LeishMANIAdb
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Glycerol uptake protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycerol uptake protein, putative
Gene product:
glycerol uptake protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H769_LEIDO
TriTrypDb:
LdCL_190018700 , LDHU3_19.1620
Length:
684

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 33
NetGPI no yes: 0, no: 33
Cellular components
Term Name Level Count
GO:0016020 membrane 2 34
GO:0110165 cellular anatomical entity 1 34
GO:0005737 cytoplasm 2 4
GO:0005783 endoplasmic reticulum 5 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4

Expansion

Sequence features

A0A3S5H769
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H769

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016740 transferase activity 2 5
GO:0016746 acyltransferase activity 3 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 209 213 PF00656 0.342
CLV_C14_Caspase3-7 628 632 PF00656 0.401
CLV_NRD_NRD_1 135 137 PF00675 0.421
CLV_NRD_NRD_1 366 368 PF00675 0.316
CLV_NRD_NRD_1 448 450 PF00675 0.286
CLV_NRD_NRD_1 536 538 PF00675 0.417
CLV_NRD_NRD_1 564 566 PF00675 0.541
CLV_NRD_NRD_1 577 579 PF00675 0.441
CLV_PCSK_KEX2_1 134 136 PF00082 0.529
CLV_PCSK_KEX2_1 448 450 PF00082 0.286
CLV_PCSK_KEX2_1 536 538 PF00082 0.417
CLV_PCSK_KEX2_1 54 56 PF00082 0.377
CLV_PCSK_KEX2_1 564 566 PF00082 0.412
CLV_PCSK_KEX2_1 577 579 PF00082 0.459
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.223
CLV_PCSK_PC7_1 573 579 PF00082 0.387
CLV_PCSK_SKI1_1 14 18 PF00082 0.674
CLV_PCSK_SKI1_1 371 375 PF00082 0.317
CLV_PCSK_SKI1_1 485 489 PF00082 0.461
CLV_PCSK_SKI1_1 54 58 PF00082 0.426
CLV_PCSK_SKI1_1 565 569 PF00082 0.395
CLV_PCSK_SKI1_1 637 641 PF00082 0.566
CLV_PCSK_SKI1_1 71 75 PF00082 0.404
DEG_APCC_DBOX_1 484 492 PF00400 0.538
DEG_APCC_DBOX_1 564 572 PF00400 0.599
DEG_MDM2_SWIB_1 17 24 PF02201 0.337
DEG_Nend_Nbox_1 1 3 PF02207 0.294
DEG_SCF_FBW7_1 643 648 PF00400 0.357
DEG_SPOP_SBC_1 359 363 PF00917 0.543
DOC_CDC14_PxL_1 389 397 PF14671 0.397
DOC_CYCLIN_RxL_1 68 78 PF00134 0.392
DOC_CYCLIN_yCln2_LP_2 337 343 PF00134 0.379
DOC_MAPK_DCC_7 485 495 PF00069 0.330
DOC_MAPK_gen_1 246 253 PF00069 0.371
DOC_MAPK_gen_1 483 490 PF00069 0.476
DOC_MAPK_gen_1 54 61 PF00069 0.225
DOC_MAPK_MEF2A_6 483 490 PF00069 0.573
DOC_MAPK_MEF2A_6 54 63 PF00069 0.372
DOC_MAPK_NFAT4_5 54 62 PF00069 0.246
DOC_PP1_RVXF_1 257 264 PF00149 0.301
DOC_PP1_SILK_1 374 379 PF00149 0.350
DOC_PP2B_LxvP_1 337 340 PF13499 0.379
DOC_PP4_FxxP_1 167 170 PF00568 0.334
DOC_USP7_MATH_1 346 350 PF00917 0.336
DOC_USP7_MATH_1 352 356 PF00917 0.494
DOC_USP7_MATH_1 360 364 PF00917 0.495
DOC_USP7_MATH_1 563 567 PF00917 0.604
