DNA polymerase eta, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S5H795_LEIDO

TriTrypDb:

LdBPK_210690.1 , LdCL_210011800 , LDHU3_21.0730

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H795

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H795

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.594
CLV_C14_Caspase3-7	369	373	PF00656	0.662
CLV_C14_Caspase3-7	379	383	PF00656	0.452
CLV_NRD_NRD_1	181	183	PF00675	0.247
CLV_NRD_NRD_1	471	473	PF00675	0.544
CLV_NRD_NRD_1	519	521	PF00675	0.613
CLV_NRD_NRD_1	626	628	PF00675	0.617
CLV_NRD_NRD_1	65	67	PF00675	0.255
CLV_NRD_NRD_1	731	733	PF00675	0.517
CLV_PCSK_KEX2_1	181	183	PF00082	0.271
CLV_PCSK_KEX2_1	471	473	PF00082	0.544
CLV_PCSK_KEX2_1	519	521	PF00082	0.626
CLV_PCSK_KEX2_1	628	630	PF00082	0.619
CLV_PCSK_KEX2_1	65	67	PF00082	0.247
CLV_PCSK_KEX2_1	678	680	PF00082	0.612
CLV_PCSK_KEX2_1	731	733	PF00082	0.517
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.609
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.606
CLV_PCSK_SKI1_1	118	122	PF00082	0.247
CLV_PCSK_SKI1_1	234	238	PF00082	0.247
CLV_PCSK_SKI1_1	410	414	PF00082	0.350
CLV_PCSK_SKI1_1	508	512	PF00082	0.406
CLV_PCSK_SKI1_1	731	735	PF00082	0.632
CLV_Separin_Metazoa	202	206	PF03568	0.447
DEG_APCC_DBOX_1	148	156	PF00400	0.496
DEG_SCF_FBW7_1	524	529	PF00400	0.566
DOC_CYCLIN_RxL_1	231	242	PF00134	0.447
DOC_MAPK_gen_1	449	459	PF00069	0.418
DOC_MAPK_gen_1	477	485	PF00069	0.419
DOC_MAPK_gen_1	728	738	PF00069	0.584
DOC_MAPK_MEF2A_6	452	461	PF00069	0.394
DOC_MAPK_RevD_3	168	182	PF00069	0.452
DOC_PP2B_LxvP_1	285	288	PF13499	0.343
DOC_PP2B_LxvP_1	555	558	PF13499	0.468
DOC_PP4_FxxP_1	200	203	PF00568	0.447
DOC_PP4_FxxP_1	296	299	PF00568	0.348
DOC_USP7_MATH_1	160	164	PF00917	0.496
DOC_USP7_MATH_1	288	292	PF00917	0.326
DOC_USP7_MATH_1	312	316	PF00917	0.416
DOC_USP7_MATH_1	420	424	PF00917	0.437
DOC_USP7_MATH_1	5	9	PF00917	0.560
DOC_USP7_MATH_1	548	552	PF00917	0.643
DOC_USP7_MATH_1	597	601	PF00917	0.531
DOC_USP7_MATH_1	612	616	PF00917	0.663
DOC_USP7_MATH_1	713	717	PF00917	0.499
DOC_USP7_MATH_1	748	752	PF00917	0.597
DOC_USP7_UBL2_3	535	539	PF12436	0.537
DOC_WW_Pin1_4	124	129	PF00397	0.421
DOC_WW_Pin1_4	39	44	PF00397	0.465
DOC_WW_Pin1_4	520	525	PF00397	0.652
DOC_WW_Pin1_4	526	531	PF00397	0.628
DOC_WW_Pin1_4	593	598	PF00397	0.563
DOC_WW_Pin1_4	622	627	PF00397	0.604
DOC_WW_Pin1_4	679	684	PF00397	0.644
DOC_WW_Pin1_4	693	698	PF00397	0.631
DOC_WW_Pin1_4	82	87	PF00397	0.479
LIG_14-3-3_CanoR_1	192	197	PF00244	0.447
LIG_14-3-3_CanoR_1	290	299	PF00244	0.331
LIG_14-3-3_CanoR_1	442	450	PF00244	0.449
LIG_14-3-3_CanoR_1	731	737	PF00244	0.606
LIG_APCC_ABBAyCdc20_2	249	255	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.459
LIG_BIR_III_4	349	353	PF00653	0.562
LIG_BIR_III_4	382	386	PF00653	0.381
LIG_BRCT_BRCA1_1	218	222	PF00533	0.447
LIG_BRCT_BRCA1_1	292	296	PF00533	0.315
LIG_BRCT_BRCA1_1	414	418	PF00533	0.337
LIG_CSL_BTD_1	745	748	PF09270	0.568
