Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H760_LEIDO

TriTrypDb:

LdBPK_190750.1 , LdCL_190012500 , LDHU3_19.0830

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H760

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H760

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.672
CLV_NRD_NRD_1	110	112	PF00675	0.567
CLV_NRD_NRD_1	312	314	PF00675	0.473
CLV_NRD_NRD_1	319	321	PF00675	0.637
CLV_NRD_NRD_1	394	396	PF00675	0.382
CLV_NRD_NRD_1	43	45	PF00675	0.564
CLV_PCSK_KEX2_1	109	111	PF00082	0.512
CLV_PCSK_KEX2_1	143	145	PF00082	0.746
CLV_PCSK_KEX2_1	312	314	PF00082	0.439
CLV_PCSK_KEX2_1	318	320	PF00082	0.582
CLV_PCSK_KEX2_1	394	396	PF00082	0.367
CLV_PCSK_KEX2_1	43	45	PF00082	0.563
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.492
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.741
CLV_PCSK_PC7_1	105	111	PF00082	0.487
CLV_PCSK_SKI1_1	105	109	PF00082	0.398
CLV_PCSK_SKI1_1	270	274	PF00082	0.462
CLV_PCSK_SKI1_1	312	316	PF00082	0.409
DEG_Nend_UBRbox_2	1	3	PF02207	0.691
DEG_SPOP_SBC_1	137	141	PF00917	0.714
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.416
DOC_PP2B_LxvP_1	272	275	PF13499	0.406
DOC_PP4_FxxP_1	229	232	PF00568	0.371
DOC_USP7_MATH_1	132	136	PF00917	0.696
DOC_USP7_MATH_1	152	156	PF00917	0.752
DOC_USP7_MATH_1	342	346	PF00917	0.501
DOC_USP7_MATH_1	359	363	PF00917	0.490
DOC_USP7_MATH_1	58	62	PF00917	0.772
DOC_USP7_MATH_1	63	67	PF00917	0.768
DOC_WW_Pin1_4	144	149	PF00397	0.729
DOC_WW_Pin1_4	325	330	PF00397	0.742
DOC_WW_Pin1_4	404	409	PF00397	0.426
DOC_WW_Pin1_4	436	441	PF00397	0.614
LIG_14-3-3_CanoR_1	202	211	PF00244	0.535
LIG_14-3-3_CanoR_1	3	8	PF00244	0.664
LIG_14-3-3_CanoR_1	435	440	PF00244	0.580
LIG_BIR_III_2	287	291	PF00653	0.487
LIG_BIR_III_4	433	437	PF00653	0.538
LIG_BRCT_BRCA1_1	352	356	PF00533	0.382
LIG_BRCT_BRCA1_1	399	403	PF00533	0.397
LIG_Clathr_ClatBox_1	294	298	PF01394	0.432
LIG_deltaCOP1_diTrp_1	419	426	PF00928	0.492
LIG_DLG_GKlike_1	3	11	PF00625	0.547
LIG_eIF4E_1	225	231	PF01652	0.341
LIG_FHA_1	379	385	PF00498	0.467
LIG_FHA_1	416	422	PF00498	0.513
LIG_FHA_1	451	457	PF00498	0.485
LIG_FHA_1	47	53	PF00498	0.573
LIG_FHA_2	380	386	PF00498	0.408
LIG_FHA_2	414	420	PF00498	0.454
LIG_FHA_2	83	89	PF00498	0.590
LIG_LIR_Apic_2	227	232	PF02991	0.343
LIG_LIR_Apic_2	446	450	PF02991	0.451
LIG_LIR_Gen_1	300	311	PF02991	0.477
LIG_LIR_Gen_1	458	466	PF02991	0.520
LIG_LIR_LC3C_4	366	371	PF02991	0.445
LIG_LIR_Nem_3	300	306	PF02991	0.483
LIG_PCNA_PIPBox_1	372	381	PF02747	0.469
LIG_Pex14_1	262	266	PF04695	0.440
LIG_Pex14_1	443	447	PF04695	0.498
LIG_REV1ctd_RIR_1	312	322	PF16727	0.508
LIG_SH2_PTP2	447	450	PF00017	0.447
LIG_SH2_SRC	181	184	PF00017	0.392
LIG_SH2_SRC	447	450	PF00017	0.479
LIG_SH2_STAP1	174	178	PF00017	0.498
LIG_SH2_STAT3	38	41	PF00017	0.493
