Eukaryotic translation initiation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-2

Species:

Leishmania donovani

UniProt:

A0A3S5H774_LEIDO

TriTrypDb:

LdBPK_191520.1 , LdCL_190021000 , LDHU3_19.1850

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H774

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H774

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1
GO:0000342	RNA cap 4 binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.725
CLV_NRD_NRD_1	190	192	PF00675	0.295
CLV_NRD_NRD_1	5	7	PF00675	0.457
CLV_NRD_NRD_1	83	85	PF00675	0.257
CLV_NRD_NRD_1	97	99	PF00675	0.208
CLV_PCSK_KEX2_1	5	7	PF00082	0.457
CLV_PCSK_KEX2_1	97	99	PF00082	0.285
CLV_Separin_Metazoa	217	221	PF03568	0.679
DEG_Nend_UBRbox_2	1	3	PF02207	0.702
DOC_CYCLIN_RxL_1	189	200	PF00134	0.498
DOC_MAPK_gen_1	267	276	PF00069	0.537
DOC_MAPK_gen_1	97	106	PF00069	0.463
DOC_MAPK_MEF2A_6	267	276	PF00069	0.566
DOC_USP7_MATH_1	76	80	PF00917	0.537
DOC_WW_Pin1_4	218	223	PF00397	0.753
LIG_14-3-3_CanoR_1	152	157	PF00244	0.508
LIG_14-3-3_CanoR_1	267	273	PF00244	0.560
LIG_deltaCOP1_diTrp_1	167	173	PF00928	0.463
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.537
LIG_FHA_1	124	130	PF00498	0.518
LIG_FHA_1	160	166	PF00498	0.548
LIG_FHA_1	269	275	PF00498	0.528
LIG_FHA_1	41	47	PF00498	0.501
LIG_FHA_2	201	207	PF00498	0.642
LIG_FHA_2	212	218	PF00498	0.648
LIG_FHA_2	9	15	PF00498	0.602
LIG_GBD_Chelix_1	186	194	PF00786	0.337
LIG_LIR_Gen_1	121	132	PF02991	0.463
LIG_LIR_Gen_1	26	32	PF02991	0.451
LIG_LIR_Nem_3	121	127	PF02991	0.463
LIG_LIR_Nem_3	59	65	PF02991	0.451
LIG_LIR_Nem_3	79	83	PF02991	0.320
LIG_PCNA_yPIPBox_3	180	190	PF02747	0.478
LIG_PDZ_Class_3	276	281	PF00595	0.627
LIG_Pex14_1	102	106	PF04695	0.451
LIG_Pex14_2	61	65	PF04695	0.537
LIG_SH2_STAP1	270	274	PF00017	0.517
LIG_SH2_STAT5	189	192	PF00017	0.558
LIG_SH2_STAT5	242	245	PF00017	0.349
LIG_SH2_STAT5	270	273	PF00017	0.520
LIG_SH2_STAT5	81	84	PF00017	0.492
LIG_SH3_2	219	224	PF14604	0.743
LIG_SH3_3	113	119	PF00018	0.333
LIG_SH3_3	216	222	PF00018	0.774
LIG_SUMO_SIM_par_1	270	275	PF11976	0.555
LIG_TRAF2_1	251	254	PF00917	0.481
MOD_CDC14_SPxK_1	221	224	PF00782	0.739
MOD_CDK_SPxK_1	218	224	PF00069	0.744
MOD_CDK_SPxxK_3	222	229	PF00069	0.747
MOD_CK1_1	10	16	PF00069	0.611
MOD_CK1_1	110	116	PF00069	0.522
MOD_CK1_1	163	169	PF00069	0.484
MOD_CK1_1	200	206	PF00069	0.689
MOD_CK1_1	235	241	PF00069	0.579
MOD_CK2_1	211	217	PF00069	0.778
MOD_CMANNOS	22	25	PF00535	0.251
MOD_GlcNHglycan	129	132	PF01048	0.323
