RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H797_LEIDO

TriTrypDb:

LdBPK_211030.1 , LdCL_210015300 , LDHU3_21.1220

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H797

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H797

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	3
GO:0051537	2 iron, 2 sulfur cluster binding	4	3
GO:0051540	metal cluster binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.651
CLV_C14_Caspase3-7	223	227	PF00656	0.612
CLV_C14_Caspase3-7	615	619	PF00656	0.570
CLV_C14_Caspase3-7	77	81	PF00656	0.789
CLV_NRD_NRD_1	267	269	PF00675	0.544
CLV_NRD_NRD_1	577	579	PF00675	0.577
CLV_NRD_NRD_1	7	9	PF00675	0.648
CLV_PCSK_FUR_1	575	579	PF00082	0.651
CLV_PCSK_KEX2_1	266	268	PF00082	0.544
CLV_PCSK_KEX2_1	574	576	PF00082	0.580
CLV_PCSK_KEX2_1	577	579	PF00082	0.535
CLV_PCSK_KEX2_1	7	9	PF00082	0.648
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.650
CLV_PCSK_PC7_1	3	9	PF00082	0.653
CLV_PCSK_SKI1_1	191	195	PF00082	0.595
CLV_PCSK_SKI1_1	307	311	PF00082	0.500
CLV_PCSK_SKI1_1	47	51	PF00082	0.697
CLV_PCSK_SKI1_1	497	501	PF00082	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DEG_SPOP_SBC_1	98	102	PF00917	0.726
DOC_CKS1_1	19	24	PF01111	0.628
DOC_CYCLIN_RxL_1	494	502	PF00134	0.591
DOC_MAPK_gen_1	358	365	PF00069	0.495
DOC_MAPK_MEF2A_6	177	184	PF00069	0.654
DOC_MAPK_MEF2A_6	343	352	PF00069	0.338
DOC_PP1_RVXF_1	129	135	PF00149	0.655
DOC_SPAK_OSR1_1	360	364	PF12202	0.524
DOC_USP7_MATH_1	146	150	PF00917	0.785
DOC_USP7_MATH_1	222	226	PF00917	0.541
DOC_USP7_MATH_1	232	236	PF00917	0.732
DOC_USP7_MATH_1	302	306	PF00917	0.661
DOC_USP7_MATH_1	404	408	PF00917	0.733
DOC_USP7_MATH_1	412	416	PF00917	0.736
DOC_USP7_MATH_1	462	466	PF00917	0.472
DOC_USP7_MATH_1	523	527	PF00917	0.685
DOC_USP7_MATH_1	557	561	PF00917	0.519
DOC_USP7_MATH_1	58	62	PF00917	0.629
DOC_USP7_MATH_1	612	616	PF00917	0.546
DOC_USP7_MATH_1	74	78	PF00917	0.771
DOC_USP7_MATH_1	99	103	PF00917	0.753
DOC_WW_Pin1_4	15	20	PF00397	0.722
DOC_WW_Pin1_4	166	171	PF00397	0.756
DOC_WW_Pin1_4	176	181	PF00397	0.613
DOC_WW_Pin1_4	33	38	PF00397	0.473
DOC_WW_Pin1_4	402	407	PF00397	0.776
DOC_WW_Pin1_4	419	424	PF00397	0.658
DOC_WW_Pin1_4	447	452	PF00397	0.419
DOC_WW_Pin1_4	460	465	PF00397	0.528
DOC_WW_Pin1_4	508	513	PF00397	0.675
DOC_WW_Pin1_4	526	531	PF00397	0.671
DOC_WW_Pin1_4	54	59	PF00397	0.803
DOC_WW_Pin1_4	662	667	PF00397	0.451
DOC_WW_Pin1_4	87	92	PF00397	0.730
LIG_14-3-3_CanoR_1	191	197	PF00244	0.527
LIG_14-3-3_CanoR_1	257	265	PF00244	0.574
LIG_14-3-3_CanoR_1	360	366	PF00244	0.536
LIG_14-3-3_CanoR_1	456	461	PF00244	0.515
LIG_14-3-3_CanoR_1	658	668	PF00244	0.517
LIG_Actin_WH2_2	178	196	PF00022	0.565
LIG_APCC_ABBA_1	561	566	PF00400	0.465
LIG_BIR_III_2	520	524	PF00653	0.473
LIG_BIR_III_4	147	151	PF00653	0.705
LIG_Clathr_ClatBox_1	184	188	PF01394	0.570
LIG_FHA_1	153	159	PF00498	0.767
LIG_FHA_1	166	172	PF00498	0.607
LIG_FHA_1	177	183	PF00498	0.546
LIG_FHA_1	19	25	PF00498	0.689
LIG_FHA_1	260	266	PF00498	0.596
LIG_FHA_2	193	199	PF00498	0.542
LIG_FHA_2	299	305	PF00498	0.638
LIG_FHA_2	91	97	PF00498	0.730
LIG_Integrin_RGDW_4	642	645	PF00362	0.419
LIG_LIR_Apic_2	644	648	PF02991	0.462
LIG_LIR_Gen_1	118	124	PF02991	0.699
LIG_LIR_Gen_1	214	222	PF02991	0.509
LIG_LIR_Gen_1	308	317	PF02991	0.607
LIG_LIR_Gen_1	477	487	PF02991	0.512
LIG_LIR_Gen_1	550	561	PF02991	0.596
LIG_LIR_Nem_3	118	122	PF02991	0.704
LIG_LIR_Nem_3	214	220	PF02991	0.499
LIG_LIR_Nem_3	477	482	PF02991	0.521
LIG_LIR_Nem_3	550	556	PF02991	0.568
LIG_NRBOX	495	501	PF00104	0.463
LIG_Pex14_1	134	138	PF04695	0.697
LIG_SH2_CRK	479	483	PF00017	0.550
LIG_SH2_CRK	553	557	PF00017	0.592
LIG_SH3_2	423	428	PF14604	0.439
LIG_SH3_2	666	671	PF14604	0.497
LIG_SH3_3	107	113	PF00018	0.564
LIG_SH3_3	16	22	PF00018	0.667
LIG_SH3_3	362	368	PF00018	0.384
LIG_SH3_3	420	426	PF00018	0.703
LIG_SH3_3	663	669	PF00018	0.459
LIG_SUMO_SIM_par_1	183	189	PF11976	0.562
LIG_TRAF2_1	195	198	PF00917	0.520
MOD_CDC14_SPxK_1	425	428	PF00782	0.429
MOD_CDK_SPK_2	176	181	PF00069	0.621
MOD_CDK_SPK_2	526	531	PF00069	0.585
MOD_CDK_SPK_2	662	667	PF00069	0.451
MOD_CDK_SPxK_1	422	428	PF00069	0.443
MOD_CK1_1	140	146	PF00069	0.702
MOD_CK1_1	153	159	PF00069	0.606
MOD_CK1_1	176	182	PF00069	0.649
MOD_CK1_1	18	24	PF00069	0.701
MOD_CK1_1	183	189	PF00069	0.590
MOD_CK1_1	225	231	PF00069	0.693
MOD_CK1_1	233	239	PF00069	0.753
MOD_CK1_1	298	304	PF00069	0.669
MOD_CK1_1	366	372	PF00069	0.521
MOD_CK1_1	405	411	PF00069	0.747
MOD_CK1_1	438	444	PF00069	0.449
MOD_CK1_1	526	532	PF00069	0.631
MOD_CK1_1	638	644	PF00069	0.443
MOD_CK1_1	649	655	PF00069	0.405
MOD_CK1_1	662	668	PF00069	0.355
MOD_CK1_1	90	96	PF00069	0.732
MOD_CK2_1	146	152	PF00069	0.738
MOD_CK2_1	192	198	PF00069	0.541
MOD_CK2_1	302	308	PF00069	0.587
MOD_CK2_1	90	96	PF00069	0.742
MOD_Cter_Amidation	575	578	PF01082	0.579
MOD_GlcNHglycan	101	104	PF01048	0.745
MOD_GlcNHglycan	142	145	PF01048	0.686
MOD_GlcNHglycan	147	151	PF01048	0.715
MOD_GlcNHglycan	152	155	PF01048	0.711
MOD_GlcNHglycan	229	232	PF01048	0.724
MOD_GlcNHglycan	28	31	PF01048	0.689
MOD_GlcNHglycan	407	410	PF01048	0.741
MOD_GlcNHglycan	414	417	PF01048	0.717
MOD_GlcNHglycan	460	463	PF01048	0.575
MOD_GlcNHglycan	501	504	PF01048	0.614
MOD_GlcNHglycan	508	511	PF01048	0.644
MOD_GlcNHglycan	514	517	PF01048	0.625
MOD_GSK3_1	136	143	PF00069	0.682
MOD_GSK3_1	14	21	PF00069	0.633
MOD_GSK3_1	146	153	PF00069	0.739
MOD_GSK3_1	171	178	PF00069	0.708
MOD_GSK3_1	192	199	PF00069	0.549
MOD_GSK3_1	211	218	PF00069	0.334
MOD_GSK3_1	222	229	PF00069	0.665
MOD_GSK3_1	232	239	PF00069	0.683
MOD_GSK3_1	257	264	PF00069	0.590
MOD_GSK3_1	298	305	PF00069	0.687
MOD_GSK3_1	327	334	PF00069	0.533
MOD_GSK3_1	400	407	PF00069	0.780
MOD_GSK3_1	408	415	PF00069	0.653
MOD_GSK3_1	437	444	PF00069	0.587
MOD_GSK3_1	456	463	PF00069	0.548
MOD_GSK3_1	504	511	PF00069	0.596
MOD_GSK3_1	54	61	PF00069	0.579
MOD_GSK3_1	85	92	PF00069	0.658
MOD_GSK3_1	99	106	PF00069	0.660
MOD_LATS_1	6	12	PF00433	0.623
MOD_N-GLC_1	150	155	PF02516	0.719
MOD_N-GLC_1	226	231	PF02516	0.733
MOD_N-GLC_1	331	336	PF02516	0.605
MOD_N-GLC_1	438	443	PF02516	0.582
MOD_NEK2_1	171	176	PF00069	0.746
MOD_NEK2_1	361	366	PF00069	0.428
MOD_NEK2_1	499	504	PF00069	0.596
MOD_NEK2_1	541	546	PF00069	0.435
MOD_NEK2_1	59	64	PF00069	0.727
MOD_NEK2_1	620	625	PF00069	0.511
MOD_NEK2_1	636	641	PF00069	0.554
MOD_NEK2_2	248	253	PF00069	0.540
MOD_PIKK_1	302	308	PF00454	0.679
MOD_PIKK_1	438	444	PF00454	0.540
MOD_PIKK_1	66	72	PF00454	0.659
MOD_PK_1	295	301	PF00069	0.515
MOD_PKA_2	2	8	PF00069	0.734
MOD_PKA_2	311	317	PF00069	0.631
MOD_PKA_2	332	338	PF00069	0.507
MOD_PKA_2	455	461	PF00069	0.516
MOD_PKA_2	659	665	PF00069	0.530
MOD_Plk_1	438	444	PF00069	0.534
MOD_Plk_1	557	563	PF00069	0.529
MOD_Plk_4	154	160	PF00069	0.696
MOD_Plk_4	180	186	PF00069	0.572
MOD_Plk_4	462	468	PF00069	0.550
MOD_ProDKin_1	15	21	PF00069	0.721
MOD_ProDKin_1	166	172	PF00069	0.758
MOD_ProDKin_1	176	182	PF00069	0.610
MOD_ProDKin_1	33	39	PF00069	0.475
MOD_ProDKin_1	402	408	PF00069	0.777
MOD_ProDKin_1	419	425	PF00069	0.654
MOD_ProDKin_1	447	453	PF00069	0.415
MOD_ProDKin_1	460	466	PF00069	0.515
MOD_ProDKin_1	508	514	PF00069	0.678
MOD_ProDKin_1	526	532	PF00069	0.652
MOD_ProDKin_1	54	60	PF00069	0.805
MOD_ProDKin_1	662	668	PF00069	0.453
MOD_ProDKin_1	87	93	PF00069	0.732
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.681
TRG_ENDOCYTIC_2	479	482	PF00928	0.547
TRG_ENDOCYTIC_2	553	556	PF00928	0.561
TRG_ER_diArg_1	265	268	PF00400	0.673
TRG_ER_diArg_1	482	485	PF00400	0.424
TRG_ER_diArg_1	575	578	PF00400	0.657
TRG_ER_diArg_1	655	658	PF00400	0.556
TRG_ER_diArg_1	7	9	PF00400	0.643
TRG_NLS_MonoExtC_3	573	578	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ9	Leptomonas seymouri	42%	100%
A0A1X0NXN9	Trypanosomatidae	32%	100%
A0A422NWI0	Trypanosoma rangeli	35%	100%
A4HBU1	Leishmania braziliensis	71%	100%
A4HZ88	Leishmania infantum	99%	100%
D0A1D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AV63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCB8	Leishmania major	91%	100%
V5BMW0	Trypanosoma cruzi	33%	100%