Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H768_LEIDO

TriTrypDb:

LdBPK_191300.1 , LdCL_190018100 , LDHU3_19.1570

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H768

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H768

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.811
CLV_C14_Caspase3-7	234	238	PF00656	0.711
CLV_C14_Caspase3-7	244	248	PF00656	0.679
CLV_C14_Caspase3-7	299	303	PF00656	0.608
CLV_C14_Caspase3-7	439	443	PF00656	0.756
CLV_C14_Caspase3-7	598	602	PF00656	0.671
CLV_C14_Caspase3-7	611	615	PF00656	0.662
CLV_C14_Caspase3-7	757	761	PF00656	0.783
CLV_C14_Caspase3-7	889	893	PF00656	0.748
CLV_NRD_NRD_1	154	156	PF00675	0.825
CLV_NRD_NRD_1	160	162	PF00675	0.722
CLV_NRD_NRD_1	287	289	PF00675	0.756
CLV_NRD_NRD_1	363	365	PF00675	0.863
CLV_NRD_NRD_1	417	419	PF00675	0.854
CLV_NRD_NRD_1	579	581	PF00675	0.806
CLV_NRD_NRD_1	64	66	PF00675	0.808
CLV_NRD_NRD_1	868	870	PF00675	0.763
CLV_PCSK_KEX2_1	287	289	PF00082	0.756
CLV_PCSK_KEX2_1	363	365	PF00082	0.863
CLV_PCSK_KEX2_1	417	419	PF00082	0.854
CLV_PCSK_KEX2_1	579	581	PF00082	0.806
CLV_PCSK_KEX2_1	64	66	PF00082	0.808
CLV_PCSK_KEX2_1	749	751	PF00082	0.790
CLV_PCSK_KEX2_1	868	870	PF00082	0.763
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.790
CLV_PCSK_SKI1_1	364	368	PF00082	0.860
CLV_PCSK_SKI1_1	379	383	PF00082	0.597
CLV_PCSK_SKI1_1	579	583	PF00082	0.800
CLV_PCSK_SKI1_1	772	776	PF00082	0.618
CLV_Separin_Metazoa	116	120	PF03568	0.652
DEG_APCC_DBOX_1	668	676	PF00400	0.737
DEG_Nend_UBRbox_2	1	3	PF02207	0.848
DEG_SPOP_SBC_1	246	250	PF00917	0.743
DEG_SPOP_SBC_1	527	531	PF00917	0.647
DOC_ANK_TNKS_1	205	212	PF00023	0.739
DOC_ANK_TNKS_1	63	70	PF00023	0.794
DOC_CKS1_1	619	624	PF01111	0.631
DOC_CKS1_1	937	942	PF01111	0.638
DOC_CYCLIN_RxL_1	576	585	PF00134	0.799
DOC_CYCLIN_RxL_1	769	778	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	918	924	PF00134	0.831
DOC_PP1_RVXF_1	954	961	PF00149	0.773
DOC_PP2B_LxvP_1	736	739	PF13499	0.791
DOC_USP7_MATH_1	150	154	PF00917	0.829
DOC_USP7_MATH_1	184	188	PF00917	0.747
DOC_USP7_MATH_1	196	200	PF00917	0.669
DOC_USP7_MATH_1	216	220	PF00917	0.559
DOC_USP7_MATH_1	245	249	PF00917	0.752
DOC_USP7_MATH_1	369	373	PF00917	0.766
DOC_USP7_MATH_1	42	46	PF00917	0.873
DOC_USP7_MATH_1	48	52	PF00917	0.773
DOC_USP7_MATH_1	528	532	PF00917	0.718
