RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7A9_LEIDO

TriTrypDb:

LdBPK_220730.1 , LdCL_220014600 , LDHU3_22.1180

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.636
CLV_C14_Caspase3-7	268	272	PF00656	0.599
CLV_C14_Caspase3-7	43	47	PF00656	0.642
CLV_C14_Caspase3-7	453	457	PF00656	0.689
CLV_NRD_NRD_1	424	426	PF00675	0.479
CLV_NRD_NRD_1	598	600	PF00675	0.428
CLV_NRD_NRD_1	636	638	PF00675	0.591
CLV_NRD_NRD_1	697	699	PF00675	0.589
CLV_NRD_NRD_1	707	709	PF00675	0.399
CLV_NRD_NRD_1	866	868	PF00675	0.476
CLV_NRD_NRD_1	875	877	PF00675	0.381
CLV_NRD_NRD_1	921	923	PF00675	0.614
CLV_PCSK_FUR_1	491	495	PF00082	0.526
CLV_PCSK_KEX2_1	306	308	PF00082	0.475
CLV_PCSK_KEX2_1	424	426	PF00082	0.479
CLV_PCSK_KEX2_1	493	495	PF00082	0.535
CLV_PCSK_KEX2_1	598	600	PF00082	0.428
CLV_PCSK_KEX2_1	636	638	PF00082	0.591
CLV_PCSK_KEX2_1	696	698	PF00082	0.464
CLV_PCSK_KEX2_1	707	709	PF00082	0.447
CLV_PCSK_KEX2_1	877	879	PF00082	0.349
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.475
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.535
CLV_PCSK_PC1ET2_1	877	879	PF00082	0.349
CLV_PCSK_SKI1_1	235	239	PF00082	0.542
CLV_PCSK_SKI1_1	282	286	PF00082	0.425
CLV_PCSK_SKI1_1	676	680	PF00082	0.504
DEG_APCC_DBOX_1	675	683	PF00400	0.411
DEG_SPOP_SBC_1	90	94	PF00917	0.657
DOC_CKS1_1	549	554	PF01111	0.458
DOC_CKS1_1	727	732	PF01111	0.450
DOC_CYCLIN_RxL_1	300	313	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.467
DOC_MAPK_DCC_7	412	421	PF00069	0.519
DOC_MAPK_gen_1	306	316	PF00069	0.495
DOC_MAPK_gen_1	407	415	PF00069	0.523
DOC_MAPK_gen_1	491	501	PF00069	0.533
DOC_MAPK_gen_1	527	537	PF00069	0.617
DOC_MAPK_JIP1_4	409	415	PF00069	0.526
DOC_MAPK_MEF2A_6	235	244	PF00069	0.521
DOC_MAPK_MEF2A_6	412	421	PF00069	0.525
DOC_MAPK_MEF2A_6	581	588	PF00069	0.388
DOC_MAPK_MEF2A_6	828	835	PF00069	0.357
DOC_MAPK_NFAT4_5	828	836	PF00069	0.357
DOC_PP1_RVXF_1	304	311	PF00149	0.486
DOC_PP1_RVXF_1	832	838	PF00149	0.384
DOC_PP1_RVXF_1	875	882	PF00149	0.341
DOC_PP2B_LxvP_1	240	243	PF13499	0.552
DOC_PP2B_LxvP_1	413	416	PF13499	0.534
DOC_PP2B_LxvP_1	444	447	PF13499	0.444
DOC_USP7_MATH_1	184	188	PF00917	0.689
DOC_USP7_MATH_1	260	264	PF00917	0.626
DOC_USP7_MATH_1	325	329	PF00917	0.595
DOC_USP7_MATH_1	382	386	PF00917	0.563
DOC_USP7_MATH_1	758	762	PF00917	0.650
DOC_USP7_MATH_1	803	807	PF00917	0.628
DOC_USP7_MATH_1	90	94	PF00917	0.657
DOC_WW_Pin1_4	104	109	PF00397	0.639
DOC_WW_Pin1_4	127	132	PF00397	0.705
DOC_WW_Pin1_4	512	517	PF00397	0.560
DOC_WW_Pin1_4	548	553	PF00397	0.458
DOC_WW_Pin1_4	668	673	PF00397	0.548
DOC_WW_Pin1_4	726	731	PF00397	0.465
DOC_WW_Pin1_4	759	764	PF00397	0.532
DOC_WW_Pin1_4	770	775	PF00397	0.571
DOC_WW_Pin1_4	786	791	PF00397	0.619
DOC_WW_Pin1_4	793	798	PF00397	0.710
DOC_WW_Pin1_4	808	813	PF00397	0.528
LIG_14-3-3_CanoR_1	133	138	PF00244	0.579
LIG_14-3-3_CanoR_1	239	243	PF00244	0.479
LIG_14-3-3_CanoR_1	425	431	PF00244	0.493
LIG_14-3-3_CanoR_1	530	536	PF00244	0.532
LIG_14-3-3_CanoR_1	539	549	PF00244	0.474
LIG_14-3-3_CanoR_1	569	577	PF00244	0.410
LIG_14-3-3_CanoR_1	708	714	PF00244	0.429
LIG_14-3-3_CanoR_1	744	753	PF00244	0.465
LIG_14-3-3_CanoR_1	788	798	PF00244	0.557
LIG_14-3-3_CanoR_1	834	840	PF00244	0.477
LIG_14-3-3_CanoR_1	89	98	PF00244	0.667
LIG_14-3-3_CanoR_1	922	930	PF00244	0.626
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_CaM_IQ_9	585	601	PF13499	0.402
LIG_deltaCOP1_diTrp_1	346	354	PF00928	0.550
LIG_Dynein_DLC8_1	528	534	PF01221	0.531
LIG_EH1_1	468	476	PF00400	0.482
LIG_FHA_1	222	228	PF00498	0.488
LIG_FHA_1	239	245	PF00498	0.481
LIG_FHA_1	311	317	PF00498	0.619
LIG_FHA_1	518	524	PF00498	0.735
LIG_FHA_1	530	536	PF00498	0.515
LIG_FHA_1	549	555	PF00498	0.385
LIG_FHA_1	722	728	PF00498	0.496
LIG_FHA_1	799	805	PF00498	0.650
LIG_FHA_1	847	853	PF00498	0.416
LIG_FHA_2	155	161	PF00498	0.640
LIG_FHA_2	373	379	PF00498	0.557
LIG_FHA_2	541	547	PF00498	0.486
LIG_FHA_2	571	577	PF00498	0.518
LIG_FHA_2	681	687	PF00498	0.420
LIG_FHA_2	701	707	PF00498	0.348
LIG_FHA_2	836	842	PF00498	0.388
LIG_FHA_2	900	906	PF00498	0.573
LIG_LIR_Gen_1	107	116	PF02991	0.642
LIG_LIR_Gen_1	429	437	PF02991	0.476
LIG_LIR_Gen_1	563	572	PF02991	0.456
LIG_LIR_Gen_1	645	654	PF02991	0.413
LIG_LIR_Gen_1	67	74	PF02991	0.567
LIG_LIR_Gen_1	740	747	PF02991	0.396
LIG_LIR_Nem_3	107	113	PF02991	0.624
LIG_LIR_Nem_3	283	288	PF02991	0.482
LIG_LIR_Nem_3	511	517	PF02991	0.523
LIG_LIR_Nem_3	563	567	PF02991	0.489
LIG_LIR_Nem_3	645	649	PF02991	0.414
LIG_LIR_Nem_3	67	71	PF02991	0.576
LIG_LIR_Nem_3	740	745	PF02991	0.390
LIG_LIR_Nem_3	889	895	PF02991	0.437
LIG_MYND_1	668	672	PF01753	0.530
LIG_NRBOX	828	834	PF00104	0.362
LIG_RPA_C_Fungi	136	148	PF08784	0.583
LIG_RPA_C_Fungi	899	911	PF08784	0.473
LIG_SH2_CRK	68	72	PF00017	0.641
LIG_SH2_CRK	892	896	PF00017	0.467
LIG_SH2_NCK_1	110	114	PF00017	0.625
LIG_SH2_NCK_1	892	896	PF00017	0.467
LIG_SH2_SRC	104	107	PF00017	0.642
LIG_SH2_SRC	110	113	PF00017	0.608
LIG_SH2_STAP1	430	434	PF00017	0.475
LIG_SH2_STAT5	401	404	PF00017	0.496
LIG_SH2_STAT5	486	489	PF00017	0.559
LIG_SH2_STAT5	571	574	PF00017	0.434
LIG_SH3_1	205	211	PF00018	0.662
LIG_SH3_2	208	213	PF14604	0.629
LIG_SH3_2	479	484	PF14604	0.526
LIG_SH3_3	205	211	PF00018	0.665
LIG_SH3_3	215	221	PF00018	0.552
LIG_SH3_3	241	247	PF00018	0.488
LIG_SH3_3	476	482	PF00018	0.516
LIG_SH3_3	50	56	PF00018	0.713
LIG_SH3_3	546	552	PF00018	0.459
LIG_SH3_3	564	570	PF00018	0.435
LIG_SH3_3	724	730	PF00018	0.509
LIG_SH3_3	784	790	PF00018	0.663
LIG_SH3_3	9	15	PF00018	0.641
LIG_SH3_CIN85_PxpxPR_1	208	213	PF14604	0.629
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.583
LIG_SUMO_SIM_par_1	223	228	PF11976	0.508
LIG_SUMO_SIM_par_1	277	283	PF11976	0.476
LIG_SUMO_SIM_par_1	678	686	PF11976	0.401
LIG_TRAF2_1	21	24	PF00917	0.587
LIG_TRAF2_1	356	359	PF00917	0.533
LIG_TRAF2_1	703	706	PF00917	0.471
LIG_TRAF2_1	73	76	PF00917	0.657
LIG_UBA3_1	587	596	PF00899	0.475
LIG_WW_3	210	214	PF00397	0.630
LIG_WW_3	54	58	PF00397	0.712
MOD_CDC14_SPxK_1	130	133	PF00782	0.703
MOD_CDC14_SPxK_1	762	765	PF00782	0.521
MOD_CDK_SPK_2	548	553	PF00069	0.458
MOD_CDK_SPxK_1	127	133	PF00069	0.706
MOD_CDK_SPxK_1	759	765	PF00069	0.512
MOD_CK1_1	143	149	PF00069	0.692
MOD_CK1_1	17	23	PF00069	0.816
MOD_CK1_1	187	193	PF00069	0.683
MOD_CK1_1	526	532	PF00069	0.512
MOD_CK1_1	540	546	PF00069	0.517
MOD_CK1_1	759	765	PF00069	0.660
MOD_CK1_1	772	778	PF00069	0.547
MOD_CK1_1	789	795	PF00069	0.557
MOD_CK1_1	843	849	PF00069	0.552
MOD_CK1_1	871	877	PF00069	0.478
MOD_CK2_1	1	7	PF00069	0.667
MOD_CK2_1	133	139	PF00069	0.633
MOD_CK2_1	17	23	PF00069	0.619
MOD_CK2_1	372	378	PF00069	0.565
MOD_CK2_1	426	432	PF00069	0.545
MOD_CK2_1	540	546	PF00069	0.490
MOD_CK2_1	570	576	PF00069	0.485
MOD_CK2_1	668	674	PF00069	0.580
MOD_CK2_1	680	686	PF00069	0.307
MOD_CK2_1	700	706	PF00069	0.332
MOD_CK2_1	835	841	PF00069	0.391
MOD_Cter_Amidation	422	425	PF01082	0.452
MOD_Cter_Amidation	865	868	PF01082	0.473
MOD_GlcNHglycan	117	122	PF01048	0.740
MOD_GlcNHglycan	127	130	PF01048	0.598
MOD_GlcNHglycan	142	145	PF01048	0.538
MOD_GlcNHglycan	179	182	PF01048	0.665
MOD_GlcNHglycan	197	200	PF01048	0.601
MOD_GlcNHglycan	262	265	PF01048	0.692
MOD_GlcNHglycan	267	270	PF01048	0.532
MOD_GlcNHglycan	3	6	PF01048	0.705
MOD_GlcNHglycan	321	324	PF01048	0.675
MOD_GlcNHglycan	327	330	PF01048	0.681
MOD_GlcNHglycan	41	45	PF01048	0.723
MOD_GlcNHglycan	452	455	PF01048	0.698
MOD_GlcNHglycan	46	49	PF01048	0.668
MOD_GlcNHglycan	641	644	PF01048	0.448
MOD_GlcNHglycan	749	752	PF01048	0.487
MOD_GlcNHglycan	758	761	PF01048	0.634
MOD_GlcNHglycan	791	794	PF01048	0.612
MOD_GlcNHglycan	805	808	PF01048	0.670
MOD_GlcNHglycan	822	825	PF01048	0.452
MOD_GlcNHglycan	841	845	PF01048	0.402
MOD_GSK3_1	14	21	PF00069	0.631
MOD_GSK3_1	143	150	PF00069	0.785
MOD_GSK3_1	221	228	PF00069	0.490
MOD_GSK3_1	250	257	PF00069	0.613
MOD_GSK3_1	40	47	PF00069	0.652
MOD_GSK3_1	446	453	PF00069	0.597
MOD_GSK3_1	517	524	PF00069	0.646
MOD_GSK3_1	531	538	PF00069	0.464
MOD_GSK3_1	770	777	PF00069	0.616
MOD_GSK3_1	789	796	PF00069	0.652
MOD_GSK3_1	842	849	PF00069	0.509
MOD_N-GLC_1	195	200	PF02516	0.700
MOD_N-GLC_1	265	270	PF02516	0.556
MOD_NEK2_1	265	270	PF00069	0.647
MOD_NEK2_1	310	315	PF00069	0.589
MOD_NEK2_1	517	522	PF00069	0.515
MOD_NEK2_1	523	528	PF00069	0.561
MOD_NEK2_1	535	540	PF00069	0.535
MOD_NEK2_1	709	714	PF00069	0.558
MOD_NEK2_1	745	750	PF00069	0.412
MOD_NEK2_1	842	847	PF00069	0.491
MOD_NEK2_1	899	904	PF00069	0.505
MOD_NEK2_2	91	96	PF00069	0.664
MOD_PIKK_1	151	157	PF00454	0.655
MOD_PIKK_1	187	193	PF00454	0.683
MOD_PIKK_1	502	508	PF00454	0.517
MOD_PIKK_1	529	535	PF00454	0.540
MOD_PIKK_1	729	735	PF00454	0.423
MOD_PIKK_1	846	852	PF00454	0.478
MOD_PIKK_1	912	918	PF00454	0.490
MOD_PK_1	133	139	PF00069	0.636
MOD_PKA_2	140	146	PF00069	0.608
MOD_PKA_2	187	193	PF00069	0.623
MOD_PKA_2	238	244	PF00069	0.475
MOD_PKA_2	250	256	PF00069	0.586
MOD_PKA_2	44	50	PF00069	0.645
MOD_PKA_2	526	532	PF00069	0.532
MOD_PKB_1	87	95	PF00069	0.704
MOD_Plk_1	17	23	PF00069	0.595
MOD_Plk_1	225	231	PF00069	0.559
MOD_Plk_1	868	874	PF00069	0.439
MOD_Plk_2-3	18	24	PF00069	0.627
MOD_Plk_4	227	233	PF00069	0.517
MOD_Plk_4	245	251	PF00069	0.534
MOD_Plk_4	310	316	PF00069	0.608
MOD_Plk_4	382	388	PF00069	0.614
MOD_Plk_4	810	816	PF00069	0.485
MOD_Plk_4	843	849	PF00069	0.474
MOD_ProDKin_1	104	110	PF00069	0.641
MOD_ProDKin_1	127	133	PF00069	0.706
MOD_ProDKin_1	512	518	PF00069	0.557
MOD_ProDKin_1	548	554	PF00069	0.460
MOD_ProDKin_1	668	674	PF00069	0.546
MOD_ProDKin_1	726	732	PF00069	0.455
MOD_ProDKin_1	759	765	PF00069	0.536
MOD_ProDKin_1	770	776	PF00069	0.567
MOD_ProDKin_1	786	792	PF00069	0.617
MOD_ProDKin_1	793	799	PF00069	0.709
MOD_ProDKin_1	808	814	PF00069	0.528
MOD_SUMO_rev_2	248	258	PF00179	0.581
MOD_SUMO_rev_2	62	66	PF00179	0.577
MOD_SUMO_rev_2	684	690	PF00179	0.352
TRG_DiLeu_BaEn_1	851	856	PF01217	0.384
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.584
TRG_ENDOCYTIC_2	110	113	PF00928	0.650
TRG_ENDOCYTIC_2	430	433	PF00928	0.481
TRG_ENDOCYTIC_2	514	517	PF00928	0.515
TRG_ENDOCYTIC_2	68	71	PF00928	0.707
TRG_ENDOCYTIC_2	742	745	PF00928	0.389
TRG_ENDOCYTIC_2	892	895	PF00928	0.465
TRG_ER_diArg_1	307	310	PF00400	0.452
TRG_ER_diArg_1	406	409	PF00400	0.473
TRG_ER_diArg_1	598	601	PF00400	0.427
TRG_ER_diArg_1	635	637	PF00400	0.607
TRG_ER_diArg_1	696	698	PF00400	0.464
TRG_ER_diArg_1	707	709	PF00400	0.399
TRG_ER_diArg_1	86	89	PF00400	0.617
TRG_ER_diArg_1	875	878	PF00400	0.386
TRG_ER_diArg_1	906	909	PF00400	0.494
TRG_NES_CRM1_1	283	297	PF08389	0.452
TRG_NES_CRM1_1	576	589	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI1	Leptomonas seymouri	50%	99%
A4HCD9	Leishmania braziliensis	71%	97%
A4HZW4	Leishmania infantum	99%	100%
E9AVS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QBQ7	Leishmania major	90%	100%