Major Facilitator Superfamily/Sugar (And other) transporter/Organic Anion Transporter Polypeptide (OATP) family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7B0_LEIDO

TriTrypDb:

LdBPK_220870.1 , LdCL_220016100 , LDHU3_22.1380

Length:

965

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H7B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7B0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.536
CLV_C14_Caspase3-7	57	61	PF00656	0.733
CLV_C14_Caspase3-7	69	73	PF00656	0.643
CLV_NRD_NRD_1	299	301	PF00675	0.314
CLV_NRD_NRD_1	377	379	PF00675	0.295
CLV_NRD_NRD_1	475	477	PF00675	0.295
CLV_NRD_NRD_1	55	57	PF00675	0.478
CLV_NRD_NRD_1	714	716	PF00675	0.645
CLV_PCSK_KEX2_1	180	182	PF00082	0.301
CLV_PCSK_KEX2_1	471	473	PF00082	0.298
CLV_PCSK_KEX2_1	475	477	PF00082	0.309
CLV_PCSK_KEX2_1	55	57	PF00082	0.478
CLV_PCSK_KEX2_1	714	716	PF00082	0.645
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.301
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.288
CLV_PCSK_PC7_1	176	182	PF00082	0.275
CLV_PCSK_SKI1_1	12	16	PF00082	0.461
CLV_PCSK_SKI1_1	180	184	PF00082	0.275
CLV_PCSK_SKI1_1	278	282	PF00082	0.312
CLV_PCSK_SKI1_1	476	480	PF00082	0.295
CLV_PCSK_SKI1_1	502	506	PF00082	0.529
DEG_APCC_DBOX_1	501	509	PF00400	0.329
DEG_COP1_1	69	79	PF00400	0.701
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DEG_ODPH_VHL_1	451	464	PF01847	0.388
DEG_SCF_TRCP1_1	127	132	PF00400	0.312
DEG_SCF_TRCP1_1	323	328	PF00400	0.434
DEG_SCF_TRCP1_1	719	724	PF00400	0.485
DEG_SPOP_SBC_1	154	158	PF00917	0.340
DEG_SPOP_SBC_1	264	268	PF00917	0.329
DEG_SPOP_SBC_1	806	810	PF00917	0.475
DEG_SPOP_SBC_1	90	94	PF00917	0.699
DOC_CKS1_1	222	227	PF01111	0.312
DOC_CKS1_1	753	758	PF01111	0.503
DOC_CKS1_1	771	776	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	743	749	PF00134	0.482
DOC_MAPK_gen_1	12	20	PF00069	0.696
DOC_MAPK_gen_1	471	479	PF00069	0.491
DOC_MAPK_gen_1	499	507	PF00069	0.252
DOC_MAPK_HePTP_8	207	219	PF00069	0.388
DOC_MAPK_MEF2A_6	210	219	PF00069	0.388
DOC_MAPK_MEF2A_6	569	577	PF00069	0.475
DOC_MAPK_MEF2A_6	729	736	PF00069	0.436
DOC_PP1_RVXF_1	473	480	PF00149	0.528
DOC_PP2B_LxvP_1	135	138	PF13499	0.329
DOC_PP2B_LxvP_1	281	284	PF13499	0.341
DOC_PP4_FxxP_1	552	555	PF00568	0.475
DOC_PP4_FxxP_1	753	756	PF00568	0.494
DOC_PP4_MxPP_1	772	775	PF00568	0.435
DOC_SPAK_OSR1_1	210	214	PF12202	0.312
DOC_USP7_MATH_1	154	158	PF00917	0.340
DOC_USP7_MATH_1	264	268	PF00917	0.338
