Nuclear cap binding complex subunit CBP30, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding complex subunit CBP30, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H755_LEIDO

TriTrypDb:

LdBPK_190470.1 , LdCL_190009700 , LDHU3_19.0520

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H755

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H755

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.395
CLV_C14_Caspase3-7	172	176	PF00656	0.235
CLV_NRD_NRD_1	104	106	PF00675	0.416
CLV_NRD_NRD_1	276	278	PF00675	0.292
CLV_NRD_NRD_1	305	307	PF00675	0.452
CLV_NRD_NRD_1	318	320	PF00675	0.347
CLV_NRD_NRD_1	43	45	PF00675	0.268
CLV_PCSK_KEX2_1	103	105	PF00082	0.308
CLV_PCSK_KEX2_1	305	307	PF00082	0.359
CLV_PCSK_KEX2_1	318	320	PF00082	0.218
CLV_PCSK_SKI1_1	278	282	PF00082	0.292
CLV_PCSK_SKI1_1	61	65	PF00082	0.271
DEG_SPOP_SBC_1	147	151	PF00917	0.289
DEG_SPOP_SBC_1	158	162	PF00917	0.216
DOC_CKS1_1	22	27	PF01111	0.271
DOC_CYCLIN_RxL_1	29	39	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.289
DOC_MAPK_DCC_7	238	247	PF00069	0.335
DOC_MAPK_FxFP_2	207	210	PF00069	0.271
DOC_MAPK_gen_1	318	325	PF00069	0.292
DOC_MAPK_gen_1	44	53	PF00069	0.299
DOC_PP2B_PxIxI_1	221	227	PF00149	0.335
DOC_PP4_FxxP_1	207	210	PF00568	0.271
DOC_USP7_MATH_1	147	151	PF00917	0.381
DOC_USP7_MATH_1	158	162	PF00917	0.372
DOC_USP7_MATH_1	178	182	PF00917	0.311
DOC_USP7_MATH_1	194	198	PF00917	0.443
DOC_USP7_MATH_1	286	290	PF00917	0.335
DOC_WW_Pin1_4	119	124	PF00397	0.458
DOC_WW_Pin1_4	21	26	PF00397	0.271
DOC_WW_Pin1_4	240	245	PF00397	0.307
LIG_14-3-3_CanoR_1	265	272	PF00244	0.404
LIG_Actin_WH2_2	342	359	PF00022	0.404
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BRCT_BRCA1_1	267	271	PF00533	0.404
LIG_CtBP_PxDLS_1	54	58	PF00389	0.404
LIG_DLG_GKlike_1	267	275	PF00625	0.404
LIG_FHA_1	33	39	PF00498	0.404
LIG_FHA_2	133	139	PF00498	0.440
LIG_FHA_2	151	157	PF00498	0.265
LIG_FHA_2	170	176	PF00498	0.353
LIG_FHA_2	225	231	PF00498	0.375
LIG_FHA_2	244	250	PF00498	0.358
LIG_FHA_2	331	337	PF00498	0.355
LIG_LIR_Gen_1	17	26	PF02991	0.314
LIG_LIR_Gen_1	70	80	PF02991	0.405
LIG_LIR_Nem_3	17	22	PF02991	0.314
LIG_LIR_Nem_3	211	215	PF02991	0.405
LIG_LIR_Nem_3	62	67	PF02991	0.326
LIG_LIR_Nem_3	70	76	PF02991	0.297
LIG_MYND_1	89	93	PF01753	0.289
LIG_Pex14_1	60	64	PF04695	0.271
LIG_SH2_CRK	212	216	PF00017	0.292
LIG_SH2_NCK_1	328	332	PF00017	0.335
LIG_SH2_PTP2	241	244	PF00017	0.314
LIG_SH2_SRC	328	331	PF00017	0.335
LIG_SH2_STAP1	73	77	PF00017	0.370
LIG_SH2_STAT5	241	244	PF00017	0.271
LIG_SH2_STAT5	30	33	PF00017	0.404
LIG_SH3_2	301	306	PF14604	0.237
LIG_SH3_2	93	98	PF14604	0.335
