EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H753_LEIDO

TriTrypDb:

LdBPK_190340.1 , LdCL_190008400 , LDHU3_19.0390

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S5H753

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H753

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.482
CLV_NRD_NRD_1	166	168	PF00675	0.553
CLV_NRD_NRD_1	194	196	PF00675	0.475
CLV_NRD_NRD_1	225	227	PF00675	0.454
CLV_NRD_NRD_1	292	294	PF00675	0.348
CLV_NRD_NRD_1	402	404	PF00675	0.366
CLV_PCSK_FUR_1	192	196	PF00082	0.506
CLV_PCSK_KEX2_1	166	168	PF00082	0.520
CLV_PCSK_KEX2_1	194	196	PF00082	0.475
CLV_PCSK_KEX2_1	292	294	PF00082	0.340
CLV_PCSK_KEX2_1	402	404	PF00082	0.366
CLV_PCSK_PC7_1	162	168	PF00082	0.387
CLV_PCSK_SKI1_1	226	230	PF00082	0.505
CLV_PCSK_SKI1_1	341	345	PF00082	0.464
CLV_PCSK_SKI1_1	447	451	PF00082	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SPOP_SBC_1	95	99	PF00917	0.571
DOC_CYCLIN_RxL_1	192	203	PF00134	0.451
DOC_MAPK_gen_1	192	199	PF00069	0.429
DOC_MAPK_gen_1	314	324	PF00069	0.396
DOC_PP1_RVXF_1	315	322	PF00149	0.390
DOC_PP2B_LxvP_1	274	277	PF13499	0.354
DOC_PP4_FxxP_1	371	374	PF00568	0.395
DOC_USP7_MATH_1	147	151	PF00917	0.618
DOC_USP7_MATH_1	200	204	PF00917	0.472
DOC_USP7_MATH_1	277	281	PF00917	0.285
DOC_USP7_MATH_1	329	333	PF00917	0.579
DOC_USP7_MATH_1	367	371	PF00917	0.494
DOC_USP7_MATH_1	432	436	PF00917	0.387
DOC_USP7_MATH_1	90	94	PF00917	0.716
DOC_USP7_MATH_1	95	99	PF00917	0.692
DOC_USP7_UBL2_3	227	231	PF12436	0.333
DOC_USP7_UBL2_3	415	419	PF12436	0.434
DOC_WW_Pin1_4	103	108	PF00397	0.693
DOC_WW_Pin1_4	305	310	PF00397	0.511
DOC_WW_Pin1_4	349	354	PF00397	0.416
LIG_14-3-3_CanoR_1	10	17	PF00244	0.723
LIG_14-3-3_CanoR_1	114	124	PF00244	0.671
LIG_14-3-3_CanoR_1	128	134	PF00244	0.647
LIG_14-3-3_CanoR_1	68	78	PF00244	0.635
LIG_AP2alpha_1	362	366	PF02296	0.375
LIG_eIF4E_1	38	44	PF01652	0.671
LIG_FHA_1	104	110	PF00498	0.493
LIG_FHA_1	119	125	PF00498	0.713
LIG_FHA_1	208	214	PF00498	0.624
LIG_FHA_1	240	246	PF00498	0.471
LIG_FHA_1	352	358	PF00498	0.581
LIG_FHA_1	376	382	PF00498	0.499
LIG_FHA_1	38	44	PF00498	0.584
LIG_FHA_2	108	114	PF00498	0.529
LIG_FHA_2	141	147	PF00498	0.667
LIG_FHA_2	412	418	PF00498	0.429
LIG_Integrin_isoDGR_2	290	292	PF01839	0.311
LIG_Integrin_isoDGR_2	410	412	PF01839	0.429
LIG_LIR_Apic_2	158	163	PF02991	0.475
LIG_LIR_Apic_2	368	374	PF02991	0.381
LIG_LIR_Gen_1	121	127	PF02991	0.653
LIG_LIR_Gen_1	275	285	PF02991	0.457
LIG_LIR_Gen_1	320	329	PF02991	0.536
LIG_LIR_Nem_3	121	125	PF02991	0.653
LIG_LIR_Nem_3	275	281	PF02991	0.448
LIG_LIR_Nem_3	298	304	PF02991	0.397
LIG_LIR_Nem_3	320	324	PF02991	0.511
LIG_MYND_1	138	142	PF01753	0.646
LIG_NRBOX	432	438	PF00104	0.424
LIG_Pex14_1	71	75	PF04695	0.558
LIG_Pex14_2	344	348	PF04695	0.348
LIG_Pex14_2	362	366	PF04695	0.477
LIG_SH2_CRK	301	305	PF00017	0.386
LIG_SH2_PTP2	160	163	PF00017	0.573
LIG_SH2_PTP2	173	176	PF00017	0.570
LIG_SH2_PTP2	278	281	PF00017	0.349
LIG_SH2_SRC	173	176	PF00017	0.529
LIG_SH2_SRC	27	30	PF00017	0.577