LIG_SH2_STAT5	199	202	PF00017	0.365
LIG_SH2_STAT5	225	228	PF00017	0.355
LIG_SH2_STAT5	378	381	PF00017	0.390
LIG_SH2_STAT5	447	450	PF00017	0.479
LIG_SH3_3	114	120	PF00018	0.464
LIG_SH3_3	166	172	PF00018	0.498
LIG_SH3_3	402	408	PF00018	0.400
LIG_SH3_3	67	73	PF00018	0.742
LIG_SUMO_SIM_anti_2	365	373	PF11976	0.341
LIG_SUMO_SIM_par_1	245	252	PF11976	0.431
LIG_TRAF2_1	85	88	PF00917	0.648
LIG_UBA3_1	7	12	PF00899	0.531
LIG_WRC_WIRS_1	414	419	PF05994	0.496
MOD_CK1_1	155	161	PF00069	0.690
MOD_CK1_1	362	368	PF00069	0.475
MOD_CK1_1	6	12	PF00069	0.613
MOD_CK1_1	61	67	PF00069	0.775
MOD_CK1_1	71	77	PF00069	0.588
MOD_CK2_1	379	385	PF00069	0.381
MOD_CK2_1	443	449	PF00069	0.416
MOD_CK2_1	82	88	PF00069	0.712
MOD_DYRK1A_RPxSP_1	144	148	PF00069	0.710
MOD_GlcNHglycan	148	151	PF01048	0.622
MOD_GlcNHglycan	154	157	PF01048	0.643
MOD_GlcNHglycan	163	166	PF01048	0.688
MOD_GlcNHglycan	361	364	PF01048	0.485
MOD_GlcNHglycan	399	402	PF01048	0.462
MOD_GlcNHglycan	65	68	PF01048	0.696
MOD_GlcNHglycan	73	76	PF01048	0.816
MOD_GlcNHglycan	8	11	PF01048	0.584
MOD_GSK3_1	132	139	PF00069	0.675
MOD_GSK3_1	146	153	PF00069	0.717
MOD_GSK3_1	212	219	PF00069	0.341
MOD_GSK3_1	238	245	PF00069	0.520
MOD_GSK3_1	54	61	PF00069	0.710
MOD_LATS_1	484	490	PF00433	0.594
MOD_N-GLC_1	472	477	PF02516	0.665
MOD_N-GLC_1	82	87	PF02516	0.500
MOD_NEK2_1	299	304	PF00069	0.503
MOD_NEK2_1	364	369	PF00069	0.481
MOD_NEK2_1	379	384	PF00069	0.507
MOD_NEK2_1	410	415	PF00069	0.370
MOD_PIKK_1	216	222	PF00454	0.346
MOD_PIKK_1	304	310	PF00454	0.450
MOD_PK_1	246	252	PF00069	0.481
MOD_PKA_2	434	440	PF00069	0.591
MOD_PKB_1	144	152	PF00069	0.721
MOD_Plk_1	137	143	PF00069	0.528
MOD_Plk_1	299	305	PF00069	0.478
MOD_Plk_1	365	371	PF00069	0.384
MOD_Plk_1	410	416	PF00069	0.398
MOD_Plk_2-3	472	478	PF00069	0.702
MOD_Plk_2-3	82	88	PF00069	0.569
MOD_Plk_4	299	305	PF00069	0.478
MOD_Plk_4	3	9	PF00069	0.655
MOD_Plk_4	365	371	PF00069	0.450
MOD_Plk_4	443	449	PF00069	0.405
MOD_ProDKin_1	144	150	PF00069	0.731
MOD_ProDKin_1	325	331	PF00069	0.743
MOD_ProDKin_1	404	410	PF00069	0.425
MOD_ProDKin_1	436	442	PF00069	0.611
MOD_SUMO_rev_2	185	195	PF00179	0.491
MOD_SUMO_rev_2	335	342	PF00179	0.493
TRG_ER_diArg_1	110	112	PF00400	0.570
TRG_ER_diArg_1	312	314	PF00400	0.516
TRG_ER_diArg_1	318	320	PF00400	0.660
TRG_ER_diArg_1	393	395	PF00400	0.431
TRG_NLS_MonoExtC_3	108	113	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I161	Leptomonas seymouri	47%	100%
A0A0S4IWK0	Bodo saltans	26%	100%
A0A1X0P685	Trypanosomatidae	32%	99%
A0A3R7KFJ2	Trypanosoma rangeli	31%	100%
A4HA32	Leishmania braziliensis	74%	99%
A4HY95	Leishmania infantum	99%	100%
D0A0M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AS27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDE6	Leishmania major	92%	100%
V5B315	Trypanosoma cruzi	30%	100%