MOD_GlcNHglycan	157	160	PF01048	0.327
MOD_GlcNHglycan	175	178	PF01048	0.295
MOD_GlcNHglycan	208	211	PF01048	0.755
MOD_GlcNHglycan	237	240	PF01048	0.535
MOD_GlcNHglycan	56	59	PF01048	0.312
MOD_GSK3_1	123	130	PF00069	0.506
MOD_GSK3_1	155	162	PF00069	0.508
MOD_GSK3_1	197	204	PF00069	0.727
MOD_GSK3_1	218	225	PF00069	0.793
MOD_GSK3_1	227	234	PF00069	0.624
MOD_GSK3_1	65	72	PF00069	0.451
MOD_N-GLC_1	211	216	PF02516	0.559
MOD_N-GLC_1	65	70	PF02516	0.324
MOD_N-GLC_1	76	81	PF02516	0.290
MOD_NEK2_1	127	132	PF00069	0.537
MOD_NEK2_1	65	70	PF00069	0.537
MOD_PIKK_1	179	185	PF00454	0.476
MOD_PIKK_1	69	75	PF00454	0.476
MOD_PKA_2	179	185	PF00069	0.492
MOD_PKB_1	150	158	PF00069	0.508
MOD_Plk_1	211	217	PF00069	0.560
MOD_Plk_1	231	237	PF00069	0.367
MOD_Plk_1	65	71	PF00069	0.512
MOD_Plk_2-3	211	217	PF00069	0.683
MOD_Plk_4	16	22	PF00069	0.510
MOD_Plk_4	160	166	PF00069	0.495
MOD_Plk_4	211	217	PF00069	0.683
MOD_Plk_4	238	244	PF00069	0.481
MOD_Plk_4	65	71	PF00069	0.537
MOD_Plk_4	76	82	PF00069	0.537
MOD_ProDKin_1	218	224	PF00069	0.755
MOD_SUMO_for_1	251	254	PF00179	0.558
MOD_SUMO_rev_2	163	170	PF00179	0.541
MOD_SUMO_rev_2	200	209	PF00179	0.646
TRG_DiLeu_BaEn_1	211	216	PF01217	0.717
TRG_ENDOCYTIC_2	80	83	PF00928	0.463
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A8	Leptomonas seymouri	65%	100%
A0A0N0P8F2	Leptomonas seymouri	23%	100%
A0A0S4KG92	Bodo saltans	44%	96%
A0A1X0P6Z9	Trypanosomatidae	36%	100%
A0A3Q7I7R4	Solanum lycopersicum	27%	100%
A0A3Q8IE78	Leishmania donovani	22%	100%
A0A3S5IRX1	Trypanosoma rangeli	36%	97%
A4HA98	Leishmania braziliensis	81%	100%
A4HYH8	Leishmania infantum	99%	100%
A4I2V4	Leishmania infantum	22%	100%
C6ZJZ3	Glycine max	30%	100%
D0A0V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O04663	Arabidopsis thaliana	28%	100%
O61955	Caenorhabditis elegans	27%	100%
P06730	Homo sapiens	28%	100%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P29338	Oryctolagus cuniculus	28%	100%
P48598	Drosophila melanogaster	28%	100%
P63073	Mus musculus	28%	100%
P63074	Rattus norvegicus	28%	100%
P78954	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q03389	Triticum aestivum	28%	100%
Q0GRC4	Pisum sativum	29%	100%
Q21693	Caenorhabditis elegans	28%	100%
Q3UTA9	Mus musculus	25%	100%
Q4QD60	Leishmania major	94%	100%
Q4QXS7	Hordeum vulgare subsp. vulgare	27%	100%
Q66WU1	Nicotiana tabacum	26%	100%
Q9C7P6	Arabidopsis thaliana	25%	100%
Q9N0T5	Bos taurus	28%	100%
Q9P974	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
V5AP07	Trypanosoma cruzi	42%	100%