LeishMANIAdb
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Intraflagellar transport protein 52, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Intraflagellar transport protein 52, putative
Gene product:
intraflagellar transport protein 52
Species:
Leishmania donovani
UniProt:
A0A3S5H752_LEIDO
TriTrypDb:
LdBPK_190320.1 * , LdCL_190008200 , LDHU3_19.0370
Length:
673

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0031514 motile cilium 5 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:0005814 centriole 5 1
GO:0005815 microtubule organizing center 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0035869 ciliary transition zone 2 1
GO:0036064 ciliary basal body 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S5H752
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H752

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0010970 transport along microtubule 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0044782 cilium organization 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0099111 microtubule-based transport 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 631 635 PF00656 0.337
CLV_NRD_NRD_1 304 306 PF00675 0.416
CLV_NRD_NRD_1 39 41 PF00675 0.383
CLV_NRD_NRD_1 62 64 PF00675 0.475
CLV_PCSK_KEX2_1 304 306 PF00082 0.418
CLV_PCSK_SKI1_1 150 154 PF00082 0.483
CLV_PCSK_SKI1_1 179 183 PF00082 0.503
CLV_PCSK_SKI1_1 203 207 PF00082 0.655
CLV_PCSK_SKI1_1 384 388 PF00082 0.435
CLV_PCSK_SKI1_1 504 508 PF00082 0.391
CLV_PCSK_SKI1_1 664 668 PF00082 0.481
CLV_Separin_Metazoa 381 385 PF03568 0.446
DEG_APCC_DBOX_1 462 470 PF00400 0.491
DEG_APCC_DBOX_1 503 511 PF00400 0.385
DEG_APCC_DBOX_1 663 671 PF00400 0.488
DEG_SCF_FBW7_2 94 100 PF00400 0.454
DOC_ANK_TNKS_1 106 113 PF00023 0.423
DOC_CKS1_1 426 431 PF01111 0.522
DOC_CKS1_1 94 99 PF01111 0.446
DOC_CYCLIN_yCln2_LP_2 285 291 PF00134 0.331
DOC_CYCLIN_yCln2_LP_2 421 424 PF00134 0.474
DOC_MAPK_DCC_7 411 421 PF00069 0.578
DOC_MAPK_DCC_7 443 452 PF00069 0.503
DOC_MAPK_FxFP_2 258 261 PF00069 0.298
DOC_MAPK_gen_1 304 313 PF00069 0.348
DOC_MAPK_gen_1 63 73 PF00069 0.363
DOC_MAPK_MEF2A_6 443 452 PF00069 0.491
DOC_MAPK_RevD_3 505 519 PF00069 0.408
DOC_PP1_RVXF_1 38 45 PF00149 0.399
DOC_PP2B_LxvP_1 421 424 PF13499 0.474
DOC_PP4_FxxP_1 258 261 PF00568 0.298
DOC_PP4_FxxP_1 426 429 PF00568 0.493
DOC_PP4_FxxP_1 91 94 PF00568 0.393
DOC_USP7_UBL2_3 175 179 PF12436 0.424
DOC_USP7_UBL2_3 411 415 PF12436 0.430
DOC_WW_Pin1_4 185 190 PF00397 0.563
DOC_WW_Pin1_4 3 8 PF00397 0.649
DOC_WW_Pin1_4 425 430 PF00397 0.526
DOC_WW_Pin1_4 494 499 PF00397 0.483
DOC_WW_Pin1_4 566 571 PF00397 0.448
DOC_WW_Pin1_4 93 98 PF00397 0.517
LIG_14-3-3_CanoR_1 82 92 PF00244 0.528
LIG_Actin_WH2_2 636 654 PF00022 0.377
LIG_BIR_II_1 1 5 PF00653 0.596
LIG_BIR_III_2 567 571 PF00653 0.504
LIG_BRCT_BRCA1_1 189 193 PF00533 0.584
LIG_BRCT_BRCA1_1 254 258 PF00533 0.367
LIG_BRCT_BRCA1_1 276 280 PF00533 0.325
LIG_BRCT_BRCA1_1 333 337 PF00533 0.387
LIG_BRCT_BRCA1_1 599 603 PF00533 0.427
LIG_CaM_NSCaTE_8 626 633 PF13499 0.491
LIG_Clathr_ClatBox_1 389 393 PF01394 0.505
LIG_Clathr_ClatBox_1 452 456 PF01394 0.482
LIG_FHA_1 163 169 PF00498 0.442
LIG_FHA_1 18 24 PF00498 0.719
LIG_FHA_1 195 201 PF00498 0.676
LIG_FHA_1 205 211 PF00498 0.731
LIG_FHA_1 252 258 PF00498 0.384
LIG_FHA_1 263 269 PF00498 0.327
LIG_FHA_1 363 369 PF00498 0.494
LIG_FHA_1 397 403 PF00498 0.430
LIG_FHA_1 490 496 PF00498 0.435
LIG_FHA_1 68 74 PF00498 0.354
LIG_FHA_1 83 89 PF00498 0.316
LIG_FHA_2 132 138 PF00498 0.369
LIG_FHA_2 140 146 PF00498 0.351
LIG_FHA_2 567 573 PF00498 0.465
LIG_FHA_2 667 673 PF00498 0.547
LIG_GBD_Chelix_1 332 340 PF00786 0.453
LIG_LIR_Apic_2 14 19 PF02991 0.647
LIG_LIR_Apic_2 255 261 PF02991 0.326
LIG_LIR_Apic_2 425 429 PF02991 0.493
LIG_LIR_Gen_1 334 344 PF02991 0.333
LIG_LIR_Gen_1 357 366 PF02991 0.445
LIG_LIR_Gen_1 385 392 PF02991 0.435
LIG_LIR_Gen_1 407 416 PF02991 0.408
LIG_LIR_Nem_3 136 141 PF02991 0.369
LIG_LIR_Nem_3 277 283 PF02991 0.332
LIG_LIR_Nem_3 334 340 PF02991 0.415
LIG_LIR_Nem_3 357 362 PF02991 0.458
LIG_LIR_Nem_3 385 389 PF02991 0.427
LIG_LIR_Nem_3 407 412 PF02991 0.399
LIG_LIR_Nem_3 477 483 PF02991 0.395
LIG_LIR_Nem_3 508 514 PF02991 0.387
LIG_LIR_Nem_3 516 520 PF02991 0.435
LIG_LIR_Nem_3 55 61 PF02991 0.322
LIG_LIR_Nem_3 625 629 PF02991 0.380
LIG_PDZ_Class_3 668 673 PF00595 0.418
LIG_Pex14_2 319 323 PF04695 0.475
LIG_Pex14_2 386 390 PF04695 0.429
LIG_SH2_CRK 128 132 PF00017 0.388
LIG_SH2_CRK 409 413 PF00017 0.423
LIG_SH2_CRK 517 521 PF00017 0.486
LIG_SH2_GRB2like 130 133 PF00017 0.368
LIG_SH2_PTP2 640 643 PF00017 0.482
LIG_SH2_SRC 109 112 PF00017 0.396
LIG_SH2_SRC 156 159 PF00017 0.395
LIG_SH2_SRC 339 342 PF00017 0.456
LIG_SH2_SRC 580 583 PF00017 0.483
LIG_SH2_STAT3 481 484 PF00017 0.377
LIG_SH2_STAT5 109 112 PF00017 0.336
LIG_SH2_STAT5 130 133 PF00017 0.418
LIG_SH2_STAT5 156 159 PF00017 0.380
LIG_SH2_STAT5 339 342 PF00017 0.441
LIG_SH2_STAT5 481 484 PF00017 0.362
LIG_SH2_STAT5 509 512 PF00017 0.435
LIG_SH2_STAT5 580 583 PF00017 0.483
LIG_SH2_STAT5 640 643 PF00017 0.484
LIG_SH2_STAT5 668 671 PF00017 0.512
LIG_SH3_1 48 54 PF00018 0.359
LIG_SH3_2 429 434 PF14604 0.501
LIG_SH3_2 51 56 PF14604 0.371
LIG_SH3_3 1 7 PF00018 0.586
LIG_SH3_3 265 271 PF00018 0.369
LIG_SH3_3 426 432 PF00018 0.486
LIG_SH3_3 442 448 PF00018 0.486
LIG_SH3_3 48 54 PF00018 0.359
LIG_SH3_3 521 527 PF00018 0.479
LIG_SH3_3 86 92 PF00018 0.478
LIG_SUMO_SIM_anti_2 417 423 PF11976 0.461
LIG_SUMO_SIM_anti_2 99 107 PF11976 0.399
LIG_SUMO_SIM_par_1 115 122 PF11976 0.421
LIG_SUMO_SIM_par_1 309 315 PF11976 0.312
LIG_TRAF2_1 249 252 PF00917 0.658
LIG_TRAF2_1 526 529 PF00917 0.713
LIG_TRAF2_1 669 672 PF00917 0.502
LIG_TYR_ITIM 478 483 PF00017 0.524
LIG_TYR_ITIM 515 520 PF00017 0.461
LIG_TYR_ITIM 638 643 PF00017 0.479
LIG_UBA3_1 336 345 PF00899 0.330
LIG_UBA3_1 389 396 PF00899 0.480
LIG_WRC_WIRS_1 392 397 PF05994 0.450
MOD_CDC14_SPxK_1 6 9 PF00782 0.585
MOD_CDK_SPK_2 494 499 PF00069 0.483
MOD_CDK_SPxK_1 3 9 PF00069 0.589
MOD_CDK_SPxxK_3 494 501 PF00069 0.477
MOD_CK1_1 17 23 PF00069 0.507
MOD_CK1_1 188 194 PF00069 0.689
MOD_CK1_1 410 416 PF00069 0.492
MOD_CK1_1 467 473 PF00069 0.397
MOD_CK2_1 139 145 PF00069 0.346
MOD_CK2_1 364 370 PF00069 0.442
MOD_CK2_1 666 672 PF00069 0.533
MOD_Cter_Amidation 177 180 PF01082 0.421
MOD_Cter_Amidation 302 305 PF01082 0.476
MOD_GlcNHglycan 114 117 PF01048 0.344
MOD_GlcNHglycan 16 19 PF01048 0.646
MOD_GlcNHglycan 190 193 PF01048 0.706
MOD_GlcNHglycan 234 237 PF01048 0.664
MOD_GlcNHglycan 239 242 PF01048 0.652
MOD_GlcNHglycan 277 280 PF01048 0.344
MOD_GlcNHglycan 314 317 PF01048 0.322
MOD_GlcNHglycan 521 524 PF01048 0.629
MOD_GSK3_1 162 169 PF00069 0.438
MOD_GSK3_1 209 216 PF00069 0.564
MOD_GSK3_1 327 334 PF00069 0.469
MOD_GSK3_1 362 369 PF00069 0.479
MOD_GSK3_1 558 565 PF00069 0.612
MOD_N-GLC_1 131 136 PF02516 0.309
MOD_N-GLC_1 217 222 PF02516 0.565
MOD_N-GLC_1 328 333 PF02516 0.446
MOD_N-GLC_2 45 47 PF02516 0.375
MOD_N-GLC_2 471 473 PF02516 0.399
MOD_NEK2_1 217 222 PF00069 0.588
MOD_NEK2_1 232 237 PF00069 0.544
MOD_NEK2_1 275 280 PF00069 0.435
MOD_NEK2_1 489 494 PF00069 0.428
MOD_NEK2_1 597 602 PF00069 0.442
MOD_PIKK_1 34 40 PF00454 0.631
MOD_PIKK_1 384 390 PF00454 0.577
MOD_PIKK_1 464 470 PF00454 0.404
MOD_PKA_2 464 470 PF00069 0.395
MOD_PKA_2 558 564 PF00069 0.466
MOD_PKA_2 81 87 PF00069 0.559
MOD_Plk_1 101 107 PF00069 0.344
MOD_Plk_1 131 137 PF00069 0.334
MOD_Plk_1 217 223 PF00069 0.632
MOD_Plk_1 251 257 PF00069 0.549
MOD_Plk_1 327 333 PF00069 0.457
MOD_Plk_1 384 390 PF00069 0.540
MOD_Plk_1 598 604 PF00069 0.527
MOD_Plk_1 76 82 PF00069 0.409
MOD_Plk_2-3 364 370 PF00069 0.442
MOD_Plk_2-3 76 82 PF00069 0.409
MOD_Plk_4 101 107 PF00069 0.392
MOD_Plk_4 126 132 PF00069 0.491
MOD_Plk_4 210 216 PF00069 0.672
MOD_Plk_4 252 258 PF00069 0.386
MOD_Plk_4 331 337 PF00069 0.349
MOD_Plk_4 417 423 PF00069 0.473
MOD_ProDKin_1 185 191 PF00069 0.564
MOD_ProDKin_1 3 9 PF00069 0.651
MOD_ProDKin_1 425 431 PF00069 0.523
MOD_ProDKin_1 494 500 PF00069 0.479
MOD_ProDKin_1 566 572 PF00069 0.446
MOD_ProDKin_1 93 99 PF00069 0.518
MOD_SUMO_for_1 414 417 PF00179 0.421
MOD_SUMO_rev_2 338 344 PF00179 0.356
MOD_SUMO_rev_2 607 617 PF00179 0.569
TRG_DiLeu_BaEn_1 252 257 PF01217 0.524
TRG_DiLeu_BaEn_1 417 422 PF01217 0.459
TRG_DiLeu_BaEn_4 327 333 PF01217 0.339
TRG_DiLeu_BaLyEn_6 271 276 PF01217 0.462
TRG_ENDOCYTIC_2 128 131 PF00928 0.388
TRG_ENDOCYTIC_2 359 362 PF00928 0.464
TRG_ENDOCYTIC_2 409 412 PF00928 0.404
TRG_ENDOCYTIC_2 480 483 PF00928 0.512
TRG_ENDOCYTIC_2 517 520 PF00928 0.478
TRG_ENDOCYTIC_2 58 61 PF00928 0.404
TRG_ENDOCYTIC_2 640 643 PF00928 0.470
TRG_ER_diArg_1 371 374 PF00400 0.531
TRG_ER_diArg_1 463 466 PF00400 0.465
TRG_ER_diArg_1 498 501 PF00400 0.498
TRG_ER_diArg_1 8 11 PF00400 0.602
TRG_NES_CRM1_1 380 393 PF08389 0.566
TRG_Pf-PMV_PEXEL_1 504 508 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 63 67 PF00026 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDM4 Leptomonas seymouri 80% 99%
A0A0S4KG78 Bodo saltans 55% 100%
A0A1X0P7F0 Trypanosomatidae 66% 100%
A0A3R7NUY6 Trypanosoma rangeli 64% 100%
A4H9Z0 Leishmania braziliensis 86% 99%
A4HY54 Leishmania infantum 100% 100%
D0A0G1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9ARY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QDI9 Leishmania major 95% 100%
V5DTK4 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS