Centromere/microtubule binding protein cbf5, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centromere/microtubule binding protein cbf5, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7A3_LEIDO

TriTrypDb:

LdBPK_212130.1 , LdCL_210027000 , LDHU3_21.2540

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0031429	box H/ACA snoRNP complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0072588	box H/ACA RNP complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A3

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000495	box H/ACA RNA 3'-end processing	10	1
GO:0006364	rRNA processing	8	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016556	mRNA modification	6	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0031120	snRNA pseudouridine synthesis	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0033979	box H/ACA RNA metabolic process	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034964	box H/ACA RNA processing	9	1
GO:0040031	snRNA modification	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:1990481	mRNA pseudouridine synthesis	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.359
CLV_NRD_NRD_1	227	229	PF00675	0.359
CLV_NRD_NRD_1	263	265	PF00675	0.359
CLV_NRD_NRD_1	358	360	PF00675	0.500
CLV_NRD_NRD_1	61	63	PF00675	0.361
CLV_PCSK_FUR_1	345	349	PF00082	0.320
CLV_PCSK_KEX2_1	171	173	PF00082	0.468
CLV_PCSK_KEX2_1	227	229	PF00082	0.359
CLV_PCSK_KEX2_1	263	265	PF00082	0.359
CLV_PCSK_KEX2_1	277	279	PF00082	0.320
CLV_PCSK_KEX2_1	347	349	PF00082	0.320
CLV_PCSK_KEX2_1	358	360	PF00082	0.500
CLV_PCSK_KEX2_1	369	371	PF00082	0.483
CLV_PCSK_KEX2_1	420	422	PF00082	0.691
CLV_PCSK_KEX2_1	61	63	PF00082	0.363
CLV_PCSK_KEX2_1	91	93	PF00082	0.320
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.468
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.331
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.320
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.499
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.691
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.320
CLV_PCSK_SKI1_1	122	126	PF00082	0.329
CLV_PCSK_SKI1_1	264	268	PF00082	0.359
CLV_PCSK_SKI1_1	91	95	PF00082	0.320
DEG_APCC_DBOX_1	358	366	PF00400	0.515
DOC_MAPK_DCC_7	358	367	PF00069	0.514
DOC_MAPK_MEF2A_6	207	215	PF00069	0.359
DOC_MAPK_MEF2A_6	309	316	PF00069	0.520
DOC_PP2B_LxvP_1	295	298	PF13499	0.520
DOC_PP4_FxxP_1	15	18	PF00568	0.452
DOC_PP4_FxxP_1	161	164	PF00568	0.429
DOC_USP7_UBL2_3	38	42	PF12436	0.453
DOC_USP7_UBL2_3	91	95	PF12436	0.520
DOC_WW_Pin1_4	385	390	PF00397	0.512
DOC_WW_Pin1_4	55	60	PF00397	0.359
LIG_14-3-3_CanoR_1	46	53	PF00244	0.378
LIG_BRCT_BRCA1_1	11	15	PF00533	0.544
LIG_BRCT_BRCA1_1	46	50	PF00533	0.359
LIG_EVH1_2	389	393	PF00568	0.463
LIG_FHA_1	108	114	PF00498	0.520
LIG_FHA_1	119	125	PF00498	0.520
LIG_FHA_1	206	212	PF00498	0.363
LIG_FHA_1	229	235	PF00498	0.359
LIG_FHA_2	196	202	PF00498	0.399
LIG_FHA_2	233	239	PF00498	0.389
LIG_FHA_2	240	246	PF00498	0.330
LIG_FHA_2	316	322	PF00498	0.520
LIG_FHA_2	386	392	PF00498	0.512
LIG_FHA_2	400	406	PF00498	0.548
LIG_FHA_2	49	55	PF00498	0.446
LIG_GBD_Chelix_1	64	72	PF00786	0.484
LIG_GBD_Chelix_1	86	94	PF00786	0.359
LIG_KLC1_Yacidic_2	391	396	PF13176	0.543
LIG_LIR_Apic_2	12	18	PF02991	0.473
LIG_LIR_Apic_2	379	384	PF02991	0.524
LIG_LIR_Gen_1	47	54	PF02991	0.359
LIG_LIR_Nem_3	133	137	PF02991	0.520
LIG_LIR_Nem_3	31	36	PF02991	0.372
LIG_LIR_Nem_3	391	397	PF02991	0.556
LIG_LIR_Nem_3	47	53	PF02991	0.320
LIG_LIR_Nem_3	54	60	PF02991	0.359
LIG_LIR_Nem_3	66	70	PF02991	0.436
LIG_SH2_CRK	381	385	PF00017	0.519
LIG_SH2_CRK	397	401	PF00017	0.582
LIG_SH2_CRK	70	74	PF00017	0.371
LIG_SH2_GRB2like	180	183	PF00017	0.433
LIG_SH2_GRB2like	253	256	PF00017	0.375
LIG_SH2_PTP2	134	137	PF00017	0.520
LIG_SH2_STAP1	180	184	PF00017	0.456
LIG_SH2_STAT3	180	183	PF00017	0.468
LIG_SH2_STAT5	134	137	PF00017	0.520
LIG_SH2_STAT5	205	208	PF00017	0.393
LIG_SH2_STAT5	261	264	PF00017	0.367
LIG_SH2_STAT5	271	274	PF00017	0.375
LIG_SH2_STAT5	394	397	PF00017	0.581
LIG_SH2_STAT5	67	70	PF00017	0.359
LIG_SH3_3	262	268	PF00018	0.369
LIG_SH3_3	75	81	PF00018	0.380
LIG_SUMO_SIM_anti_2	310	318	PF11976	0.520
LIG_SUMO_SIM_par_1	310	318	PF11976	0.520
LIG_TRAF2_1	29	32	PF00917	0.604
LIG_TYR_ITIM	395	400	PF00017	0.596
LIG_TYR_ITIM	68	73	PF00017	0.359
LIG_UBA3_1	72	77	PF00899	0.359
MOD_CDC14_SPxK_1	58	61	PF00782	0.359
MOD_CDK_SPxK_1	55	61	PF00069	0.359
MOD_CDK_SPxxK_3	55	62	PF00069	0.359
MOD_CK1_1	414	420	PF00069	0.780
MOD_CK1_1	79	85	PF00069	0.375
MOD_CK2_1	195	201	PF00069	0.414
MOD_CK2_1	315	321	PF00069	0.527
MOD_CK2_1	399	405	PF00069	0.548
MOD_CK2_1	48	54	PF00069	0.453
MOD_CK2_1	79	85	PF00069	0.359
MOD_Cter_Amidation	1	4	PF01082	0.756
MOD_GlcNHglycan	25	28	PF01048	0.564
MOD_GlcNHglycan	283	286	PF01048	0.323
MOD_GlcNHglycan	416	419	PF01048	0.725
MOD_GSK3_1	114	121	PF00069	0.620
MOD_GSK3_1	201	208	PF00069	0.401
MOD_GSK3_1	228	235	PF00069	0.359
MOD_GSK3_1	330	337	PF00069	0.520
MOD_GSK3_1	44	51	PF00069	0.409
MOD_GSK3_1	76	83	PF00069	0.359
MOD_NEK2_1	123	128	PF00069	0.520
MOD_NEK2_1	140	145	PF00069	0.520
MOD_NEK2_1	315	320	PF00069	0.547
MOD_NEK2_1	330	335	PF00069	0.526
MOD_PIKK_1	123	129	PF00454	0.520
MOD_PIKK_1	142	148	PF00454	0.520
MOD_PIKK_1	330	336	PF00454	0.520
MOD_PKA_1	368	374	PF00069	0.499
MOD_PKA_2	118	124	PF00069	0.526
MOD_PKA_2	154	160	PF00069	0.445
MOD_PKA_2	352	358	PF00069	0.453
MOD_PKA_2	45	51	PF00069	0.359
MOD_Plk_1	257	263	PF00069	0.359
MOD_Plk_4	130	136	PF00069	0.520
MOD_Plk_4	201	207	PF00069	0.404
MOD_Plk_4	257	263	PF00069	0.359
MOD_Plk_4	85	91	PF00069	0.377
MOD_ProDKin_1	385	391	PF00069	0.517
MOD_ProDKin_1	55	61	PF00069	0.359
TRG_DiLeu_BaEn_1	32	37	PF01217	0.453
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.447
TRG_DiLeu_LyEn_5	31	36	PF01217	0.419
TRG_ENDOCYTIC_2	134	137	PF00928	0.520
TRG_ENDOCYTIC_2	327	330	PF00928	0.520
TRG_ENDOCYTIC_2	397	400	PF00928	0.601
TRG_ENDOCYTIC_2	40	43	PF00928	0.359
TRG_ENDOCYTIC_2	70	73	PF00928	0.371
TRG_ER_diArg_1	174	177	PF00400	0.433
TRG_ER_diArg_1	226	228	PF00400	0.359
TRG_ER_diArg_1	262	264	PF00400	0.359
TRG_ER_diArg_1	357	359	PF00400	0.483
TRG_ER_diArg_1	421	424	PF00400	0.783
TRG_ER_diArg_1	60	62	PF00400	0.359
TRG_NLS_Bipartite_1	358	372	PF00514	0.517
TRG_NLS_MonoExtC_3	2	8	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G4	Leptomonas seymouri	94%	100%
A0A0S4IXQ5	Bodo saltans	82%	99%
A0A1X0NHA8	Trypanosomatidae	86%	100%
A0A3R7NFD2	Trypanosoma rangeli	85%	100%
A1RTL7	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	41%	100%
A1UET1	Mycobacterium sp. (strain KMS)	28%	100%
A1WLI1	Verminephrobacter eiseniae (strain EF01-2)	28%	100%
A2RL47	Lactococcus lactis subsp. cremoris (strain MG1363)	26%	100%
A3CMF2	Streptococcus sanguinis (strain SK36)	27%	100%
A3MS77	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	43%	100%
A3PY88	Mycobacterium sp. (strain JLS)	28%	100%
A4G0N3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	41%	100%
A4HC40	Leishmania braziliensis	97%	100%
A4HZI2	Leishmania infantum	100%	100%
A4IME0	Geobacillus thermodenitrificans (strain NG80-2)	30%	100%
A4WH37	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	41%	100%
A5GF89	Geotalea uraniireducens (strain Rf4)	28%	100%
A5IIS7	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	27%	100%
A5ISF5	Staphylococcus aureus (strain JH9)	28%	100%
A5VTB4	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	27%	100%
A6LLV6	Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)	26%	100%
A6QGH0	Staphylococcus aureus (strain Newman)	28%	100%
A6U190	Staphylococcus aureus (strain JH1)	28%	100%
A6UWC6	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	39%	100%
A6VHV2	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	41%	100%
A6WWW3	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	28%	100%
A7X1Q5	Staphylococcus aureus (strain Mu3 / ATCC 700698)	28%	100%
A7Z4T7	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	29%	100%
A8Z3V1	Staphylococcus aureus (strain USA300 / TCH1516)	28%	100%
A9A8X7	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	41%	100%
A9M9Z6	Brucella canis (strain ATCC 23365 / NCTC 10854)	27%	100%
B0CK13	Brucella suis (strain ATCC 23445 / NCTC 10510)	27%	100%
B1L793	Korarchaeum cryptofilum (strain OPF8)	44%	100%
B1YA64	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	44%	100%
B2UAA5	Ralstonia pickettii (strain 12J)	28%	100%
B3R1E2	Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)	29%	100%
B4RMB1	Neisseria gonorrhoeae (strain NCCP11945)	28%	100%
B5FA81	Aliivibrio fischeri (strain MJ11)	26%	100%
B6YSP4	Thermococcus onnurineus (strain NA1)	42%	100%
B7VJH5	Vibrio atlanticus (strain LGP32)	25%	100%
C4L8X2	Tolumonas auensis (strain DSM 9187 / TA4)	29%	100%
C5A255	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	42%	100%
D0A0Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
E9AVH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
G0SGK0	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	63%	89%
O13473	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	65%	91%
O14007	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	64%	91%
O17919	Caenorhabditis elegans	59%	97%
O26140	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O30001	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
O43100	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	64%	89%
O43101	Candida albicans (strain SC5314 / ATCC MYA-2876)	63%	90%
O43102	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	64%	88%
O44081	Drosophila melanogaster	59%	85%
O59357	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	45%	100%
O60832	Homo sapiens	58%	84%
P32732	Bacillus subtilis (strain 168)	28%	100%
P33322	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	65%	89%
P40615	Rattus norvegicus	59%	84%
P59876	Brucella suis biovar 1 (strain 1330)	27%	100%
P60346	Nanoarchaeum equitans (strain Kin4-M)	39%	100%
P65854	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P65855	Staphylococcus aureus (strain N315)	28%	100%
P65856	Streptococcus agalactiae serotype III (strain NEM316)	27%	100%
P65857	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	27%	100%
P74696	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
Q02Z55	Lactococcus lactis subsp. cremoris (strain SK11)	27%	100%
Q0AYI5	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	26%	100%
Q0HXR3	Shewanella sp. (strain MR-7)	26%	100%
Q18BH7	Clostridioides difficile (strain 630)	27%	100%
Q1BA81	Mycobacterium sp. (strain MCS)	28%	100%
Q2FHG7	Staphylococcus aureus (strain USA300)	28%	100%
Q2G2Q3	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
Q2LWU1	Syntrophus aciditrophicus (strain SB)	33%	100%
Q2RJM2	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	29%	100%
Q2RMR8	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	27%	100%
Q2YQR5	Brucella abortus (strain 2308)	27%	100%
Q2YXP5	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q38W87	Latilactobacillus sakei subsp. sakei (strain 23K)	26%	100%
Q39VA3	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	26%	100%
Q3K189	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	27%	100%
Q3Z7U5	Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)	28%	100%
Q46GC3	Methanosarcina barkeri (strain Fusaro / DSM 804)	44%	100%
Q49X59	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	29%	100%
Q4L5X4	Staphylococcus haemolyticus (strain JCSC1435)	26%	100%
Q4QC07	Leishmania major	99%	100%
Q54T81	Dictyostelium discoideum	61%	80%
Q57612	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	42%	100%
Q57A98	Brucella abortus biovar 1 (strain 9-941)	27%	100%
Q5E7L3	Aliivibrio fischeri (strain ATCC 700601 / ES114)	25%	100%
Q5F8W8	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)	28%	100%
Q5HGG0	Staphylococcus aureus (strain COL)	28%	100%
Q5JJE8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	43%	100%
Q5LZV2	Streptococcus thermophilus (strain CNRZ 1066)	26%	100%
Q5M4G2	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	26%	100%
Q5NQ30	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	25%	100%
Q5UXH1	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	37%	100%
Q5ZJH9	Gallus gallus	58%	83%
Q60YA8	Caenorhabditis briggsae	59%	97%
Q65JH8	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	29%	100%
Q6F7I5	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	25%	100%
Q6G9U2	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GHG4	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6LWM3	Methanococcus maripaludis (strain S2 / LL)	40%	100%
Q7LWY0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	43%	100%
Q895J5	Clostridium tetani (strain Massachusetts / E88)	29%	100%
Q8NWZ0	Staphylococcus aureus (strain MW2)	28%	100%
Q8PV20	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	45%	100%
Q8TRR5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	45%	100%
Q8TZ08	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	45%	100%
Q8YEB5	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	27%	100%
Q8ZYB3	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	43%	100%
Q975L5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	37%	100%
Q97BU9	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	35%	100%
Q9CMQ7	Pasteurella multocida (strain Pm70)	26%	100%
Q9ESX5	Mus musculus	59%	84%
Q9JTX5	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	28%	100%
Q9JYY1	Neisseria meningitidis serogroup B (strain MC58)	28%	100%
Q9LD90	Arabidopsis thaliana	67%	76%
Q9V1A5	Pyrococcus abyssi (strain GE5 / Orsay)	45%	100%
Q9WZW0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	26%	100%
Q9YDC3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	44%	100%
V5BRH3	Trypanosoma cruzi	85%	100%