DOC_USP7_MATH_1 83 87 PF00917 0.817
DOC_USP7_MATH_1 94 98 PF00917 0.625
DOC_WW_Pin1_4 126 131 PF00397 0.655
DOC_WW_Pin1_4 214 219 PF00397 0.287
DOC_WW_Pin1_4 577 582 PF00397 0.683
DOC_WW_Pin1_4 641 646 PF00397 0.465
DOC_WW_Pin1_4 79 84 PF00397 0.657
DOC_WW_Pin1_4 90 95 PF00397 0.625
LIG_14-3-3_CanoR_1 123 128 PF00244 0.633
LIG_14-3-3_CanoR_1 254 259 PF00244 0.339
LIG_14-3-3_CanoR_1 358 366 PF00244 0.582
LIG_14-3-3_CanoR_1 378 387 PF00244 0.249
LIG_14-3-3_CanoR_1 404 408 PF00244 0.302
LIG_14-3-3_CanoR_1 485 491 PF00244 0.415
LIG_14-3-3_CanoR_1 564 568 PF00244 0.586
LIG_14-3-3_CanoR_1 573 581 PF00244 0.684
LIG_14-3-3_CanoR_1 670 676 PF00244 0.523
LIG_14-3-3_CanoR_1 71 77 PF00244 0.605
LIG_Actin_WH2_2 244 261 PF00022 0.327
LIG_Actin_WH2_2 410 426 PF00022 0.307
LIG_BRCT_BRCA1_1 396 400 PF00533 0.294
LIG_BRCT_BRCA1_1 431 435 PF00533 0.618
LIG_BRCT_BRCA1_1 524 528 PF00533 0.400
LIG_CSL_BTD_1 110 113 PF09270 0.625
LIG_CtBP_PxDLS_1 444 448 PF00389 0.489
LIG_deltaCOP1_diTrp_1 43 49 PF00928 0.329
LIG_deltaCOP1_diTrp_1 463 471 PF00928 0.494
LIG_EH_1 26 30 PF12763 0.322
LIG_eIF4E_1 332 338 PF01652 0.408
LIG_FHA_1 136 142 PF00498 0.714
LIG_FHA_1 215 221 PF00498 0.457
LIG_FHA_1 222 228 PF00498 0.468
LIG_FHA_1 255 261 PF00498 0.354
LIG_FHA_1 285 291 PF00498 0.420
LIG_FHA_1 452 458 PF00498 0.481
LIG_FHA_1 543 549 PF00498 0.644
LIG_FHA_1 596 602 PF00498 0.377
LIG_FHA_1 646 652 PF00498 0.439
LIG_FHA_2 404 410 PF00498 0.309
LIG_FHA_2 628 634 PF00498 0.428
LIG_Integrin_isoDGR_2 555 557 PF01839 0.446
LIG_LIR_Apic_2 144 148 PF02991 0.455
LIG_LIR_Gen_1 18 29 PF02991 0.442
LIG_LIR_Gen_1 326 335 PF02991 0.291
LIG_LIR_Gen_1 348 357 PF02991 0.354
LIG_LIR_Gen_1 382 392 PF02991 0.418
LIG_LIR_Gen_1 397 408 PF02991 0.252
LIG_LIR_Gen_1 432 443 PF02991 0.598
LIG_LIR_Gen_1 674 682 PF02991 0.511
LIG_LIR_Nem_3 10 16 PF02991 0.405
LIG_LIR_Nem_3 18 24 PF02991 0.425
LIG_LIR_Nem_3 217 222 PF02991 0.434
LIG_LIR_Nem_3 326 332 PF02991 0.299
LIG_LIR_Nem_3 348 353 PF02991 0.378
LIG_LIR_Nem_3 382 387 PF02991 0.406
LIG_LIR_Nem_3 397 403 PF02991 0.232
LIG_LIR_Nem_3 43 49 PF02991 0.311
LIG_LIR_Nem_3 432 438 PF02991 0.608
LIG_LIR_Nem_3 51 56 PF02991 0.305
LIG_LIR_Nem_3 585 591 PF02991 0.624
LIG_LIR_Nem_3 67 73 PF02991 0.429
LIG_LIR_Nem_3 674 678 PF02991 0.574
LIG_NRBOX 58 64 PF00104 0.435
LIG_PAM2_1 577 589 PF00658 0.536
LIG_Pex14_1 219 223 PF04695 0.409
LIG_Pex14_1 249 253 PF04695 0.323
LIG_Pex14_1 464 468 PF04695 0.487
LIG_Pex14_1 471 475 PF04695 0.487
LIG_Pex14_2 17 21 PF04695 0.338
LIG_Pex14_2 425 429 PF04695 0.344
LIG_Pex14_2 460 464 PF04695 0.489
LIG_Pex14_2 496 500 PF04695 0.340
LIG_PTB_Apo_2 24 31 PF02174 0.333
LIG_REV1ctd_RIR_1 27 36 PF16727 0.337
LIG_SH2_CRK 151 155 PF00017 0.316
LIG_SH2_CRK 327 331 PF00017 0.291
LIG_SH2_CRK 384 388 PF00017 0.455
LIG_SH2_CRK 398 402 PF00017 0.330
LIG_SH2_CRK 475 479 PF00017 0.487
LIG_SH2_CRK 70 74 PF00017 0.512
LIG_SH2_NCK_1 151 155 PF00017 0.331
LIG_SH2_SRC 38 41 PF00017 0.314
LIG_SH2_STAP1 223 227 PF00017 0.392
LIG_SH2_STAP1 332 336 PF00017 0.350
LIG_SH2_STAP1 38 42 PF00017 0.348
LIG_SH2_STAP1 398 402 PF00017 0.298
LIG_SH2_STAP1 656 660 PF00017 0.314
LIG_SH2_STAT5 151 154 PF00017 0.342
LIG_SH2_STAT5 178 181 PF00017 0.391
LIG_SH2_STAT5 206 209 PF00017 0.471
LIG_SH2_STAT5 223 226 PF00017 0.476
LIG_SH2_STAT5 335 338 PF00017 0.343
LIG_SH2_STAT5 342 345 PF00017 0.331
LIG_SH2_STAT5 380 383 PF00017 0.334
LIG_SH2_STAT5 384 387 PF00017 0.340
LIG_SH2_STAT5 420 423 PF00017 0.387
LIG_SH2_STAT5 477 480 PF00017 0.487
LIG_SH2_STAT5 675 678 PF00017 0.527
LIG_SH3_3 107 113 PF00018 0.639
LIG_SH3_3 159 165 PF00018 0.434
LIG_SH3_3 333 339 PF00018 0.453
LIG_SH3_3 387 393 PF00018 0.397
LIG_SUMO_SIM_par_1 206 212 PF11976 0.526
LIG_TRFH_1 335 339 PF08558 0.460
LIG_TYR_ITIM 418 423 PF00017 0.434
LIG_TYR_ITIM 473 478 PF00017 0.327
LIG_UBA3_1 417 424 PF00899 0.350
LIG_UBA3_1 678 683 PF00899 0.512
LIG_WRC_WIRS_1 347 352 PF05994 0.348
LIG_WRC_WIRS_1 8 13 PF05994 0.369
LIG_WW_1 339 342 PF00397 0.412
LIG_WW_3 112 116 PF00397 0.488
MOD_CK1_1 627 633 PF00069 0.674
MOD_CK1_1 75 81 PF00069 0.523
MOD_CK1_1 86 92 PF00069 0.550
MOD_CK1_1 95 101 PF00069 0.600
MOD_CK2_1 403 409 PF00069 0.425
MOD_CK2_1 436 442 PF00069 0.354
MOD_CMANNOS 461 464 PF00535 0.332
MOD_GlcNHglycan 130 133 PF01048 0.686
MOD_GlcNHglycan 301 304 PF01048 0.484
MOD_GlcNHglycan 438 441 PF01048 0.408
MOD_GlcNHglycan 524 527 PF01048 0.343
MOD_GlcNHglycan 574 577 PF01048 0.554
MOD_GlcNHglycan 627 630 PF01048 0.693
MOD_GlcNHglycan 658 661 PF01048 0.376
MOD_GlcNHglycan 66 69 PF01048 0.466
MOD_GlcNHglycan 79 82 PF01048 0.738
MOD_GlcNHglycan 94 97 PF01048 0.541
MOD_GlcNHglycan 99 103 PF01048 0.554
MOD_GSK3_1 119 126 PF00069 0.597
MOD_GSK3_1 222 229 PF00069 0.399
MOD_GSK3_1 542 549 PF00069 0.499
MOD_GSK3_1 641 648 PF00069 0.521
MOD_GSK3_1 72 79 PF00069 0.523
MOD_GSK3_1 85 92 PF00069 0.538
MOD_GSK3_1 94 101 PF00069 0.562
MOD_LATS_1 356 362 PF00433 0.304
MOD_NEK2_1 141 146 PF00069 0.482
MOD_NEK2_1 253 258 PF00069 0.366
MOD_NEK2_1 403 408 PF00069 0.366
MOD_NEK2_1 423 428 PF00069 0.305
MOD_NEK2_1 451 456 PF00069 0.340
MOD_NEK2_1 582 587 PF00069 0.505
MOD_NEK2_1 654 659 PF00069 0.384
MOD_NEK2_1 74 79 PF00069 0.562
MOD_PKA_1 135 141 PF00069 0.427
MOD_PKA_2 135 141 PF00069 0.469
MOD_PKA_2 253 259 PF00069 0.420
MOD_PKA_2 403 409 PF00069 0.350
MOD_PKA_2 556 562 PF00069 0.548
MOD_PKA_2 563 569 PF00069 0.643
MOD_PKA_2 572 578 PF00069 0.516
MOD_PKB_1 121 129 PF00069 0.513
