Kelch_domain-containing_protein/GeneDB:LmjF.20.02 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kelch domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3S5H781_LEIDO

TriTrypDb:

LdBPK_200230.1 , LdCL_200007100 , LDHU3_20.0240

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H781

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H781

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.591
CLV_NRD_NRD_1	147	149	PF00675	0.407
CLV_NRD_NRD_1	312	314	PF00675	0.485
CLV_NRD_NRD_1	76	78	PF00675	0.459
CLV_NRD_NRD_1	79	81	PF00675	0.449
CLV_PCSK_KEX2_1	147	149	PF00082	0.407
CLV_PCSK_KEX2_1	76	78	PF00082	0.459
CLV_PCSK_SKI1_1	12	16	PF00082	0.700
CLV_PCSK_SKI1_1	408	412	PF00082	0.566
DEG_MDM2_SWIB_1	297	305	PF02201	0.464
DOC_CKS1_1	163	168	PF01111	0.576
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.499
DOC_MAPK_gen_1	49	56	PF00069	0.445
DOC_PP2B_LxvP_1	350	353	PF13499	0.533
DOC_PP4_FxxP_1	361	364	PF00568	0.489
DOC_PP4_MxPP_1	35	38	PF00568	0.529
DOC_PP4_MxPP_1	88	91	PF00568	0.569
DOC_USP7_MATH_1	2	6	PF00917	0.730
DOC_USP7_MATH_1	288	292	PF00917	0.574
DOC_USP7_MATH_1	334	338	PF00917	0.437
DOC_USP7_MATH_1	83	87	PF00917	0.563
DOC_USP7_MATH_1	94	98	PF00917	0.426
DOC_WW_Pin1_4	111	116	PF00397	0.426
DOC_WW_Pin1_4	137	142	PF00397	0.556
DOC_WW_Pin1_4	162	167	PF00397	0.554
DOC_WW_Pin1_4	230	235	PF00397	0.380
LIG_14-3-3_CanoR_1	130	134	PF00244	0.478
LIG_14-3-3_CanoR_1	250	255	PF00244	0.453
LIG_14-3-3_CanoR_1	269	275	PF00244	0.242
LIG_14-3-3_CanoR_1	335	339	PF00244	0.470
LIG_14-3-3_CanoR_1	374	381	PF00244	0.575
LIG_BRCT_BRCA1_1	293	297	PF00533	0.535
LIG_BRCT_BRCA1_1	335	339	PF00533	0.419
LIG_eIF4E_1	48	54	PF01652	0.321
LIG_FHA_1	200	206	PF00498	0.391
LIG_FHA_1	389	395	PF00498	0.637
LIG_FHA_2	163	169	PF00498	0.571
LIG_FHA_2	195	201	PF00498	0.663
LIG_LIR_Apic_2	359	364	PF02991	0.457
LIG_LIR_Gen_1	128	139	PF02991	0.418
LIG_LIR_Gen_1	181	192	PF02991	0.427
LIG_LIR_Gen_1	278	288	PF02991	0.452
LIG_LIR_Gen_1	294	305	PF02991	0.331
LIG_LIR_Gen_1	50	56	PF02991	0.340
LIG_LIR_Nem_3	128	134	PF02991	0.403
LIG_LIR_Nem_3	15	21	PF02991	0.564
LIG_LIR_Nem_3	181	187	PF02991	0.410
LIG_LIR_Nem_3	253	257	PF02991	0.312
LIG_LIR_Nem_3	278	283	PF02991	0.465
LIG_LIR_Nem_3	294	300	PF02991	0.297
LIG_LIR_Nem_3	311	315	PF02991	0.486
LIG_LIR_Nem_3	50	55	PF02991	0.340
LIG_LYPXL_SIV_4	330	338	PF13949	0.425
LIG_MLH1_MIPbox_1	293	297	PF16413	0.535
LIG_Pex14_2	16	20	PF04695	0.680
LIG_Pex14_2	297	301	PF04695	0.366
LIG_PTB_Apo_2	239	246	PF02174	0.321
LIG_PTB_Apo_2	63	70	PF02174	0.340
LIG_PTB_Phospho_1	63	69	PF10480	0.318
LIG_SH2_GRB2like	240	243	PF00017	0.340
LIG_SH2_PTP2	280	283	PF00017	0.440
LIG_SH2_SRC	118	121	PF00017	0.379
LIG_SH2_SRC	240	243	PF00017	0.355
LIG_SH2_STAP1	118	122	PF00017	0.399
LIG_SH2_STAP1	270	274	PF00017	0.334
LIG_SH2_STAP1	356	360	PF00017	0.342
LIG_SH2_STAT3	107	110	PF00017	0.363
LIG_SH2_STAT3	367	370	PF00017	0.642
LIG_SH2_STAT5	160	163	PF00017	0.367
LIG_SH2_STAT5	176	179	PF00017	0.349
LIG_SH2_STAT5	220	223	PF00017	0.314
LIG_SH2_STAT5	240	243	PF00017	0.453
LIG_SH2_STAT5	280	283	PF00017	0.387
LIG_SH2_STAT5	296	299	PF00017	0.317
LIG_SH2_STAT5	331	334	PF00017	0.374
LIG_SH2_STAT5	52	55	PF00017	0.369
LIG_SH2_STAT5	69	72	PF00017	0.177
LIG_SH3_1	258	264	PF00018	0.557
LIG_SH3_3	138	144	PF00018	0.469
LIG_SH3_3	163	169	PF00018	0.585
LIG_SH3_3	258	264	PF00018	0.478
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.335
LIG_SUMO_SIM_par_1	119	125	PF11976	0.428
LIG_TRAF2_1	410	413	PF00917	0.621
LIG_TYR_ITIM	116	121	PF00017	0.426
LIG_TYR_ITIM	174	179	PF00017	0.500
LIG_WW_3	89	93	PF00397	0.453
MOD_CK1_1	212	218	PF00069	0.397
MOD_CK1_1	27	33	PF00069	0.621
MOD_CK1_1	291	297	PF00069	0.577
MOD_CK1_1	324	330	PF00069	0.345
MOD_CK1_1	393	399	PF00069	0.689
MOD_CK2_1	162	168	PF00069	0.486
MOD_CK2_1	240	246	PF00069	0.364
MOD_CK2_1	393	399	PF00069	0.661
MOD_GlcNHglycan	211	214	PF01048	0.327
MOD_GlcNHglycan	24	27	PF01048	0.647
MOD_GlcNHglycan	323	326	PF01048	0.354
MOD_GlcNHglycan	367	370	PF01048	0.645
MOD_GlcNHglycan	96	99	PF01048	0.303
MOD_GSK3_1	125	132	PF00069	0.375
MOD_GSK3_1	195	202	PF00069	0.650
MOD_GSK3_1	208	215	PF00069	0.393
MOD_GSK3_1	246	253	PF00069	0.439
MOD_GSK3_1	291	298	PF00069	0.535
MOD_GSK3_1	329	336	PF00069	0.401
MOD_GSK3_1	365	372	PF00069	0.538
MOD_GSK3_1	72	79	PF00069	0.340
MOD_N-GLC_1	288	293	PF02516	0.582
MOD_NEK2_1	365	370	PF00069	0.500
MOD_NEK2_1	373	378	PF00069	0.528
MOD_NEK2_1	93	98	PF00069	0.376
MOD_NEK2_2	240	245	PF00069	0.321
MOD_NEK2_2	334	339	PF00069	0.405
MOD_NEK2_2	369	374	PF00069	0.619
MOD_PKA_1	76	82	PF00069	0.459
MOD_PKA_2	129	135	PF00069	0.489
MOD_PKA_2	27	33	PF00069	0.685
MOD_PKA_2	334	340	PF00069	0.416
MOD_PKA_2	373	379	PF00069	0.588
MOD_PKA_2	388	394	PF00069	0.603
MOD_PKA_2	76	82	PF00069	0.391
MOD_Plk_1	12	18	PF00069	0.696
MOD_Plk_1	291	297	PF00069	0.519
MOD_Plk_1	348	354	PF00069	0.527
MOD_Plk_4	187	193	PF00069	0.569
MOD_Plk_4	200	206	PF00069	0.472
MOD_Plk_4	240	246	PF00069	0.333
MOD_Plk_4	27	33	PF00069	0.603
MOD_Plk_4	291	297	PF00069	0.560
MOD_Plk_4	334	340	PF00069	0.384
MOD_Plk_4	41	47	PF00069	0.284
MOD_ProDKin_1	111	117	PF00069	0.426
MOD_ProDKin_1	137	143	PF00069	0.548
MOD_ProDKin_1	162	168	PF00069	0.568
MOD_ProDKin_1	230	236	PF00069	0.380
TRG_ENDOCYTIC_2	118	121	PF00928	0.376
TRG_ENDOCYTIC_2	160	163	PF00928	0.353
TRG_ENDOCYTIC_2	176	179	PF00928	0.335
TRG_ENDOCYTIC_2	280	283	PF00928	0.399
TRG_ENDOCYTIC_2	52	55	PF00928	0.424
TRG_ER_diArg_1	147	149	PF00400	0.408
TRG_ER_diArg_1	76	78	PF00400	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I272	Leptomonas seymouri	50%	100%
A0A0S4JFE6	Bodo saltans	34%	100%
A0A0S4KG66	Bodo saltans	24%	72%
A0A1X0NVZ5	Trypanosomatidae	23%	100%
A0A1X0NY29	Trypanosomatidae	41%	100%
A0A422NEH9	Trypanosoma rangeli	42%	100%
A0A422NWK7	Trypanosoma rangeli	23%	100%
A4HYL2	Leishmania infantum	100%	100%
C9ZHV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AI75	Leishmania braziliensis	83%	100%
E9AUG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q0IIC2	Bos taurus	24%	94%
Q10AZ7	Oryza sativa subsp. japonica	23%	83%
Q4QD23	Leishmania major	94%	100%
Q5U3Y0	Rattus norvegicus	23%	100%
Q6AYI2	Rattus norvegicus	26%	100%
Q6PAR0	Mus musculus	24%	95%
Q6PID8	Homo sapiens	24%	94%
Q8VEM9	Mus musculus	26%	100%
Q9BQ90	Homo sapiens	26%	100%
V5BAH1	Trypanosoma cruzi	23%	100%
V5DS74	Trypanosoma cruzi	43%	100%