Enkuring domain-containig protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enkuring domain-containig protein

Species:

Leishmania donovani

UniProt:

A0A3S5H782_LEIDO

TriTrypDb:

LdBPK_200300.1 , LdCL_200007800 , LDHU3_20.0330

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H782

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H782

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.550
CLV_NRD_NRD_1	220	222	PF00675	0.488
CLV_NRD_NRD_1	230	232	PF00675	0.486
CLV_NRD_NRD_1	291	293	PF00675	0.356
CLV_NRD_NRD_1	312	314	PF00675	0.320
CLV_PCSK_FUR_1	243	247	PF00082	0.384
CLV_PCSK_KEX2_1	219	221	PF00082	0.492
CLV_PCSK_KEX2_1	245	247	PF00082	0.366
CLV_PCSK_KEX2_1	290	292	PF00082	0.404
CLV_PCSK_KEX2_1	314	316	PF00082	0.272
CLV_PCSK_KEX2_1	9	11	PF00082	0.503
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.511
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.384
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.314
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.503
CLV_PCSK_SKI1_1	199	203	PF00082	0.557
CLV_PCSK_SKI1_1	335	339	PF00082	0.442
CLV_PCSK_SKI1_1	73	77	PF00082	0.496
CLV_PCSK_SKI1_1	94	98	PF00082	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.514
DOC_ANK_TNKS_1	77	84	PF00023	0.505
DOC_MAPK_gen_1	331	340	PF00069	0.253
DOC_MAPK_MEF2A_6	321	330	PF00069	0.292
DOC_USP7_MATH_1	160	164	PF00917	0.572
DOC_USP7_MATH_1	170	174	PF00917	0.510
DOC_USP7_MATH_1	239	243	PF00917	0.307
DOC_USP7_MATH_1	363	367	PF00917	0.536
DOC_USP7_UBL2_3	113	117	PF12436	0.485
DOC_USP7_UBL2_3	32	36	PF12436	0.704
DOC_USP7_UBL2_3	357	361	PF12436	0.512
DOC_USP7_UBL2_3	94	98	PF12436	0.477
DOC_WW_Pin1_4	121	126	PF00397	0.566
DOC_WW_Pin1_4	234	239	PF00397	0.300
DOC_WW_Pin1_4	36	41	PF00397	0.694
LIG_14-3-3_CanoR_1	231	235	PF00244	0.478
LIG_14-3-3_CanoR_1	313	323	PF00244	0.320
LIG_Actin_WH2_2	83	99	PF00022	0.503
LIG_APCC_ABBA_1	338	343	PF00400	0.374
LIG_BRCT_BRCA1_1	122	126	PF00533	0.705
LIG_BRCT_BRCA1_1	57	61	PF00533	0.513
LIG_BRCT_BRCA1_2	57	63	PF00533	0.512
LIG_FHA_1	205	211	PF00498	0.357
LIG_FHA_2	315	321	PF00498	0.423
LIG_FHA_2	57	63	PF00498	0.538
LIG_Integrin_RGD_1	188	190	PF01839	0.487
LIG_LIR_Apic_2	112	118	PF02991	0.527
LIG_LIR_Gen_1	56	61	PF02991	0.615
LIG_LIR_Nem_3	18	24	PF02991	0.530
LIG_LIR_Nem_3	38	44	PF02991	0.705
LIG_LIR_Nem_3	56	60	PF02991	0.573
LIG_MAD2	32	40	PF02301	0.430
LIG_MLH1_MIPbox_1	57	61	PF16413	0.513
LIG_REV1ctd_RIR_1	58	67	PF16727	0.493
LIG_REV1ctd_RIR_1	72	82	PF16727	0.628
LIG_SH2_CRK	115	119	PF00017	0.625
LIG_SH2_CRK	41	45	PF00017	0.567
LIG_SH2_PTP2	104	107	PF00017	0.476
LIG_SH2_PTP2	273	276	PF00017	0.432
LIG_SH2_STAP1	24	28	PF00017	0.484
LIG_SH2_STAP1	45	49	PF00017	0.530
LIG_SH2_STAP1	57	61	PF00017	0.480
LIG_SH2_STAT3	298	301	PF00017	0.270
LIG_SH2_STAT5	104	107	PF00017	0.599
LIG_SH2_STAT5	273	276	PF00017	0.392
LIG_SH2_STAT5	41	44	PF00017	0.537
LIG_SH2_STAT5	95	98	PF00017	0.608
LIG_SH3_3	49	55	PF00018	0.581
LIG_SH3_3	5	11	PF00018	0.437
LIG_SUMO_SIM_par_1	207	214	PF11976	0.545
LIG_TRAF2_1	109	112	PF00917	0.538
LIG_TRAF2_1	257	260	PF00917	0.349
LIG_TRAF2_1	278	281	PF00917	0.394
LIG_UBA3_1	20	26	PF00899	0.534
LIG_WRC_WIRS_1	57	62	PF05994	0.497
MOD_CK1_1	16	22	PF00069	0.560
MOD_CK1_1	230	236	PF00069	0.532
MOD_CK1_1	306	312	PF00069	0.349
MOD_CK1_1	39	45	PF00069	0.637
MOD_CK1_1	56	62	PF00069	0.443
MOD_CK2_1	230	236	PF00069	0.518
MOD_CK2_1	24	30	PF00069	0.532
MOD_CK2_1	254	260	PF00069	0.349
MOD_CK2_1	314	320	PF00069	0.311
MOD_CK2_1	32	38	PF00069	0.500
MOD_CK2_1	56	62	PF00069	0.539
MOD_GlcNHglycan	131	134	PF01048	0.646
MOD_GlcNHglycan	136	139	PF01048	0.600
MOD_GlcNHglycan	15	18	PF01048	0.524
MOD_GlcNHglycan	162	165	PF01048	0.729
MOD_GlcNHglycan	166	170	PF01048	0.728
MOD_GlcNHglycan	172	175	PF01048	0.700
MOD_GlcNHglycan	183	186	PF01048	0.537
MOD_GlcNHglycan	26	29	PF01048	0.673
MOD_GSK3_1	120	127	PF00069	0.724
MOD_GSK3_1	195	202	PF00069	0.613
MOD_GSK3_1	226	233	PF00069	0.488
MOD_GSK3_1	32	39	PF00069	0.612
MOD_N-GLC_1	121	126	PF02516	0.596
MOD_N-GLC_1	154	159	PF02516	0.614
MOD_NEK2_1	205	210	PF00069	0.419
MOD_NEK2_1	254	259	PF00069	0.292
MOD_NEK2_1	285	290	PF00069	0.292
MOD_NEK2_1	319	324	PF00069	0.308
MOD_PIKK_1	124	130	PF00454	0.649
MOD_PKA_1	314	320	PF00069	0.311
MOD_PKA_2	230	236	PF00069	0.487
MOD_PKA_2	314	320	PF00069	0.325
MOD_Plk_1	319	325	PF00069	0.290
MOD_Plk_4	16	22	PF00069	0.544
MOD_Plk_4	56	62	PF00069	0.523
MOD_ProDKin_1	121	127	PF00069	0.571
MOD_ProDKin_1	234	240	PF00069	0.300
MOD_ProDKin_1	36	42	PF00069	0.694
MOD_SUMO_for_1	244	247	PF00179	0.289
MOD_SUMO_rev_2	247	254	PF00179	0.438
MOD_SUMO_rev_2	256	263	PF00179	0.374
MOD_SUMO_rev_2	27	34	PF00179	0.551
TRG_DiLeu_BaEn_1	281	286	PF01217	0.289
TRG_DiLeu_BaEn_2	249	255	PF01217	0.292
TRG_ENDOCYTIC_2	273	276	PF00928	0.432
TRG_ENDOCYTIC_2	41	44	PF00928	0.686
TRG_ENDOCYTIC_2	57	60	PF00928	0.504
TRG_ER_diArg_1	289	292	PF00400	0.348
TRG_ER_diArg_1	312	315	PF00400	0.305
TRG_NES_CRM1_1	295	308	PF08389	0.215
TRG_NLS_MonoCore_2	218	223	PF00514	0.510
TRG_NLS_MonoCore_2	312	317	PF00514	0.404
TRG_NLS_MonoExtC_3	312	318	PF00514	0.404
TRG_NLS_MonoExtN_4	218	223	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA5	Leptomonas seymouri	55%	100%
A0A1X0NWL2	Trypanosomatidae	38%	96%
A0A3R7MDK6	Trypanosoma rangeli	38%	93%
A4HYL9	Leishmania infantum	99%	100%
C9ZHT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AI83	Leishmania braziliensis	77%	100%
E9AUG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD16	Leishmania major	92%	100%
V5DS69	Trypanosoma cruzi	38%	93%