DOC_USP7_MATH_1	551	555	PF00917	0.834
DOC_USP7_MATH_1	711	715	PF00917	0.823
DOC_USP7_MATH_1	731	735	PF00917	0.690
DOC_USP7_MATH_1	787	791	PF00917	0.741
DOC_USP7_MATH_1	850	854	PF00917	0.631
DOC_USP7_MATH_1	935	939	PF00917	0.778
DOC_USP7_MATH_1	952	956	PF00917	0.786
DOC_USP7_MATH_1	967	971	PF00917	0.433
DOC_WW_Pin1_4	106	111	PF00397	0.731
DOC_WW_Pin1_4	160	165	PF00397	0.858
DOC_WW_Pin1_4	235	240	PF00397	0.861
DOC_WW_Pin1_4	258	263	PF00397	0.729
DOC_WW_Pin1_4	268	273	PF00397	0.750
DOC_WW_Pin1_4	348	353	PF00397	0.799
DOC_WW_Pin1_4	355	360	PF00397	0.744
DOC_WW_Pin1_4	380	385	PF00397	0.823
DOC_WW_Pin1_4	389	394	PF00397	0.687
DOC_WW_Pin1_4	441	446	PF00397	0.777
DOC_WW_Pin1_4	448	453	PF00397	0.735
DOC_WW_Pin1_4	53	58	PF00397	0.855
DOC_WW_Pin1_4	555	560	PF00397	0.634
DOC_WW_Pin1_4	618	623	PF00397	0.603
DOC_WW_Pin1_4	76	81	PF00397	0.713
DOC_WW_Pin1_4	906	911	PF00397	0.709
DOC_WW_Pin1_4	936	941	PF00397	0.805
DOC_WW_Pin1_4	946	951	PF00397	0.561
DOC_WW_Pin1_4	97	102	PF00397	0.803
DOC_WW_Pin1_4	971	976	PF00397	0.778
LIG_14-3-3_CanoR_1	119	124	PF00244	0.656
LIG_14-3-3_CanoR_1	155	165	PF00244	0.842
LIG_14-3-3_CanoR_1	204	210	PF00244	0.809
LIG_14-3-3_CanoR_1	475	479	PF00244	0.701
LIG_14-3-3_CanoR_1	649	659	PF00244	0.809
LIG_14-3-3_CanoR_1	70	78	PF00244	0.695
LIG_14-3-3_CanoR_1	735	739	PF00244	0.688
LIG_BIR_III_2	190	194	PF00653	0.639
LIG_BIR_III_2	442	446	PF00653	0.758
LIG_BRCT_BRCA1_1	458	462	PF00533	0.616
LIG_BRCT_BRCA1_1	969	973	PF00533	0.684
LIG_eIF4E_1	270	276	PF01652	0.779
LIG_FHA_1	195	201	PF00498	0.766
LIG_FHA_1	259	265	PF00498	0.621
LIG_FHA_1	408	414	PF00498	0.862
LIG_FHA_1	427	433	PF00498	0.502
LIG_FHA_1	837	843	PF00498	0.751
LIG_FHA_1	90	96	PF00498	0.778
LIG_FHA_2	180	186	PF00498	0.647
LIG_FHA_2	19	25	PF00498	0.691
LIG_FHA_2	269	275	PF00498	0.792
LIG_FHA_2	295	301	PF00498	0.646
LIG_FHA_2	437	443	PF00498	0.750
LIG_FHA_2	475	481	PF00498	0.761
LIG_FHA_2	609	615	PF00498	0.625
LIG_FHA_2	659	665	PF00498	0.799
LIG_FHA_2	669	675	PF00498	0.608
LIG_FHA_2	757	763	PF00498	0.780
LIG_FHA_2	937	943	PF00498	0.735
LIG_FHA_2	961	967	PF00498	0.618
LIG_LIR_Gen_1	24	33	PF02991	0.674
LIG_LIR_Gen_1	436	446	PF02991	0.653
LIG_LIR_Gen_1	966	976	PF02991	0.761
LIG_LIR_LC3C_4	273	277	PF02991	0.767
LIG_LIR_Nem_3	21	25	PF02991	0.742
LIG_LIR_Nem_3	459	465	PF02991	0.814
LIG_LIR_Nem_3	575	581	PF02991	0.803
LIG_LIR_Nem_3	966	971	PF02991	0.744
LIG_PDZ_Class_1	971	976	PF00595	0.778
LIG_SH2_CRK	578	582	PF00017	0.804
LIG_SH2_STAP1	22	26	PF00017	0.765
LIG_SH2_STAP1	793	797	PF00017	0.793
LIG_SH2_STAP1	968	972	PF00017	0.754
LIG_SH2_STAT5	270	273	PF00017	0.797
LIG_SH2_STAT5	350	353	PF00017	0.771
LIG_SH3_1	54	60	PF00018	0.660
LIG_SH3_1	725	731	PF00018	0.627
LIG_SH3_2	59	64	PF14604	0.795
LIG_SH3_3	151	157	PF00018	0.702
LIG_SH3_3	233	239	PF00018	0.857
LIG_SH3_3	483	489	PF00018	0.691
LIG_SH3_3	54	60	PF00018	0.874
LIG_SH3_3	725	731	PF00018	0.685
LIG_SH3_3	77	83	PF00018	0.778
LIG_SH3_3	870	876	PF00018	0.626
LIG_SH3_3	913	919	PF00018	0.775
LIG_SH3_3	922	928	PF00018	0.745
LIG_SH3_3	934	940	PF00018	0.653
LIG_SUMO_SIM_par_1	670	677	PF11976	0.816
LIG_SUMO_SIM_par_1	836	845	PF11976	0.624
LIG_ULM_U2AF65_1	868	873	PF00076	0.625
LIG_WW_2	916	919	PF00397	0.755
MOD_CDC14_SPxK_1	909	912	PF00782	0.738
MOD_CDK_SPK_2	235	240	PF00069	0.784
MOD_CDK_SPK_2	76	81	PF00069	0.659
MOD_CDK_SPxK_1	389	395	PF00069	0.775
MOD_CDK_SPxK_1	906	912	PF00069	0.735
MOD_CDK_SPxxK_3	441	448	PF00069	0.821
MOD_CK1_1	227	233	PF00069	0.686
MOD_CK1_1	294	300	PF00069	0.793
MOD_CK1_1	353	359	PF00069	0.805
MOD_CK1_1	380	386	PF00069	0.741
MOD_CK1_1	405	411	PF00069	0.785
MOD_CK1_1	426	432	PF00069	0.820
MOD_CK1_1	436	442	PF00069	0.658
MOD_CK1_1	456	462	PF00069	0.505
MOD_CK1_1	554	560	PF00069	0.841
MOD_CK1_1	618	624	PF00069	0.621
MOD_CK1_1	645	651	PF00069	0.768
MOD_CK1_1	677	683	PF00069	0.728
MOD_CK1_1	712	718	PF00069	0.715
MOD_CK1_1	726	732	PF00069	0.627
MOD_CK1_1	734	740	PF00069	0.776
MOD_CK1_1	836	842	PF00069	0.823
MOD_CK1_1	85	91	PF00069	0.780
MOD_CK1_1	886	892	PF00069	0.687
MOD_CK1_1	938	944	PF00069	0.726
MOD_CK2_1	18	24	PF00069	0.694
MOD_CK2_1	196	202	PF00069	0.768
MOD_CK2_1	300	306	PF00069	0.823
MOD_CK2_1	391	397	PF00069	0.738
MOD_CK2_1	528	534	PF00069	0.682
MOD_CK2_1	544	550	PF00069	0.637
MOD_CK2_1	621	627	PF00069	0.833
MOD_CK2_1	658	664	PF00069	0.771
MOD_CK2_1	668	674	PF00069	0.686
MOD_CK2_1	677	683	PF00069	0.625
MOD_CK2_1	698	704	PF00069	0.722
MOD_CK2_1	756	762	PF00069	0.728
MOD_CK2_1	936	942	PF00069	0.784
MOD_Cter_Amidation	415	418	PF01082	0.865
MOD_Cter_Amidation	747	750	PF01082	0.744
MOD_DYRK1A_RPxSP_1	936	940	PF00069	0.719
