Translation initiation factor SUI1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7A8_LEIDO

TriTrypDb:

LdBPK_220610.1 , LdCL_220013400 , LDHU3_22.1040

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H7A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A8

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.514
CLV_NRD_NRD_1	152	154	PF00675	0.525
CLV_NRD_NRD_1	472	474	PF00675	0.390
CLV_NRD_NRD_1	50	52	PF00675	0.504
CLV_PCSK_KEX2_1	291	293	PF00082	0.332
CLV_PCSK_KEX2_1	50	52	PF00082	0.512
CLV_PCSK_KEX2_1	560	562	PF00082	0.447
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.332
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.386
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.464
CLV_PCSK_SKI1_1	136	140	PF00082	0.399
CLV_PCSK_SKI1_1	211	215	PF00082	0.519
CLV_PCSK_SKI1_1	331	335	PF00082	0.397
CLV_PCSK_SKI1_1	427	431	PF00082	0.476
CLV_PCSK_SKI1_1	439	443	PF00082	0.620
CLV_PCSK_SKI1_1	561	565	PF00082	0.512
CLV_PCSK_SKI1_1	582	586	PF00082	0.242
CLV_PCSK_SKI1_1	622	626	PF00082	0.274
DEG_APCC_DBOX_1	234	242	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DOC_CKS1_1	458	463	PF01111	0.415
DOC_CYCLIN_RxL_1	424	433	PF00134	0.500
DOC_MAPK_DCC_7	497	505	PF00069	0.479
DOC_MAPK_DCC_7	564	573	PF00069	0.295
DOC_MAPK_gen_1	153	160	PF00069	0.430
DOC_MAPK_gen_1	20	29	PF00069	0.427
DOC_MAPK_gen_1	326	336	PF00069	0.455
DOC_MAPK_gen_1	497	505	PF00069	0.474
DOC_MAPK_gen_1	536	543	PF00069	0.410
DOC_MAPK_gen_1	622	632	PF00069	0.484
DOC_MAPK_MEF2A_6	187	196	PF00069	0.435
DOC_MAPK_MEF2A_6	367	376	PF00069	0.327
DOC_MAPK_MEF2A_6	497	505	PF00069	0.455
DOC_MAPK_MEF2A_6	516	524	PF00069	0.426
DOC_MAPK_MEF2A_6	564	573	PF00069	0.295
DOC_MAPK_MEF2A_6	625	634	PF00069	0.436
DOC_MAPK_RevD_3	38	52	PF00069	0.393
DOC_PP1_RVXF_1	330	337	PF00149	0.544
DOC_PP2B_LxvP_1	144	147	PF13499	0.362
DOC_PP2B_LxvP_1	298	301	PF13499	0.375
DOC_PP2B_LxvP_1	435	438	PF13499	0.560
DOC_PP2B_LxvP_1	95	98	PF13499	0.393
DOC_USP7_MATH_1	318	322	PF00917	0.530
DOC_USP7_MATH_1	57	61	PF00917	0.454
DOC_USP7_UBL2_3	16	20	PF12436	0.354
DOC_USP7_UBL2_3	246	250	PF12436	0.538
DOC_USP7_UBL2_3	481	485	PF12436	0.522
DOC_USP7_UBL2_3	5	9	PF12436	0.448
DOC_USP7_UBL2_3	560	564	PF12436	0.498
DOC_USP7_UBL2_3	625	629	PF12436	0.462
DOC_WW_Pin1_4	153	158	PF00397	0.476
DOC_WW_Pin1_4	263	268	PF00397	0.718
DOC_WW_Pin1_4	291	296	PF00397	0.522
DOC_WW_Pin1_4	347	352	PF00397	0.581
DOC_WW_Pin1_4	457	462	PF00397	0.575
LIG_14-3-3_CanoR_1	131	139	PF00244	0.345
LIG_14-3-3_CanoR_1	473	477	PF00244	0.427
LIG_BRCT_BRCA1_1	58	62	PF00533	0.481
LIG_BRCT_BRCA1_1	591	595	PF00533	0.542
LIG_BRCT_BRCA1_1	90	94	PF00533	0.448
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.357
LIG_deltaCOP1_diTrp_1	602	608	PF00928	0.529
LIG_eIF4E_1	471	477	PF01652	0.502
LIG_FHA_1	154	160	PF00498	0.452
LIG_FHA_1	264	270	PF00498	0.683
LIG_FHA_1	304	310	PF00498	0.515
LIG_FHA_1	318	324	PF00498	0.494
LIG_FHA_1	351	357	PF00498	0.573
LIG_FHA_1	449	455	PF00498	0.535
LIG_FHA_2	249	255	PF00498	0.775
LIG_FHA_2	343	349	PF00498	0.406
LIG_FHA_2	5	11	PF00498	0.567
LIG_FHA_2	543	549	PF00498	0.528
LIG_FHA_2	85	91	PF00498	0.544
LIG_Integrin_RGD_1	113	115	PF01839	0.354
LIG_LIR_Apic_2	412	418	PF02991	0.426
LIG_LIR_Gen_1	115	125	PF02991	0.532
LIG_LIR_Gen_1	202	213	PF02991	0.422
LIG_LIR_Gen_1	270	275	PF02991	0.528
LIG_LIR_Gen_1	303	313	PF02991	0.410
LIG_LIR_Gen_1	36	42	PF02991	0.440
LIG_LIR_Gen_1	90	100	PF02991	0.432
LIG_LIR_LC3C_4	156	160	PF02991	0.320
LIG_LIR_LC3C_4	39	42	PF02991	0.442
LIG_LIR_Nem_3	115	120	PF02991	0.491
LIG_LIR_Nem_3	202	208	PF02991	0.379
LIG_LIR_Nem_3	270	274	PF02991	0.547
LIG_LIR_Nem_3	303	308	PF02991	0.422
LIG_LIR_Nem_3	36	41	PF02991	0.442
LIG_LIR_Nem_3	401	407	PF02991	0.407
LIG_LIR_Nem_3	440	446	PF02991	0.595
LIG_LIR_Nem_3	90	95	PF02991	0.435
LIG_LIR_Nem_3	99	104	PF02991	0.264
LIG_MYND_1	222	226	PF01753	0.291
LIG_MYND_1	295	299	PF01753	0.421
LIG_NRBOX	105	111	PF00104	0.489
LIG_NRP_CendR_1	662	664	PF00754	0.502
LIG_OCRL_FandH_1	102	114	PF00620	0.481
LIG_Pex14_1	604	608	PF04695	0.441
LIG_Pex14_2	208	212	PF04695	0.499
LIG_Pex14_2	336	340	PF04695	0.491
LIG_REV1ctd_RIR_1	99	109	PF16727	0.448
LIG_SH2_CRK	271	275	PF00017	0.487
LIG_SH2_CRK	415	419	PF00017	0.493
LIG_SH2_GRB2like	271	274	PF00017	0.382
LIG_SH2_NCK_1	271	275	PF00017	0.508
LIG_SH2_SRC	271	274	PF00017	0.473
LIG_SH2_STAP1	271	275	PF00017	0.564
LIG_SH2_STAT5	373	376	PF00017	0.318
LIG_SH2_STAT5	407	410	PF00017	0.456
LIG_SH2_STAT5	471	474	PF00017	0.449
LIG_SH2_STAT5	483	486	PF00017	0.358
LIG_SH3_3	168	174	PF00018	0.466
LIG_SH3_3	220	226	PF00018	0.423
LIG_SH3_3	452	458	PF00018	0.616
LIG_SH3_3	517	523	PF00018	0.424
LIG_SH3_3	611	617	PF00018	0.484
LIG_SH3_5	267	271	PF00018	0.580
LIG_Sin3_3	645	652	PF02671	0.456
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.390
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.481
LIG_SUMO_SIM_par_1	156	162	PF11976	0.501
LIG_SUMO_SIM_par_1	236	243	PF11976	0.574
LIG_SUMO_SIM_par_1	342	350	PF11976	0.427
LIG_SUMO_SIM_par_1	427	433	PF11976	0.507
LIG_SUMO_SIM_par_1	488	494	PF11976	0.492
LIG_TYR_ITIM	269	274	PF00017	0.539
LIG_UBA3_1	145	154	PF00899	0.399
LIG_UBA3_1	531	538	PF00899	0.490
LIG_WRC_WIRS_1	590	595	PF05994	0.534
MOD_CK1_1	182	188	PF00069	0.500
MOD_CK1_1	217	223	PF00069	0.502
MOD_CK1_1	350	356	PF00069	0.485
MOD_CK1_1	575	581	PF00069	0.581
MOD_CK1_1	589	595	PF00069	0.530
MOD_CK1_1	8	14	PF00069	0.370
MOD_CK2_1	248	254	PF00069	0.731
MOD_CK2_1	342	348	PF00069	0.411
MOD_CK2_1	4	10	PF00069	0.524
MOD_CK2_1	542	548	PF00069	0.505
MOD_CK2_1	62	68	PF00069	0.486
MOD_Cter_Amidation	42	45	PF01082	0.438
MOD_GlcNHglycan	242	245	PF01048	0.607
MOD_GlcNHglycan	320	323	PF01048	0.522
MOD_GlcNHglycan	361	364	PF01048	0.549
MOD_GlcNHglycan	409	412	PF01048	0.479
MOD_GlcNHglycan	611	614	PF01048	0.352
MOD_GlcNHglycan	625	628	PF01048	0.240
MOD_GSK3_1	149	156	PF00069	0.477
MOD_GSK3_1	178	185	PF00069	0.454
MOD_GSK3_1	273	280	PF00069	0.525
MOD_GSK3_1	300	307	PF00069	0.498
MOD_GSK3_1	342	349	PF00069	0.439
MOD_GSK3_1	350	357	PF00069	0.489
MOD_GSK3_1	4	11	PF00069	0.550
MOD_GSK3_1	507	514	PF00069	0.457
MOD_GSK3_1	572	579	PF00069	0.527
MOD_GSK3_1	582	589	PF00069	0.508
MOD_GSK3_1	84	91	PF00069	0.494
MOD_N-GLC_1	182	187	PF02516	0.474
MOD_N-GLC_1	214	219	PF02516	0.501
MOD_N-GLC_1	359	364	PF02516	0.420
MOD_N-GLC_2	283	285	PF02516	0.369
MOD_NEK2_1	165	170	PF00069	0.336
MOD_NEK2_1	325	330	PF00069	0.402
MOD_NEK2_1	376	381	PF00069	0.493
MOD_NEK2_1	511	516	PF00069	0.579
MOD_NEK2_1	608	613	PF00069	0.480
MOD_NEK2_1	62	67	PF00069	0.299
MOD_NEK2_2	530	535	PF00069	0.311
MOD_NEK2_2	57	62	PF00069	0.429
MOD_PIKK_1	217	223	PF00454	0.468
MOD_PIKK_1	300	306	PF00454	0.499
MOD_PIKK_1	354	360	PF00454	0.422
MOD_PIKK_1	654	660	PF00454	0.549
MOD_PIKK_1	8	14	PF00454	0.370
MOD_PIKK_1	84	90	PF00454	0.463
MOD_PK_1	499	505	PF00069	0.570
MOD_PKA_1	4	10	PF00069	0.458
MOD_PKA_1	44	50	PF00069	0.447
MOD_PKA_2	130	136	PF00069	0.281
MOD_PKA_2	472	478	PF00069	0.492
MOD_Plk_1	214	220	PF00069	0.508
MOD_Plk_1	277	283	PF00069	0.495
MOD_Plk_1	505	511	PF00069	0.455
MOD_Plk_2-3	342	348	PF00069	0.400
MOD_Plk_4	116	122	PF00069	0.453
MOD_Plk_4	25	31	PF00069	0.482
MOD_Plk_4	277	283	PF00069	0.461
MOD_Plk_4	293	299	PF00069	0.365
MOD_Plk_4	304	310	PF00069	0.459
MOD_Plk_4	462	468	PF00069	0.584
MOD_Plk_4	472	478	PF00069	0.428
MOD_Plk_4	507	513	PF00069	0.413
MOD_Plk_4	530	536	PF00069	0.528
MOD_Plk_4	542	548	PF00069	0.383
MOD_Plk_4	57	63	PF00069	0.367
MOD_Plk_4	96	102	PF00069	0.294
MOD_ProDKin_1	153	159	PF00069	0.475
MOD_ProDKin_1	263	269	PF00069	0.707
MOD_ProDKin_1	291	297	PF00069	0.526
MOD_ProDKin_1	347	353	PF00069	0.579
MOD_ProDKin_1	457	463	PF00069	0.569
MOD_SUMO_for_1	537	540	PF00179	0.352
MOD_SUMO_rev_2	256	266	PF00179	0.761
TRG_DiLeu_BaEn_1	116	121	PF01217	0.423
TRG_DiLeu_BaEn_2	67	73	PF01217	0.484
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.433
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.295
TRG_ENDOCYTIC_2	271	274	PF00928	0.581
TRG_ENDOCYTIC_2	373	376	PF00928	0.375
TRG_NES_CRM1_1	588	602	PF08389	0.456
TRG_NLS_Bipartite_1	3	24	PF00514	0.499
TRG_NLS_MonoExtC_3	152	157	PF00514	0.480
TRG_NLS_MonoExtC_3	19	25	PF00514	0.438
TRG_NLS_MonoExtC_3	49	54	PF00514	0.306
TRG_NLS_MonoExtN_4	50	55	PF00514	0.305
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I577	Leptomonas seymouri	57%	95%
A0A0S4INV2	Bodo saltans	25%	75%
A0A1X0NTA4	Trypanosomatidae	32%	100%
A0A422N4G3	Trypanosoma rangeli	33%	100%
A4HCD6	Leishmania braziliensis	76%	100%
A4HZV3	Leishmania infantum	99%	100%
C9ZSH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBR8	Leishmania major	88%	100%
V5BLJ1	Trypanosoma cruzi	34%	92%