Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H764_LEIDO

TriTrypDb:

LdBPK_190920.1 , LdCL_190014600 , LDHU3_19.1120

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 7
NetGPI	no	yes: 0, no: 15

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S5H764

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H764

Function

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Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	16
GO:0003824	catalytic activity	1	16
GO:0016853	isomerase activity	2	16
GO:0016859	cis-trans isomerase activity	3	16
GO:0140096	catalytic activity, acting on a protein	2	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.339
CLV_NRD_NRD_1	69	71	PF00675	0.427
CLV_PCSK_KEX2_1	108	110	PF00082	0.339
CLV_PCSK_KEX2_1	69	71	PF00082	0.427
CLV_PCSK_SKI1_1	183	187	PF00082	0.481
CLV_PCSK_SKI1_1	49	53	PF00082	0.535
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.261
DOC_PP2B_LxvP_1	133	136	PF13499	0.302
DOC_USP7_MATH_1	54	58	PF00917	0.417
DOC_USP7_UBL2_3	143	147	PF12436	0.232

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	31%	100%
A0A0N1II12	Leptomonas seymouri	66%	100%
A0A1X0P7N1	Trypanosomatidae	40%	95%
A0A3Q8IB31	Leishmania donovani	30%	100%
A0A3S5IR72	Trypanosoma rangeli	40%	100%
A4H677	Leishmania braziliensis	31%	100%
A4HA48	Leishmania braziliensis	77%	100%
A4HUK1	Leishmania infantum	30%	100%
A4HYB4	Leishmania infantum	100%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%

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