LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7A1_LEIDO
TriTrypDb:
LdBPK_211800.1 , LdCL_210023800 , LDHU3_21.2130
Length:
544

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S5H7A1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 408 414 PF00089 0.477
CLV_NRD_NRD_1 142 144 PF00675 0.334
CLV_NRD_NRD_1 320 322 PF00675 0.498
CLV_NRD_NRD_1 337 339 PF00675 0.561
CLV_NRD_NRD_1 513 515 PF00675 0.480
CLV_NRD_NRD_1 79 81 PF00675 0.605
CLV_PCSK_KEX2_1 235 237 PF00082 0.453
CLV_PCSK_KEX2_1 336 338 PF00082 0.563
CLV_PCSK_KEX2_1 513 515 PF00082 0.480
CLV_PCSK_KEX2_1 79 81 PF00082 0.605
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.425
CLV_PCSK_SKI1_1 102 106 PF00082 0.475
CLV_PCSK_SKI1_1 170 174 PF00082 0.567
CLV_PCSK_SKI1_1 232 236 PF00082 0.386
CLV_PCSK_SKI1_1 380 384 PF00082 0.492
CLV_PCSK_SKI1_1 80 84 PF00082 0.626
DEG_APCC_DBOX_1 432 440 PF00400 0.690
DEG_SPOP_SBC_1 330 334 PF00917 0.757
DOC_CKS1_1 14 19 PF01111 0.690
DOC_CKS1_1 355 360 PF01111 0.644
DOC_CKS1_1 381 386 PF01111 0.693
DOC_CYCLIN_yClb1_LxF_4 123 128 PF00134 0.516
DOC_CYCLIN_yCln2_LP_2 64 70 PF00134 0.382
DOC_MAPK_gen_1 223 231 PF00069 0.585
DOC_MAPK_MEF2A_6 223 231 PF00069 0.592
DOC_PP1_RVXF_1 123 129 PF00149 0.521
DOC_PP2B_LxvP_1 347 350 PF13499 0.710
DOC_PP2B_LxvP_1 525 528 PF13499 0.703
DOC_PP2B_LxvP_1 64 67 PF13499 0.391
DOC_USP7_MATH_1 181 185 PF00917 0.393
DOC_USP7_MATH_1 259 263 PF00917 0.684
DOC_USP7_MATH_1 330 334 PF00917 0.757
DOC_USP7_MATH_1 376 380 PF00917 0.700
DOC_USP7_MATH_1 46 50 PF00917 0.336
DOC_USP7_MATH_1 507 511 PF00917 0.782
DOC_USP7_MATH_1 517 521 PF00917 0.767
DOC_WW_Pin1_4 13 18 PF00397 0.706
DOC_WW_Pin1_4 281 286 PF00397 0.693
DOC_WW_Pin1_4 354 359 PF00397 0.668
DOC_WW_Pin1_4 380 385 PF00397 0.693
DOC_WW_Pin1_4 499 504 PF00397 0.681
DOC_WW_Pin1_4 526 531 PF00397 0.691
LIG_14-3-3_CanoR_1 183 190 PF00244 0.361
LIG_14-3-3_CanoR_1 24 29 PF00244 0.529
LIG_14-3-3_CanoR_1 279 284 PF00244 0.693
LIG_14-3-3_CanoR_1 327 335 PF00244 0.671
LIG_14-3-3_CanoR_1 336 345 PF00244 0.836
LIG_Actin_WH2_2 448 463 PF00022 0.672
LIG_APCC_ABBA_1 193 198 PF00400 0.357
LIG_BRCT_BRCA1_1 185 189 PF00533 0.466
LIG_BRCT_BRCA1_1 52 56 PF00533 0.349
LIG_deltaCOP1_diTrp_1 19 28 PF00928 0.582
LIG_EVH1_2 352 356 PF00568 0.664
LIG_FHA_1 121 127 PF00498 0.443
LIG_FHA_1 130 136 PF00498 0.551
LIG_FHA_1 147 153 PF00498 0.327
LIG_FHA_1 160 166 PF00498 0.242
LIG_FHA_1 171 177 PF00498 0.345
