Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H756_LEIDO

TriTrypDb:

LdBPK_190500.1 , LdCL_190010000 , LDHU3_19.0550

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H756

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H756

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.795
CLV_NRD_NRD_1	42	44	PF00675	0.543
CLV_NRD_NRD_1	67	69	PF00675	0.654
CLV_NRD_NRD_1	75	77	PF00675	0.551
CLV_NRD_NRD_1	93	95	PF00675	0.531
CLV_PCSK_KEX2_1	215	217	PF00082	0.744
CLV_PCSK_KEX2_1	41	43	PF00082	0.546
CLV_PCSK_KEX2_1	67	69	PF00082	0.636
CLV_PCSK_KEX2_1	75	77	PF00082	0.547
CLV_PCSK_KEX2_1	93	95	PF00082	0.560
CLV_PCSK_PC7_1	211	217	PF00082	0.783
CLV_PCSK_SKI1_1	144	148	PF00082	0.561
CLV_PCSK_SKI1_1	166	170	PF00082	0.572
CLV_PCSK_SKI1_1	244	248	PF00082	0.748
DEG_APCC_DBOX_1	150	158	PF00400	0.598
DEG_APCC_DBOX_1	83	91	PF00400	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.673
DOC_ANK_TNKS_1	184	191	PF00023	0.608
DOC_MAPK_gen_1	67	73	PF00069	0.502
DOC_MIT_MIM_1	162	171	PF04212	0.569
DOC_PP4_FxxP_1	117	120	PF00568	0.610
DOC_USP7_MATH_1	231	235	PF00917	0.782
DOC_USP7_UBL2_3	57	61	PF12436	0.562
DOC_WW_Pin1_4	225	230	PF00397	0.693
DOC_WW_Pin1_4	234	239	PF00397	0.628
DOC_WW_Pin1_4	9	14	PF00397	0.606
LIG_14-3-3_CanoR_1	171	177	PF00244	0.533
LIG_14-3-3_CanoR_1	185	189	PF00244	0.424
LIG_BRCT_BRCA1_1	113	117	PF00533	0.650
LIG_FHA_1	2	8	PF00498	0.691
LIG_FHA_2	121	127	PF00498	0.512
LIG_FHA_2	171	177	PF00498	0.533
LIG_FHA_2	76	82	PF00498	0.583
LIG_LIR_Apic_2	114	120	PF02991	0.618
LIG_LIR_Gen_1	164	174	PF02991	0.500
LIG_LIR_Nem_3	16	22	PF02991	0.573
LIG_LIR_Nem_3	164	170	PF02991	0.504
LIG_NRBOX	34	40	PF00104	0.590
LIG_SH2_PTP2	22	25	PF00017	0.593
LIG_SH2_STAT5	22	25	PF00017	0.593
LIG_SH3_1	22	28	PF00018	0.592
LIG_SH3_3	106	112	PF00018	0.543
LIG_SH3_3	202	208	PF00018	0.618
LIG_SH3_3	22	28	PF00018	0.559
LIG_SH3_3	63	69	PF00018	0.600
LIG_SH3_4	57	64	PF00018	0.594
LIG_TRAF2_1	101	104	PF00917	0.649
LIG_TRAF2_1	173	176	PF00917	0.545
LIG_TRAF2_1	77	80	PF00917	0.535
MOD_CK1_1	194	200	PF00069	0.715
MOD_CK1_1	224	230	PF00069	0.788
MOD_CK1_1	234	240	PF00069	0.717
MOD_CK1_1	26	32	PF00069	0.575
MOD_CK1_1	260	266	PF00069	0.571
MOD_CK2_1	120	126	PF00069	0.523
MOD_CK2_1	170	176	PF00069	0.559
MOD_CK2_1	260	266	PF00069	0.594
MOD_CK2_1	75	81	PF00069	0.540
MOD_Cter_Amidation	73	76	PF01082	0.563
MOD_GlcNHglycan	186	189	PF01048	0.617
MOD_GlcNHglycan	196	199	PF01048	0.642
MOD_GlcNHglycan	223	226	PF01048	0.608
MOD_GlcNHglycan	233	236	PF01048	0.776
MOD_GSK3_1	210	217	PF00069	0.738
MOD_GSK3_1	219	226	PF00069	0.700
MOD_GSK3_1	23	30	PF00069	0.559
MOD_GSK3_1	245	252	PF00069	0.745
MOD_GSK3_1	257	264	PF00069	0.565
MOD_GSK3_1	273	280	PF00069	0.598
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	170	175	PF00069	0.527
MOD_NEK2_1	184	189	PF00069	0.449
MOD_PIKK_1	210	216	PF00454	0.777
MOD_PKA_1	75	81	PF00069	0.539
MOD_PKA_2	170	176	PF00069	0.535
MOD_PKA_2	184	190	PF00069	0.653
MOD_PKA_2	210	216	PF00069	0.726
MOD_PKA_2	252	258	PF00069	0.577
MOD_PKA_2	75	81	PF00069	0.540
MOD_PKA_2	92	98	PF00069	0.562
MOD_Plk_1	1	7	PF00069	0.695
MOD_Plk_4	201	207	PF00069	0.562
MOD_Plk_4	277	283	PF00069	0.556
MOD_ProDKin_1	225	231	PF00069	0.694
MOD_ProDKin_1	234	240	PF00069	0.628
MOD_ProDKin_1	9	15	PF00069	0.594
MOD_SUMO_rev_2	255	263	PF00179	0.547
TRG_ER_diArg_1	151	154	PF00400	0.556
TRG_ER_diArg_1	41	43	PF00400	0.593
TRG_ER_diArg_1	66	68	PF00400	0.570
TRG_ER_diArg_1	75	77	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK6	Leptomonas seymouri	61%	98%
A0A1X0P771	Trypanosomatidae	35%	100%
A4HA08	Leishmania braziliensis	80%	100%
A4HY72	Leishmania infantum	99%	100%
E9AS02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDH1	Leishmania major	92%	100%
V5DTM1	Trypanosoma cruzi	40%	100%