Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7B1_LEIDO

TriTrypDb:

LdBPK_221010.1 , LdCL_220017600 , LDHU3_22.1530

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H7B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B1

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	14
GO:0006575	cellular modified amino acid metabolic process	3	14
GO:0006749	glutathione metabolic process	4	14
GO:0006751	glutathione catabolic process	5	14
GO:0006790	sulfur compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0042219	cellular modified amino acid catabolic process	4	14
GO:0043171	peptide catabolic process	4	14
GO:0043603	amide metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044273	sulfur compound catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901565	organonitrogen compound catabolic process	4	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0003839	gamma-glutamylcyclotransferase activity	5	14
GO:0016829	lyase activity	2	14
GO:0016840	carbon-nitrogen lyase activity	3	14
GO:0016842	amidine-lyase activity	4	14
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.414
CLV_NRD_NRD_1	189	191	PF00675	0.287
CLV_PCSK_KEX2_1	259	261	PF00082	0.347
CLV_PCSK_KEX2_1	274	276	PF00082	0.427
CLV_PCSK_KEX2_1	56	58	PF00082	0.257
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.407
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.487
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.288
CLV_PCSK_SKI1_1	146	150	PF00082	0.229
CLV_PCSK_SKI1_1	259	263	PF00082	0.374
CLV_PCSK_SKI1_1	275	279	PF00082	0.454
CLV_PCSK_SKI1_1	56	60	PF00082	0.245
CLV_PCSK_SKI1_1	75	79	PF00082	0.245
DEG_APCC_DBOX_1	230	238	PF00400	0.526
DOC_MAPK_gen_1	102	112	PF00069	0.508
DOC_MAPK_gen_1	190	196	PF00069	0.490
DOC_PP4_FxxP_1	179	182	PF00568	0.481
DOC_PP4_FxxP_1	18	21	PF00568	0.498
DOC_USP7_MATH_1	224	228	PF00917	0.456
DOC_WW_Pin1_4	134	139	PF00397	0.518
LIG_14-3-3_CanoR_1	119	125	PF00244	0.498
LIG_14-3-3_CanoR_1	275	280	PF00244	0.398
LIG_14-3-3_CanoR_1	75	80	PF00244	0.450
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_FHA_1	129	135	PF00498	0.511
LIG_FHA_1	152	158	PF00498	0.582
LIG_LIR_Apic_2	153	159	PF02991	0.432
LIG_LIR_Apic_2	16	21	PF02991	0.525
LIG_LIR_Apic_2	177	182	PF02991	0.481
LIG_LIR_Gen_1	114	125	PF02991	0.519
LIG_LIR_Gen_1	232	241	PF02991	0.490
LIG_LIR_Gen_1	25	36	PF02991	0.468
LIG_LIR_Nem_3	114	120	PF02991	0.519
LIG_LIR_Nem_3	232	236	PF02991	0.515
LIG_LIR_Nem_3	25	31	PF02991	0.504
LIG_LIR_Nem_3	45	51	PF02991	0.389
LIG_PDZ_Class_1	275	280	PF00595	0.525
LIG_Pex14_1	38	42	PF04695	0.445
LIG_SH2_CRK	117	121	PF00017	0.502
LIG_SH2_CRK	33	37	PF00017	0.445
LIG_SH2_CRK	55	59	PF00017	0.445
LIG_SH2_CRK	94	98	PF00017	0.518
LIG_SH2_NCK_1	117	121	PF00017	0.431
LIG_SH2_PTP2	156	159	PF00017	0.407
LIG_SH2_SRC	156	159	PF00017	0.407
LIG_SH2_STAP1	48	52	PF00017	0.494
LIG_SH2_STAT3	14	17	PF00017	0.557
LIG_SH2_STAT5	156	159	PF00017	0.407
LIG_SH2_STAT5	198	201	PF00017	0.459
LIG_SH2_STAT5	207	210	PF00017	0.433
LIG_SH2_STAT5	233	236	PF00017	0.445
LIG_SH2_STAT5	51	54	PF00017	0.495
LIG_SH3_1	67	73	PF00018	0.463
LIG_SH3_1	94	100	PF00018	0.478
LIG_SH3_2	70	75	PF14604	0.463
LIG_SH3_2	97	102	PF14604	0.526
LIG_SH3_3	135	141	PF00018	0.453
LIG_SH3_3	154	160	PF00018	0.358
LIG_SH3_3	179	185	PF00018	0.498
LIG_SH3_3	67	73	PF00018	0.445
LIG_SH3_3	94	100	PF00018	0.495
LIG_SUMO_SIM_par_1	173	180	PF11976	0.420
LIG_WRC_WIRS_1	20	25	PF05994	0.475
LIG_WW_3	158	162	PF00397	0.420
MOD_CK1_1	147	153	PF00069	0.426
MOD_CK1_1	2	8	PF00069	0.567
MOD_CK2_1	162	168	PF00069	0.490
MOD_CK2_1	226	232	PF00069	0.380
MOD_GlcNHglycan	226	229	PF01048	0.245
MOD_GSK3_1	128	135	PF00069	0.506
MOD_GSK3_1	140	147	PF00069	0.512
MOD_GSK3_1	2	9	PF00069	0.654
MOD_GSK3_1	75	82	PF00069	0.463
MOD_N-GLC_1	132	137	PF02516	0.320
MOD_N-GLC_1	162	167	PF02516	0.290
MOD_PIKK_1	151	157	PF00454	0.420
MOD_PKA_2	9	15	PF00069	0.583
MOD_Plk_1	209	215	PF00069	0.420
MOD_Plk_4	120	126	PF00069	0.497
MOD_Plk_4	32	38	PF00069	0.460
MOD_Plk_4	47	53	PF00069	0.461
MOD_Plk_4	75	81	PF00069	0.445
MOD_ProDKin_1	134	140	PF00069	0.518
MOD_SUMO_for_1	148	151	PF00179	0.420
TRG_DiLeu_BaEn_2	231	237	PF01217	0.490
TRG_ENDOCYTIC_2	117	120	PF00928	0.473
TRG_ENDOCYTIC_2	233	236	PF00928	0.516
TRG_ENDOCYTIC_2	33	36	PF00928	0.445
TRG_ENDOCYTIC_2	55	58	PF00928	0.460
TRG_ER_diArg_1	262	265	PF00400	0.458
TRG_NES_CRM1_1	101	114	PF08389	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	68%	100%
A0A1X0NTG7	Trypanosomatidae	41%	100%
A0A3Q8ILN3	Leishmania donovani	64%	87%
A0A3R7NMW8	Trypanosoma rangeli	43%	100%
A4HCF7	Leishmania braziliensis	85%	100%
A4HZZ0	Leishmania infantum	64%	87%
A4HZZ1	Leishmania infantum	99%	100%
B3STU3	Rattus norvegicus	30%	100%
C9ZSN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AVV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	88%
E9AVV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P87305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q4QBM7	Leishmania major	94%	100%
Q4QBM8	Leishmania major	64%	90%
Q5SPB6	Danio rerio	31%	100%
Q84QC1	Arabidopsis thaliana	33%	100%
Q8GY54	Arabidopsis thaliana	30%	100%
Q8R3J5	Mus musculus	31%	100%