DOC_USP7_MATH_1	32	36	PF00917	0.770
DOC_USP7_MATH_1	321	325	PF00917	0.433
DOC_USP7_MATH_1	355	359	PF00917	0.539
DOC_USP7_MATH_1	54	58	PF00917	0.703
DOC_USP7_MATH_1	564	568	PF00917	0.545
DOC_USP7_MATH_1	683	687	PF00917	0.502
DOC_USP7_MATH_1	691	695	PF00917	0.462
DOC_USP7_MATH_1	7	11	PF00917	0.732
DOC_USP7_MATH_1	749	753	PF00917	0.610
DOC_USP7_MATH_1	806	810	PF00917	0.492
DOC_USP7_MATH_1	879	883	PF00917	0.564
DOC_USP7_MATH_1	909	913	PF00917	0.534
DOC_USP7_MATH_1	91	95	PF00917	0.705
DOC_WW_Pin1_4	221	226	PF00397	0.312
DOC_WW_Pin1_4	678	683	PF00397	0.470
DOC_WW_Pin1_4	699	704	PF00397	0.480
DOC_WW_Pin1_4	742	747	PF00397	0.564
DOC_WW_Pin1_4	752	757	PF00397	0.547
DOC_WW_Pin1_4	760	765	PF00397	0.458
DOC_WW_Pin1_4	770	775	PF00397	0.481
DOC_WW_Pin1_4	922	927	PF00397	0.460
LIG_14-3-3_CanoR_1	181	189	PF00244	0.279
LIG_14-3-3_CanoR_1	236	240	PF00244	0.468
LIG_14-3-3_CanoR_1	356	360	PF00244	0.481
LIG_14-3-3_CanoR_1	365	370	PF00244	0.466
LIG_14-3-3_CanoR_1	389	399	PF00244	0.482
LIG_14-3-3_CanoR_1	42	49	PF00244	0.642
LIG_14-3-3_CanoR_1	55	62	PF00244	0.691
LIG_14-3-3_CanoR_1	737	743	PF00244	0.457
LIG_14-3-3_CanoR_1	82	87	PF00244	0.703
LIG_14-3-3_CanoR_1	849	854	PF00244	0.541
LIG_Actin_WH2_2	107	123	PF00022	0.468
LIG_Actin_WH2_2	460	477	PF00022	0.340
LIG_Actin_WH2_2	554	571	PF00022	0.509
LIG_BIR_III_4	563	567	PF00653	0.517
LIG_BRCT_BRCA1_1	127	131	PF00533	0.312
LIG_BRCT_BRCA1_1	156	160	PF00533	0.312
LIG_BRCT_BRCA1_1	215	219	PF00533	0.388
LIG_BRCT_BRCA1_1	271	275	PF00533	0.340
LIG_BRCT_BRCA1_1	412	416	PF00533	0.312
LIG_Clathr_ClatBox_1	840	844	PF01394	0.452
LIG_EH1_1	569	577	PF00400	0.475
LIG_eIF4E_1	111	117	PF01652	0.565
LIG_eIF4E_1	276	282	PF01652	0.388
LIG_eIF4E_1	570	576	PF01652	0.475
LIG_FHA_1	142	148	PF00498	0.327
LIG_FHA_1	154	160	PF00498	0.258
LIG_FHA_1	183	189	PF00498	0.497
LIG_FHA_1	264	270	PF00498	0.329
LIG_FHA_1	372	378	PF00498	0.486
LIG_FHA_1	424	430	PF00498	0.275
LIG_FHA_1	445	451	PF00498	0.326
LIG_FHA_1	563	569	PF00498	0.523
LIG_FHA_1	572	578	PF00498	0.312
LIG_FHA_1	619	625	PF00498	0.513
LIG_FHA_1	693	699	PF00498	0.472
LIG_FHA_1	79	85	PF00498	0.612
LIG_FHA_2	365	371	PF00498	0.495
LIG_FHA_2	498	504	PF00498	0.308
LIG_GBD_Chelix_1	188	196	PF00786	0.255
LIG_LIR_Apic_2	752	756	PF02991	0.442
LIG_LIR_Gen_1	108	118	PF02991	0.567
LIG_LIR_Gen_1	191	201	PF02991	0.312
LIG_LIR_Gen_1	216	226	PF02991	0.312
LIG_LIR_Gen_1	501	512	PF02991	0.301
LIG_LIR_Gen_1	544	552	PF02991	0.460
LIG_LIR_Nem_3	108	114	PF02991	0.573
LIG_LIR_Nem_3	191	196	PF02991	0.312
LIG_LIR_Nem_3	216	222	PF02991	0.312
LIG_LIR_Nem_3	270	276	PF02991	0.275
LIG_LIR_Nem_3	501	507	PF02991	0.301
LIG_LIR_Nem_3	544	549	PF02991	0.460
LIG_LIR_Nem_3	567	573	PF02991	0.557
LIG_MLH1_MIPbox_1	412	416	PF16413	0.312
LIG_MYND_1	875	879	PF01753	0.525
LIG_NRBOX	253	259	PF00104	0.388
LIG_Pex14_1	227	231	PF04695	0.475
LIG_Pex14_1	271	275	PF04695	0.312
LIG_Pex14_2	480	484	PF04695	0.312
LIG_PTB_Apo_2	206	213	PF02174	0.312
LIG_PTB_Apo_2	398	405	PF02174	0.297
LIG_PTB_Phospho_1	398	404	PF10480	0.297
LIG_SH2_CRK	546	550	PF00017	0.460
LIG_SH2_CRK	570	574	PF00017	0.475
LIG_SH2_SRC	312	315	PF00017	0.495
LIG_SH2_STAP1	392	396	PF00017	0.495
LIG_SH2_STAT5	111	114	PF00017	0.566
LIG_SH2_STAT5	223	226	PF00017	0.312
LIG_SH2_STAT5	256	259	PF00017	0.314
LIG_SH2_STAT5	276	279	PF00017	0.286
LIG_SH2_STAT5	288	291	PF00017	0.272
LIG_SH2_STAT5	415	418	PF00017	0.381
LIG_SH2_STAT5	428	431	PF00017	0.275
LIG_SH3_2	775	780	PF14604	0.489
LIG_SH3_2	802	807	PF14604	0.466
LIG_SH3_2	875	880	PF14604	0.528
LIG_SH3_3	219	225	PF00018	0.312
LIG_SH3_3	703	709	PF00018	0.506
LIG_SH3_3	743	749	PF00018	0.576
LIG_SH3_3	753	759	PF00018	0.521
LIG_SH3_3	772	778	PF00018	0.476
LIG_SH3_3	799	805	PF00018	0.454
LIG_SH3_3	81	87	PF00018	0.718
LIG_SH3_3	869	875	PF00018	0.504
LIG_SH3_3	892	898	PF00018	0.519
LIG_SH3_3	921	927	PF00018	0.460
LIG_SUMO_SIM_anti_2	503	509	PF11976	0.340
LIG_SUMO_SIM_anti_2	837	842	PF11976	0.457
LIG_SUMO_SIM_par_1	279	285	PF11976	0.312
LIG_SUMO_SIM_par_1	407	413	PF11976	0.312
LIG_SUMO_SIM_par_1	573	579	PF11976	0.312
LIG_SUMO_SIM_par_1	732	739	PF11976	0.445
LIG_TYR_ITIM	221	226	PF00017	0.312
LIG_TYR_ITIM	568	573	PF00017	0.501
LIG_UBA3_1	116	121	PF00899	0.312
LIG_UBA3_1	463	471	PF00899	0.316
LIG_WRC_WIRS_1	123	128	PF05994	0.312
LIG_WRC_WIRS_1	192	197	PF05994	0.312
LIG_WW_3	877	881	PF00397	0.525
MOD_CK1_1	125	131	PF00069	0.312
MOD_CK1_1	267	273	PF00069	0.329
MOD_CK1_1	296	302	PF00069	0.486
MOD_CK1_1	407	413	PF00069	0.290
MOD_CK1_1	681	687	PF00069	0.498
MOD_CK1_1	717	723	PF00069	0.530
MOD_CK1_1	739	745	PF00069	0.504
MOD_CK1_1	752	758	PF00069	0.512
MOD_CK1_1	809	815	PF00069	0.537
MOD_CK1_1	882	888	PF00069	0.565
MOD_CK1_1	912	918	PF00069	0.550
MOD_CK1_1	93	99	PF00069	0.640
MOD_CK1_1	931	937	PF00069	0.405
MOD_CK2_1	364	370	PF00069	0.495
MOD_CK2_1	691	697	PF00069	0.488
MOD_CK2_1	808	814	PF00069	0.462
MOD_CK2_1	886	892	PF00069	0.539
MOD_GlcNHglycan	127	130	PF01048	0.338
MOD_GlcNHglycan	131	134	PF01048	0.372
MOD_GlcNHglycan	302	305	PF01048	0.396
MOD_GlcNHglycan	323	326	PF01048	0.268
MOD_GlcNHglycan	327	330	PF01048	0.319
MOD_GlcNHglycan	332	335	PF01048	0.346
MOD_GlcNHglycan	341	344	PF01048	0.232
MOD_GlcNHglycan	357	360	PF01048	0.274
MOD_GlcNHglycan	44	47	PF01048	0.549
MOD_GlcNHglycan	52	55	PF01048	0.530
MOD_GlcNHglycan	552	555	PF01048	0.275
MOD_GlcNHglycan	578	581	PF01048	0.255
MOD_GlcNHglycan	598	601	PF01048	0.609
MOD_GlcNHglycan	602	605	PF01048	0.645
MOD_GlcNHglycan	611	614	PF01048	0.614
MOD_GlcNHglycan	638	641	PF01048	0.708
MOD_GlcNHglycan	688	691	PF01048	0.737
MOD_GlcNHglycan	719	722	PF01048	0.811
MOD_GlcNHglycan	72	75	PF01048	0.512
MOD_GlcNHglycan	738	741	PF01048	0.681
MOD_GlcNHglycan	789	793	PF01048	0.698
MOD_GlcNHglycan	84	87	PF01048	0.536
MOD_GlcNHglycan	917	920	PF01048	0.753
MOD_GlcNHglycan	93	96	PF01048	0.452
MOD_GSK3_1	125	132	PF00069	0.347
MOD_GSK3_1	141	148	PF00069	0.268
MOD_GSK3_1	263	270	PF00069	0.329
MOD_GSK3_1	27	34	PF00069	0.714
MOD_GSK3_1	289	296	PF00069	0.340
MOD_GSK3_1	321	328	PF00069	0.490
MOD_GSK3_1	360	367	PF00069	0.485
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	50	57	PF00069	0.603
MOD_GSK3_1	571	578	PF00069	0.475
MOD_GSK3_1	596	603	PF00069	0.458
MOD_GSK3_1	717	724	PF00069	0.542
MOD_GSK3_1	735	742	PF00069	0.532
MOD_GSK3_1	78	85	PF00069	0.611
MOD_GSK3_1	784	791	PF00069	0.535
MOD_GSK3_1	805	812	PF00069	0.649
MOD_GSK3_1	845	852	PF00069	0.538
MOD_GSK3_1	880	887	PF00069	0.602
MOD_GSK3_1	89	96	PF00069	0.646
MOD_GSK3_1	908	915	PF00069	0.542
MOD_GSK3_1	950	957	PF00069	0.521
MOD_LATS_1	80	86	PF00433	0.698
MOD_N-GLC_1	434	439	PF02516	0.529
MOD_N-GLC_1	50	55	PF02516	0.500
MOD_N-GLC_1	550	555	PF02516	0.275
MOD_N-GLC_1	82	87	PF02516	0.576
MOD_N-GLC_1	909	914	PF02516	0.705
MOD_NEK2_1	155	160	PF00069	0.308
MOD_NEK2_1	265	270	PF00069	0.329
MOD_NEK2_1	344	349	PF00069	0.476
MOD_NEK2_1	364	369	PF00069	0.450
MOD_NEK2_1	391	396	PF00069	0.529
MOD_NEK2_1	416	421	PF00069	0.312
MOD_NEK2_1	434	439	PF00069	0.275
MOD_NEK2_1	497	502	PF00069	0.312
MOD_NEK2_1	506	511	PF00069	0.312
MOD_NEK2_1	541	546	PF00069	0.470
MOD_NEK2_1	575	580	PF00069	0.312
MOD_NEK2_1	608	613	PF00069	0.502
MOD_NEK2_1	636	641	PF00069	0.469
MOD_NEK2_1	735	740	PF00069	0.543
MOD_NEK2_1	886	891	PF00069	0.527
MOD_NEK2_1	98	103	PF00069	0.647