LIG_SH3_3	280	286	PF00018	0.336
LIG_SH3_3	298	304	PF00018	0.366
LIG_SH3_3	320	326	PF00018	0.237
LIG_SH3_3	48	54	PF00018	0.245
LIG_SH3_3	86	92	PF00018	0.271
LIG_SUMO_SIM_par_1	34	39	PF11976	0.404
LIG_TRAF2_1	227	230	PF00917	0.271
LIG_TRAF2_1	248	251	PF00917	0.295
LIG_TRAF2_1	254	257	PF00917	0.283
LIG_TRAF2_1	334	337	PF00917	0.335
LIG_TRAF2_1	68	71	PF00917	0.335
LIG_WRC_WIRS_1	73	78	PF05994	0.292
MOD_CK1_1	150	156	PF00069	0.406
MOD_CK1_1	157	163	PF00069	0.428
MOD_CK1_1	173	179	PF00069	0.272
MOD_CK1_1	2	8	PF00069	0.635
MOD_CK1_1	243	249	PF00069	0.335
MOD_CK1_1	314	320	PF00069	0.482
MOD_CK2_1	224	230	PF00069	0.271
MOD_CK2_1	243	249	PF00069	0.326
MOD_CK2_1	330	336	PF00069	0.390
MOD_CK2_1	43	49	PF00069	0.330
MOD_CK2_1	65	71	PF00069	0.335
MOD_GlcNHglycan	128	131	PF01048	0.487
MOD_GlcNHglycan	156	159	PF01048	0.396
MOD_GlcNHglycan	16	19	PF01048	0.237
MOD_GlcNHglycan	172	175	PF01048	0.243
MOD_GlcNHglycan	216	219	PF01048	0.273
MOD_GlcNHglycan	288	291	PF01048	0.330
MOD_GlcNHglycan	38	41	PF01048	0.404
MOD_GlcNHglycan	4	7	PF01048	0.615
MOD_GlcNHglycan	8	11	PF01048	0.573
MOD_GSK3_1	128	135	PF00069	0.457
MOD_GSK3_1	146	153	PF00069	0.315
MOD_GSK3_1	154	161	PF00069	0.378
MOD_GSK3_1	162	169	PF00069	0.475
MOD_GSK3_1	178	185	PF00069	0.254
MOD_GSK3_1	2	9	PF00069	0.571
MOD_GSK3_1	24	31	PF00069	0.345
MOD_GSK3_1	261	268	PF00069	0.298
MOD_GSK3_1	32	39	PF00069	0.355
MOD_N-GLC_1	166	171	PF02516	0.437
MOD_NEK2_1	1	6	PF00069	0.745
MOD_NEK2_1	117	122	PF00069	0.493
MOD_NEK2_1	126	131	PF00069	0.456
MOD_NEK2_1	261	266	PF00069	0.271
MOD_NEK2_1	36	41	PF00069	0.404
MOD_PKA_2	14	20	PF00069	0.314
MOD_PKA_2	162	168	PF00069	0.392
MOD_PKA_2	43	49	PF00069	0.402
MOD_PKA_2	65	71	PF00069	0.335
MOD_PKB_1	265	273	PF00069	0.317
MOD_Plk_4	267	273	PF00069	0.349
MOD_Plk_4	55	61	PF00069	0.349
MOD_ProDKin_1	119	125	PF00069	0.458
MOD_ProDKin_1	21	27	PF00069	0.271
MOD_ProDKin_1	240	246	PF00069	0.307
MOD_SUMO_rev_2	332	341	PF00179	0.292
TRG_DiLeu_BaEn_4	256	262	PF01217	0.311
TRG_DiLeu_BaEn_4	336	342	PF01217	0.335
TRG_ENDOCYTIC_2	212	215	PF00928	0.292
TRG_ENDOCYTIC_2	73	76	PF00928	0.410
TRG_ER_diArg_1	102	105	PF00400	0.388
TRG_ER_diArg_1	304	306	PF00400	0.355
TRG_ER_diArg_1	41	44	PF00400	0.269
TRG_NLS_MonoExtC_3	43	49	PF00514	0.378
TRG_NLS_MonoExtN_4	42	48	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD4	Leptomonas seymouri	58%	100%
A0A1X0P6J9	Trypanosomatidae	45%	100%
A0A3R7N3C2	Trypanosoma rangeli	43%	100%
A4HA05	Leishmania braziliensis	76%	100%
A4HY69	Leishmania infantum	100%	100%
D0A0I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDH4	Leishmania major	94%	100%
V5BBW3	Trypanosoma cruzi	37%	100%