Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7B4_LEIDO

TriTrypDb:

LdBPK_221510.1 , LdCL_220022400 , LDHU3_22.2160

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.586
CLV_C14_Caspase3-7	281	285	PF00656	0.649
CLV_C14_Caspase3-7	513	517	PF00656	0.437
CLV_C14_Caspase3-7	567	571	PF00656	0.493
CLV_C14_Caspase3-7	78	82	PF00656	0.599
CLV_NRD_NRD_1	385	387	PF00675	0.518
CLV_NRD_NRD_1	416	418	PF00675	0.372
CLV_NRD_NRD_1	435	437	PF00675	0.510
CLV_NRD_NRD_1	50	52	PF00675	0.519
CLV_NRD_NRD_1	527	529	PF00675	0.363
CLV_PCSK_KEX2_1	385	387	PF00082	0.518
CLV_PCSK_KEX2_1	416	418	PF00082	0.372
CLV_PCSK_KEX2_1	435	437	PF00082	0.510
CLV_PCSK_KEX2_1	527	529	PF00082	0.363
CLV_PCSK_SKI1_1	217	221	PF00082	0.492
CLV_PCSK_SKI1_1	386	390	PF00082	0.589
CLV_PCSK_SKI1_1	416	420	PF00082	0.463
CLV_PCSK_SKI1_1	534	538	PF00082	0.367
DEG_APCC_DBOX_1	415	423	PF00400	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DEG_SPOP_SBC_1	117	121	PF00917	0.521
DEG_SPOP_SBC_1	186	190	PF00917	0.697
DEG_SPOP_SBC_1	569	573	PF00917	0.423
DOC_CKS1_1	540	545	PF01111	0.458
DOC_CYCLIN_RxL_1	214	221	PF00134	0.490
DOC_CYCLIN_RxL_1	230	240	PF00134	0.277
DOC_CYCLIN_RxL_1	413	421	PF00134	0.450
DOC_CYCLIN_RxL_1	528	542	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.513
DOC_MAPK_gen_1	320	329	PF00069	0.450
DOC_MAPK_gen_1	342	352	PF00069	0.391
DOC_MAPK_gen_1	416	424	PF00069	0.385
DOC_MAPK_MEF2A_6	320	329	PF00069	0.450
DOC_MAPK_MEF2A_6	345	352	PF00069	0.449
DOC_PP1_RVXF_1	231	238	PF00149	0.398
DOC_PP2B_LxvP_1	126	129	PF13499	0.581
DOC_PP2B_LxvP_1	144	147	PF13499	0.398
DOC_USP7_MATH_1	110	114	PF00917	0.511
DOC_USP7_MATH_1	118	122	PF00917	0.553
DOC_USP7_MATH_1	139	143	PF00917	0.511
DOC_USP7_MATH_1	157	161	PF00917	0.593
DOC_USP7_MATH_1	177	181	PF00917	0.605
DOC_USP7_MATH_1	186	190	PF00917	0.698
DOC_USP7_MATH_1	222	226	PF00917	0.471
DOC_USP7_MATH_1	461	465	PF00917	0.527
DOC_USP7_MATH_1	498	502	PF00917	0.541
DOC_USP7_MATH_1	526	530	PF00917	0.368
DOC_USP7_MATH_1	93	97	PF00917	0.480
DOC_WW_Pin1_4	135	140	PF00397	0.545
DOC_WW_Pin1_4	218	223	PF00397	0.573
DOC_WW_Pin1_4	502	507	PF00397	0.656
DOC_WW_Pin1_4	539	544	PF00397	0.442
DOC_WW_Pin1_4	588	593	PF00397	0.484
DOC_WW_Pin1_4	72	77	PF00397	0.576
LIG_14-3-3_CanoR_1	179	184	PF00244	0.660
LIG_14-3-3_CanoR_1	37	45	PF00244	0.673
LIG_14-3-3_CanoR_1	385	389	PF00244	0.544
LIG_14-3-3_CanoR_1	395	399	PF00244	0.422
LIG_14-3-3_CanoR_1	417	423	PF00244	0.415
LIG_14-3-3_CanoR_1	527	535	PF00244	0.379
LIG_Actin_WH2_2	411	428	PF00022	0.395
LIG_APCC_ABBA_1	22	27	PF00400	0.505
LIG_APCC_ABBA_1	303	308	PF00400	0.395
LIG_APCC_ABBA_1	518	523	PF00400	0.434
LIG_BRCT_BRCA1_1	466	470	PF00533	0.285
LIG_CaM_IQ_9	259	274	PF13499	0.435
LIG_DLG_GKlike_1	179	187	PF00625	0.584
LIG_EH1_1	575	583	PF00400	0.401
LIG_eIF4E_1	576	582	PF01652	0.404
LIG_FHA_1	139	145	PF00498	0.527
LIG_FHA_1	189	195	PF00498	0.624
LIG_FHA_1	243	249	PF00498	0.478
LIG_FHA_1	273	279	PF00498	0.437
LIG_FHA_1	299	305	PF00498	0.383
LIG_FHA_1	400	406	PF00498	0.469
LIG_FHA_1	535	541	PF00498	0.399
LIG_FHA_1	594	600	PF00498	0.370
LIG_IBAR_NPY_1	23	25	PF08397	0.516
LIG_LIR_Gen_1	160	170	PF02991	0.484
LIG_LIR_Gen_1	323	332	PF02991	0.383
LIG_LIR_Gen_1	428	433	PF02991	0.410
LIG_LIR_Gen_1	464	471	PF02991	0.376
LIG_LIR_Nem_3	160	165	PF02991	0.480
LIG_LIR_Nem_3	323	327	PF02991	0.402
LIG_LIR_Nem_3	397	401	PF02991	0.460
LIG_LIR_Nem_3	428	432	PF02991	0.416
LIG_LIR_Nem_3	464	468	PF02991	0.402
LIG_LIR_Nem_3	559	564	PF02991	0.326
LIG_NRBOX	418	424	PF00104	0.501
LIG_PCNA_yPIPBox_3	342	356	PF02747	0.374
LIG_PCNA_yPIPBox_3	579	588	PF02747	0.455
LIG_PDZ_Class_2	611	616	PF00595	0.506
LIG_Pex14_1	384	388	PF04695	0.487
LIG_REV1ctd_RIR_1	559	567	PF16727	0.320
LIG_SH2_PTP2	162	165	PF00017	0.483
LIG_SH2_PTP2	324	327	PF00017	0.430
LIG_SH2_SRC	98	101	PF00017	0.457
LIG_SH2_STAP1	401	405	PF00017	0.401
LIG_SH2_STAT3	576	579	PF00017	0.476
LIG_SH2_STAT5	162	165	PF00017	0.512
LIG_SH2_STAT5	168	171	PF00017	0.526
LIG_SH2_STAT5	324	327	PF00017	0.430
LIG_SH2_STAT5	401	404	PF00017	0.360
LIG_SH2_STAT5	576	579	PF00017	0.529
LIG_SH2_STAT5	601	604	PF00017	0.406
LIG_SH2_STAT5	98	101	PF00017	0.530
LIG_SH3_3	169	175	PF00018	0.504
LIG_SH3_3	199	205	PF00018	0.438
LIG_SH3_3	224	230	PF00018	0.390
LIG_SH3_3	245	251	PF00018	0.400
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.468
LIG_WRC_WIRS_1	254	259	PF05994	0.317
MOD_CDK_SPxxK_3	588	595	PF00069	0.482
MOD_CDK_SPxxK_3	72	79	PF00069	0.583
MOD_CK1_1	138	144	PF00069	0.518
MOD_CK1_1	188	194	PF00069	0.695
MOD_CK1_1	316	322	PF00069	0.603
MOD_CK1_1	464	470	PF00069	0.415
MOD_CK1_1	501	507	PF00069	0.662
MOD_CK1_1	75	81	PF00069	0.778
MOD_CK1_1	82	88	PF00069	0.654
MOD_CK2_1	3	9	PF00069	0.534
MOD_CK2_1	40	46	PF00069	0.532
MOD_CK2_1	425	431	PF00069	0.409
MOD_CK2_1	507	513	PF00069	0.590
MOD_GlcNHglycan	120	123	PF01048	0.711
MOD_GlcNHglycan	141	144	PF01048	0.511
MOD_GlcNHglycan	155	158	PF01048	0.619
MOD_GlcNHglycan	159	162	PF01048	0.556
MOD_GlcNHglycan	199	202	PF01048	0.685
MOD_GlcNHglycan	213	216	PF01048	0.420
MOD_GlcNHglycan	239	242	PF01048	0.416
MOD_GlcNHglycan	298	301	PF01048	0.398
MOD_GlcNHglycan	315	318	PF01048	0.341
MOD_GlcNHglycan	337	340	PF01048	0.480
MOD_GlcNHglycan	528	531	PF01048	0.535
MOD_GlcNHglycan	572	575	PF01048	0.435
MOD_GlcNHglycan	68	71	PF01048	0.553
MOD_GlcNHglycan	95	98	PF01048	0.540
MOD_GSK3_1	135	142	PF00069	0.499
MOD_GSK3_1	153	160	PF00069	0.681
MOD_GSK3_1	175	182	PF00069	0.634
MOD_GSK3_1	184	191	PF00069	0.666
MOD_GSK3_1	218	225	PF00069	0.595
MOD_GSK3_1	23	30	PF00069	0.542
MOD_GSK3_1	457	464	PF00069	0.438
MOD_GSK3_1	492	499	PF00069	0.549
MOD_GSK3_1	501	508	PF00069	0.653
MOD_GSK3_1	593	600	PF00069	0.356
MOD_GSK3_1	68	75	PF00069	0.703
MOD_GSK3_1	89	96	PF00069	0.524
MOD_LATS_1	532	538	PF00433	0.299
MOD_N-GLC_1	588	593	PF02516	0.447
MOD_NEK2_1	185	190	PF00069	0.576
MOD_NEK2_1	2	7	PF00069	0.715
MOD_NEK2_1	237	242	PF00069	0.371
MOD_NEK2_1	289	294	PF00069	0.448
MOD_NEK2_1	298	303	PF00069	0.318
MOD_NEK2_1	371	376	PF00069	0.416
MOD_NEK2_1	418	423	PF00069	0.475
MOD_NEK2_1	425	430	PF00069	0.474
MOD_NEK2_1	492	497	PF00069	0.536
MOD_NEK2_1	599	604	PF00069	0.612
MOD_NEK2_1	91	96	PF00069	0.646
MOD_NEK2_2	110	115	PF00069	0.581
MOD_NEK2_2	3	8	PF00069	0.597
MOD_NEK2_2	401	406	PF00069	0.370
MOD_PIKK_1	291	297	PF00454	0.361
MOD_PIKK_1	79	85	PF00454	0.709
MOD_PKA_2	178	184	PF00069	0.680
MOD_PKA_2	344	350	PF00069	0.386
MOD_PKA_2	384	390	PF00069	0.545
MOD_PKA_2	394	400	PF00069	0.506
MOD_PKA_2	425	431	PF00069	0.510
MOD_PKA_2	492	498	PF00069	0.502
MOD_PKA_2	526	532	PF00069	0.385
MOD_Plk_1	18	24	PF00069	0.542
MOD_Plk_1	8	14	PF00069	0.670
MOD_Plk_4	223	229	PF00069	0.503
MOD_Plk_4	27	33	PF00069	0.346
MOD_Plk_4	418	424	PF00069	0.410
MOD_Plk_4	464	470	PF00069	0.518
MOD_Plk_4	8	14	PF00069	0.683
MOD_ProDKin_1	135	141	PF00069	0.541
MOD_ProDKin_1	218	224	PF00069	0.563
MOD_ProDKin_1	502	508	PF00069	0.645
MOD_ProDKin_1	539	545	PF00069	0.455
MOD_ProDKin_1	588	594	PF00069	0.485
MOD_ProDKin_1	72	78	PF00069	0.579
MOD_SUMO_rev_2	591	596	PF00179	0.627
TRG_DiLeu_BaEn_1	531	536	PF01217	0.399
TRG_DiLeu_BaEn_1	560	565	PF01217	0.364
TRG_DiLeu_BaEn_2	465	471	PF01217	0.275
TRG_DiLeu_BaEn_4	358	364	PF01217	0.408
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.444
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.443
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.385
TRG_DiLeu_LyEn_5	531	536	PF01217	0.300
TRG_ENDOCYTIC_2	162	165	PF00928	0.512
TRG_ENDOCYTIC_2	25	28	PF00928	0.504
TRG_ENDOCYTIC_2	324	327	PF00928	0.407
TRG_ER_diArg_1	384	386	PF00400	0.523
TRG_ER_diArg_1	416	418	PF00400	0.377
TRG_ER_diArg_1	434	436	PF00400	0.519
TRG_ER_diArg_1	48	51	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK4	Leptomonas seymouri	47%	99%
A0A1X0NU19	Trypanosomatidae	29%	100%
A0A3R7K6E0	Trypanosoma rangeli	28%	100%
A4HCK7	Leishmania braziliensis	76%	100%
A4I025	Leishmania infantum	100%	100%
E9AVZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBI1	Leishmania major	92%	100%