Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7A1_LEIDO

TriTrypDb:

LdBPK_211800.1 , LdCL_210023800 , LDHU3_21.2130

Length:

544

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H7A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	408	414	PF00089	0.477
CLV_NRD_NRD_1	142	144	PF00675	0.334
CLV_NRD_NRD_1	320	322	PF00675	0.498
CLV_NRD_NRD_1	337	339	PF00675	0.561
CLV_NRD_NRD_1	513	515	PF00675	0.480
CLV_NRD_NRD_1	79	81	PF00675	0.605
CLV_PCSK_KEX2_1	235	237	PF00082	0.453
CLV_PCSK_KEX2_1	336	338	PF00082	0.563
CLV_PCSK_KEX2_1	513	515	PF00082	0.480
CLV_PCSK_KEX2_1	79	81	PF00082	0.605
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.425
CLV_PCSK_SKI1_1	102	106	PF00082	0.475
CLV_PCSK_SKI1_1	170	174	PF00082	0.567
CLV_PCSK_SKI1_1	232	236	PF00082	0.386
CLV_PCSK_SKI1_1	380	384	PF00082	0.492
CLV_PCSK_SKI1_1	80	84	PF00082	0.626
DEG_APCC_DBOX_1	432	440	PF00400	0.690
DEG_SPOP_SBC_1	330	334	PF00917	0.757
DOC_CKS1_1	14	19	PF01111	0.690
DOC_CKS1_1	355	360	PF01111	0.644
DOC_CKS1_1	381	386	PF01111	0.693
DOC_CYCLIN_yClb1_LxF_4	123	128	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.382
DOC_MAPK_gen_1	223	231	PF00069	0.585
DOC_MAPK_MEF2A_6	223	231	PF00069	0.592
DOC_PP1_RVXF_1	123	129	PF00149	0.521
DOC_PP2B_LxvP_1	347	350	PF13499	0.710
DOC_PP2B_LxvP_1	525	528	PF13499	0.703
DOC_PP2B_LxvP_1	64	67	PF13499	0.391
DOC_USP7_MATH_1	181	185	PF00917	0.393
DOC_USP7_MATH_1	259	263	PF00917	0.684
DOC_USP7_MATH_1	330	334	PF00917	0.757
DOC_USP7_MATH_1	376	380	PF00917	0.700
DOC_USP7_MATH_1	46	50	PF00917	0.336
DOC_USP7_MATH_1	507	511	PF00917	0.782
DOC_USP7_MATH_1	517	521	PF00917	0.767
DOC_WW_Pin1_4	13	18	PF00397	0.706
DOC_WW_Pin1_4	281	286	PF00397	0.693
DOC_WW_Pin1_4	354	359	PF00397	0.668
DOC_WW_Pin1_4	380	385	PF00397	0.693
DOC_WW_Pin1_4	499	504	PF00397	0.681
DOC_WW_Pin1_4	526	531	PF00397	0.691
LIG_14-3-3_CanoR_1	183	190	PF00244	0.361
LIG_14-3-3_CanoR_1	24	29	PF00244	0.529
LIG_14-3-3_CanoR_1	279	284	PF00244	0.693
LIG_14-3-3_CanoR_1	327	335	PF00244	0.671
LIG_14-3-3_CanoR_1	336	345	PF00244	0.836
LIG_Actin_WH2_2	448	463	PF00022	0.672
LIG_APCC_ABBA_1	193	198	PF00400	0.357
LIG_BRCT_BRCA1_1	185	189	PF00533	0.466
LIG_BRCT_BRCA1_1	52	56	PF00533	0.349
LIG_deltaCOP1_diTrp_1	19	28	PF00928	0.582
LIG_EVH1_2	352	356	PF00568	0.664
LIG_FHA_1	121	127	PF00498	0.443
LIG_FHA_1	130	136	PF00498	0.551
LIG_FHA_1	147	153	PF00498	0.327
LIG_FHA_1	160	166	PF00498	0.242
LIG_FHA_1	171	177	PF00498	0.345