MOD_NEK2_2	271	276	PF00069	0.388
MOD_NEK2_2	360	365	PF00069	0.452
MOD_NEK2_2	384	389	PF00069	0.529
MOD_NEK2_2	564	569	PF00069	0.543
MOD_NEK2_2	683	688	PF00069	0.503
MOD_NEK2_2	749	754	PF00069	0.448
MOD_PIKK_1	371	377	PF00454	0.521
MOD_PIKK_1	423	429	PF00454	0.275
MOD_PIKK_1	539	545	PF00454	0.475
MOD_PIKK_1	773	779	PF00454	0.484
MOD_PIKK_1	931	937	PF00454	0.499
MOD_PKA_1	300	306	PF00069	0.495
MOD_PKA_1	714	720	PF00069	0.445
MOD_PKA_2	235	241	PF00069	0.475
MOD_PKA_2	355	361	PF00069	0.481
MOD_PKA_2	364	370	PF00069	0.466
MOD_PKA_2	498	504	PF00069	0.252
MOD_PKA_2	54	60	PF00069	0.688
MOD_PKA_2	70	76	PF00069	0.662
MOD_PKA_2	714	720	PF00069	0.473
MOD_PKA_2	721	727	PF00069	0.475
MOD_PKA_2	736	742	PF00069	0.405
MOD_PKA_2	806	812	PF00069	0.584
MOD_PKA_2	879	885	PF00069	0.550
MOD_PKA_2	950	956	PF00069	0.522
MOD_Plk_1	369	375	PF00069	0.512
MOD_Plk_1	434	440	PF00069	0.275
MOD_Plk_1	845	851	PF00069	0.496
MOD_Plk_1	909	915	PF00069	0.507
MOD_Plk_1	99	105	PF00069	0.635
MOD_Plk_2-3	942	948	PF00069	0.519
MOD_Plk_4	106	112	PF00069	0.664
MOD_Plk_4	155	161	PF00069	0.308
MOD_Plk_4	188	194	PF00069	0.341
MOD_Plk_4	215	221	PF00069	0.312
MOD_Plk_4	235	241	PF00069	0.475
MOD_Plk_4	282	288	PF00069	0.340
MOD_Plk_4	404	410	PF00069	0.312
MOD_Plk_4	44	50	PF00069	0.605
MOD_Plk_4	506	512	PF00069	0.312
MOD_Plk_4	541	547	PF00069	0.460
MOD_ProDKin_1	221	227	PF00069	0.312
MOD_ProDKin_1	678	684	PF00069	0.471
MOD_ProDKin_1	699	705	PF00069	0.480
MOD_ProDKin_1	742	748	PF00069	0.565
MOD_ProDKin_1	752	758	PF00069	0.547
MOD_ProDKin_1	760	766	PF00069	0.461
MOD_ProDKin_1	770	776	PF00069	0.485
MOD_ProDKin_1	922	928	PF00069	0.462
MOD_SUMO_rev_2	175	182	PF00179	0.529
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.444
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.735
TRG_ENDOCYTIC_2	111	114	PF00928	0.572
TRG_ENDOCYTIC_2	197	200	PF00928	0.388
TRG_ENDOCYTIC_2	223	226	PF00928	0.312
TRG_ENDOCYTIC_2	392	395	PF00928	0.529
TRG_ENDOCYTIC_2	546	549	PF00928	0.475
TRG_ENDOCYTIC_2	570	573	PF00928	0.501
TRG_ER_diArg_1	474	476	PF00400	0.495
TRG_ER_diArg_1	713	715	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	888	892	PF00026	0.725
TRG_PTS1	962	965	PF00515	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL7	Leptomonas seymouri	50%	100%
A4HCC5	Leishmania braziliensis	71%	97%
A4HZX7	Leishmania infantum	100%	100%
E9AVT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBP2	Leishmania major	91%	100%