BAR_domain_containing_protein_putative/Pfam:PF031 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H792_LEIDO

TriTrypDb:

LdBPK_210070.1 , LdCL_210005600 , LDHU3_21.0080

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H792

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H792

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.304
CLV_NRD_NRD_1	150	152	PF00675	0.579
CLV_NRD_NRD_1	168	170	PF00675	0.358
CLV_NRD_NRD_1	24	26	PF00675	0.513
CLV_NRD_NRD_1	51	53	PF00675	0.569
CLV_PCSK_FUR_1	24	28	PF00082	0.520
CLV_PCSK_KEX2_1	127	129	PF00082	0.539
CLV_PCSK_KEX2_1	168	170	PF00082	0.446
CLV_PCSK_KEX2_1	24	26	PF00082	0.427
CLV_PCSK_KEX2_1	51	53	PF00082	0.520
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.509
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.499
CLV_PCSK_PC7_1	123	129	PF00082	0.305
CLV_PCSK_SKI1_1	154	158	PF00082	0.422
CLV_PCSK_SKI1_1	194	198	PF00082	0.473
CLV_PCSK_SKI1_1	27	31	PF00082	0.489
CLV_PCSK_SKI1_1	8	12	PF00082	0.565
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DOC_CYCLIN_RxL_1	151	159	PF00134	0.361
DOC_MAPK_gen_1	6	13	PF00069	0.652
DOC_USP7_MATH_1	102	106	PF00917	0.477
DOC_USP7_MATH_1	175	179	PF00917	0.462
DOC_USP7_MATH_1	204	208	PF00917	0.394
DOC_USP7_MATH_1	35	39	PF00917	0.439
DOC_USP7_MATH_1	46	50	PF00917	0.447
DOC_USP7_UBL2_3	154	158	PF12436	0.505
DOC_USP7_UBL2_3	26	30	PF12436	0.468
DOC_USP7_UBL2_3	8	12	PF12436	0.573
LIG_14-3-3_CanoR_1	151	157	PF00244	0.630
LIG_14-3-3_CanoR_1	194	202	PF00244	0.578
LIG_Actin_WH2_2	209	226	PF00022	0.517
LIG_BRCT_BRCA1_1	60	64	PF00533	0.451
LIG_FHA_1	109	115	PF00498	0.495
LIG_FHA_1	145	151	PF00498	0.602
LIG_FHA_1	197	203	PF00498	0.541
LIG_FHA_2	135	141	PF00498	0.568
LIG_FHA_2	15	21	PF00498	0.522
LIG_FHA_2	195	201	PF00498	0.571
LIG_FHA_2	39	45	PF00498	0.445
LIG_LIR_Apic_2	226	232	PF02991	0.364
LIG_LIR_Gen_1	61	71	PF02991	0.493
LIG_LIR_Nem_3	134	138	PF02991	0.464
LIG_LIR_Nem_3	61	67	PF02991	0.392
LIG_LIR_Nem_3	94	99	PF02991	0.475
LIG_LYPXL_yS_3	70	73	PF13949	0.351
LIG_Rb_pABgroove_1	112	120	PF01858	0.333
LIG_SH2_PTP2	229	232	PF00017	0.364
LIG_SH2_STAP1	162	166	PF00017	0.447
LIG_SH2_STAT5	149	152	PF00017	0.594
LIG_SH2_STAT5	229	232	PF00017	0.364
LIG_SH3_3	68	74	PF00018	0.542
LIG_Sin3_3	81	88	PF02671	0.256
LIG_UBA3_1	4	12	PF00899	0.671
MOD_CK1_1	207	213	PF00069	0.343
MOD_CK1_1	38	44	PF00069	0.458
MOD_CK2_1	134	140	PF00069	0.511
MOD_CK2_1	14	20	PF00069	0.577
MOD_CK2_1	38	44	PF00069	0.472
MOD_GlcNHglycan	177	180	PF01048	0.429
MOD_GlcNHglycan	214	219	PF01048	0.383
MOD_GlcNHglycan	33	36	PF01048	0.488
MOD_GSK3_1	102	109	PF00069	0.424
MOD_GSK3_1	140	147	PF00069	0.492
MOD_GSK3_1	152	159	PF00069	0.476
MOD_GSK3_1	190	197	PF00069	0.447
MOD_GSK3_1	31	38	PF00069	0.491
MOD_NEK2_1	103	108	PF00069	0.325
MOD_NEK2_1	150	155	PF00069	0.483
MOD_NEK2_1	156	161	PF00069	0.462
MOD_NEK2_1	190	195	PF00069	0.530
MOD_NEK2_1	84	89	PF00069	0.463
MOD_NEK2_2	46	51	PF00069	0.582
MOD_PKA_1	144	150	PF00069	0.451
MOD_PKA_2	150	156	PF00069	0.521
MOD_Plk_1	103	109	PF00069	0.421
MOD_Plk_2-3	134	140	PF00069	0.515
MOD_Plk_4	103	109	PF00069	0.410
MOD_Plk_4	152	158	PF00069	0.637
MOD_SUMO_rev_2	177	183	PF00179	0.539
TRG_ENDOCYTIC_2	70	73	PF00928	0.511
TRG_ER_diArg_1	24	27	PF00400	0.516
TRG_ER_diArg_1	50	52	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	56%	100%
A0A0N1PD85	Leptomonas seymouri	34%	100%
A0A0N1PG41	Leptomonas seymouri	24%	77%
A0A1X0NEE3	Trypanosomatidae	24%	89%
A0A1X0NFG5	Trypanosomatidae	24%	89%
A0A1X0NXA6	Trypanosomatidae	27%	81%
A0A1X0NXA8	Trypanosomatidae	36%	100%
A0A3Q8IKU7	Leishmania donovani	32%	100%
A0A3S5H7I1	Leishmania donovani	24%	72%
A0A422MZP2	Trypanosoma rangeli	27%	81%
A4HBJ9	Leishmania braziliensis	34%	100%
A4HBK0	Leishmania braziliensis	63%	100%
A4HFU7	Leishmania braziliensis	22%	72%
A4HZL5	Leishmania infantum	100%	100%
A4HZL6	Leishmania infantum	32%	100%
A4I2W4	Leishmania infantum	24%	72%
E9ADF0	Leishmania major	21%	72%
E9AHL0	Leishmania infantum	24%	79%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	72%
Q4Q6I6	Leishmania major	25%	100%
Q4QCL3	Leishmania major	87%	100%
Q4QCL4	Leishmania major	32%	100%
V5BG41	Trypanosoma cruzi	38%	100%
V5BKK3	Trypanosoma cruzi	25%	81%