LIG_FHA_1 195 201 PF00498 0.275
LIG_FHA_1 25 31 PF00498 0.550
LIG_FHA_1 381 387 PF00498 0.694
LIG_FHA_1 490 496 PF00498 0.715
LIG_FHA_1 56 62 PF00498 0.369
LIG_FHA_2 14 20 PF00498 0.554
LIG_FHA_2 146 152 PF00498 0.321
LIG_FHA_2 383 389 PF00498 0.654
LIG_FHA_2 535 541 PF00498 0.704
LIG_GBD_Chelix_1 30 38 PF00786 0.312
LIG_LIR_Gen_1 134 142 PF02991 0.547
LIG_LIR_Gen_1 148 157 PF02991 0.312
LIG_LIR_Gen_1 27 35 PF02991 0.439
LIG_LIR_Gen_1 388 398 PF02991 0.801
LIG_LIR_Gen_1 466 473 PF02991 0.689
LIG_LIR_Nem_3 134 140 PF02991 0.549
LIG_LIR_Nem_3 148 153 PF02991 0.312
LIG_LIR_Nem_3 246 251 PF02991 0.585
LIG_LIR_Nem_3 27 31 PF02991 0.455
LIG_LIR_Nem_3 388 393 PF02991 0.800
LIG_LIR_Nem_3 466 470 PF02991 0.690
LIG_PCNA_yPIPBox_3 169 183 PF02747 0.377
LIG_PDZ_Class_2 539 544 PF00595 0.723
LIG_PTB_Apo_2 103 110 PF02174 0.312
LIG_PTB_Apo_2 210 217 PF02174 0.312
LIG_PTB_Apo_2 51 58 PF02174 0.334
LIG_PTB_Apo_2 83 90 PF02174 0.366
LIG_PTB_Phospho_1 103 109 PF10480 0.312
LIG_PTB_Phospho_1 83 89 PF10480 0.372
LIG_SH2_CRK 137 141 PF00017 0.550
LIG_SH2_CRK 190 194 PF00017 0.375
LIG_SH2_CRK 467 471 PF00017 0.689
LIG_SH2_NCK_1 190 194 PF00017 0.395
LIG_SH2_NCK_1 390 394 PF00017 0.754
LIG_SH2_NCK_1 467 471 PF00017 0.689
LIG_SH2_SRC 109 112 PF00017 0.376
LIG_SH2_SRC 203 206 PF00017 0.340
LIG_SH2_STAP1 196 200 PF00017 0.275
LIG_SH2_STAT5 109 112 PF00017 0.312
LIG_SH2_STAT5 175 178 PF00017 0.342
LIG_SH2_STAT5 196 199 PF00017 0.334
LIG_SH2_STAT5 203 206 PF00017 0.359
LIG_SH2_STAT5 68 71 PF00017 0.324
LIG_SH2_STAT5 98 101 PF00017 0.322
LIG_SH3_2 358 363 PF14604 0.655
LIG_SH3_3 347 353 PF00018 0.733
LIG_SH3_3 355 361 PF00018 0.652
LIG_SH3_3 375 381 PF00018 0.741
LIG_SH3_3 390 396 PF00018 0.766
LIG_SH3_3 500 506 PF00018 0.715
LIG_SH3_3 524 530 PF00018 0.710
LIG_SUMO_SIM_anti_2 151 156 PF11976 0.388
LIG_SUMO_SIM_anti_2 27 33 PF11976 0.388
LIG_SUMO_SIM_par_1 151 158 PF11976 0.340
LIG_SUMO_SIM_par_1 202 208 PF11976 0.310
LIG_TYR_ITIM 135 140 PF00017 0.551
LIG_WRC_WIRS_1 156 161 PF05994 0.310
MOD_CDK_SPxxK_3 13 20 PF00069 0.622
MOD_CK1_1 254 260 PF00069 0.637
MOD_CK1_1 329 335 PF00069 0.665
MOD_CK1_1 428 434 PF00069 0.696
MOD_CK1_1 488 494 PF00069 0.711
MOD_CK1_1 55 61 PF00069 0.368
MOD_CK2_1 13 19 PF00069 0.558
MOD_CK2_1 145 151 PF00069 0.488
MOD_CK2_1 336 342 PF00069 0.760
MOD_CK2_1 382 388 PF00069 0.654
MOD_CK2_1 483 489 PF00069 0.779
MOD_DYRK1A_RPxSP_1 380 384 PF00069 0.692
