Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7A2_LEIDO

TriTrypDb:

LdBPK_212000.1 , LdCL_210025700 , LDHU3_21.2390

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	12	14	PF00082	0.596
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.596
CLV_PCSK_SKI1_1	208	212	PF00082	0.486
CLV_PCSK_SKI1_1	6	10	PF00082	0.718
CLV_PCSK_SKI1_1	80	84	PF00082	0.407
DEG_APCC_DBOX_1	79	87	PF00400	0.392
DOC_CDC14_PxL_1	195	203	PF14671	0.488
DOC_CYCLIN_yCln2_LP_2	197	200	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.426
DOC_PP1_RVXF_1	59	66	PF00149	0.559
DOC_PP2B_LxvP_1	197	200	PF13499	0.498
DOC_USP7_MATH_1	200	204	PF00917	0.497
DOC_USP7_MATH_1	210	214	PF00917	0.600
DOC_USP7_MATH_1	220	224	PF00917	0.493
DOC_USP7_MATH_2	88	94	PF00917	0.455
LIG_14-3-3_CanoR_1	61	66	PF00244	0.625
LIG_BIR_III_2	193	197	PF00653	0.510
LIG_deltaCOP1_diTrp_1	175	180	PF00928	0.454
LIG_FHA_1	112	118	PF00498	0.427
LIG_FHA_1	119	125	PF00498	0.448
LIG_FHA_1	25	31	PF00498	0.548
LIG_FHA_1	57	63	PF00498	0.540
LIG_FHA_2	18	24	PF00498	0.592
LIG_LIR_Gen_1	175	184	PF02991	0.514
LIG_LIR_Gen_1	50	58	PF02991	0.575
LIG_LIR_Gen_1	98	109	PF02991	0.394
LIG_LIR_Nem_3	137	143	PF02991	0.636
LIG_LIR_Nem_3	154	160	PF02991	0.464
LIG_LIR_Nem_3	169	173	PF02991	0.512
LIG_LIR_Nem_3	175	180	PF02991	0.702
LIG_LIR_Nem_3	193	198	PF02991	0.589
LIG_LIR_Nem_3	50	55	PF02991	0.452
LIG_LIR_Nem_3	77	82	PF02991	0.429
LIG_LIR_Nem_3	98	104	PF02991	0.421
LIG_LYPXL_S_1	156	160	PF13949	0.447
LIG_LYPXL_yS_3	157	160	PF13949	0.458
LIG_MYND_1	196	200	PF01753	0.498
LIG_PCNA_yPIPBox_3	127	140	PF02747	0.556
LIG_PDZ_Class_1	226	231	PF00595	0.617
LIG_SH2_CRK	170	174	PF00017	0.535
LIG_SH2_CRK	52	56	PF00017	0.475
LIG_SH2_STAP1	42	46	PF00017	0.629
LIG_SH2_STAP1	52	56	PF00017	0.256
LIG_SH2_STAP1	96	100	PF00017	0.405
LIG_SH2_STAT5	218	221	PF00017	0.511
LIG_SH3_3	193	199	PF00018	0.562
LIG_SH3_3	43	49	PF00018	0.462
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.500
LIG_SUMO_SIM_par_1	120	125	PF11976	0.443
LIG_TRFH_1	195	199	PF08558	0.452
LIG_WRC_WIRS_1	62	67	PF05994	0.445
MOD_CK1_1	103	109	PF00069	0.577
MOD_CK1_1	111	117	PF00069	0.476
MOD_CK1_1	185	191	PF00069	0.578
MOD_CK1_1	44	50	PF00069	0.627
MOD_CK2_1	131	137	PF00069	0.583
MOD_GlcNHglycan	189	193	PF01048	0.614
MOD_GlcNHglycan	212	215	PF01048	0.430
MOD_GlcNHglycan	31	35	PF01048	0.590
MOD_GlcNHglycan	43	46	PF01048	0.536
MOD_GlcNHglycan	52	55	PF01048	0.561
MOD_GSK3_1	216	223	PF00069	0.556
MOD_GSK3_1	22	29	PF00069	0.632
MOD_GSK3_1	96	103	PF00069	0.451
MOD_LATS_1	129	135	PF00433	0.527
MOD_NEK2_1	100	105	PF00069	0.470
MOD_NEK2_1	226	231	PF00069	0.551
MOD_NEK2_2	96	101	PF00069	0.368
MOD_PKA_2	72	78	PF00069	0.417
MOD_Plk_1	22	28	PF00069	0.765
MOD_Plk_4	47	53	PF00069	0.405
MOD_Plk_4	96	102	PF00069	0.419
MOD_SUMO_rev_2	144	150	PF00179	0.496
TRG_DiLeu_BaEn_1	81	86	PF01217	0.377
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.514
TRG_ENDOCYTIC_2	157	160	PF00928	0.468
TRG_ENDOCYTIC_2	170	173	PF00928	0.491
TRG_ENDOCYTIC_2	52	55	PF00928	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NI68	Trypanosomatidae	31%	73%
A0A422N8A3	Trypanosoma rangeli	33%	78%
A4HC26	Leishmania braziliensis	70%	100%
A4HZG9	Leishmania infantum	99%	100%
D0A106	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	76%
E9AVF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QC20	Leishmania major	90%	100%
V5B1W6	Trypanosoma cruzi	32%	77%