LIG_SH2_STAT5	160	163	PF00017	0.596
LIG_SH2_STAT5	173	176	PF00017	0.570
LIG_SH2_STAT5	267	270	PF00017	0.420
LIG_SH2_STAT5	27	30	PF00017	0.577
LIG_SH2_STAT5	278	281	PF00017	0.301
LIG_SH3_3	451	457	PF00018	0.457
LIG_SH3_3	79	85	PF00018	0.671
LIG_SH3_4	181	188	PF00018	0.467
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.392
LIG_TRAF2_1	143	146	PF00917	0.535
LIG_TRAF2_1	414	417	PF00917	0.375
LIG_WRC_WIRS_1	304	309	PF05994	0.364
MOD_CK1_1	118	124	PF00069	0.667
MOD_CK1_1	132	138	PF00069	0.478
MOD_CK1_1	151	157	PF00069	0.581
MOD_CK1_1	183	189	PF00069	0.548
MOD_CK2_1	140	146	PF00069	0.631
MOD_CK2_1	277	283	PF00069	0.442
MOD_CK2_1	411	417	PF00069	0.408
MOD_Cter_Amidation	290	293	PF01082	0.297
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.419
MOD_GlcNHglycan	185	188	PF01048	0.494
MOD_GlcNHglycan	214	217	PF01048	0.417
MOD_GlcNHglycan	331	334	PF01048	0.446
MOD_GlcNHglycan	335	338	PF01048	0.395
MOD_GlcNHglycan	389	392	PF01048	0.351
MOD_GlcNHglycan	90	93	PF01048	0.673
MOD_GSK3_1	103	110	PF00069	0.649
MOD_GSK3_1	147	154	PF00069	0.507
MOD_GSK3_1	28	35	PF00069	0.433
MOD_GSK3_1	329	336	PF00069	0.448
MOD_GSK3_1	351	358	PF00069	0.526
MOD_GSK3_1	375	382	PF00069	0.458
MOD_GSK3_1	9	16	PF00069	0.698
MOD_GSK3_1	90	97	PF00069	0.723
MOD_N-GLC_1	397	402	PF02516	0.371
MOD_N-GLC_1	45	50	PF02516	0.582
MOD_N-GLC_1	80	85	PF02516	0.558
MOD_NEK2_1	156	161	PF00069	0.538
MOD_NEK2_1	296	301	PF00069	0.496
MOD_NEK2_1	303	308	PF00069	0.453
MOD_NEK2_1	379	384	PF00069	0.429
MOD_NEK2_1	88	93	PF00069	0.667
MOD_OFUCOSY	396	401	PF10250	0.518
MOD_PIKK_1	112	118	PF00454	0.621
MOD_PIKK_1	181	187	PF00454	0.563
MOD_PIKK_1	355	361	PF00454	0.556
MOD_PKA_2	411	417	PF00069	0.418
MOD_PKA_2	9	15	PF00069	0.583
MOD_Plk_1	112	118	PF00069	0.588
MOD_Plk_1	367	373	PF00069	0.336
MOD_Plk_1	375	381	PF00069	0.357
MOD_Plk_4	118	124	PF00069	0.572
MOD_Plk_4	156	162	PF00069	0.586
MOD_Plk_4	209	215	PF00069	0.601
MOD_Plk_4	277	283	PF00069	0.432
MOD_Plk_4	296	302	PF00069	0.427
MOD_Plk_4	39	45	PF00069	0.665
MOD_Plk_4	432	438	PF00069	0.583
MOD_ProDKin_1	103	109	PF00069	0.691
MOD_ProDKin_1	305	311	PF00069	0.507
MOD_ProDKin_1	349	355	PF00069	0.408
MOD_SUMO_rev_2	164	172	PF00179	0.601
MOD_SUMO_rev_2	53	62	PF00179	0.571
TRG_DiLeu_BaEn_1	260	265	PF01217	0.349
TRG_ENDOCYTIC_2	278	281	PF00928	0.472
TRG_ENDOCYTIC_2	301	304	PF00928	0.368
TRG_ENDOCYTIC_2	75	78	PF00928	0.545
TRG_ER_diArg_1	165	167	PF00400	0.493
TRG_ER_diArg_1	191	194	PF00400	0.410
TRG_ER_diArg_1	402	404	PF00400	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K5	Leptomonas seymouri	58%	100%
A0A0S4J8I1	Bodo saltans	39%	100%
A0A0S4J9L9	Bodo saltans	38%	100%
A0A1X0P6D5	Trypanosomatidae	46%	100%
A0A3R7KYH1	Trypanosoma rangeli	43%	100%
A4H9Z2	Leishmania braziliensis	82%	97%
A4HY56	Leishmania infantum	99%	100%
D0A0G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ARY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDI7	Leishmania major	92%	100%
V5C1T2	Trypanosoma cruzi	46%	100%