	503	507	PF00082	0.469
CLV_Separin_Metazoa	21	25	PF03568	0.509
DEG_APCC_DBOX_1	104	112	PF00400	0.378
DEG_APCC_DBOX_1	26	34	PF00400	0.495
DOC_CDC14_PxL_1	241	249	PF14671	0.580
DOC_CYCLIN_RxL_1	253	265	PF00134	0.582
DOC_MAPK_DCC_7	105	113	PF00069	0.464
DOC_MAPK_gen_1	160	169	PF00069	0.506
DOC_MAPK_gen_1	24	32	PF00069	0.450
DOC_MAPK_gen_1	467	475	PF00069	0.480
DOC_MAPK_gen_1	500	509	PF00069	0.454
DOC_MAPK_HePTP_8	497	509	PF00069	0.536
DOC_MAPK_MEF2A_6	105	113	PF00069	0.433
DOC_MAPK_MEF2A_6	233	241	PF00069	0.499
DOC_MAPK_MEF2A_6	500	509	PF00069	0.544
DOC_PP1_RVXF_1	158	164	PF00149	0.455
DOC_PP1_RVXF_1	192	198	PF00149	0.464
DOC_SPAK_OSR1_1	455	459	PF12202	0.349
DOC_USP7_MATH_1	173	177	PF00917	0.562
DOC_USP7_MATH_1	2	6	PF00917	0.542
DOC_USP7_MATH_1	359	363	PF00917	0.494
DOC_USP7_MATH_1	433	437	PF00917	0.439
DOC_WW_Pin1_4	95	100	PF00397	0.553
LIG_14-3-3_CanoR_1	162	168	PF00244	0.458
LIG_14-3-3_CanoR_1	249	253	PF00244	0.518
LIG_14-3-3_CanoR_1	259	268	PF00244	0.413
LIG_14-3-3_CanoR_1	27	33	PF00244	0.547
LIG_14-3-3_CanoR_1	285	294	PF00244	0.429
LIG_14-3-3_CanoR_1	317	326	PF00244	0.566
LIG_14-3-3_CanoR_1	361	367	PF00244	0.347
LIG_14-3-3_CanoR_1	397	406	PF00244	0.457
LIG_14-3-3_CanoR_1	447	453	PF00244	0.555
LIG_14-3-3_CanoR_1	469	474	PF00244	0.486
LIG_14-3-3_CanoR_1	511	516	PF00244	0.413
LIG_APCC_ABBA_1	316	321	PF00400	0.543
LIG_CaM_NSCaTE_8	370	377	PF13499	0.443
LIG_EH1_1	458	466	PF00400	0.499
LIG_FHA_1	120	126	PF00498	0.518
LIG_FHA_1	164	170	PF00498	0.474
LIG_FHA_1	197	203	PF00498	0.574
LIG_FHA_1	226	232	PF00498	0.595
LIG_FHA_1	281	287	PF00498	0.488
LIG_FHA_1	313	319	PF00498	0.493
LIG_FHA_1	362	368	PF00498	0.457
LIG_FHA_1	408	414	PF00498	0.514
LIG_FHA_1	485	491	PF00498	0.490
LIG_FHA_1	83	89	PF00498	0.500
LIG_FHA_1	92	98	PF00498	0.594
LIG_FHA_2	198	204	PF00498	0.479
LIG_FHA_2	211	217	PF00498	0.461
LIG_FHA_2	249	255	PF00498	0.518
LIG_FHA_2	271	277	PF00498	0.574
LIG_FHA_2	398	404	PF00498	0.492
LIG_FHA_2	410	416	PF00498	0.542
LIG_FHA_2	452	458	PF00498	0.409
LIG_GBD_Chelix_1	150	158	PF00786	0.496
LIG_Integrin_RGD_1	302	304	PF01839	0.428
LIG_Integrin_RGD_1	329	331	PF01839	0.425
LIG_LIR_Gen_1	428	435	PF02991	0.417
LIG_LIR_Gen_1	451	461	PF02991	0.496
LIG_LIR_Nem_3	135	140	PF02991	0.453
LIG_LIR_Nem_3	335	340	PF02991	0.462
LIG_LIR_Nem_3	428	434	PF02991	0.401
LIG_LIR_Nem_3	451	456	PF02991	0.510
LIG_LYPXL_yS_3	337	340	PF13949	0.570
LIG_MAD2	496	504	PF02301	0.462
LIG_NRBOX	257	263	PF00104	0.565
LIG_PCNA_PIPBox_1	6	15	PF02747	0.413
LIG_PCNA_yPIPBox_3	249	262	PF02747	0.516
LIG_PCNA_yPIPBox_3	6	16	PF02747	0.423
LIG_PTB_Apo_2	131	138	PF02174	0.630
LIG_SH2_CRK	356	360	PF00017	0.380
LIG_SH2_CRK	485	489	PF00017	0.411
LIG_SH2_GRB2like	132	135	PF00017	0.601
LIG_SH2_SRC	235	238	PF00017	0.557
LIG_SH2_SRC	356	359	PF00017	0.489
LIG_SH2_STAT5	101	104	PF00017	0.433