LIG_FHA_1	195	201	PF00498	0.275
LIG_FHA_1	25	31	PF00498	0.550
LIG_FHA_1	381	387	PF00498	0.694
LIG_FHA_1	490	496	PF00498	0.715
LIG_FHA_1	56	62	PF00498	0.369
LIG_FHA_2	14	20	PF00498	0.554
LIG_FHA_2	146	152	PF00498	0.321
LIG_FHA_2	383	389	PF00498	0.654
LIG_FHA_2	535	541	PF00498	0.704
LIG_GBD_Chelix_1	30	38	PF00786	0.312
LIG_LIR_Gen_1	134	142	PF02991	0.547
LIG_LIR_Gen_1	148	157	PF02991	0.312
LIG_LIR_Gen_1	27	35	PF02991	0.439
LIG_LIR_Gen_1	388	398	PF02991	0.801
LIG_LIR_Gen_1	466	473	PF02991	0.689
LIG_LIR_Nem_3	134	140	PF02991	0.549
LIG_LIR_Nem_3	148	153	PF02991	0.312
LIG_LIR_Nem_3	246	251	PF02991	0.585
LIG_LIR_Nem_3	27	31	PF02991	0.455
LIG_LIR_Nem_3	388	393	PF02991	0.800
LIG_LIR_Nem_3	466	470	PF02991	0.690
LIG_PCNA_yPIPBox_3	169	183	PF02747	0.377
LIG_PDZ_Class_2	539	544	PF00595	0.723
LIG_PTB_Apo_2	103	110	PF02174	0.312
LIG_PTB_Apo_2	210	217	PF02174	0.312
LIG_PTB_Apo_2	51	58	PF02174	0.334
LIG_PTB_Apo_2	83	90	PF02174	0.366
LIG_PTB_Phospho_1	103	109	PF10480	0.312
LIG_PTB_Phospho_1	83	89	PF10480	0.372
LIG_SH2_CRK	137	141	PF00017	0.550
LIG_SH2_CRK	190	194	PF00017	0.375
LIG_SH2_CRK	467	471	PF00017	0.689
LIG_SH2_NCK_1	190	194	PF00017	0.395
LIG_SH2_NCK_1	390	394	PF00017	0.754
LIG_SH2_NCK_1	467	471	PF00017	0.689
LIG_SH2_SRC	109	112	PF00017	0.376
LIG_SH2_SRC	203	206	PF00017	0.340
LIG_SH2_STAP1	196	200	PF00017	0.275
LIG_SH2_STAT5	109	112	PF00017	0.312
LIG_SH2_STAT5	175	178	PF00017	0.342
LIG_SH2_STAT5	196	199	PF00017	0.334
LIG_SH2_STAT5	203	206	PF00017	0.359
LIG_SH2_STAT5	68	71	PF00017	0.324
LIG_SH2_STAT5	98	101	PF00017	0.322
LIG_SH3_2	358	363	PF14604	0.655
LIG_SH3_3	347	353	PF00018	0.733
LIG_SH3_3	355	361	PF00018	0.652
LIG_SH3_3	375	381	PF00018	0.741
LIG_SH3_3	390	396	PF00018	0.766
LIG_SH3_3	500	506	PF00018	0.715
LIG_SH3_3	524	530	PF00018	0.710
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.388
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.388
LIG_SUMO_SIM_par_1	151	158	PF11976	0.340
LIG_SUMO_SIM_par_1	202	208	PF11976	0.310
LIG_TYR_ITIM	135	140	PF00017	0.551
LIG_WRC_WIRS_1	156	161	PF05994	0.310
MOD_CDK_SPxxK_3	13	20	PF00069	0.622
MOD_CK1_1	254	260	PF00069	0.637
MOD_CK1_1	329	335	PF00069	0.665
MOD_CK1_1	428	434	PF00069	0.696
MOD_CK1_1	488	494	PF00069	0.711
MOD_CK1_1	55	61	PF00069	0.368
MOD_CK2_1	13	19	PF00069	0.558
MOD_CK2_1	145	151	PF00069	0.488
MOD_CK2_1	336	342	PF00069	0.760
MOD_CK2_1	382	388	PF00069	0.654
MOD_CK2_1	483	489	PF00069	0.779
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.692
MOD_GlcNHglycan	120	123	PF01048	0.388
MOD_GlcNHglycan	185	188	PF01048	0.632
MOD_GlcNHglycan	207	210	PF01048	0.279
MOD_GlcNHglycan	328	331	PF01048	0.471
MOD_GlcNHglycan	430	433	PF01048	0.495
MOD_GlcNHglycan	476	479	PF01048	0.595
MOD_GlcNHglycan	485	488	PF01048	0.519
MOD_GlcNHglycan	509	512	PF01048	0.532
MOD_GSK3_1	155	162	PF00069	0.314
MOD_GSK3_1	170	177	PF00069	0.329
MOD_GSK3_1	199	206	PF00069	0.297
MOD_GSK3_1	20	27	PF00069	0.651
MOD_GSK3_1	251	258	PF00069	0.674
MOD_GSK3_1	326	333	PF00069	0.714
MOD_GSK3_1	376	383	PF00069	0.697
MOD_GSK3_1	46	53	PF00069	0.340
MOD_GSK3_1	485	492	PF00069	0.711
MOD_GSK3_1	534	541	PF00069	0.707
MOD_N-GLC_1	181	186	PF02516	0.552
MOD_N-GLC_1	219	224	PF02516	0.383
MOD_N-GLC_1	456	461	PF02516	0.440
MOD_N-GLC_1	75	80	PF02516	0.530
MOD_NEK2_1	155	160	PF00069	0.308
MOD_NEK2_1	189	194	PF00069	0.423
MOD_NEK2_1	199	204	PF00069	0.262
MOD_NEK2_1	52	57	PF00069	0.353
MOD_PIKK_1	259	265	PF00454	0.642
MOD_PIKK_1	266	272	PF00454	0.637
MOD_PKA_1	336	342	PF00069	0.760
MOD_PKA_2	182	188	PF00069	0.362
MOD_PKA_2	278	284	PF00069	0.650
MOD_PKA_2	326	332	PF00069	0.685
MOD_PKA_2	336	342	PF00069	0.698
MOD_PKB_1	336	344	PF00069	0.761
MOD_PKB_1	481	489	PF00069	0.728
MOD_Plk_1	456	462	PF00069	0.688
MOD_Plk_1	538	544	PF00069	0.705
MOD_Plk_4	155	161	PF00069	0.340
MOD_Plk_4	199	205	PF00069	0.371
MOD_Plk_4	207	213	PF00069	0.455
MOD_Plk_4	24	30	PF00069	0.559
MOD_Plk_4	36	42	PF00069	0.441
MOD_Plk_4	465	471	PF00069	0.688
MOD_Plk_4	52	58	PF00069	0.298
MOD_ProDKin_1	13	19	PF00069	0.699
MOD_ProDKin_1	281	287	PF00069	0.693
MOD_ProDKin_1	354	360	PF00069	0.666
MOD_ProDKin_1	380	386	PF00069	0.694
MOD_ProDKin_1	499	505	PF00069	0.680
MOD_ProDKin_1	526	532	PF00069	0.692
MOD_SUMO_rev_2	339	347	PF00179	0.812
MOD_SUMO_rev_2	452	458	PF00179	0.674
TRG_ENDOCYTIC_2	137	140	PF00928	0.553
TRG_ENDOCYTIC_2	190	193	PF00928	0.365
TRG_ENDOCYTIC_2	196	199	PF00928	0.310
TRG_ENDOCYTIC_2	248	251	PF00928	0.603
TRG_ENDOCYTIC_2	390	393	PF00928	0.754
TRG_ENDOCYTIC_2	467	470	PF00928	0.690
TRG_ER_diArg_1	335	338	PF00400	0.709
TRG_ER_diArg_1	480	483	PF00400	0.734
TRG_NES_CRM1_1	151	167	PF08389	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA63	Leptomonas seymouri	52%	94%
A4HC03	Leishmania braziliensis	66%	94%
A4HZG0	Leishmania infantum	99%	100%
E9AVE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QC39	Leishmania major	88%	97%