Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H766_LEIDO

TriTrypDb:

LdBPK_191160.1 , LdCL_190016700 , LDHU3_19.1400

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H766

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H766

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.660
CLV_C14_Caspase3-7	30	34	PF00656	0.580
CLV_C14_Caspase3-7	419	423	PF00656	0.528
CLV_C14_Caspase3-7	594	598	PF00656	0.661
CLV_NRD_NRD_1	163	165	PF00675	0.705
CLV_NRD_NRD_1	20	22	PF00675	0.658
CLV_NRD_NRD_1	50	52	PF00675	0.663
CLV_NRD_NRD_1	628	630	PF00675	0.686
CLV_PCSK_KEX2_1	101	103	PF00082	0.674
CLV_PCSK_KEX2_1	163	165	PF00082	0.705
CLV_PCSK_KEX2_1	20	22	PF00082	0.658
CLV_PCSK_KEX2_1	637	639	PF00082	0.688
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.655
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.688
CLV_PCSK_SKI1_1	135	139	PF00082	0.698
CLV_PCSK_SKI1_1	284	288	PF00082	0.687
CLV_PCSK_SKI1_1	421	425	PF00082	0.536
CLV_PCSK_SKI1_1	427	431	PF00082	0.501
CLV_PCSK_SKI1_1	433	437	PF00082	0.460
CLV_PCSK_SKI1_1	486	490	PF00082	0.531
CLV_PCSK_SKI1_1	561	565	PF00082	0.532
CLV_PCSK_SKI1_1	596	600	PF00082	0.649
CLV_PCSK_SKI1_1	875	879	PF00082	0.460
DEG_Nend_UBRbox_3	1	3	PF02207	0.648
DEG_SPOP_SBC_1	172	176	PF00917	0.677
DEG_SPOP_SBC_1	181	185	PF00917	0.636
DEG_SPOP_SBC_1	188	192	PF00917	0.583
DEG_SPOP_SBC_1	285	289	PF00917	0.627
DEG_SPOP_SBC_1	598	602	PF00917	0.677
DOC_CKS1_1	223	228	PF01111	0.669
DOC_CKS1_1	365	370	PF01111	0.575
DOC_CYCLIN_RxL_1	427	440	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.704
DOC_MAPK_gen_1	20	26	PF00069	0.655
DOC_PP1_RVXF_1	133	139	PF00149	0.692
DOC_PP1_RVXF_1	898	904	PF00149	0.532
DOC_PP1_RVXF_1	99	106	PF00149	0.691
DOC_USP7_MATH_1	120	124	PF00917	0.637
DOC_USP7_MATH_1	144	148	PF00917	0.680
DOC_USP7_MATH_1	172	176	PF00917	0.674
DOC_USP7_MATH_1	179	183	PF00917	0.626
DOC_USP7_MATH_1	188	192	PF00917	0.586
DOC_USP7_MATH_1	234	238	PF00917	0.703
DOC_USP7_MATH_1	273	277	PF00917	0.639
DOC_USP7_MATH_1	303	307	PF00917	0.602
DOC_USP7_MATH_1	328	332	PF00917	0.680
DOC_USP7_MATH_1	335	339	PF00917	0.636
DOC_USP7_MATH_1	39	43	PF00917	0.673
DOC_USP7_MATH_1	390	394	PF00917	0.598
DOC_USP7_MATH_1	398	402	PF00917	0.636
DOC_USP7_MATH_1	502	506	PF00917	0.554
DOC_USP7_MATH_1	542	546	PF00917	0.686
DOC_USP7_MATH_1	586	590	PF00917	0.715
DOC_USP7_MATH_1	591	595	PF00917	0.657
DOC_USP7_MATH_1	598	602	PF00917	0.603
DOC_USP7_MATH_1	613	617	PF00917	0.584
DOC_USP7_MATH_1	657	661	PF00917	0.620
DOC_USP7_MATH_1	712	716	PF00917	0.664
DOC_USP7_MATH_1	717	721	PF00917	0.614
DOC_USP7_MATH_1	723	727	PF00917	0.525
DOC_USP7_MATH_1	791	795	PF00917	0.578
DOC_USP7_MATH_1	8	12	PF00917	0.604
DOC_USP7_MATH_1	827	831	PF00917	0.579
DOC_USP7_MATH_1	925	929	PF00917	0.682
DOC_USP7_MATH_2	768	774	PF00917	0.666
DOC_USP7_UBL2_3	637	641	PF12436	0.682
DOC_WW_Pin1_4	182	187	PF00397	0.690
DOC_WW_Pin1_4	195	200	PF00397	0.588
DOC_WW_Pin1_4	2	7	PF00397	0.620
DOC_WW_Pin1_4	222	227	PF00397	0.701
DOC_WW_Pin1_4	242	247	PF00397	0.508
DOC_WW_Pin1_4	287	292	PF00397	0.681
DOC_WW_Pin1_4	293	298	PF00397	0.658
DOC_WW_Pin1_4	320	325	PF00397	0.670
DOC_WW_Pin1_4	341	346	PF00397	0.664
DOC_WW_Pin1_4	351	356	PF00397	0.667
DOC_WW_Pin1_4	364	369	PF00397	0.556
DOC_WW_Pin1_4	377	382	PF00397	0.545
DOC_WW_Pin1_4	394	399	PF00397	0.618
DOC_WW_Pin1_4	42	47	PF00397	0.672
DOC_WW_Pin1_4	449	454	PF00397	0.694
DOC_WW_Pin1_4	455	460	PF00397	0.666
DOC_WW_Pin1_4	536	541	PF00397	0.765
DOC_WW_Pin1_4	629	634	PF00397	0.629
DOC_WW_Pin1_4	760	765	PF00397	0.709
DOC_WW_Pin1_4	771	776	PF00397	0.620
DOC_WW_Pin1_4	811	816	PF00397	0.619
DOC_WW_Pin1_4	854	859	PF00397	0.596
DOC_WW_Pin1_4	915	920	PF00397	0.682
DOC_WW_Pin1_4	927	932	PF00397	0.571
DOC_WW_Pin1_4	94	99	PF00397	0.632
LIG_14-3-3_CanoR_1	118	126	PF00244	0.644
LIG_14-3-3_CanoR_1	141	149	PF00244	0.664
LIG_14-3-3_CanoR_1	163	169	PF00244	0.663
LIG_14-3-3_CanoR_1	173	181	PF00244	0.610
LIG_14-3-3_CanoR_1	284	291	PF00244	0.686
LIG_14-3-3_CanoR_1	384	392	PF00244	0.661
LIG_14-3-3_CanoR_1	486	495	PF00244	0.525
LIG_14-3-3_CanoR_1	503	510	PF00244	0.434
LIG_14-3-3_CanoR_1	51	56	PF00244	0.585
LIG_14-3-3_CanoR_1	638	647	PF00244	0.646
LIG_14-3-3_CanoR_1	84	93	PF00244	0.661
LIG_14-3-3_CanoR_1	849	854	PF00244	0.612
LIG_14-3-3_CanoR_1	900	904	PF00244	0.559
LIG_Actin_WH2_2	406	423	PF00022	0.552
LIG_Actin_WH2_2	59	76	PF00022	0.580
LIG_APCC_ABBA_1	856	861	PF00400	0.616
LIG_BIR_III_2	230	234	PF00653	0.590
LIG_BIR_III_2	352	356	PF00653	0.600
LIG_BRCT_BRCA1_1	725	729	PF00533	0.528
LIG_CtBP_PxDLS_1	921	925	PF00389	0.637
LIG_FHA_1	190	196	PF00498	0.709
LIG_FHA_1	207	213	PF00498	0.540
LIG_FHA_1	267	273	PF00498	0.642
LIG_FHA_1	294	300	PF00498	0.670
