Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H764_LEIDO

TriTrypDb:

LdBPK_190920.1 , LdCL_190014600 , LDHU3_19.1120

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 7
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H764

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H764

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	16
GO:0003824	catalytic activity	1	16
GO:0016853	isomerase activity	2	16
GO:0016859	cis-trans isomerase activity	3	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.339
CLV_NRD_NRD_1	69	71	PF00675	0.427
CLV_PCSK_KEX2_1	108	110	PF00082	0.339
CLV_PCSK_KEX2_1	69	71	PF00082	0.427
CLV_PCSK_SKI1_1	183	187	PF00082	0.481
CLV_PCSK_SKI1_1	49	53	PF00082	0.535
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.261
DOC_PP2B_LxvP_1	133	136	PF13499	0.302
DOC_USP7_MATH_1	54	58	PF00917	0.417
DOC_USP7_UBL2_3	143	147	PF12436	0.232
DOC_WW_Pin1_4	107	112	PF00397	0.356
LIG_14-3-3_CanoR_1	3	8	PF00244	0.546
LIG_14-3-3_CanoR_1	37	42	PF00244	0.400
LIG_Clathr_ClatBox_1	64	68	PF01394	0.307
LIG_FHA_1	14	20	PF00498	0.448
LIG_FHA_2	171	177	PF00498	0.322
LIG_LIR_Apic_2	88	94	PF02991	0.218
LIG_LIR_Gen_1	129	139	PF02991	0.279
LIG_LIR_Gen_1	197	201	PF02991	0.653
LIG_LIR_Gen_1	2	12	PF02991	0.333
LIG_LIR_Gen_1	40	47	PF02991	0.336
LIG_LIR_Nem_3	129	135	PF02991	0.287
LIG_LIR_Nem_3	197	201	PF02991	0.653
LIG_LIR_Nem_3	2	7	PF02991	0.432
LIG_LIR_Nem_3	40	44	PF02991	0.342
LIG_OCRL_FandH_1	3	15	PF00620	0.370
LIG_PAM2_1	22	34	PF00658	0.295
LIG_PDZ_Class_1	196	201	PF00595	0.408
LIG_SH2_CRK	41	45	PF00017	0.313
LIG_SH2_CRK	91	95	PF00017	0.286
LIG_SH2_NCK_1	41	45	PF00017	0.369
LIG_SH2_SRC	132	135	PF00017	0.320
LIG_SH2_STAP1	87	91	PF00017	0.218
LIG_SH2_STAT5	132	135	PF00017	0.350
LIG_SH2_STAT5	180	183	PF00017	0.459
LIG_SH2_STAT5	198	201	PF00017	0.637
LIG_SH2_STAT5	46	49	PF00017	0.364
LIG_SH2_STAT5	87	90	PF00017	0.245
LIG_SUMO_SIM_par_1	15	20	PF11976	0.396
LIG_SUMO_SIM_par_1	22	27	PF11976	0.359
LIG_TYR_ITIM	196	201	PF00017	0.524
MOD_CK1_1	170	176	PF00069	0.343
MOD_CK1_1	29	35	PF00069	0.426
MOD_CK1_1	6	12	PF00069	0.466
MOD_CK2_1	170	176	PF00069	0.335
MOD_GlcNHglycan	167	170	PF01048	0.407
MOD_GlcNHglycan	173	176	PF01048	0.320
MOD_GlcNHglycan	56	59	PF01048	0.326
MOD_GlcNHglycan	60	63	PF01048	0.351
MOD_GSK3_1	13	20	PF00069	0.379
MOD_GSK3_1	167	174	PF00069	0.368
MOD_GSK3_1	2	9	PF00069	0.448
MOD_GSK3_1	22	29	PF00069	0.388
MOD_GSK3_1	54	61	PF00069	0.454
MOD_N-GLC_1	54	59	PF02516	0.421
MOD_NEK2_1	17	22	PF00069	0.398
MOD_NEK2_1	85	90	PF00069	0.263
MOD_PIKK_1	109	115	PF00454	0.398
MOD_PKA_2	2	8	PF00069	0.559
MOD_Plk_1	26	32	PF00069	0.380
MOD_Plk_1	54	60	PF00069	0.427
MOD_Plk_4	13	19	PF00069	0.402
MOD_Plk_4	26	32	PF00069	0.266
MOD_Plk_4	6	12	PF00069	0.477
MOD_ProDKin_1	107	113	PF00069	0.356
MOD_SUMO_rev_2	144	152	PF00179	0.247
TRG_DiLeu_BaEn_1	120	125	PF01217	0.245
TRG_ENDOCYTIC_2	132	135	PF00928	0.312
TRG_ENDOCYTIC_2	198	201	PF00928	0.611
TRG_ENDOCYTIC_2	41	44	PF00928	0.368
TRG_ER_diArg_1	107	109	PF00400	0.312
TRG_NES_CRM1_1	113	127	PF08389	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	31%	100%
A0A0N1II12	Leptomonas seymouri	66%	100%
A0A1X0P7N1	Trypanosomatidae	40%	95%
A0A3Q8IB31	Leishmania donovani	30%	100%
A0A3S5IR72	Trypanosoma rangeli	40%	100%
A4H677	Leishmania braziliensis	31%	100%
A4HA48	Leishmania braziliensis	77%	100%
A4HUK1	Leishmania infantum	30%	100%
A4HYB4	Leishmania infantum	100%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q09734	Trypanosoma cruzi	39%	100%
Q4QDB9	Leishmania major	96%	100%
Q4QHC5	Leishmania major	30%	100%
Q9JYI8	Neisseria meningitidis serogroup B (strain MC58)	29%	74%