MOD_GlcNHglycan	12	15	PF01048	0.809
MOD_GlcNHglycan	145	149	PF01048	0.807
MOD_GlcNHglycan	158	161	PF01048	0.640
MOD_GlcNHglycan	177	180	PF01048	0.547
MOD_GlcNHglycan	225	229	PF01048	0.816
MOD_GlcNHglycan	243	246	PF01048	0.604
MOD_GlcNHglycan	249	252	PF01048	0.638
MOD_GlcNHglycan	309	312	PF01048	0.808
MOD_GlcNHglycan	352	355	PF01048	0.851
MOD_GlcNHglycan	404	407	PF01048	0.846
MOD_GlcNHglycan	414	417	PF01048	0.721
MOD_GlcNHglycan	425	428	PF01048	0.652
MOD_GlcNHglycan	455	458	PF01048	0.680
MOD_GlcNHglycan	549	554	PF01048	0.685
MOD_GlcNHglycan	623	626	PF01048	0.763
MOD_GlcNHglycan	72	75	PF01048	0.690
MOD_GlcNHglycan	885	888	PF01048	0.686
MOD_GlcNHglycan	903	906	PF01048	0.611
MOD_GlcNHglycan	950	953	PF01048	0.769
MOD_GSK3_1	10	17	PF00069	0.748
MOD_GSK3_1	117	124	PF00069	0.785
MOD_GSK3_1	156	163	PF00069	0.849
MOD_GSK3_1	175	182	PF00069	0.558
MOD_GSK3_1	223	230	PF00069	0.778
MOD_GSK3_1	241	248	PF00069	0.632
MOD_GSK3_1	25	32	PF00069	0.503
MOD_GSK3_1	307	314	PF00069	0.839
MOD_GSK3_1	353	360	PF00069	0.817
MOD_GSK3_1	369	376	PF00069	0.616
MOD_GSK3_1	380	387	PF00069	0.617
MOD_GSK3_1	398	405	PF00069	0.657
MOD_GSK3_1	407	414	PF00069	0.676
MOD_GSK3_1	426	433	PF00069	0.504
MOD_GSK3_1	453	460	PF00069	0.724
MOD_GSK3_1	551	558	PF00069	0.724
MOD_GSK3_1	645	652	PF00069	0.732
MOD_GSK3_1	673	680	PF00069	0.819
MOD_GSK3_1	717	724	PF00069	0.682
MOD_GSK3_1	734	741	PF00069	0.712
MOD_GSK3_1	830	837	PF00069	0.839
MOD_GSK3_1	85	92	PF00069	0.751
MOD_GSK3_1	901	908	PF00069	0.718
MOD_GSK3_1	944	951	PF00069	0.726
MOD_GSK3_1	967	974	PF00069	0.744
MOD_N-GLC_1	300	305	PF02516	0.637
MOD_N-GLC_1	348	353	PF02516	0.805
MOD_N-GLC_1	657	662	PF02516	0.748
MOD_N-GLC_1	712	717	PF02516	0.783
MOD_N-GLC_1	721	726	PF02516	0.650
MOD_N-GLC_1	76	81	PF02516	0.659
MOD_NEK2_1	118	123	PF00069	0.875
MOD_NEK2_1	255	260	PF00069	0.793
MOD_NEK2_1	526	531	PF00069	0.754
MOD_NEK2_1	721	726	PF00069	0.727
MOD_NEK2_1	792	797	PF00069	0.784
MOD_NEK2_2	150	155	PF00069	0.793
MOD_NEK2_2	196	201	PF00069	0.740
MOD_NEK2_2	457	462	PF00069	0.620
MOD_PIKK_1	396	402	PF00454	0.790
MOD_PIKK_1	497	503	PF00454	0.771
MOD_PKA_1	155	161	PF00069	0.792
MOD_PKA_2	118	124	PF00069	0.657
MOD_PKA_2	194	200	PF00069	0.819
MOD_PKA_2	205	211	PF00069	0.717
MOD_PKA_2	223	229	PF00069	0.577
MOD_PKA_2	474	480	PF00069	0.741
MOD_PKA_2	497	503	PF00069	0.771
MOD_PKA_2	668	674	PF00069	0.697
MOD_PKA_2	69	75	PF00069	0.656
MOD_PKA_2	734	740	PF00069	0.758
MOD_PKA_2	819	825	PF00069	0.628
MOD_PKA_2	881	887	PF00069	0.661
MOD_PKA_2	935	941	PF00069	0.677
MOD_Plk_1	311	317	PF00069	0.698
MOD_Plk_1	482	488	PF00069	0.725
MOD_Plk_1	645	651	PF00069	0.757
MOD_Plk_1	657	663	PF00069	0.715
MOD_Plk_1	944	950	PF00069	0.763
MOD_Plk_2-3	474	480	PF00069	0.761
MOD_Plk_2-3	544	550	PF00069	0.672
MOD_Plk_4	205	211	PF00069	0.778
MOD_Plk_4	25	31	PF00069	0.594
MOD_Plk_4	377	383	PF00069	0.727
MOD_Plk_4	433	439	PF00069	0.810
MOD_Plk_4	457	463	PF00069	0.833
MOD_Plk_4	572	578	PF00069	0.805
MOD_Plk_4	668	674	PF00069	0.812
MOD_Plk_4	787	793	PF00069	0.747
MOD_Plk_4	836	842	PF00069	0.823
MOD_Plk_4	967	973	PF00069	0.754
MOD_ProDKin_1	106	112	PF00069	0.732
MOD_ProDKin_1	160	166	PF00069	0.854
MOD_ProDKin_1	235	241	PF00069	0.864
MOD_ProDKin_1	258	264	PF00069	0.729
MOD_ProDKin_1	268	274	PF00069	0.744
MOD_ProDKin_1	348	354	PF00069	0.801
MOD_ProDKin_1	355	361	PF00069	0.745
MOD_ProDKin_1	380	386	PF00069	0.823
MOD_ProDKin_1	389	395	PF00069	0.688
MOD_ProDKin_1	441	447	PF00069	0.778
MOD_ProDKin_1	448	454	PF00069	0.736
MOD_ProDKin_1	53	59	PF00069	0.854
MOD_ProDKin_1	555	561	PF00069	0.635
MOD_ProDKin_1	618	624	PF00069	0.603
MOD_ProDKin_1	76	82	PF00069	0.711
MOD_ProDKin_1	906	912	PF00069	0.711
MOD_ProDKin_1	936	942	PF00069	0.803
MOD_ProDKin_1	946	952	PF00069	0.555
MOD_ProDKin_1	97	103	PF00069	0.802
MOD_SUMO_rev_2	372	381	PF00179	0.726
MOD_SUMO_rev_2	464	473	PF00179	0.743
TRG_DiLeu_BaEn_2	805	811	PF01217	0.741
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.668
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.767
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.782
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.656
TRG_ENDOCYTIC_2	578	581	PF00928	0.804
TRG_ENDOCYTIC_2	968	971	PF00928	0.751
TRG_ER_diArg_1	286	288	PF00400	0.740
TRG_ER_diArg_1	578	580	PF00400	0.803
TRG_ER_diArg_1	64	66	PF00400	0.808
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.799
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HA78	Leishmania braziliensis	57%	97%
A4HYE9	Leishmania infantum	99%	99%
E9AS82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QD84	Leishmania major	86%	100%