LIG_eIF4E_1	231	237	PF01652	0.447
LIG_FHA_1	125	131	PF00498	0.421
LIG_FHA_1	173	179	PF00498	0.447
LIG_FHA_1	282	288	PF00498	0.343
LIG_FHA_1	339	345	PF00498	0.422
LIG_FHA_1	720	726	PF00498	0.629
LIG_FHA_1	733	739	PF00498	0.543
LIG_FHA_2	367	373	PF00498	0.528
LIG_FHA_2	400	406	PF00498	0.481
LIG_FHA_2	701	707	PF00498	0.574
LIG_GBD_Chelix_1	435	443	PF00786	0.322
LIG_Integrin_RGD_1	366	368	PF01839	0.563
LIG_LIR_Apic_2	293	299	PF02991	0.332
LIG_LIR_Apic_2	326	331	PF02991	0.330
LIG_LIR_Gen_1	138	148	PF02991	0.447
LIG_LIR_Gen_1	24	35	PF02991	0.453
LIG_LIR_Gen_1	438	446	PF02991	0.365
LIG_LIR_Gen_1	502	510	PF02991	0.416
LIG_LIR_Gen_1	603	613	PF02991	0.545
LIG_LIR_Nem_3	138	144	PF02991	0.465
LIG_LIR_Nem_3	24	30	PF02991	0.453
LIG_LIR_Nem_3	438	443	PF02991	0.353
LIG_LIR_Nem_3	47	52	PF02991	0.466
LIG_LIR_Nem_3	502	506	PF02991	0.396
LIG_LIR_Nem_3	603	608	PF02991	0.563
LIG_PCNA_PIPBox_1	701	710	PF02747	0.583
LIG_SH2_NCK_1	27	31	PF00017	0.447
LIG_SH2_PTP2	141	144	PF00017	0.447
LIG_SH2_SRC	141	144	PF00017	0.447
LIG_SH2_STAP1	258	262	PF00017	0.447
LIG_SH2_STAP1	446	450	PF00017	0.456
LIG_SH2_STAT3	479	482	PF00017	0.461
LIG_SH2_STAT5	141	144	PF00017	0.465
LIG_SH2_STAT5	464	467	PF00017	0.432
LIG_SH3_2	530	535	PF14604	0.540
LIG_SH3_3	167	173	PF00018	0.447
LIG_SH3_3	400	406	PF00018	0.435
LIG_SH3_3	480	486	PF00018	0.430
LIG_SH3_3	518	524	PF00018	0.599
LIG_SH3_3	52	58	PF00018	0.447
LIG_SH3_3	527	533	PF00018	0.569
LIG_SH3_3	538	544	PF00018	0.798
LIG_SH3_3	742	748	PF00018	0.611
LIG_SH3_4	279	286	PF00018	0.349
LIG_SH3_4	535	542	PF00018	0.536
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.387
LIG_SUMO_SIM_anti_2	564	569	PF11976	0.488
LIG_SUMO_SIM_par_1	283	289	PF11976	0.347
LIG_SUMO_SIM_par_1	42	47	PF11976	0.367
LIG_SUMO_SIM_par_1	561	566	PF11976	0.406
LIG_SUMO_SIM_par_1	646	653	PF11976	0.622
LIG_SUMO_SIM_par_1	80	85	PF11976	0.383
LIG_TRAF2_1	148	151	PF00917	0.391
MOD_CDC14_SPxK_1	596	599	PF00782	0.520
MOD_CDC14_SPxK_1	625	628	PF00782	0.606
MOD_CDK_SPK_2	622	627	PF00069	0.604
MOD_CDK_SPxK_1	593	599	PF00069	0.561
MOD_CDK_SPxK_1	622	628	PF00069	0.605
MOD_CDK_SPxxK_3	622	629	PF00069	0.606
MOD_CDK_SPxxK_3	679	686	PF00069	0.612
MOD_CDK_SPxxK_3	82	89	PF00069	0.192
MOD_CK1_1	423	429	PF00069	0.380
MOD_CK1_1	606	612	PF00069	0.519
MOD_CK1_1	615	621	PF00069	0.597
MOD_CK1_1	68	74	PF00069	0.225
MOD_CK1_1	7	13	PF00069	0.480
MOD_CK1_1	724	730	PF00069	0.590
MOD_CK1_1	751	757	PF00069	0.545
MOD_CK2_1	133	139	PF00069	0.192
MOD_CK2_1	441	447	PF00069	0.444
MOD_CK2_1	715	721	PF00069	0.697
MOD_CK2_1	751	757	PF00069	0.580
MOD_Cter_Amidation	676	679	PF01082	0.716
MOD_DYRK1A_RPxSP_1	520	524	PF00069	0.600
MOD_DYRK1A_RPxSP_1	679	683	PF00069	0.601
MOD_GlcNHglycan	189	192	PF01048	0.328
MOD_GlcNHglycan	259	263	PF01048	0.282
MOD_GlcNHglycan	274	277	PF01048	0.356
MOD_GlcNHglycan	289	293	PF01048	0.344
MOD_GlcNHglycan	300	303	PF01048	0.365
MOD_GlcNHglycan	314	317	PF01048	0.262
MOD_GlcNHglycan	361	364	PF01048	0.551
MOD_GlcNHglycan	551	554	PF01048	0.744
MOD_GlcNHglycan	592	596	PF01048	0.714
MOD_GlcNHglycan	605	608	PF01048	0.523
MOD_GlcNHglycan	614	617	PF01048	0.595
MOD_GlcNHglycan	631	634	PF01048	0.592
MOD_GlcNHglycan	688	691	PF01048	0.599
MOD_GlcNHglycan	715	718	PF01048	0.584
MOD_GlcNHglycan	759	762	PF01048	0.495
MOD_GSK3_1	102	109	PF00069	0.282
MOD_GSK3_1	187	194	PF00069	0.301
MOD_GSK3_1	3	10	PF00069	0.541
MOD_GSK3_1	44	51	PF00069	0.170
MOD_GSK3_1	441	448	PF00069	0.447
MOD_GSK3_1	522	529	PF00069	0.721
MOD_GSK3_1	531	538	PF00069	0.606
MOD_GSK3_1	544	551	PF00069	0.596
MOD_GSK3_1	593	600	PF00069	0.683
MOD_GSK3_1	677	684	PF00069	0.697
MOD_GSK3_1	709	716	PF00069	0.623
MOD_GSK3_1	753	760	PF00069	0.611
MOD_N-GLC_1	658	663	PF02516	0.549
MOD_N-GLC_1	68	73	PF02516	0.170
MOD_NEK2_1	216	221	PF00069	0.350
MOD_NEK2_1	44	49	PF00069	0.170
MOD_NEK2_1	90	95	PF00069	0.195
MOD_OFUCOSY	336	342	PF10250	0.334
MOD_PIKK_1	44	50	PF00454	0.170
MOD_PIKK_1	681	687	PF00454	0.550
MOD_PIKK_1	92	98	PF00454	0.192
MOD_PKA_1	65	71	PF00069	0.170
MOD_PKA_1	731	737	PF00069	0.505
MOD_PKA_2	191	197	PF00069	0.282
MOD_PKA_2	441	447	PF00069	0.425
MOD_PKA_2	65	71	PF00069	0.181
MOD_PKA_2	709	715	PF00069	0.618
MOD_PKA_2	731	737	PF00069	0.505
MOD_PKB_1	627	635	PF00069	0.616
MOD_Plk_1	563	569	PF00069	0.411
MOD_Plk_2-3	133	139	PF00069	0.192
MOD_Plk_2-3	658	664	PF00069	0.601
MOD_Plk_4	281	287	PF00069	0.344
MOD_Plk_4	48	54	PF00069	0.262
MOD_Plk_4	563	569	PF00069	0.336
MOD_ProDKin_1	124	130	PF00069	0.246
MOD_ProDKin_1	39	45	PF00069	0.307
MOD_ProDKin_1	520	526	PF00069	0.651
MOD_ProDKin_1	593	599	PF00069	0.561
MOD_ProDKin_1	622	628	PF00069	0.605
MOD_ProDKin_1	679	685	PF00069	0.645
MOD_ProDKin_1	693	699	PF00069	0.625
MOD_ProDKin_1	82	88	PF00069	0.328
MOD_SUMO_rev_2	362	371	PF00179	0.562
MOD_SUMO_rev_2	673	680	PF00179	0.617
TRG_DiLeu_BaEn_1	233	238	PF01217	0.350
TRG_DiLeu_BaEn_1	453	458	PF01217	0.399
TRG_DiLeu_BaEn_1	502	507	PF01217	0.364
TRG_DiLeu_BaEn_3	739	745	PF01217	0.510
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.282
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.370
TRG_ENDOCYTIC_2	141	144	PF00928	0.312
TRG_ENDOCYTIC_2	253	256	PF00928	0.357
TRG_ENDOCYTIC_2	27	30	PF00928	0.282
TRG_ER_diArg_1	248	251	PF00400	0.291
TRG_ER_diArg_1	393	396	PF00400	0.319
TRG_ER_diArg_1	519	521	PF00400	0.603
TRG_ER_diArg_1	570	573	PF00400	0.411
TRG_ER_diArg_1	626	629	PF00400	0.619
TRG_ER_diArg_1	64	66	PF00400	0.294
TRG_ER_diArg_1	730	732	PF00400	0.515
TRG_NES_CRM1_1	564	576	PF08389	0.330
TRG_NLS_MonoExtC_3	626	631	PF00514	0.609
TRG_NLS_MonoExtN_4	626	632	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	702	706	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	49%	97%
A4HBQ9	Leishmania braziliensis	74%	100%
A4HZ61	Leishmania infantum	93%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AV29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCF3	Leishmania major	86%	100%
Q8H2D5	Arabidopsis thaliana	27%	100%