LIG_FHA_1	413	419	PF00498	0.526
LIG_FHA_1	487	493	PF00498	0.537
LIG_FHA_1	54	60	PF00498	0.584
LIG_FHA_1	686	692	PF00498	0.556
LIG_FHA_1	824	830	PF00498	0.580
LIG_FHA_2	126	132	PF00498	0.662
LIG_FHA_2	73	79	PF00498	0.512
LIG_LIR_Apic_2	814	820	PF02991	0.670
LIG_LIR_Apic_2	852	858	PF02991	0.540
LIG_LIR_Gen_1	726	736	PF02991	0.525
LIG_LIR_LC3C_4	505	510	PF02991	0.558
LIG_LIR_Nem_3	726	732	PF02991	0.572
LIG_MYND_1	680	684	PF01753	0.669
LIG_Pex14_1	566	570	PF04695	0.601
LIG_PTAP_UEV_1	713	718	PF05743	0.636
LIG_SH2_CRK	695	699	PF00017	0.675
LIG_SH2_PTP2	855	858	PF00017	0.534
LIG_SH2_STAP1	55	59	PF00017	0.586
LIG_SH2_STAP1	570	574	PF00017	0.615
LIG_SH2_STAP1	798	802	PF00017	0.576
LIG_SH2_STAT3	871	874	PF00017	0.591
LIG_SH2_STAT3	876	879	PF00017	0.525
LIG_SH2_STAT5	55	58	PF00017	0.616
LIG_SH2_STAT5	718	721	PF00017	0.603
LIG_SH2_STAT5	855	858	PF00017	0.607
LIG_SH2_STAT5	859	862	PF00017	0.599
LIG_SH2_STAT5	876	879	PF00017	0.417
LIG_SH3_3	113	119	PF00018	0.594
LIG_SH3_3	294	300	PF00018	0.664
LIG_SH3_3	308	314	PF00018	0.542
LIG_SH3_3	35	41	PF00018	0.656
LIG_SH3_3	358	364	PF00018	0.604
LIG_SH3_3	4	10	PF00018	0.622
LIG_SH3_3	467	473	PF00018	0.662
LIG_SH3_3	653	659	PF00018	0.610
LIG_SH3_3	674	680	PF00018	0.613
LIG_SH3_3	703	709	PF00018	0.683
LIG_SH3_3	711	717	PF00018	0.592
LIG_SH3_3	761	767	PF00018	0.691
LIG_SH3_3	772	778	PF00018	0.612
LIG_SH3_3	916	922	PF00018	0.686
LIG_SH3_3	928	934	PF00018	0.564
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.661
LIG_SUMO_SIM_par_1	108	114	PF11976	0.661
LIG_SUMO_SIM_par_1	414	422	PF11976	0.524
LIG_SUMO_SIM_par_1	434	440	PF11976	0.411
LIG_TRAF2_1	535	538	PF00917	0.613
LIG_WW_3	115	119	PF00397	0.565
LIG_WW_3	458	462	PF00397	0.680
MOD_CDC14_SPxK_1	452	455	PF00782	0.678
MOD_CDC14_SPxK_1	632	635	PF00782	0.626
MOD_CDK_SPxK_1	449	455	PF00069	0.674
MOD_CDK_SPxK_1	629	635	PF00069	0.630
MOD_CDK_SPxxK_3	377	384	PF00069	0.559
MOD_CDK_SPxxK_3	94	101	PF00069	0.616
MOD_CK1_1	121	127	PF00069	0.686
MOD_CK1_1	175	181	PF00069	0.685
MOD_CK1_1	182	188	PF00069	0.639
MOD_CK1_1	191	197	PF00069	0.578
MOD_CK1_1	236	242	PF00069	0.664
MOD_CK1_1	276	282	PF00069	0.674
MOD_CK1_1	42	48	PF00069	0.693
MOD_CK1_1	545	551	PF00069	0.675
MOD_CK1_1	686	692	PF00069	0.650
MOD_CK1_1	697	703	PF00069	0.599
MOD_CK1_1	773	779	PF00069	0.654
MOD_CK1_1	822	828	PF00069	0.679
