MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H793_LEIDO

TriTrypDb:

LdBPK_210270.1 , LdCL_210007500 , LDHU3_21.0270

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H793

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H793

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.634
CLV_NRD_NRD_1	141	143	PF00675	0.512
CLV_NRD_NRD_1	221	223	PF00675	0.567
CLV_NRD_NRD_1	245	247	PF00675	0.546
CLV_NRD_NRD_1	304	306	PF00675	0.566
CLV_NRD_NRD_1	376	378	PF00675	0.449
CLV_NRD_NRD_1	389	391	PF00675	0.442
CLV_PCSK_KEX2_1	141	143	PF00082	0.512
CLV_PCSK_KEX2_1	221	223	PF00082	0.574
CLV_PCSK_KEX2_1	245	247	PF00082	0.546
CLV_PCSK_KEX2_1	304	306	PF00082	0.480
CLV_PCSK_KEX2_1	376	378	PF00082	0.449
CLV_PCSK_KEX2_1	389	391	PF00082	0.442
CLV_PCSK_SKI1_1	179	183	PF00082	0.494
CLV_PCSK_SKI1_1	314	318	PF00082	0.459
CLV_PCSK_SKI1_1	384	388	PF00082	0.454
CLV_PCSK_SKI1_1	456	460	PF00082	0.749
DEG_APCC_DBOX_1	389	397	PF00400	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.781
DOC_CYCLIN_RxL_1	374	385	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.559
DOC_MAPK_DCC_7	221	229	PF00069	0.614
DOC_MAPK_gen_1	139	147	PF00069	0.467
DOC_MAPK_gen_1	221	229	PF00069	0.614
DOC_MAPK_gen_1	245	253	PF00069	0.576
DOC_MAPK_gen_1	304	312	PF00069	0.521
DOC_MAPK_gen_1	376	383	PF00069	0.492
DOC_MAPK_gen_1	389	395	PF00069	0.537
DOC_MAPK_gen_1	453	461	PF00069	0.651
DOC_MAPK_MEF2A_6	139	147	PF00069	0.345
DOC_MAPK_MEF2A_6	179	186	PF00069	0.551
DOC_MAPK_MEF2A_6	222	231	PF00069	0.596
DOC_MAPK_MEF2A_6	246	255	PF00069	0.484
DOC_MAPK_MEF2A_6	26	33	PF00069	0.436
DOC_MAPK_MEF2A_6	376	383	PF00069	0.492
DOC_MAPK_MEF2A_6	70	77	PF00069	0.433
DOC_MAPK_NFAT4_5	376	384	PF00069	0.496
DOC_USP7_MATH_1	439	443	PF00917	0.731
DOC_USP7_MATH_1	60	64	PF00917	0.548
DOC_WW_Pin1_4	278	283	PF00397	0.681
DOC_WW_Pin1_4	437	442	PF00397	0.774
LIG_14-3-3_CanoR_1	376	380	PF00244	0.470
LIG_14-3-3_CanoR_1	460	464	PF00244	0.696
LIG_Actin_WH2_2	296	313	PF00022	0.374
LIG_BIR_III_2	249	253	PF00653	0.570
LIG_Clathr_ClatBox_1	407	411	PF01394	0.509
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.584
LIG_deltaCOP1_diTrp_1	483	488	PF00928	0.545
LIG_EVH1_1	431	435	PF00568	0.756
LIG_FHA_1	138	144	PF00498	0.573
LIG_FHA_1	191	197	PF00498	0.530
LIG_FHA_1	199	205	PF00498	0.524
LIG_FHA_1	232	238	PF00498	0.550
LIG_FHA_1	351	357	PF00498	0.452
LIG_FHA_1	453	459	PF00498	0.676
LIG_FHA_1	7	13	PF00498	0.739
LIG_FHA_2	380	386	PF00498	0.520
LIG_FHA_2	89	95	PF00498	0.545
LIG_GBD_Chelix_1	379	387	PF00786	0.499
LIG_GBD_Chelix_1	400	408	PF00786	0.514
LIG_LIR_Apic_2	363	369	PF02991	0.523
LIG_LIR_Gen_1	483	494	PF02991	0.571
LIG_LIR_Nem_3	483	489	PF02991	0.573
LIG_LYPXL_SIV_4	338	346	PF13949	0.540
LIG_NRBOX	382	388	PF00104	0.551
LIG_NRBOX	399	405	PF00104	0.344
LIG_NRBOX	73	79	PF00104	0.496
LIG_PCNA_yPIPBox_3	389	399	PF02747	0.513
LIG_SH2_STAT3	150	153	PF00017	0.480
LIG_SH2_STAT5	352	355	PF00017	0.526
LIG_SH2_STAT5	366	369	PF00017	0.406
LIG_SH2_STAT5	505	508	PF00017	0.521
LIG_SH3_3	123	129	PF00018	0.494
LIG_SH3_3	155	161	PF00018	0.565
LIG_SH3_3	262	268	PF00018	0.457
LIG_SH3_3	429	435	PF00018	0.714
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.322
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.431
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.450
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.478
LIG_SUMO_SIM_par_1	167	173	PF11976	0.371
LIG_SUMO_SIM_par_1	182	187	PF11976	0.504
LIG_SUMO_SIM_par_1	227	235	PF11976	0.591
LIG_SUMO_SIM_par_1	405	412	PF11976	0.499
LIG_SUMO_SIM_par_1	73	79	PF11976	0.470
LIG_TRAF2_1	85	88	PF00917	0.403
LIG_TYR_ITIM	81	86	PF00017	0.399
MOD_CK1_1	190	196	PF00069	0.518
MOD_CK1_1	476	482	PF00069	0.703
MOD_CK2_1	29	35	PF00069	0.555
MOD_CK2_1	379	385	PF00069	0.502
MOD_GlcNHglycan	189	192	PF01048	0.303
MOD_GlcNHglycan	241	244	PF01048	0.471
MOD_GlcNHglycan	411	414	PF01048	0.590
MOD_GlcNHglycan	420	423	PF01048	0.699
MOD_GlcNHglycan	441	444	PF01048	0.577
MOD_GlcNHglycan	475	478	PF01048	0.749
MOD_GlcNHglycan	499	502	PF01048	0.464
MOD_GlcNHglycan	52	55	PF01048	0.628
MOD_GlcNHglycan	56	59	PF01048	0.614
MOD_GSK3_1	133	140	PF00069	0.570
MOD_GSK3_1	274	281	PF00069	0.613
MOD_GSK3_1	375	382	PF00069	0.443
MOD_GSK3_1	437	444	PF00069	0.755
MOD_GSK3_1	50	57	PF00069	0.647
MOD_NEK2_1	231	236	PF00069	0.545
MOD_NEK2_1	370	375	PF00069	0.506
MOD_NEK2_1	379	384	PF00069	0.432
MOD_NEK2_1	402	407	PF00069	0.499
MOD_NEK2_1	459	464	PF00069	0.720
MOD_NEK2_2	216	221	PF00069	0.588
MOD_PIKK_1	111	117	PF00454	0.519
MOD_PIKK_1	21	27	PF00454	0.723
MOD_PKA_2	133	139	PF00069	0.523
MOD_PKA_2	375	381	PF00069	0.480
MOD_PKA_2	452	458	PF00069	0.678
MOD_PKA_2	459	465	PF00069	0.562
MOD_Plk_1	198	204	PF00069	0.383
MOD_Plk_1	232	238	PF00069	0.514
MOD_Plk_1	482	488	PF00069	0.575
MOD_Plk_1	87	93	PF00069	0.516
MOD_Plk_2-3	274	280	PF00069	0.612
MOD_Plk_2-3	515	521	PF00069	0.564
MOD_Plk_2-3	88	94	PF00069	0.543
MOD_Plk_4	153	159	PF00069	0.566
MOD_Plk_4	232	238	PF00069	0.551
MOD_Plk_4	29	35	PF00069	0.572
MOD_Plk_4	402	408	PF00069	0.468
MOD_ProDKin_1	278	284	PF00069	0.664
MOD_ProDKin_1	437	443	PF00069	0.775
MOD_SUMO_for_1	92	95	PF00179	0.550
TRG_DiLeu_BaEn_1	394	399	PF01217	0.526
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.518
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.549
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.419
TRG_ENDOCYTIC_2	83	86	PF00928	0.407
TRG_ER_diArg_1	131	134	PF00400	0.530
TRG_ER_diArg_1	141	143	PF00400	0.433
TRG_ER_diArg_1	220	222	PF00400	0.645
TRG_ER_diArg_1	244	246	PF00400	0.535
TRG_ER_diArg_1	303	305	PF00400	0.563
TRG_ER_diArg_1	388	390	PF00400	0.487
TRG_ER_diArg_1	40	43	PF00400	0.531
TRG_NES_CRM1_1	397	411	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I200	Leptomonas seymouri	45%	90%
A0A0S4IXJ4	Bodo saltans	26%	100%
A0A3R7KNI1	Trypanosoma rangeli	30%	89%
A4HBM0	Leishmania braziliensis	78%	100%
A4HZA8	Leishmania infantum	100%	100%
E9AUY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCJ4	Leishmania major	94%	100%
V5DGY6	Trypanosoma cruzi	30%	100%