MOD_GlcNHglycan 120 123 PF01048 0.388
MOD_GlcNHglycan 185 188 PF01048 0.632
MOD_GlcNHglycan 207 210 PF01048 0.279
MOD_GlcNHglycan 328 331 PF01048 0.471
MOD_GlcNHglycan 430 433 PF01048 0.495
MOD_GlcNHglycan 476 479 PF01048 0.595
MOD_GlcNHglycan 485 488 PF01048 0.519
MOD_GlcNHglycan 509 512 PF01048 0.532
MOD_GSK3_1 155 162 PF00069 0.314
MOD_GSK3_1 170 177 PF00069 0.329
MOD_GSK3_1 199 206 PF00069 0.297
MOD_GSK3_1 20 27 PF00069 0.651
MOD_GSK3_1 251 258 PF00069 0.674
MOD_GSK3_1 326 333 PF00069 0.714
MOD_GSK3_1 376 383 PF00069 0.697
MOD_GSK3_1 46 53 PF00069 0.340
MOD_GSK3_1 485 492 PF00069 0.711
MOD_GSK3_1 534 541 PF00069 0.707
MOD_N-GLC_1 181 186 PF02516 0.552
MOD_N-GLC_1 219 224 PF02516 0.383
MOD_N-GLC_1 456 461 PF02516 0.440
MOD_N-GLC_1 75 80 PF02516 0.530
MOD_NEK2_1 155 160 PF00069 0.308
MOD_NEK2_1 189 194 PF00069 0.423
MOD_NEK2_1 199 204 PF00069 0.262
MOD_NEK2_1 52 57 PF00069 0.353
MOD_PIKK_1 259 265 PF00454 0.642
MOD_PIKK_1 266 272 PF00454 0.637
MOD_PKA_1 336 342 PF00069 0.760
MOD_PKA_2 182 188 PF00069 0.362
MOD_PKA_2 278 284 PF00069 0.650
MOD_PKA_2 326 332 PF00069 0.685
MOD_PKA_2 336 342 PF00069 0.698
MOD_PKB_1 336 344 PF00069 0.761
MOD_PKB_1 481 489 PF00069 0.728
MOD_Plk_1 456 462 PF00069 0.688
MOD_Plk_1 538 544 PF00069 0.705
MOD_Plk_4 155 161 PF00069 0.340
MOD_Plk_4 199 205 PF00069 0.371
MOD_Plk_4 207 213 PF00069 0.455
MOD_Plk_4 24 30 PF00069 0.559
MOD_Plk_4 36 42 PF00069 0.441
MOD_Plk_4 465 471 PF00069 0.688
MOD_Plk_4 52 58 PF00069 0.298
MOD_ProDKin_1 13 19 PF00069 0.699
MOD_ProDKin_1 281 287 PF00069 0.693
MOD_ProDKin_1 354 360 PF00069 0.666
MOD_ProDKin_1 380 386 PF00069 0.694
MOD_ProDKin_1 499 505 PF00069 0.680
MOD_ProDKin_1 526 532 PF00069 0.692
MOD_SUMO_rev_2 339 347 PF00179 0.812
MOD_SUMO_rev_2 452 458 PF00179 0.674
TRG_ENDOCYTIC_2 137 140 PF00928 0.553
TRG_ENDOCYTIC_2 190 193 PF00928 0.365
TRG_ENDOCYTIC_2 196 199 PF00928 0.310
TRG_ENDOCYTIC_2 248 251 PF00928 0.603
TRG_ENDOCYTIC_2 390 393 PF00928 0.754
TRG_ENDOCYTIC_2 467 470 PF00928 0.690
TRG_ER_diArg_1 335 338 PF00400 0.709
TRG_ER_diArg_1 480 483 PF00400 0.734
TRG_NES_CRM1_1 151 167 PF08389 0.334

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA63 Leptomonas seymouri 52% 94%
A4HC03 Leishmania braziliensis 66% 94%
A4HZG0 Leishmania infantum 99% 100%
E9AVE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QC39 Leishmania major 88% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS