Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H778_LEIDO

TriTrypDb:

LdBPK_200080.1 , LdCL_200005700 , LDHU3_20.0090

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H778

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H778

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.255
CLV_NRD_NRD_1	124	126	PF00675	0.334
CLV_NRD_NRD_1	96	98	PF00675	0.335
CLV_PCSK_FUR_1	94	98	PF00082	0.344
CLV_PCSK_KEX2_1	108	110	PF00082	0.318
CLV_PCSK_KEX2_1	122	124	PF00082	0.292
CLV_PCSK_KEX2_1	22	24	PF00082	0.453
CLV_PCSK_KEX2_1	96	98	PF00082	0.334
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.339
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.256
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.540
CLV_PCSK_PC7_1	104	110	PF00082	0.365
CLV_PCSK_SKI1_1	108	112	PF00082	0.433
CLV_PCSK_SKI1_1	138	142	PF00082	0.427
DEG_APCC_DBOX_1	4	12	PF00400	0.611
DOC_CYCLIN_RxL_1	104	112	PF00134	0.433
DOC_CYCLIN_RxL_1	135	143	PF00134	0.433
DOC_MAPK_gen_1	94	103	PF00069	0.355
DOC_MAPK_MEF2A_6	147	154	PF00069	0.387
DOC_PP4_FxxP_1	192	195	PF00568	0.301
DOC_USP7_MATH_1	114	118	PF00917	0.324
DOC_USP7_MATH_1	38	42	PF00917	0.531
DOC_WW_Pin1_4	191	196	PF00397	0.438
DOC_WW_Pin1_4	3	8	PF00397	0.654
LIG_14-3-3_CanoR_1	138	143	PF00244	0.425
LIG_14-3-3_CanoR_1	147	153	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	86	90	PF00533	0.433
LIG_FHA_1	170	176	PF00498	0.393
LIG_FHA_1	180	186	PF00498	0.447
LIG_FHA_1	195	201	PF00498	0.150
LIG_FHA_2	43	49	PF00498	0.472
LIG_FHA_2	50	56	PF00498	0.438
LIG_LIR_Gen_1	133	144	PF02991	0.433
LIG_LIR_Gen_1	157	167	PF02991	0.387
LIG_LIR_Gen_1	45	51	PF02991	0.452
LIG_LIR_Nem_3	133	139	PF02991	0.433
LIG_LIR_Nem_3	157	162	PF02991	0.387
LIG_LIR_Nem_3	197	202	PF02991	0.408
LIG_LIR_Nem_3	45	50	PF02991	0.446
LIG_NRBOX	141	147	PF00104	0.433
LIG_NRBOX	87	93	PF00104	0.433
LIG_SH2_CRK	136	140	PF00017	0.433
LIG_SH2_CRK	159	163	PF00017	0.330
LIG_SH2_NCK_1	170	174	PF00017	0.433
LIG_SH2_PTP2	149	152	PF00017	0.433
LIG_SH2_PTP2	199	202	PF00017	0.426
LIG_SH2_STAP1	136	140	PF00017	0.433
LIG_SH2_STAT5	144	147	PF00017	0.310
LIG_SH2_STAT5	149	152	PF00017	0.310
LIG_SH2_STAT5	199	202	PF00017	0.426
LIG_SH3_3	147	153	PF00018	0.389
LIG_SH3_3	31	37	PF00018	0.477
LIG_SH3_3	8	14	PF00018	0.533
LIG_SUMO_SIM_par_1	138	143	PF11976	0.433
MOD_CK1_1	16	22	PF00069	0.511
MOD_CK1_1	169	175	PF00069	0.431
MOD_CK1_1	194	200	PF00069	0.459
MOD_CK1_1	3	9	PF00069	0.627
MOD_CK1_1	42	48	PF00069	0.488
MOD_GlcNHglycan	116	119	PF01048	0.352
MOD_GlcNHglycan	163	166	PF01048	0.429
MOD_GlcNHglycan	186	189	PF01048	0.452
MOD_GlcNHglycan	41	44	PF01048	0.561
MOD_GlcNHglycan	63	66	PF01048	0.543
MOD_GSK3_1	109	116	PF00069	0.431
MOD_GSK3_1	13	20	PF00069	0.539
MOD_GSK3_1	38	45	PF00069	0.547
MOD_GSK3_1	82	89	PF00069	0.311
MOD_N-GLC_1	179	184	PF02516	0.433
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	148	153	PF00069	0.393
MOD_NEK2_1	17	22	PF00069	0.501
MOD_NEK2_1	49	54	PF00069	0.464
MOD_NEK2_1	61	66	PF00069	0.515
MOD_NEK2_1	82	87	PF00069	0.380
MOD_PKA_2	114	120	PF00069	0.393
MOD_PKA_2	32	38	PF00069	0.549
MOD_Plk_1	179	185	PF00069	0.425
MOD_Plk_4	13	19	PF00069	0.528
MOD_Plk_4	42	48	PF00069	0.461
MOD_Plk_4	86	92	PF00069	0.357
MOD_ProDKin_1	191	197	PF00069	0.438
MOD_ProDKin_1	3	9	PF00069	0.653
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.433
TRG_ENDOCYTIC_2	136	139	PF00928	0.433
TRG_ENDOCYTIC_2	149	152	PF00928	0.370
TRG_ENDOCYTIC_2	159	162	PF00928	0.281
TRG_ENDOCYTIC_2	199	202	PF00928	0.426
TRG_ENDOCYTIC_2	47	50	PF00928	0.472
TRG_ER_diArg_1	123	125	PF00400	0.359
TRG_ER_diArg_1	96	98	PF00400	0.334
TRG_NES_CRM1_1	143	157	PF08389	0.387
TRG_NLS_Bipartite_1	108	126	PF00514	0.433
TRG_NLS_MonoCore_2	121	126	PF00514	0.330
TRG_NLS_MonoExtC_3	121	127	PF00514	0.310
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX14	Leptomonas seymouri	74%	100%
A0A0S4IPP5	Bodo saltans	24%	99%
A0A1X0NWK9	Trypanosomatidae	35%	100%
A0A3R7K4I3	Trypanosoma rangeli	37%	100%
A4HBH6	Leishmania braziliensis	86%	100%
A4HYK0	Leishmania infantum	100%	100%
C9ZHU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AUE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD37	Leishmania major	95%	100%