MOD_Plk_1 38 44 PF00069 0.415
MOD_Plk_1 382 388 PF00069 0.505
MOD_Plk_4 149 155 PF00069 0.456
MOD_Plk_4 200 206 PF00069 0.378
MOD_Plk_4 382 388 PF00069 0.413
MOD_Plk_4 403 409 PF00069 0.377
MOD_Plk_4 486 492 PF00069 0.430
MOD_Plk_4 582 588 PF00069 0.566
MOD_Plk_4 596 602 PF00069 0.327
MOD_Plk_4 671 677 PF00069 0.373
MOD_ProDKin_1 126 132 PF00069 0.558
MOD_ProDKin_1 214 220 PF00069 0.323
MOD_ProDKin_1 577 583 PF00069 0.598
MOD_ProDKin_1 641 647 PF00069 0.570
MOD_ProDKin_1 79 85 PF00069 0.571
MOD_ProDKin_1 90 96 PF00069 0.522
TRG_DiLeu_BaEn_2 408 414 PF01217 0.393
TRG_DiLeu_BaLyEn_6 167 172 PF01217 0.377
TRG_DiLeu_BaLyEn_6 256 261 PF01217 0.429
TRG_ENDOCYTIC_2 13 16 PF00928 0.546
TRG_ENDOCYTIC_2 151 154 PF00928 0.323
TRG_ENDOCYTIC_2 178 181 PF00928 0.348
TRG_ENDOCYTIC_2 190 193 PF00928 0.290
TRG_ENDOCYTIC_2 327 330 PF00928 0.333
TRG_ENDOCYTIC_2 335 338 PF00928 0.331
TRG_ENDOCYTIC_2 384 387 PF00928 0.354
TRG_ENDOCYTIC_2 398 401 PF00928 0.351
TRG_ENDOCYTIC_2 420 423 PF00928 0.377
TRG_ENDOCYTIC_2 475 478 PF00928 0.330
TRG_ENDOCYTIC_2 53 56 PF00928 0.446
TRG_ENDOCYTIC_2 588 591 PF00928 0.369
TRG_ENDOCYTIC_2 675 678 PF00928 0.448
TRG_ENDOCYTIC_2 70 73 PF00928 0.514
TRG_ER_diArg_1 120 123 PF00400 0.774
TRG_ER_diArg_1 134 136 PF00400 0.475
TRG_ER_diArg_1 246 249 PF00400 0.526
TRG_ER_diArg_1 447 449 PF00400 0.328
TRG_ER_diArg_1 483 486 PF00400 0.343
TRG_ER_diArg_1 535 537 PF00400 0.468
TRG_ER_diArg_1 563 565 PF00400 0.717
TRG_ER_diArg_1 577 579 PF00400 0.539

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRP6 Bodo saltans 36% 100%
A0A1X0P614 Trypanosomatidae 33% 100%
A0A1X0P616 Trypanosomatidae 40% 100%
A0A1X0P718 Trypanosomatidae 40% 100%
A0A3Q8IAC1 Leishmania donovani 99% 100%
A0A3Q8IBC3 Leishmania donovani 91% 99%
A0A3Q8IBE0 Leishmania donovani 74% 100%
A0A3Q8IDD7 Leishmania donovani 99% 100%
A0A3S5IRW9 Trypanosoma rangeli 34% 100%
A0A3S7WVJ2 Leishmania donovani 74% 81%
A0A3S7WVK4 Leishmania donovani 97% 88%
A4HA75 Leishmania braziliensis 62% 100%
A4HA76 Leishmania braziliensis 62% 100%
A4HA77 Leishmania braziliensis 65% 100%
A4HA79 Leishmania braziliensis 70% 100%
A4HA80 Leishmania braziliensis 59% 100%
A4HA81 Leishmania braziliensis 66% 100%
A4HA82 Leishmania braziliensis 66% 100%
D0A0T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AGT0 Leishmania infantum 74% 100%
E9AGT1 Leishmania infantum 96% 100%
E9AGT2 Leishmania infantum 98% 100%
E9AGT3 Leishmania infantum 96% 100%
E9AGT4 Leishmania infantum 99% 100%
E9AS84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4QD78 Leishmania major 91% 100%
Q4QD79 Leishmania major 89% 100%
Q4QD80 Leishmania major 89% 100%
Q4QD81 Leishmania major 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS