Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H787_LEIDO

TriTrypDb:

LdBPK_201050.1 , LdCL_200015200 , LDHU3_20.1310

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H787

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H787

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.653
CLV_C14_Caspase3-7	194	198	PF00656	0.577
CLV_C14_Caspase3-7	306	310	PF00656	0.615
CLV_C14_Caspase3-7	425	429	PF00656	0.689
CLV_C14_Caspase3-7	497	501	PF00656	0.608
CLV_NRD_NRD_1	131	133	PF00675	0.634
CLV_NRD_NRD_1	156	158	PF00675	0.693
CLV_NRD_NRD_1	177	179	PF00675	0.630
CLV_NRD_NRD_1	360	362	PF00675	0.609
CLV_NRD_NRD_1	545	547	PF00675	0.696
CLV_NRD_NRD_1	637	639	PF00675	0.631
CLV_NRD_NRD_1	688	690	PF00675	0.557
CLV_NRD_NRD_1	788	790	PF00675	0.575
CLV_NRD_NRD_1	82	84	PF00675	0.734
CLV_NRD_NRD_1	845	847	PF00675	0.537
CLV_PCSK_FUR_1	786	790	PF00082	0.581
CLV_PCSK_KEX2_1	131	133	PF00082	0.634
CLV_PCSK_KEX2_1	313	315	PF00082	0.634
CLV_PCSK_KEX2_1	360	362	PF00082	0.618
CLV_PCSK_KEX2_1	637	639	PF00082	0.631
CLV_PCSK_KEX2_1	688	690	PF00082	0.557
CLV_PCSK_KEX2_1	788	790	PF00082	0.575
CLV_PCSK_KEX2_1	829	831	PF00082	0.468
CLV_PCSK_KEX2_1	845	847	PF00082	0.593
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.702
CLV_PCSK_PC1ET2_1	829	831	PF00082	0.464
CLV_PCSK_PC7_1	784	790	PF00082	0.586
CLV_PCSK_SKI1_1	220	224	PF00082	0.749
CLV_PCSK_SKI1_1	305	309	PF00082	0.659
CLV_PCSK_SKI1_1	332	336	PF00082	0.685
CLV_PCSK_SKI1_1	344	348	PF00082	0.567
CLV_PCSK_SKI1_1	393	397	PF00082	0.634
CLV_PCSK_SKI1_1	546	550	PF00082	0.690
CLV_PCSK_SKI1_1	608	612	PF00082	0.663
CLV_PCSK_SKI1_1	668	672	PF00082	0.627
CLV_PCSK_SKI1_1	689	693	PF00082	0.512
CLV_PCSK_SKI1_1	810	814	PF00082	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.759
DEG_SCF_FBW7_1	604	609	PF00400	0.540
DEG_SCF_FBW7_1	629	635	PF00400	0.699
DEG_SPOP_SBC_1	117	121	PF00917	0.636
DEG_SPOP_SBC_1	339	343	PF00917	0.624
DEG_SPOP_SBC_1	534	538	PF00917	0.545
DOC_CKS1_1	451	456	PF01111	0.604
DOC_CKS1_1	629	634	PF01111	0.702
DOC_CKS1_1	73	78	PF01111	0.654
DOC_CKS1_1	790	795	PF01111	0.563
DOC_CKS1_1	862	867	PF01111	0.581
DOC_MAPK_gen_1	83	90	PF00069	0.661
DOC_PP2B_LxvP_1	2	5	PF13499	0.670
DOC_PP2B_LxvP_1	231	234	PF13499	0.657
DOC_PP4_FxxP_1	549	552	PF00568	0.643
DOC_USP7_MATH_1	101	105	PF00917	0.699
DOC_USP7_MATH_1	133	137	PF00917	0.664
DOC_USP7_MATH_1	191	195	PF00917	0.684
DOC_USP7_MATH_1	196	200	PF00917	0.670
DOC_USP7_MATH_1	205	209	PF00917	0.662
DOC_USP7_MATH_1	234	238	PF00917	0.612
DOC_USP7_MATH_1	240	244	PF00917	0.597
DOC_USP7_MATH_1	283	287	PF00917	0.626
DOC_USP7_MATH_1	288	292	PF00917	0.614
DOC_USP7_MATH_1	339	343	PF00917	0.653
DOC_USP7_MATH_1	366	370	PF00917	0.642
DOC_USP7_MATH_1	386	390	PF00917	0.479
DOC_USP7_MATH_1	498	502	PF00917	0.649
DOC_USP7_MATH_1	527	531	PF00917	0.677
DOC_USP7_MATH_1	566	570	PF00917	0.591
DOC_USP7_MATH_1	586	590	PF00917	0.588
DOC_USP7_MATH_1	598	602	PF00917	0.585
DOC_USP7_MATH_1	604	608	PF00917	0.492
DOC_USP7_MATH_1	720	724	PF00917	0.446
DOC_WW_Pin1_4	106	111	PF00397	0.514
DOC_WW_Pin1_4	201	206	PF00397	0.791
DOC_WW_Pin1_4	262	267	PF00397	0.617
DOC_WW_Pin1_4	372	377	PF00397	0.647
DOC_WW_Pin1_4	38	43	PF00397	0.609
DOC_WW_Pin1_4	418	423	PF00397	0.654
DOC_WW_Pin1_4	44	49	PF00397	0.616
DOC_WW_Pin1_4	445	450	PF00397	0.656
DOC_WW_Pin1_4	465	470	PF00397	0.465
DOC_WW_Pin1_4	482	487	PF00397	0.499
DOC_WW_Pin1_4	506	511	PF00397	0.701
DOC_WW_Pin1_4	540	545	PF00397	0.615
DOC_WW_Pin1_4	600	605	PF00397	0.603
DOC_WW_Pin1_4	628	633	PF00397	0.695
DOC_WW_Pin1_4	658	663	PF00397	0.654
DOC_WW_Pin1_4	72	77	PF00397	0.671
DOC_WW_Pin1_4	789	794	PF00397	0.568
DOC_WW_Pin1_4	818	823	PF00397	0.528
DOC_WW_Pin1_4	861	866	PF00397	0.689
DOC_WW_Pin1_4	88	93	PF00397	0.788
LIG_14-3-3_CanoR_1	157	161	PF00244	0.605
LIG_14-3-3_CanoR_1	178	186	PF00244	0.696
LIG_14-3-3_CanoR_1	190	196	PF00244	0.581
LIG_14-3-3_CanoR_1	303	312	PF00244	0.657
LIG_14-3-3_CanoR_1	791	797	PF00244	0.557
LIG_APCC_ABBAyCdc20_2	157	163	PF00400	0.688
LIG_BRCT_BRCA1_1	181	185	PF00533	0.596
LIG_BRCT_BRCA1_1	472	476	PF00533	0.593
LIG_BRCT_BRCA1_1	587	591	PF00533	0.574
LIG_DCNL_PONY_1	1	4	PF03556	0.676
LIG_FHA_1	160	166	PF00498	0.745
LIG_FHA_1	245	251	PF00498	0.524
LIG_FHA_1	445	451	PF00498	0.632
LIG_FHA_1	466	472	PF00498	0.595
LIG_FHA_1	568	574	PF00498	0.636
LIG_FHA_1	629	635	PF00498	0.635
LIG_FHA_2	136	142	PF00498	0.595
LIG_FHA_2	495	501	PF00498	0.604
LIG_FHA_2	681	687	PF00498	0.693
LIG_Integrin_RGD_1	16	18	PF01839	0.628
LIG_Integrin_RGD_1	377	379	PF01839	0.652
LIG_LIR_Gen_1	473	484	PF02991	0.673
LIG_LIR_Gen_1	693	703	PF02991	0.528
LIG_LIR_Nem_3	18	24	PF02991	0.596
LIG_LIR_Nem_3	473	479	PF02991	0.632
LIG_LIR_Nem_3	693	698	PF02991	0.544
LIG_MYND_1	262	266	PF01753	0.660
LIG_NBox_RRM_1	809	819	PF00076	0.500
LIG_PCNA_yPIPBox_3	752	765	PF02747	0.461
LIG_Pex14_1	459	463	PF04695	0.597
LIG_PTAP_UEV_1	625	630	PF05743	0.633
LIG_SH2_CRK	24	28	PF00017	0.584
LIG_SH2_CRK	259	263	PF00017	0.717
LIG_SH2_CRK	61	65	PF00017	0.669
LIG_SH2_CRK	733	737	PF00017	0.564
LIG_SH2_GRB2like	325	328	PF00017	0.683
LIG_SH2_NCK_1	463	467	PF00017	0.663
LIG_SH2_NCK_1	733	737	PF00017	0.607
LIG_SH2_SRC	19	22	PF00017	0.591
LIG_SH2_SRC	733	736	PF00017	0.543
LIG_SH2_STAP1	246	250	PF00017	0.593
LIG_SH2_STAT3	856	859	PF00017	0.635
LIG_SH2_STAT5	246	249	PF00017	0.570
LIG_SH2_STAT5	457	460	PF00017	0.620
LIG_SH3_1	79	85	PF00018	0.701
LIG_SH3_2	82	87	PF14604	0.702
LIG_SH3_3	163	169	PF00018	0.619
LIG_SH3_3	260	266	PF00018	0.607
LIG_SH3_3	448	454	PF00018	0.584
LIG_SH3_3	476	482	PF00018	0.633
LIG_SH3_3	549	555	PF00018	0.630
LIG_SH3_3	571	577	PF00018	0.627
LIG_SH3_3	623	629	PF00018	0.598
LIG_SH3_3	772	778	PF00018	0.617
LIG_SH3_3	79	85	PF00018	0.675
LIG_SH3_3	816	822	PF00018	0.597
LIG_SUMO_SIM_anti_2	697	702	PF11976	0.545
LIG_SUMO_SIM_par_1	341	349	PF11976	0.607
LIG_SUMO_SIM_par_1	697	702	PF11976	0.586
LIG_UBA3_1	1	8	PF00899	0.675
LIG_WW_3	773	777	PF00397	0.612
MOD_CDK_SPK_2	372	377	PF00069	0.647
MOD_CDK_SPK_2	450	455	PF00069	0.658
MOD_CDK_SPK_2	482	487	PF00069	0.626
MOD_CDK_SPK_2	789	794	PF00069	0.568
MOD_CDK_SPxK_1	540	546	PF00069	0.607
MOD_CDK_SPxK_1	602	608	PF00069	0.551
MOD_CDK_SPxxK_3	540	547	PF00069	0.677
MOD_CDK_SPxxK_3	72	79	PF00069	0.655
MOD_CK1_1	105	111	PF00069	0.618
MOD_CK1_1	136	142	PF00069	0.608
MOD_CK1_1	148	154	PF00069	0.648
MOD_CK1_1	159	165	PF00069	0.784
MOD_CK1_1	204	210	PF00069	0.665
MOD_CK1_1	221	227	PF00069	0.589
MOD_CK1_1	265	271	PF00069	0.799
MOD_CK1_1	317	323	PF00069	0.770
MOD_CK1_1	367	373	PF00069	0.678
MOD_CK1_1	38	44	PF00069	0.793
MOD_CK1_1	389	395	PF00069	0.547
MOD_CK1_1	413	419	PF00069	0.650
MOD_CK1_1	537	543	PF00069	0.601
MOD_CK1_1	557	563	PF00069	0.557
MOD_CK1_1	646	652	PF00069	0.550
MOD_CK2_1	135	141	PF00069	0.597
MOD_CK2_1	533	539	PF00069	0.558
MOD_GlcNHglycan	10	13	PF01048	0.633
MOD_GlcNHglycan	104	107	PF01048	0.744
MOD_GlcNHglycan	138	141	PF01048	0.670
MOD_GlcNHglycan	146	150	PF01048	0.587
MOD_GlcNHglycan	193	196	PF01048	0.695
MOD_GlcNHglycan	223	226	PF01048	0.648
MOD_GlcNHglycan	281	284	PF01048	0.689
MOD_GlcNHglycan	285	288	PF01048	0.747
MOD_GlcNHglycan	305	308	PF01048	0.555
MOD_GlcNHglycan	366	369	PF01048	0.755
MOD_GlcNHglycan	37	40	PF01048	0.549
MOD_GlcNHglycan	417	420	PF01048	0.672
MOD_GlcNHglycan	422	425	PF01048	0.693
MOD_GlcNHglycan	428	431	PF01048	0.798
MOD_GlcNHglycan	504	507	PF01048	0.698
MOD_GlcNHglycan	521	524	PF01048	0.495
MOD_GlcNHglycan	529	532	PF01048	0.620
MOD_GlcNHglycan	539	542	PF01048	0.512
MOD_GlcNHglycan	559	562	PF01048	0.705
MOD_GlcNHglycan	596	599	PF01048	0.699
MOD_GlcNHglycan	600	603	PF01048	0.659
MOD_GlcNHglycan	626	629	PF01048	0.614
MOD_GlcNHglycan	722	725	PF01048	0.440
MOD_GlcNHglycan	99	102	PF01048	0.697
MOD_GSK3_1	141	148	PF00069	0.693
MOD_GSK3_1	191	198	PF00069	0.626
MOD_GSK3_1	200	207	PF00069	0.683
MOD_GSK3_1	214	221	PF00069	0.567
MOD_GSK3_1	240	247	PF00069	0.598
MOD_GSK3_1	279	286	PF00069	0.761
MOD_GSK3_1	289	296	PF00069	0.636
MOD_GSK3_1	299	306	PF00069	0.494
MOD_GSK3_1	335	342	PF00069	0.628
MOD_GSK3_1	34	41	PF00069	0.615
MOD_GSK3_1	344	351	PF00069	0.630
MOD_GSK3_1	367	374	PF00069	0.636
MOD_GSK3_1	389	396	PF00069	0.612
MOD_GSK3_1	4	11	PF00069	0.629
MOD_GSK3_1	42	49	PF00069	0.633
MOD_GSK3_1	470	477	PF00069	0.745
MOD_GSK3_1	494	501	PF00069	0.621
MOD_GSK3_1	502	509	PF00069	0.651
MOD_GSK3_1	533	540	PF00069	0.633
MOD_GSK3_1	582	589	PF00069	0.647
MOD_GSK3_1	594	601	PF00069	0.566
MOD_GSK3_1	602	609	PF00069	0.509
MOD_GSK3_1	624	631	PF00069	0.657
MOD_GSK3_1	642	649	PF00069	0.495
MOD_GSK3_1	660	667	PF00069	0.562
MOD_GSK3_1	97	104	PF00069	0.671
MOD_LATS_1	442	448	PF00433	0.652
MOD_N-GLC_1	133	138	PF02516	0.633
MOD_N-GLC_1	278	283	PF02516	0.647
MOD_N-GLC_1	393	398	PF02516	0.613
MOD_N-GLC_1	42	47	PF02516	0.732
MOD_N-GLC_1	445	450	PF02516	0.613
MOD_N-GLC_1	474	479	PF02516	0.609
MOD_N-GLC_1	502	507	PF02516	0.636
MOD_N-GLC_1	557	562	PF02516	0.700
MOD_N-GLC_1	88	93	PF02516	0.786
MOD_N-GLC_1	97	102	PF02516	0.629
MOD_NEK2_1	34	39	PF00069	0.622
MOD_NEK2_1	680	685	PF00069	0.482
MOD_NEK2_1	699	704	PF00069	0.575
MOD_NEK2_2	386	391	PF00069	0.603
MOD_PIKK_1	398	404	PF00454	0.644
MOD_PIKK_1	643	649	PF00454	0.539
MOD_PK_1	314	320	PF00069	0.640
MOD_PKA_1	179	185	PF00069	0.639
MOD_PKA_1	83	89	PF00069	0.706
MOD_PKA_2	156	162	PF00069	0.783
MOD_PKA_2	279	285	PF00069	0.569
MOD_PKA_2	364	370	PF00069	0.710
MOD_PKA_2	426	432	PF00069	0.825
MOD_PKB_1	303	311	PF00069	0.657
MOD_Plk_1	145	151	PF00069	0.694
MOD_Plk_1	474	480	PF00069	0.606
MOD_Plk_2-3	823	829	PF00069	0.488
MOD_ProDKin_1	106	112	PF00069	0.514
MOD_ProDKin_1	201	207	PF00069	0.792
MOD_ProDKin_1	262	268	PF00069	0.619
MOD_ProDKin_1	372	378	PF00069	0.649
MOD_ProDKin_1	38	44	PF00069	0.610
MOD_ProDKin_1	418	424	PF00069	0.652
MOD_ProDKin_1	445	451	PF00069	0.653
MOD_ProDKin_1	465	471	PF00069	0.469
MOD_ProDKin_1	482	488	PF00069	0.497
MOD_ProDKin_1	506	512	PF00069	0.704
MOD_ProDKin_1	540	546	PF00069	0.619
MOD_ProDKin_1	600	606	PF00069	0.595
MOD_ProDKin_1	628	634	PF00069	0.695
MOD_ProDKin_1	658	664	PF00069	0.657
MOD_ProDKin_1	72	78	PF00069	0.671
MOD_ProDKin_1	789	795	PF00069	0.563
MOD_ProDKin_1	818	824	PF00069	0.524
MOD_ProDKin_1	861	867	PF00069	0.689
MOD_ProDKin_1	88	94	PF00069	0.789
MOD_SUMO_for_1	355	358	PF00179	0.612
TRG_DiLeu_BaEn_2	830	836	PF01217	0.484
TRG_DiLeu_BaEn_4	357	363	PF01217	0.683
TRG_ENDOCYTIC_2	24	27	PF00928	0.583
TRG_ENDOCYTIC_2	61	64	PF00928	0.612
TRG_ENDOCYTIC_2	733	736	PF00928	0.555
TRG_ER_diArg_1	360	362	PF00400	0.622
TRG_ER_diArg_1	637	639	PF00400	0.631
TRG_ER_diArg_1	762	765	PF00400	0.534
TRG_ER_diArg_1	783	786	PF00400	0.622
TRG_ER_diArg_1	787	789	PF00400	0.579
TRG_ER_diArg_1	845	848	PF00400	0.545
TRG_NES_CRM1_1	750	761	PF08389	0.456
TRG_NLS_MonoExtC_3	177	183	PF00514	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V0	Leptomonas seymouri	34%	100%
A4HYU5	Leishmania infantum	99%	100%
E9AIP3	Leishmania braziliensis	71%	98%
E9AUP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCU2	Leishmania major	92%	100%