LIG_SH2_STAT5	13	16	PF00017	0.493
LIG_SH2_STAT5	205	208	PF00017	0.487
LIG_SH2_STAT5	240	243	PF00017	0.556
LIG_SH2_STAT5	332	335	PF00017	0.411
LIG_SH2_STAT5	424	427	PF00017	0.461
LIG_SH3_1	220	226	PF00018	0.627
LIG_SH3_3	19	25	PF00018	0.447
LIG_SH3_3	220	226	PF00018	0.600
LIG_SH3_3	337	343	PF00018	0.577
LIG_SH3_3	403	409	PF00018	0.438
LIG_SUMO_SIM_par_1	121	126	PF11976	0.468
LIG_TRAF2_1	213	216	PF00917	0.581
LIG_TYR_ITIM	483	488	PF00017	0.481
LIG_UBA3_1	308	312	PF00899	0.450
MOD_CK1_1	126	132	PF00069	0.367
MOD_CK1_1	141	147	PF00069	0.565
MOD_CK1_1	267	273	PF00069	0.525
MOD_CK1_1	336	342	PF00069	0.539
MOD_CK1_1	362	368	PF00069	0.460
MOD_CK1_1	407	413	PF00069	0.533
MOD_CK1_1	448	454	PF00069	0.536
MOD_CK2_1	210	216	PF00069	0.522
MOD_CK2_1	248	254	PF00069	0.475
MOD_CK2_1	270	276	PF00069	0.535
MOD_CK2_1	285	291	PF00069	0.377
MOD_CK2_1	317	323	PF00069	0.559
MOD_CK2_1	342	348	PF00069	0.483
MOD_CK2_1	36	42	PF00069	0.509
MOD_CK2_1	397	403	PF00069	0.400
MOD_CK2_1	409	415	PF00069	0.541
MOD_CK2_1	511	517	PF00069	0.472
MOD_GlcNHglycan	145	148	PF01048	0.513
MOD_GlcNHglycan	269	272	PF01048	0.496
MOD_GlcNHglycan	312	315	PF01048	0.402
MOD_GSK3_1	119	126	PF00069	0.416
MOD_GSK3_1	260	267	PF00069	0.459
MOD_GSK3_1	91	98	PF00069	0.624
MOD_N-GLC_1	126	131	PF02516	0.398
MOD_N-GLC_1	133	138	PF02516	0.649
MOD_NEK2_1	182	187	PF00069	0.460
MOD_NEK2_1	197	202	PF00069	0.482
MOD_NEK2_1	280	285	PF00069	0.520
MOD_NEK2_1	325	330	PF00069	0.490
MOD_NEK2_1	333	338	PF00069	0.489
MOD_NEK2_1	360	365	PF00069	0.462
MOD_OFUCOSY	395	401	PF10250	0.414
MOD_PIKK_1	138	144	PF00454	0.677
MOD_PIKK_1	2	8	PF00454	0.536
MOD_PIKK_1	79	85	PF00454	0.556
MOD_PK_1	469	475	PF00069	0.471
MOD_PKA_2	248	254	PF00069	0.522
MOD_PKA_2	360	366	PF00069	0.468
MOD_PKB_1	467	475	PF00069	0.483
MOD_Plk_1	126	132	PF00069	0.404
MOD_Plk_1	133	139	PF00069	0.560
MOD_Plk_2-3	248	254	PF00069	0.544
MOD_Plk_4	127	133	PF00069	0.456
MOD_Plk_4	153	159	PF00069	0.402
MOD_Plk_4	188	194	PF00069	0.538
MOD_Plk_4	28	34	PF00069	0.537
MOD_Plk_4	336	342	PF00069	0.550
MOD_Plk_4	362	368	PF00069	0.524
MOD_Plk_4	409	415	PF00069	0.541
MOD_ProDKin_1	95	101	PF00069	0.546
TRG_ENDOCYTIC_2	19	22	PF00928	0.523
TRG_ENDOCYTIC_2	319	322	PF00928	0.552
TRG_ENDOCYTIC_2	337	340	PF00928	0.516
TRG_ENDOCYTIC_2	485	488	PF00928	0.475
TRG_ER_diArg_1	159	162	PF00400	0.550
TRG_ER_diArg_1	219	222	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4S8	Leptomonas seymouri	57%	94%
A0A0S4JG45	Bodo saltans	30%	86%
A0A1X0NG29	Trypanosomatidae	37%	96%
A0A1X0NNW8	Trypanosomatidae	24%	100%
A0A422NNY9	Trypanosoma rangeli	24%	100%
A0A422NVZ8	Trypanosoma rangeli	40%	100%
A4HCN0	Leishmania braziliensis	77%	100%
A4I054	Leishmania infantum	100%	100%
D0A6V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AW17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBF9	Leishmania major	92%	100%