MOD_CK1_1	915	921	PF00069	0.654
MOD_CK1_1	923	929	PF00069	0.609
MOD_CK1_1	97	103	PF00069	0.677
MOD_CK2_1	72	78	PF00069	0.507
MOD_CMANNOS	566	569	PF00535	0.596
MOD_GlcNHglycan	120	123	PF01048	0.700
MOD_GlcNHglycan	142	145	PF01048	0.643
MOD_GlcNHglycan	177	180	PF01048	0.665
MOD_GlcNHglycan	29	32	PF01048	0.633
MOD_GlcNHglycan	306	309	PF01048	0.616
MOD_GlcNHglycan	311	314	PF01048	0.597
MOD_GlcNHglycan	318	321	PF01048	0.541
MOD_GlcNHglycan	346	349	PF01048	0.674
MOD_GlcNHglycan	392	395	PF01048	0.614
MOD_GlcNHglycan	41	44	PF01048	0.653
MOD_GlcNHglycan	443	446	PF01048	0.591
MOD_GlcNHglycan	548	551	PF01048	0.628
MOD_GlcNHglycan	572	575	PF01048	0.598
MOD_GlcNHglycan	593	596	PF01048	0.697
MOD_GlcNHglycan	614	618	PF01048	0.598
MOD_GlcNHglycan	669	672	PF01048	0.612
MOD_GlcNHglycan	685	688	PF01048	0.520
MOD_GlcNHglycan	701	704	PF01048	0.540
MOD_GlcNHglycan	714	717	PF01048	0.564
MOD_GlcNHglycan	719	722	PF01048	0.504
MOD_GlcNHglycan	725	728	PF01048	0.525
MOD_GlcNHglycan	738	741	PF01048	0.513
MOD_GlcNHglycan	745	748	PF01048	0.600
MOD_GlcNHglycan	757	760	PF01048	0.551
MOD_GlcNHglycan	789	792	PF01048	0.642
MOD_GlcNHglycan	821	824	PF01048	0.671
MOD_GlcNHglycan	829	832	PF01048	0.623
MOD_GlcNHglycan	86	89	PF01048	0.637
MOD_GlcNHglycan	913	917	PF01048	0.678
MOD_GlcNHglycan	935	938	PF01048	0.652
MOD_GSK3_1	118	125	PF00069	0.677
MOD_GSK3_1	140	147	PF00069	0.651
MOD_GSK3_1	171	178	PF00069	0.699
MOD_GSK3_1	187	194	PF00069	0.554
MOD_GSK3_1	236	243	PF00069	0.654
MOD_GSK3_1	247	254	PF00069	0.593
MOD_GSK3_1	316	323	PF00069	0.600
MOD_GSK3_1	344	351	PF00069	0.673
MOD_GSK3_1	388	395	PF00069	0.677
MOD_GSK3_1	412	419	PF00069	0.526
MOD_GSK3_1	541	548	PF00069	0.779
MOD_GSK3_1	582	589	PF00069	0.694
MOD_GSK3_1	663	670	PF00069	0.596
MOD_GSK3_1	694	701	PF00069	0.508
MOD_GSK3_1	770	777	PF00069	0.702
MOD_GSK3_1	781	788	PF00069	0.628
MOD_GSK3_1	819	826	PF00069	0.559
MOD_GSK3_1	908	915	PF00069	0.590
MOD_GSK3_1	923	930	PF00069	0.548
MOD_LATS_1	439	445	PF00433	0.559
MOD_N-GLC_1	195	200	PF02516	0.634
MOD_N-GLC_1	273	278	PF02516	0.559
MOD_N-GLC_1	441	446	PF02516	0.575
MOD_N-GLC_1	743	748	PF02516	0.601
MOD_N-GLC_1	781	786	PF02516	0.621
MOD_NEK2_1	26	31	PF00069	0.597
MOD_NEK2_1	286	291	PF00069	0.630
MOD_NEK2_1	599	604	PF00069	0.656
MOD_NEK2_1	662	667	PF00069	0.613
MOD_NEK2_1	698	703	PF00069	0.512
MOD_NEK2_1	72	77	PF00069	0.507
MOD_NEK2_1	736	741	PF00069	0.623
MOD_NEK2_1	914	919	PF00069	0.577
MOD_PIKK_1	111	117	PF00454	0.653
MOD_PIKK_1	494	500	PF00454	0.550
MOD_PIKK_1	542	548	PF00454	0.797
MOD_PIKK_1	731	737	PF00454	0.618
MOD_PIKK_1	776	782	PF00454	0.618
MOD_PIKK_1	875	881	PF00454	0.505
MOD_PK_1	177	183	PF00069	0.664
MOD_PK_1	849	855	PF00069	0.534
MOD_PKA_1	51	57	PF00069	0.581
MOD_PKA_1	663	669	PF00069	0.554
MOD_PKA_2	140	146	PF00069	0.669
MOD_PKA_2	172	178	PF00069	0.687
MOD_PKA_2	383	389	PF00069	0.652
MOD_PKA_2	502	508	PF00069	0.555
MOD_PKA_2	899	905	PF00069	0.558
MOD_PKB_1	461	469	PF00069	0.656
MOD_PKB_1	476	484	PF00069	0.453
MOD_Plk_1	276	282	PF00069	0.674
MOD_Plk_2-3	416	422	PF00069	0.523
MOD_Plk_4	106	112	PF00069	0.692
MOD_Plk_4	219	225	PF00069	0.699
MOD_Plk_4	247	253	PF00069	0.674
MOD_Plk_4	255	261	PF00069	0.586
MOD_Plk_4	657	663	PF00069	0.626
MOD_Plk_4	899	905	PF00069	0.536
MOD_ProDKin_1	182	188	PF00069	0.688
MOD_ProDKin_1	195	201	PF00069	0.585
MOD_ProDKin_1	2	8	PF00069	0.624
MOD_ProDKin_1	222	228	PF00069	0.702
MOD_ProDKin_1	242	248	PF00069	0.508
MOD_ProDKin_1	287	293	PF00069	0.684
MOD_ProDKin_1	320	326	PF00069	0.672
MOD_ProDKin_1	341	347	PF00069	0.665
MOD_ProDKin_1	351	357	PF00069	0.663
MOD_ProDKin_1	364	370	PF00069	0.559
MOD_ProDKin_1	377	383	PF00069	0.544
MOD_ProDKin_1	394	400	PF00069	0.617
MOD_ProDKin_1	42	48	PF00069	0.670
MOD_ProDKin_1	449	455	PF00069	0.697
MOD_ProDKin_1	536	542	PF00069	0.766
MOD_ProDKin_1	629	635	PF00069	0.630
MOD_ProDKin_1	760	766	PF00069	0.710
MOD_ProDKin_1	771	777	PF00069	0.620
MOD_ProDKin_1	811	817	PF00069	0.620
MOD_ProDKin_1	854	860	PF00069	0.592
MOD_ProDKin_1	915	921	PF00069	0.679
MOD_ProDKin_1	927	933	PF00069	0.568
MOD_ProDKin_1	94	100	PF00069	0.631
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.654
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.460
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.501
TRG_ENDOCYTIC_2	695	698	PF00928	0.675
TRG_ER_diArg_1	133	136	PF00400	0.690
TRG_ER_diArg_1	163	165	PF00400	0.653
TRG_ER_diArg_1	460	463	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	887	891	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HA64	Leishmania braziliensis	62%	97%
A4HYD5	Leishmania infantum	99%	100%
E9AS68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QD98	Leishmania major	84%	97%